Gene Symbol: Arpc4
Description: Actin-related protein 2/3 complex, subunit 4
Alias: ARPC4, Arc-p20, Arp-p20, BcDNA:RE43724, CG5972, Dmel\CG5972, P-20 ARC, anon-EST:Posey49, arc-p20, l(2)SH1036, l(2)SH2 1036, p20, p20Arc, Actin-related protein 2/3 complex, subunit 4, Arc-p20, Arp2/3 complex (p20 subunit), Arp2/3 subunit p20, Arpc4-PA, CG5972-PA, lethal (2) SH1036, p20 of Arp2/3 complex, p20 subunit of Arp2/3
Species: fruit fly
Elwell C, Ceesay A, Kim J, Kalman D, Engel J. RNA interference screen identifies Abl kinase and PDGFR signaling in Chlamydia trachomatis entry. PLoS Pathog. 2008;4:e1000021 pubmed publisher
..Together, our results demonstrate that PDGFRbeta and Abl kinases function redundantly to promote efficient uptake of this obligate intracellular parasite. ..
Gohl C, Banovic D, Grevelhörster A, Bogdan S. WAVE forms hetero- and homo-oligomeric complexes at integrin junctions in Drosophila visualized by bimolecular fluorescence complementation. J Biol Chem. 2010;285:40171-9 pubmed publisher
..RNAi mediated suppression of single components of the WAVE and the Arp2/3 complex in the wing further suggests that WAVE-dependent Arp2/3-mediated actin nucleation is important for the maintenance of stable integrin junctions. ..
Reed S, Serio A, Welch M. Rickettsia parkeri invasion of diverse host cells involves an Arp2/3 complex, WAVE complex and Rho-family GTPase-dependent pathway. Cell Microbiol. 2012;14:529-45 pubmed publisher
..Our results reveal a key role for the WAVE and Arp2/3 complexes, as well as a higher degree of variation than previously appreciated in actin nucleation pathways activated during Rickettsia invasion...
Cai L, Makhov A, Bear J. F-actin binding is essential for coronin 1B function in vivo. J Cell Sci. 2007;120:1779-90 pubmed
..Furthermore, our analysis indicates that F-actin binding is absolutely required for coronin 1B to exert its effects on whole-cell motility and lamellipodial dynamics. ..
Pöyhönen M, de Vanssay A, Delmarre V, Hermant C, Todeschini A, Teysset L, et al
. Homology-dependent silencing by an exogenous sequence in the Drosophila germline. G3 (Bethesda). 2012;2:331-8 pubmed publisher
..This functionally supports the hypothesis that TSE represents a general repression mechanism which can be co-opted by new transposable elements to regulate their activity after a transfer to the D. melanogaster genome. ..
Hudson A, Cooley L. A subset of dynamic actin rearrangements in Drosophila requires the Arp2/3 complex. J Cell Biol. 2002;156:677-87 pubmed
..The requirement for Arp2/3 in ring canals indicates that the polymerization of actin filaments at the ring canal plasma membrane is important for driving ring canal growth. ..
Kunda P, Craig G, Dominguez V, Baum B. Abi, Sra1, and Kette control the stability and localization of SCAR/WAVE to regulate the formation of actin-based protrusions. Curr Biol. 2003;13:1867-75 pubmed
..By controlling the stability, localization, and function of SCAR, these proteins may help to ensure that Arp2/3 activation and the generation of actin-based protrusions remain strictly dependant on local GTPase signaling. ..
Beltzner C, Pollard T. Identification of functionally important residues of Arp2/3 complex by analysis of homology models from diverse species. J Mol Biol. 2004;336:551-65 pubmed
..Other conserved residues were used with experimental constraints to propose how residues on the subunits ARPC1, ARPC2, ARPC4 and ARPC5 might interact with the mother filament at branch junctions.