Gene Symbol: Ask1
Description: Apoptotic signal-regulating kinase 1
Alias: ASK1, CG4720, D-ASK, DASK, DASK1, DPk92B/ASK1, Dmel\CG4720, MEKK5/ASK1, Pk92B, dASK, dASK1, dAsk1, pk92B, apoptotic signal-regulating kinase 1, Ask1-PB, Ask1-PC, CG4720-PB, CG4720-PC, protein kinase at 92B
Species: fruit fly

Top Publications

  1. Kuranaga E, Kanuka H, Igaki T, Sawamoto K, Ichijo H, Okano H, et al. Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila. Nat Cell Biol. 2002;4:705-10 pubmed
    ..JNK signals rescues the Reaper-induced small eye phenotype, and overexpression of DTRAF1 activates the Drosophila ASK1 (apoptosis signal-regulating kinase 1; a mitogen-activated protein kinase kinase kinase) and JNK pathway, thereby ..
  2. Ryabinina O, Subbian E, Iordanov M. D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediate the activation of D-JNK by cadmium and arsenite in Schneider cells. BMC Cell Biol. 2006;7:7 pubmed
    ..D-MEKK1, the fly orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediates the activation of D-JNK by cadmium and arsenite. ..
  3. Chen W, White M, Cobb M. Stimulus-specific requirements for MAP3 kinases in activating the JNK pathway. J Biol Chem. 2002;277:49105-10 pubmed
    ..On the other hand, sorbitol requires expression of four MAP3Ks to cause maximal JNK activation. Thus, we demonstrate that specific stimuli use different mechanisms to recruit distinct MAP3Ks to regulate the JNK pathway. ..
  4. Takeda K, Komuro y, Hayakawa T, Oguchi H, Ishida Y, Murakami S, et al. Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1. Proc Natl Acad Sci U S A. 2009;106:12301-5 pubmed publisher
    ..anchored in the mitochondrial membrane lacks PGAM activity and instead associates with the MAP kinase kinase kinase ASK1 and acts as a specific protein Ser/Thr phosphatase that activates ASK1 by dephosphorylation of inhibitory sites...
  5. Miller J, Yates B, Al Ramahi I, Berman A, Sanhueza M, Kim E, et al. A genome-scale RNA-interference screen identifies RRAS signaling as a pathologic feature of Huntington's disease. PLoS Genet. 2012;8:e1003042 pubmed publisher
    ..These data suggest that pharmacological inhibition of RRAS signaling may confer therapeutic benefit in Huntington's disease. ..
  6. Wassarman D, Solomon N, Rubin G. Pk92B: a Drosophila melanogaster protein kinase that belongs to the MEKK family. Gene. 1996;169:283-4 pubmed
    ..The deduced protein, Pk92B, has a kinase domain that is 40-48% identical to MEKK family members...
  7. Zhuang Z, Zhou Y, Yu M, Silverman N, Ge B. Regulation of Drosophila p38 activation by specific MAP2 kinase and MAP3 kinase in response to different stimuli. Cell Signal. 2006;18:441-8 pubmed
    ..Stimulation of UV and PGN activates D-p38 through D-MEKK1, heat shock-induced activation of D-p38 signals through both D-MEKK1 and D-ASK1. On the other hand, maximal activation of D-p38 by NaCl requires the expression of four MAP3Ks.
  8. Neisch A, Speck O, Stronach B, Fehon R. Rho1 regulates apoptosis via activation of the JNK signaling pathway at the plasma membrane. J Cell Biol. 2010;189:311-23 pubmed publisher
    ..Together, these results suggest that Rho1 functions at the cell cortex to regulate JNK activity and implicate Rho1 and Moe in epithelial cell survival. ..
  9. Milton V, Jarrett H, Gowers K, Chalak S, Briggs L, Robinson I, et al. Oxidative stress induces overgrowth of the Drosophila neuromuscular junction. Proc Natl Acad Sci U S A. 2011;108:17521-6 pubmed publisher
    ..Our data describe a previously unexplored link between oxidative stress and synapse overgrowth via the JNK signaling pathway. ..

More Information


  1. Wong H, Shaukat Z, Wang J, Saint R, Gregory S. JNK signaling is needed to tolerate chromosomal instability. Cell Cycle. 2014;13:622-31 pubmed publisher
    ..Our findings suggest that chromosomal instability represents a significant stress to dividing cells, and that without JNK signaling, cells undergo apoptosis because they lack a timely and effective response to DNA damage. ..
  2. Mosallanejad K, Sekine Y, Ishikura Kinoshita S, Kumagai K, Nagano T, Matsuzawa A, et al. The DEAH-box RNA helicase DHX15 activates NF-?B and MAPK signaling downstream of MAVS during antiviral responses. Sci Signal. 2014;7:ra40 pubmed publisher
    ..Thus, our findings indicate that, in RIG-I-like receptor signaling, DHX15 specifically stimulates the NF-?B and MAPK pathways downstream of MAVS and contributes to MAVS-mediated cytokine production and apoptosis. ..
  3. Cha G, Kim S, Park J, Lee E, Kim M, Lee S, et al. Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila. Proc Natl Acad Sci U S A. 2005;102:10345-50 pubmed
  4. Owusu Ansah E, Yavari A, Mandal S, Banerjee U. Distinct mitochondrial retrograde signals control the G1-S cell cycle checkpoint. Nat Genet. 2008;40:356-61 pubmed publisher
    ..Thus, our results indicate that the mitochondrion can use AMP and ROS at sublethal concentrations as independent signaling molecules to modulate cell cycle progression. ..
  5. Sekine Y, Takagahara S, Hatanaka R, Watanabe T, Oguchi H, Noguchi T, et al. p38 MAPKs regulate the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors. J Cell Sci. 2011;124:3006-16 pubmed publisher
    ..Thus, p38-regulated gene induction through NR4As appears to function in the dopamine synthesis pathway and may be involved in immune and stress responses. ..
  6. Sekine Y, Hatanaka R, Watanabe T, Sono N, Iemura S, Natsume T, et al. The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5. Mol Cell. 2012;48:692-704 pubmed publisher
    Reactive oxygen species (ROS)-induced activation of Apoptosis signal-regulating kinase 1 (ASK1) plays crucial roles in oxidative stress-mediated cell death through the activation of the JNK and p38 MAPK pathways...
  7. Lesch C, Jo J, Wu Y, Fish G, Galko M. A targeted UAS-RNAi screen in Drosophila larvae identifies wound closure genes regulating distinct cellular processes. Genetics. 2010;186:943-57 pubmed publisher