Genomes and Genes
Gene Symbol: ase
Alias: AS-C T8, AS-C T8ase, AS-T8, ASC, Ase, CG3258, Dmel\CG3258, EG:165H7.2, T1a, as-T8, ascT8, bHLHc28, sc/T8, CG3258-PA, achaete-scute proneural gene, ase-PA
Species: fruit fly
- Cis-regulation of achaete and scute: shared enhancer-like elements drive their coexpression in proneural clusters of the imaginal discsJ L Gomez-Skarmeta
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
Genes Dev 9:1869-82. 1995..Our data indicate that coexpression is accomplished by activation of both ac and sc by the same set of position-specific enhancers...
- asense is a Drosophila neural precursor gene and is capable of initiating sense organ formationM Brand
Howard Huges Medical Institute, University of California, San Francisco, CA 94143 0724, USA
Development 119:1-17. 1993..Our studies therefore serve as a cautionary note for the inference of normal gene function based on the gain-of-function phenotype after ectopic expression...
- asense, a member of the Drosophila achaete-scute complex, is a proneural and neural differentiation geneM Dominguez
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, Spain
EMBO J 12:2049-60. 1993The asense (ase) gene of the achaete-scute complex (AS-C) is expressed in the precursors of all adult sensory organs (SOs), the sensory mother cells (SMCs) and in their immediate progeny...
- Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in DrosophilaP Heitzler
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Illkirch, Strasbourg, France
Development 122:161-71. 1996..Thus there is a regulatory loop between Notch and Delta that is under the transcriptional control of the E(spl)-C and AS-C genes...
- Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetryRoger Albertson
Institute of Molecular Biology, Institute of Neuroscience, Howard Hughes Medical Institute, University of Oregon 1254, Eugene, OR 97403, USA
Nat Cell Biol 5:166-70. 2003..We conclude that Dlg/Scrib/Lgl are important in regulating cortical polarity, cell size asymmetry and mitotic spindle asymmetry in Drosophila neuroblasts...
- Adherens junctions inhibit asymmetric division in the Drosophila epitheliumB Lu
Howard Hughes Medical Institute and Department of Physiology, University of California at San Francisco, 94143 0725, USA
Nature 409:522-5. 2001..Our results indicate that neuroepithelial cells have all the necessary components to execute asymmetric division, but that this pathway is normally overridden by the planar polarity cue provided by adherens junctions...
- Proneural gene self-stimulation in neural precursors: an essential mechanism for sense organ development that is regulated by Notch signalingJ Culi
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
Genes Dev 12:2036-47. 1998..These data suggest a mechanism for SMC committment...
- daughterless is essential for neuronal precursor differentiation but not for initiation of neuronal precursor formation in Drosophila embryoH Vaessin
Howard Hughes Medical Institute, University of California, San Francisco 94143, USA
Development 120:935-45. 1994..da is not required for the initial appearance of nascent neuronal precursors but is required for these cells to express multiple neuronal precursor genes and to produce the normal number of neurons...
- Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in DrosophilaR Nolo
Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA
Cell 102:349-62. 2000..Sens is then in turn required to further activate and maintain proneural gene expression. This feedback mechanism is essential for selective enhancement and maintenance of proneural gene expression in the SOPs...
- Molecular analysis of the asense gene, a member of the achaete-scute complex of Drosophila melanogaster, and its novel role in optic lobe developmentF Gonzalez
Centro de Biologia Molecular, Universidad Autonoma de Madrid, Canto Blanco, Spain
EMBO J 8:3553-62. 1989..It comprises 22 kb of DNA and contains two transcription units, only one of which, named asense (ase), seems involved in neurogenesis...
- cato encodes a basic helix-loop-helix transcription factor implicated in the correct differentiation of Drosophila sense organsS E Goulding
Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh, EH9 3JR, United Kingdom
Dev Biol 221:120-31. 2000..Moreover, in prospero mutants, in which axon and dendrite outgrowth is defective, cato is strongly derepressed in the developing CNS...
- Regulation of spindle orientation and neural stem cell fate in the Drosophila optic lobeBoris Egger
The Wellcome Trust Cancer Research UK Gurdon Institute and Department of Physiology, Development and Neuroscience, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
Neural Dev 2:1. 2007..In some tissues cell fate appears to dictate the type of cell division, whereas in other tissues it is thought that stochastic variation in spindle position dictates subsequent sibling cell fate...
- The pan-neural bHLH proteins DEADPAN and ASENSE regulate mitotic activity and cdk inhibitor dacapo expression in the Drosophila larval optic lobesK Wallace
Department of Molecular Genetics, The Ohio State University, Columbus, Ohio, USA
Genesis 26:77-85. 2000..Thus, regulation of mitotic activity during optic lobe development may, at least in part, involve deadpan and asense mediated regulation of the cyclin dependent kinase inhibitor gene dacapo. genesis 26:77-85, 2000...
- The specificity of proneural genes in determining Drosophila sense organ identityA P Jarman
Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh EH9 3JR, UK
Mech Dev 76:117-25. 1998....
- The regulation and function of the helix-loop-helix gene, asense, in Drosophila neural precursorsA P Jarman
Howard Hughes Medical Institute, University of California, San Francisco, CA 94143 0724, USA
Development 119:19-29. 1993..asense differs from the other AS-C members in its expression pattern, regulation, mutant phenotype and some DNA-binding properities...
- inscuteable, a neural precursor gene of Drosophila, encodes a candidate for a cytoskeleton adaptor proteinR Kraut
Institut fur Entwicklungsbiologie, Universitat zu Koln, Cologne, Germany
Dev Biol 174:65-81. 1996..The inscuteable mutant phenotype, together with these other observations, suggests a possible role for the protein in cytoskeleton organization...
- The development and evolution of bristle patterns in DipteraP Simpson
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 163, C U de Strasbourg, France u strasbg fr
Development 126:1349-64. 1999....
- Segment polarity and DV patterning gene expression reveals segmental organization of the Drosophila brainRolf Urbach
Institut fur Genetik, Universitat Mainz, D 55099 Mainz, Germany
Development 130:3607-20. 2003..The labral neuromere is confined to the posterior segmental compartment. Finally, similarities in the expression of DV patterning genes between the Drosophila and vertebrate brains are discussed...
- Patterning of the Drosophila nervous system: the achaete-scute gene complexS Campuzano
Centro de Biologia Molecular, CSIC, Madrid, Spain
Trends Genet 8:202-8. 1992..Neuroblasts or sensory organ mother cells are born within these clusters. Thus, the patterns of expression of the AS-C genes help to define the topology of the nervous system...
- The achaete-scute gene complex of Drosophila melanogaster comprises four homologous genesM C Alonso
MRC Laboratory of Molecular Biology, Cambridge, UK
EMBO J 7:2585-91. 1988..We discuss the possible biochemical function of the AS-C in neurogenesis in the light of the homologies of the four genes with the mammalian myc family...
- Mitotic activation of the kinase Aurora-A requires its binding partner BoraAndrea Hutterer
Institute of Molecular Biotechnology IMBA, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
Dev Cell 11:147-57. 2006..We propose a model in which activation of Cdc2 initiates the release of Bora into the cytoplasm where it can bind and activate Aurora-A...
- The proneural gene amos promotes multiple dendritic neuron formation in the Drosophila peripheral nervous systemM L Huang
Institute of Neuroscience, National Yang Ming University, Taipei, Taiwan
Neuron 25:57-67. 2000..Loss of amos function eliminates MD neurons that remain in ASC;atonal mutants. Misexpression of amos generates ectopic MD and other types of neurons...
- Expression of achaete-scute homologues in discrete proneural clusters on the developing notum of the medfly Ceratitis capitata, suggests a common origin for the stereotyped bristle patterns of higher DipteraC Wülbeck
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 163, CU de Strasbourg, France
Development 127:1411-20. 2000..Some aspects of the transcriptional regulation have changed, however, and correlate in the notum with differences in the bristle pattern. The Ceratitis pannier gene was isolated and displays a conserved expression domain in the notum...
- Drosophila optic lobe neuroblasts triggered by a wave of proneural gene expression that is negatively regulated by JAK/STATTetsuo Yasugi
Laboratory of Pattern Formation, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 0032, Japan
Development 135:1471-80. 2008....
- Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblastsM Schober
Research Institute of Molecular Pathology, Vienna, Austria
Nature 402:548-51. 1999..Our results suggest that direct binding to Bazooka mediates the asymmetric localization of Inscuteable and connects the asymmetric division of neuroblasts to the axis of epithelial apical-basal polarity...
- Snail-type zinc finger proteins prevent neurogenesis in Scutoid and transgenic animals of DrosophilaN Fuse
National Institute of Genetics, 1111 Yata, Mishima, Shizuoka ken 411 8540, Japan
Dev Genes Evol 209:573-80. 1999..Thus, our results suggest that the Scutoid phenotype is due to an ectopic snail expression under the control of no-oceli enhancer, antagonizing neurogenesis through its inhibitory interaction with bHLH proteins...
- Antagonism of EGFR and notch signalling in the reiterative recruitment of Drosophila adult chordotonal sense organ precursorsP zur Lage
Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh, EH9 3JR, UK
Development 126:3149-57. 1999..SOP recruitment is reiterative because the inductive signal comes from previously recruited SOPs...
- Redundant mechanisms mediate bristle patterning on the Drosophila thoraxKazuya Usui
Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
Proc Natl Acad Sci U S A 105:20112-7. 2008..However, ubiquitous expression of sc or asense (ase) achieved with a heterologous promoter, in the absence of endogenous ac-sc expression, and the activity of the cis-..
- The Enhancer of split and Achaete-Scute complexes of Drosophilids derived from simple ur-complexes preserved in mosquito and honeybeeRebekka Schlatter
Universitat Hohenheim, Institut fur Genetik, Garbenstr 30, 70599 Stuttgart, Germany
BMC Evol Biol 5:67. 2005..The question arose how these complexes evolved with regard to gene number in the evolution of insects concentrating on Diptera and the Hymenoptera Apis mellifera...
- Ric-8 controls Drosophila neural progenitor asymmetric division by regulating heterotrimeric G proteinsHongyan Wang
Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore, Singapore 117604
Nat Cell Biol 7:1091-8. 2005..In addition, Gbetagamma acts to restrict Galphai (and GoLoco proteins) to the apical cortex, where Galphai (and Pins) can mediate asymmetric spindle geometry...
- An endogenous Su(Hw) insulator separates the yellow gene from the Achaete-scute gene complex in DrosophilaAnton Golovnin
Department of the Control of Genetic Processes, Institute of Gene Biology, Russian Academy of Sciences, Moscow 117334, Russia
Development 130:3249-58. 2003..Genetic analysis shows that at least two proteins, Suppressor of Hairy wing and Modifier of MDG4, required for the activity of this insulator, are involved in the transcriptional regulation of Achaete-scute...
- Heterotrimeric G proteins regulate daughter cell size asymmetry in Drosophila neuroblast divisionsNaoyuki Fuse
Laboratory for Cell Asymmetry, Center for Developmental Biology, RIKEN, Chuou ku, Kobe 650 0047, Japan
Curr Biol 13:947-54. 2003..Furthermore, the multiple equal cleavages of G beta mutant neuroblasts accompany neural defects; this finding suggests indispensable roles of eccentric division in assuring the stem cell properties of neuroblasts...
- dMec: a novel Mi-2 chromatin remodelling complex involved in transcriptional repressionNatascha Kunert
Institut fur Molekularbiologie und Tumorforschung, Universitat Marburg, Marburg, Germany
EMBO J 28:533-44. 2009..However, despite lacking a histone deacetylase subunit, only dMec contributes to the repression of proneural genes. These results reveal an unexpected complexity in the composition and function of Mi-2 complexes...
- Variability on the dot chromosome in the Drosophila simulans cladeMohamed A F Noor
Department of Biological Sciences, Life Sciences Bldg, Louisiana State University, Baton Rouge, LA 70803, USA
Genetica 118:51-8. 2003..Overall, none of the data analyzed were consistent with recent introgression exclusively between D. simulans and D. mauritiana...
- phyllopod is a target gene of proneural proteins in Drosophila external sensory organ developmentHaiwei Pi
Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan
Proc Natl Acad Sci U S A 101:8378-83. 2004..Our results provide the first example that bHLH proneural proteins promote neurogenesis through regulation of protein degradation...
- Gene duplication at the achaete-scute complex and morphological complexity of the peripheral nervous system in DipteraNick Skaer
Dept of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
Trends Genet 18:399-405. 2002..This probably coincided in time with gene duplication events, raising the possibility that an increase in gene copy number might have provided the flexibility necessary for more complex transcriptional regulation...
- Drosophila Aurora-A is required for centrosome maturation and actin-dependent asymmetric protein localization during mitosisDaniela Berdnik
Research Institute of Molecular Pathology I M P, Dr Bohr Gasse 7, A 1030, Vienna, Austria
Curr Biol 12:640-7. 2002..What triggers the asymmetric localization of Numb at the onset of mitosis is unclear...
- Precocious expression of the Glide/Gcm glial-promoting factor in Drosophila induces neurogenesisVeronique Van de Bor
Institut de Génétique et Biologie Moléculaire et Cellulaire IGBMC CNRS ULP INSERM BP 163 67404 Illkirch, C U de Strasbourg, France
Genetics 160:1095-106. 2002..These findings also emphasize the requirement for both spatial and temporal glide/gcm regulation to achieve proper cell specification within the nervous system...
- neuralized Encodes a peripheral membrane protein involved in delta signaling and endocytosisE Pavlopoulos
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Crete, Greece
Dev Cell 1:807-16. 2001..The potent modulatory effect of Neur on Dl activity makes Neur a candidate for establishing signaling asymmetries within cellular equivalence groups...
- Heterotrimeric G proteins direct two modes of asymmetric cell division in the Drosophila nervous systemM Schaefer
Research Institute of Molecular Pathology I M P, Dr Bohr Gasse 7, 1030 Vienna, Austria
Cell 107:183-94. 2001..Thus, asymmetric activation of heterotrimeric G proteins by a receptor-independent mechanism may orient asymmetric cell divisions in different cell types...
- Krüppel acts as a developmental switch gene that mediates Notch signalling-dependent tip cell differentiation in the excretory organs of DrosophilaM Hoch
Max Planck Institut fur biophysikalische Chemie, Abt Molekulare Entwicklungsbiologie, D 37077 Gottingen, Germany
EMBO J 17:5766-75. 1998....
- Asymmetry and cell fate in the Drosophila embryonic CNSS Fuerstenberg
Department of Cell and Structural Biology, University of Illinois, Urbana 61821, USA
Int J Dev Biol 42:379-83. 1998....
- Persistent expression of genes of the enhancer of split complex suppresses neural development in DrosophilaK Nakao
Institut für Entwicklungsbiologie Universität zu Köln, Germany
Neuron 16:275-86. 1996..These findings indicate that proneural and E(spl) proteins exert antagonistic functions...
- Molecular genetics of the achaete-scute gene complex of D. melanogasterS Campuzano
Cell 40:327-38. 1985..Two additional polyadenylated RNAs are transcribed from the achaete (1.1 kb) and yellow (1.9 kb) loci...
- The generation of cell diversity during early neurogenesis in DrosophilaC V Cabrera
Marie Curie Research Institute, Oxted, UK
Development 115:893-901. 1992
- Polychaetoid is required to restrict segregation of sensory organ precursors from proneural clusters in DrosophilaC M Chen
Emory University, Department of Biology, Atlanta, GA 30322, USA
Mech Dev 57:215-27. 1996..Synergistic interactions between pyd and Notch, Delta and extramacrochaetae mutations support this model. We also demonstrate that pyd is required for normal eye development...
- Early neurogenesis of the Drosophila brainA Younossi-Hartenstein
Department of Cellular Molecular and Developmental Biology, University of California Los Angeles 90024, USA
J Comp Neurol 370:313-29. 1996..With respect to their position and the expression of the markers asense (ase) and seven-up (svp), 23 small groups of one to five neuroblasts each were identified...
- Proneural genes influence gliogenesis in DrosophilaA Giangrande
Institut de Genetique et de Biologie Molecularie et Cellulaire, CNRS UPR6520 INSERM U 184 ULP, Illkirch, CU de Strasbourg, France
Development 121:429-38. 1995..These observations lead to the hypothesis that gliogenesis is induced by the presence of sensory organ cells, either the precursor or its progeny...
- Embryonic development of the stomatogastric nervous system in DrosophilaV Hartenstein
Department of Biology, University of California at Los Angeles 90024
J Comp Neurol 350:367-81. 1994..Both recurrent nerve and frontal connectives are pioneered by small subpopulations of early differentiating stomatogastric neurons that most likely derive from among the dSNSPs and iSNSPs...
- Neuronal cell fate specification in DrosophilaY N Jan
Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California, San Francisco 94143 0724
Curr Opin Neurobiol 4:8-13. 1994..Selective expression of certain neuronal-type selector genes further specifies the type of neuron(s) that a neural precursor will produce...
- The nuclear protein encoded by the Drosophila neurogenic gene mastermind is widely expressed and associates with specific chromosomal regionsD Bettler
Department of Biology, Emory University, Atlanta, Georgia 30322, USA
Genetics 143:859-75. 1996..Immunohistochemical detection of Mam on polytene chromosomes revealed binding at > 100 sites. Chromosome colocalization studies with RNA polymerase and the groucho corepressor protein implicate Mam in transcriptional regulation...
- Drosophila Notch receptor activity suppresses Hairless function during adult external sensory organ developmentD F Lyman
Department of Biology, Emory University, Atlanta, Georgia 30322, USA dlyman biology emory edu
Genetics 141:1491-505. 1995..The results suggest that H insulates SOP cells from inhibition and indicate that H activity is suppressed by Notch signaling...
- Two-step induction of chordotonal organ precursors in Drosophila embryogenesisM Okabe
Department of Molecular Neurobiology, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan
Development 124:1045-53. 1997..Three of these argos-expressing cells differentiate into the three remaining COPs and they prevent neighboring cells from becoming extra COPs...
- Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesisW Zhong
Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco, 94143, USA
Development 124:1887-97. 1997....
- The Drosophila segmentation gene runt acts as a position-specific numerator element necessary for the uniform expression of the sex-determining gene Sex-lethalJ B Duffy
Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
Genes Dev 5:2176-87. 1991..runt is distinguished from previously identified regulators of Sxl by its nonuniform role and by the absence of an identifiable helix-loop-helix (HLH) motif, indicating that the activation of Sxl is not controlled solely by HLH proteins...
- Control of neural precursor specification by proneural proteins in the CNS of DrosophilaC Parras
Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma, Madrid, Spain
EMBO J 15:6394-9. 1996....
- The function of hairy-related bHLH repressor proteins in cell fate decisionsA Fisher
Department of Cell Biology and Anatomy, Cornell University Medical College, New York, New York, USA
Bioessays 20:298-306. 1998..This general function in cell fate specification has been conserved from Drosophila to vertebrates and has implications for human disease pathogenesis...
- Asymmetric cell divisionY N Jan
Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco, 94143 0725, USA
Nature 392:775-8. 1998....
- A network of interacting transcriptional regulators involved in Drosophila neural fate specification revealed by the yeast two-hybrid systemP Alifragis
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Hellas, and Department of Biology, University of Crete, Heraklion, Greece
Proc Natl Acad Sci U S A 94:13099-104. 1997..We investigated the structural requirements for some of these interactions by site-specific and deletion mutagenesis...
- Role of helix-loop-helix proteins in Drosophila neurogenesisH Vaessin
Howard Hughes Medical Institute, University of California, San Francisco 94143
Cold Spring Harb Symp Quant Biol 55:239-45. 1990
- The Drosophila neurogenic gene big brain, which encodes a membrane-associated protein, acts cell autonomously and can act synergistically with Notch and DeltaD Doherty
Howard Hughes Medical Institute and the Department of Biochemistry, University of California, San Francisco 94143 0724, USA
Development 124:3881-93. 1997..These results are consistent with bib acting as a channel protein in proneural cluster cells that adopt the epidermal cell fate, and serving a necessary function in the response of these cells to the lateral inhibition signal...
- Nucleotide compositional constraints on genomes generate alanine-, glycine-, and proline-rich structures in transcription factorsY Nakachi
Department of Biological Sciences, Graduate School of Science, University of Tokyo, Japan
Mol Biol Evol 14:1042-9. 1997..Furthermore, reptile class III POU sequences revealed no evolutionary directionality increasing the GC contents from cold- to warm-blooded vertebrates...
- Two rat homologues of Drosophila achaete-scute specifically expressed in neuronal precursorsJ E Johnson
Division of Biology 216 76, California Institute of Technology, Pasadena 91125
Nature 346:858-61. 1990..At least one of these genes is transiently expressed in the embryonic rat nervous system, is not detected in non-neuronal tissues or cell lines, and is induced by nerve growth factor in PC12 cells...
- Specialized hepatocyte-like cells regulate Drosophila lipid metabolismEugenio Gutierrez
Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Nature 445:275-80. 2007..These findings provide evidence that some lipid-processing functions of the mammalian liver are performed in insects by oenocytes...
- Molecular markers for identified neuroblasts in the developing brain of DrosophilaRolf Urbach
Institut fur Genetik, Universitat Mainz, D 55099 Mainz, Germany
Development 130:3621-37. 2003....
- The basic-helix-loop-helix domain of Drosophila lethal of scute protein is sufficient for proneural function and activates neurogenic genesU Hinz
Institut fur Entwicklungsbiologie, Universitat zu Koln, Federal Republic of Germany
Cell 76:77-87. 1994..Finally, the bHLH domain is necessary and sufficient to mediate the proneural function, to activate neurogenic genes, and to allow lateral inhibition...
- Proneural and neurogenic genes control specification and Morphogenesis of stomatogastric nerve cell precursors in DrosophilaV Hartenstein
Department of Biology, University of California, Los Angeles 90095 1606, USA
Dev Biol 173:213-27. 1996....
- Loss of notum macrochaetae as an interspecific hybrid anomaly between Drosophila melanogaster and D. simulansT S Takano
Department of Population Genetics, National Institute of Genetics, Mishima, Shizuoka ken 411, Japan
Genetics 149:1435-50. 1998..Use of cell type markers suggests that the defect does not lie in cell fate decisions during bristle development, but in the maintenance of neural fate and/or differentiation of the descendants of sensory mother cells...
- Evolution of bHLH transcription factors: modular evolution by domain shuffling?B Morgenstern
GSF, National Research Center for Environment and Health, Institute of Biomathematics and Biometry, Neuherberg, Germany
Mol Biol Evol 16:1654-63. 1999..Drawing on several lines of evidence, we suggest that modular evolution by domain shuffling may have played an important role in the evolution of this large group of transcriptional regulators...
- tap, a Drosophila bHLH gene expressed in chemosensory organsP Gautier
Laboratoire de Neurobiologie, Universite Libre de Bruxelles, Rhode Saint Genese, Belgium
Gene 191:15-21. 1997..Sequence comparisons suggest that tap is most closely related to two bHLH genes identified in several vertebrate species, neurogenin and neuroD, which are involved respectively in neural determination and in neuronal differentiation...
- Biparous: a novel bHLH gene expressed in neuronal and glial precursors in DrosophilaA Bush
Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
Dev Biol 180:759-72. 1996..The bHLH domain is sufficiently different from previously described bHLH domains to imply a novel function...
- Tramtrack controls glial number and identity in the Drosophila embryonic CNSP Badenhorst
MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
Development 128:4093-101. 2001..I propose that Tramtrack ensures stable mature glial identity by both repressing neuroblast-specific genes and controlling glial cell proliferation...
- Population genetics of silent and replacement variation in Drosophila simulans and D. melanogaster: X/autosome differences?D J Begun
Mol Biol Evol 13:1405-7. 1996
- The genetics of the Drosophila achaete-scute gene complex: a historical appraisalJ A Campos-Ortega
Institut fur Entwicklungsbiologie, Universitat zu Koln, Germany
Int J Dev Biol 42:291-7. 1998..Due to their intricate organization, these genes have occupied geneticists and developmental biologists for many years. Here, genetic studies on the complex are discussed from a historical point of view...
- Regulatory interactions during early neurogenesis in DrosophilaB Hassan
Molecular, Cellular and Developmental Biology Program, Ohio State University, Columbus 43210, USA
Dev Genet 18:18-27. 1996..While lineage identity genes allow the various lineages to acquire specific identities, neuronal precursor genes presumably regulate functional and developmental characteristics common to all neuronal precursor cells...
- Invertebrate versus vertebrate neurogenesis: variations on the same theme?A Salzberg
Department of Molecular and Human Genetics, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas
Dev Genet 18:1-10. 1996
- Distinct roles of Galphai and Gbeta13F subunits of the heterotrimeric G protein complex in the mediation of Drosophila neuroblast asymmetric divisionsFengwei Yu
MRC Centre for Developmental Neurobiology, 4th Fl, New Hunts House, Guy s Campus, King s College London, London SE1 1UL, UK
J Cell Biol 162:623-33. 2003..Importantly, our results have also revealed a novel aspect of apical complex function, that is, the two apical pathways act redundantly to suppress the formation of basal astral microtubules in neuroblasts...
- Endocytic Control of Notch-Mediated Cell Fate Decisions in NeurogenesisFABRICE J ROEGIERS; Fiscal Year: 2010....