AP-2mu

Summary

Gene Symbol: AP-2mu
Description: Adaptor Protein complex 2, mu subunit
Alias: AP-50, AP2mu2, AP50, CG7057, Dmel\CG7057, Dmu2, MENE (3R)-D, MENE(3R)-D, anon-EST:Posey50, anon-WO0172774.104, apm4, cg7057, mu2, adaptor protein complex 2, mu subunit, AP-2mu-PA, AP-2mu-PB, AP-2mu-PC, AP-50, CG7057-PA, CG7057-PB, CG7057-PC, adaptor protein complex 2, mu2 medium chain of adaptin AP2
Species: fruit fly

Top Publications

  1. Windler S, Bilder D. Endocytic internalization routes required for delta/notch signaling. Curr Biol. 2010;20:538-43 pubmed publisher
    ..The absolute requirement for dynamin-dependent endocytosis but not endosomal entry or Rab11 activity supports "pulling force" rather than "recycling" models for Delta activation. ..
  2. Boehm M, Bonifacino J. Adaptins: the final recount. Mol Biol Cell. 2001;12:2907-20 pubmed
    ..Finally, we extend our survey to adaptin-related proteins such as the GGAs and stonins, which contain domains homologous to the adaptins. ..
  3. Worby C, Simonson Leff N, Clemens J, Kruger R, Muda M, Dixon J. The sorting nexin, DSH3PX1, connects the axonal guidance receptor, Dscam, to the actin cytoskeleton. J Biol Chem. 2001;276:41782-9 pubmed
    ..This evidence places DSH3PX1 in a complex linking cell surface receptors like Dscam to proteins involved in cytoskeletal rearrangements and/or receptor trafficking. ..
  4. Menut L, Vaccari T, Dionne H, Hill J, Wu G, Bilder D. A mosaic genetic screen for Drosophila neoplastic tumor suppressor genes based on defective pupation. Genetics. 2007;177:1667-77 pubmed
    ..The isolation of additional loci that affect hyperplastic as well as neoplastic growth indicates the utility of this screening strategy for studying epithelial growth control. ..
  5. Mohrmann R, Matthies H, Woodruff E, Broadie K. Stoned B mediates sorting of integral synaptic vesicle proteins. Neuroscience. 2008;153:1048-63 pubmed publisher
    ..We conclude that STNB organizes the endocytic sorting of a subset of integral synaptic vesicle proteins thereby regulating the fusion-competence of the recycled vesicle. ..
  6. Asensio C, Sirkis D, Edwards R. RNAi screen identifies a role for adaptor protein AP-3 in sorting to the regulated secretory pathway. J Cell Biol. 2010;191:1173-87 pubmed publisher
    ..Although vesicles with a dense core still form in the absence of AP-3, they contain substantially less synaptotagmin 1, indicating that AP-3 concentrates the proteins required for regulated exocytosis. ..
  7. Jullien Flores V, Mahe Y, Mirey G, Leprince C, Meunier Bisceuil B, Sorkin A, et al. RLIP76, an effector of the GTPase Ral, interacts with the AP2 complex: involvement of the Ral pathway in receptor endocytosis. J Cell Sci. 2000;113 ( Pt 16):2837-44 pubmed
    ..b>Mu2, the medium chain of the AP2 complex is shown to interact with RLIP76...
  8. Kametaka S, Kametaka A, Yonekura S, Haruta M, Takenoshita S, Goto S, et al. AP-1 clathrin adaptor and CG8538/Aftiphilin are involved in Notch signaling during eye development in Drosophila melanogaster. J Cell Sci. 2012;125:634-48 pubmed publisher
    ..These results suggest that AP-1 and Aftiphilin are cooperatively involved in the intracellular trafficking of Notch during eye development in Drosophila. ..
  9. Jha A, Watkins S, Traub L. The apoptotic engulfment protein Ced-6 participates in clathrin-mediated yolk uptake in Drosophila egg chambers. Mol Biol Cell. 2012;23:1742-64 pubmed publisher

More Information

Publications18

  1. Zhang Y, Broadie K. Cloning, mapping and tissue-specific expression of Drosophila clathrin-associated protein AP50 gene. Gene. 1999;233:171-9 pubmed
    The Drosophila homologue of AP50, the medium chain of clathrin-associated protein complex AP-2, was identified and characterized from the Drosophila Expressed Sequence Tag database...
  2. Boehm M, Bonifacino J. Genetic analyses of adaptin function from yeast to mammals. Gene. 2002;286:175-86 pubmed
    ..Here, we review recent progress in the genetic analysis of the function of AP complexes, focusing on studies that make use of targeted interference or naturally-occurring mutations in various model organisms. ..
  3. Mirey G, Balakireva M, L Hoste S, Rosse C, Voegeling S, Camonis J. A Ral guanine exchange factor-Ral pathway is conserved in Drosophila melanogaster and sheds new light on the connectivity of the Ral, Ras, and Rap pathways. Mol Cell Biol. 2003;23:1112-24 pubmed
    ..Thus, in vivo data show variations in the connectivity of pathways described for cell lines which might display only a subset of the biological possibilities. ..
  4. Kametaka S, Sawada N, Bonifacino J, Waguri S. Functional characterization of protein-sorting machineries at the trans-Golgi network in Drosophila melanogaster. J Cell Sci. 2010;123:460-71 pubmed publisher
  5. Benhra N, Lallet S, Cotton M, Le Bras S, Dussert A, Le Borgne R. AP-1 controls the trafficking of Notch and Sanpodo toward E-cadherin junctions in sensory organ precursors. Curr Biol. 2011;21:87-95 pubmed publisher
    ..Because AP-1 does not prevent endocytosis and recycling of the Notch ligand Delta, our data indicate that the DE-cadherin junctional domain may act as a launching pad through which endocytosed Notch ligand is trafficked for signaling. ..
  6. Fletcher G, Lucas E, Brain R, Tournier A, Thompson B. Positive feedback and mutual antagonism combine to polarize Crumbs in the Drosophila follicle cell epithelium. Curr Biol. 2012;22:1116-22 pubmed publisher
    ..Once Crb is removed from the plasma membrane, it undergoes recycling via Rab11 endosomes. Our results provide a dynamic model for understanding how epithelial polarity is maintained in Drosophila follicle cells. ..
  7. Mullins C, Hartnell L, Wassarman D, Bonifacino J. Defective expression of the mu3 subunit of the AP-3 adaptor complex in the Drosophila pigmentation mutant carmine. Mol Gen Genet. 1999;262:401-12 pubmed
    ..sequence tag (EST) database identified orthologs of family members mammalian medium (mu) chain families mu1, mu2, and mu3, of the corresponding AP complexes, and delta-COP, the analogous component of the coatomer (COPI) complex...
  8. Yang W, Peng Y, Li H, Lin H, Lin Y, Lai T, et al. Nak regulates localization of clathrin sites in higher-order dendrites to promote local dendrite growth. Neuron. 2011;72:285-99 pubmed publisher
  9. Peters N, Berg C. Dynamin-mediated endocytosis is required for tube closure, cell intercalation, and biased apical expansion during epithelial tubulogenesis in the Drosophila ovary. Dev Biol. 2016;409:39-54 pubmed publisher
    ..Thus, our studies identify novel morphogenetic roles (i.e., tube closure and biased apical expansion), and expand upon established roles (i.e., cell intercalation and adhesion remodeling), for Dynamin in tubulogenesis. ..