Gene Symbol: Arf79F
Description: ADP ribosylation factor at 79F
Alias: ARF-1, ARF1, ARF1_DROME, Arf, Arf1, Arf79f, CG8385, Darf1, Dm Arf79F, Dmel\CG8385, P61209, arf1, d-Arf1, dARF79F, dARFI, dArf1, ADP ribosylation factor at 79F, ADP ribosylation factor 79F, ADP-ribosylation factor 1, Arf79F-PA, Arf79F-PB, Arf79F-PC, Arf79F-PE, Arf79F-PF, Arf79F-PH, Arf79F-PI, Arf79F-PJ, CG8385-PA, CG8385-PB, CG8385-PC, CG8385-PE, CG8385-PF, CG8385-PH, CG8385-PI, CG8385-PJ
Species: fruit fly

Top Publications

  1. Lee F, Stevens L, Hall L, Murtagh J, Kao Y, Moss J, et al. Characterization of class II and class III ADP-ribosylation factor genes and proteins in Drosophila melanogaster. J Biol Chem. 1994;269:21555-60 pubmed
    ..phylogenetic analysis, amino acid identity, and gene structure, mammalian ARFs fall into three classes (class I, ARF1, -2, and -3; class II, ARF4 and -5; class III, ARF6). A class I ARF had been identified in Drosophila melanogaster...
  2. Pasqualato S, Renault L, Cherfils J. Arf, Arl, Arp and Sar proteins: a family of GTP-binding proteins with a structural device for 'front-back' communication. EMBO Rep. 2002;3:1035-41 pubmed
    b>Arf proteins are important regulators of cellular traffic and the founding members of an expanding family of homologous proteins and genomic sequences...
  3. Chen E, Pryce B, Tzeng J, Gonzalez G, Olson E. Control of myoblast fusion by a guanine nucleotide exchange factor, loner, and its effector ARF6. Cell. 2003;114:751-62 pubmed
    ..In muscle cells, this fusigenic mechanism is coupled to fusion receptors; in other fusion-competent cell types it may be triggered by different upstream signals. ..
  4. Dottermusch Heidel C, Groth V, Beck L, Onel S. The Arf-GEF Schizo/Loner regulates N-cadherin to induce fusion competence of Drosophila myoblasts. Dev Biol. 2012;368:18-27 pubmed publisher
    ..Based on our findings, we propose a model where N-cadherin must be removed from the myoblast membrane to induce a protein-free zone at the cell-cell contact point to permit fusion. ..
  5. Stoltzfus A, Logsdon J, Palmer J, Doolittle W. Intron "sliding" and the diversity of intron positions. Proc Natl Acad Sci U S A. 1997;94:10739-44 pubmed
    ..The results suggest that sliding, if it occurs at all, has contributed little to the diversity of intron positions. ..
  6. Gupta G, Swetha M, Kumari S, Lakshminarayan R, Dey G, Mayor S. Analysis of endocytic pathways in Drosophila cells reveals a conserved role for GBF1 in internalization via GEECs. PLoS ONE. 2009;4:e6768 pubmed publisher
    ..proteins (GPI-APs) forms GEECs (GPI-AP enriched early endosomal compartments) via an Arf1- and Cdc42-mediated, dynamin independent mechanism...
  7. Kametaka S, Sawada N, Bonifacino J, Waguri S. Functional characterization of protein-sorting machineries at the trans-Golgi network in Drosophila melanogaster. J Cell Sci. 2010;123:460-71 pubmed publisher
    ..dGGA itself is recruited from the cytosol to the TGN in an ARF1 small GTPase (dARF79F)-dependent manner...
  8. Armbruster K, Luschnig S. The Drosophila Sec7 domain guanine nucleotide exchange factor protein Gartenzwerg localizes at the cis-Golgi and is essential for epithelial tube expansion. J Cell Sci. 2012;125:1318-28 pubmed publisher
    ..We show that garz interacts genetically with the ARF1 homolog ARF79F and with the ARF1-GAP homolog Gap69C, thus placing garz in a regulatory circuit that controls COPI trafficking in ..
  9. Rodrigues F, Shao W, Harris T. The Arf GAP Asap promotes Arf1 function at the Golgi for cleavage furrow biosynthesis in Drosophila. Mol Biol Cell. 2016;27:3143-3155 pubmed
    ..The highly conserved small G protein Arf1 organizes Golgi trafficking...

More Information


  1. Wilfling F, Thiam A, Olarte M, Wang J, Beck R, Gould T, et al. Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting. elife. 2014;3:e01607 pubmed publisher
    ..The Arf1/COPI protein machinery, known for its role in vesicle trafficking, regulates LD morphology, targeting of specific ..
  2. Kametaka S, Kametaka A, Yonekura S, Haruta M, Takenoshita S, Goto S, et al. AP-1 clathrin adaptor and CG8538/Aftiphilin are involved in Notch signaling during eye development in Drosophila melanogaster. J Cell Sci. 2012;125:634-48 pubmed publisher
    ..These results suggest that AP-1 and Aftiphilin are cooperatively involved in the intracellular trafficking of Notch during eye development in Drosophila. ..
  3. Wang Y, Zhang H, Shi M, Liou Y, Lu L, Yu F. Sec71 functions as a GEF for the small GTPase Arf1 to govern dendrite pruning of Drosophila sensory neurons. Development. 2017;144:1851-1862 pubmed publisher
    ..Here, we show that the small GTPase Arf1, an important regulator of the secretory pathway, is specifically required for dendrite pruning of ddaC/D/E sensory ..
  4. Lee H, Peng Y, Guo Y. Analysis of lipid droplet dynamics and functions in Drosophila melanogaster. Methods Cell Biol. 2013;116:53-69 pubmed publisher
  5. Lee D, Rodrigues F, Yu C, Swan M, Harris T. PH Domain-Arf G Protein Interactions Localize the Arf-GEF Steppke for Cleavage Furrow Regulation in Drosophila. PLoS ONE. 2015;10:e0142562 pubmed publisher
    ..By analyzing GFP-tagged Arf and Arf-like small G proteins, we found that Arf1-GFP, Arf6-GFP and Arl4-GFP, but not Arf4-GFP, localized to furrows...
  6. Southon A, Greenough M, Hung Y, Norgate M, Burke R, Camakaris J. The ADP-ribosylation factor 1 (Arf1) is involved in regulating copper uptake. Int J Biochem Cell Biol. 2011;43:146-53 pubmed publisher
    ..Arf1 therefore affected copper levels independently of ATP7A mediated copper efflux. Knockdown of Arf79F, the Drosophila melanogasterArf1 orthologue, also reduced copper accumulation in cultured Drosophila S2 cells, ..
  7. Shao W, Wu J, Chen J, Lee D, Tishkina A, Harris T. A modifier screen for Bazooka/PAR-3 interacting genes in the Drosophila embryo epithelium. PLoS ONE. 2010;5:e9938 pubmed publisher
    ..We found that GFP fusion proteins for Drosophila ASAP, Arf79F, CG11210, Septin 5 and Sds22 could be recruited to the apical circumference of epithelial cells...
  8. Jekely G. Small GTPases and the evolution of the eukaryotic cell. Bioessays. 2003;25:1129-38 pubmed
    ..Based on the reconstruction of putative roles for ancestral small GTPases, a hypothetical scenario on the origins of the first endomembranes, the nucleus, and phagocytosis is presented. ..
  9. Renalier M, Nicoloso M, Qu L, Bachellerie J. SnoRNA U21 is also intron-encoded in Drosophila melanogaster but in a different host-gene as compared to warm-blooded vertebrates. FEBS Lett. 1996;379:212-6 pubmed
    ..In D. melanogaster, U21 is encoded within the ARF-1 (ADP ribosylation factor 1) gene, whereas in chicken and mammals it is found in the ribosomal protein L5 gene. In D...
  10. Murtagh J, Lee F, Deak P, Hall L, Monaco L, Lee C, et al. Molecular characterization of a conserved, guanine nucleotide-dependent ADP-ribosylation factor in Drosophila melanogaster. Biochemistry. 1993;32:6011-8 pubmed
    ..We cloned the Drosophila ARF 1 gene without library screening by a combination of 5 polymerase chain reactions (PCRs), yielding a 546-base open ..
  11. Humphreys D, Liu T, Davidson A, Hume P, Koronakis V. The Drosophila Arf1 homologue Arf79F is essential for lamellipodium formation. J Cell Sci. 2012;125:5630-5 pubmed publisher
    ..Here, we demonstrate that the Class 1 Arf1 homologue Arf79F colocalises with the WRC at dynamic lamellipodia...
  12. Asensio C, Sirkis D, Edwards R. RNAi screen identifies a role for adaptor protein AP-3 in sorting to the regulated secretory pathway. J Cell Biol. 2010;191:1173-87 pubmed publisher
    ..Although vesicles with a dense core still form in the absence of AP-3, they contain substantially less synaptotagmin 1, indicating that AP-3 concentrates the proteins required for regulated exocytosis. ..
  13. Khadilkar R, Rodrigues D, Mote R, Sinha A, Kulkarni V, Magadi S, et al. ARF1-GTP regulates Asrij to provide endocytic control of Drosophila blood cell homeostasis. Proc Natl Acad Sci U S A. 2014;111:4898-903 pubmed publisher
    ..Here we show that Asrij function is mediated by the Ras family GTPase Arf79F, the Drosophila homolog of ADP ribosylation factor 1 (ARF1), essential for clathrin coat assembly, Golgi architecture, and vesicular trafficking...
  14. Kitazawa D, Yamaguchi M, Mori H, Inoue Y. COPI-mediated membrane trafficking is required for cytokinesis in Drosophila male meiotic divisions. J Cell Sci. 2012;125:3649-60 pubmed
    ..Using testis-specific knockdown of COPI subunits or the small GTPase Arf or mutations of the ?COP gene, we examined the role of COPI in male meiosis...
  15. Christis C, Munro S. The small G protein Arl1 directs the trans-Golgi-specific targeting of the Arf1 exchange factors BIG1 and BIG2. J Cell Biol. 2012;196:327-35 pubmed publisher
    ..We validate this with the Drosophila melanogaster Arf1 orthologue (Arf79F) and the related class II Arf (Arf102F), which showed a similar pattern of effector binding...
  16. Johnson R, Sedgwick A, D SOUZA SCHOREY C, Cagan R. Role for a Cindr-Arf6 axis in patterning emerging epithelia. Mol Biol Cell. 2011;22:4513-26 pubmed publisher
    ..In this paper, we demonstrate that these movements require an Arf regulatory cycle that connects surface receptors to actin-based movement...