AP-1mu

Summary

Gene Symbol: AP-1mu
Description: Adaptor Protein complex 1, mu subunit
Alias: AP-1mu1, AP-47, AP1mu1, AP47, APmu1, CG9388, Dmel\CG9388, Dmu1, ap-47, apm1, cg9388, mu1, adaptor protein complex 1, mu subunit, AP-1mu-PA, AP-47, CG9388-PA
Species: fruit fly

Top Publications

  1. Boehm M, Bonifacino J. Adaptins: the final recount. Mol Biol Cell. 2001;12:2907-20 pubmed
    ..Finally, we extend our survey to adaptin-related proteins such as the GGAs and stonins, which contain domains homologous to the adaptins. ..
  2. Mahoney M, Parks A, Ruddy D, Tiong S, Esengil H, Phan A, et al. Presenilin-based genetic screens in Drosophila melanogaster identify novel notch pathway modifiers. Genetics. 2006;172:2309-24 pubmed
    ..The predicted functions of these newly identified genes are consistent with extracellular matrix and vesicular trafficking mechanisms in Presenilin and Notch pathway regulation and suggest a novel role for gamma-tubulin in the pathway. ..
  3. Benhra N, Lallet S, Cotton M, Le Bras S, Dussert A, Le Borgne R. AP-1 controls the trafficking of Notch and Sanpodo toward E-cadherin junctions in sensory organ precursors. Curr Biol. 2011;21:87-95 pubmed publisher
    ..Because AP-1 does not prevent endocytosis and recycling of the Notch ligand Delta, our data indicate that the DE-cadherin junctional domain may act as a launching pad through which endocytosed Notch ligand is trafficked for signaling. ..
  4. Peng Y, Yang W, Lin W, Lai T, Chien C. Nak regulates Dlg basal localization in Drosophila salivary gland cells. Biochem Biophys Res Commun. 2009;382:108-13 pubmed publisher
    ..Therefore, Nak regulates the transition of Dlg distribution likely through endocytosis of Dlg from the apical membrane domain and transcytosis of Dlg to the basolateral membrane domain during the maturation of SGs development. ..
  5. Hirst J, Sahlender D, Choma M, Sinka R, Harbour M, Parkinson M, et al. Spatial and functional relationship of GGAs and AP-1 in Drosophila and HeLa cells. Traffic. 2009;10:1696-710 pubmed
    ..Thus, our results indicate that the two adaptors can function independently of each other...
  6. Kametaka S, Sawada N, Bonifacino J, Waguri S. Functional characterization of protein-sorting machineries at the trans-Golgi network in Drosophila melanogaster. J Cell Sci. 2010;123:460-71 pubmed publisher
  7. Cotton M, Benhra N, Le Borgne R. Numb inhibits the recycling of Sanpodo in Drosophila sensory organ precursor. Curr Biol. 2013;23:581-7 pubmed publisher
    ..In numb mutant organs, Spdo is efficiently internalized and recycled back to the plasma membrane. We propose that Numb acts in concert with AP-1 to control the endocytic recycling of Spdo to regulate binary-fate decisions. ..
  8. Loyer N, Kolotuev I, Pinot M, Le Borgne R. Drosophila E-cadherin is required for the maintenance of ring canals anchoring to mechanically withstand tissue growth. Proc Natl Acad Sci U S A. 2015;112:12717-22 pubmed publisher
  9. Burgess J, Jauregui M, Tan J, Rollins J, Lallet S, Leventis P, et al. AP-1 and clathrin are essential for secretory granule biogenesis in Drosophila. Mol Biol Cell. 2011;22:2094-105 pubmed publisher
    ..Finally, loss of clathrin or AP-1 leads to a profound block in secretory granule formation. These findings establish a novel role for AP-1- and clathrin-dependent trafficking in the biogenesis of mucin-containing secretory granules. ..

More Information

Publications16

  1. Yang W, Peng Y, Li H, Lin H, Lin Y, Lai T, et al. Nak regulates localization of clathrin sites in higher-order dendrites to promote local dendrite growth. Neuron. 2011;72:285-99 pubmed publisher
  2. Zhang Y, Broadie K. Cloning, mapping and tissue-specific expression of Drosophila clathrin-associated protein AP50 gene. Gene. 1999;233:171-9 pubmed
    ..The two other Drosophila members of the medium-chain family of clathrin-associated protein complexes, AP47 and mu3, have also been identified and mapped to 85D20-D27 and 6E1-E4, respectively.
  3. Mullins C, Hartnell L, Wassarman D, Bonifacino J. Defective expression of the mu3 subunit of the AP-3 adaptor complex in the Drosophila pigmentation mutant carmine. Mol Gen Genet. 1999;262:401-12 pubmed
    ..expressed sequence tag (EST) database identified orthologs of family members mammalian medium (mu) chain families mu1, mu2, and mu3, of the corresponding AP complexes, and delta-COP, the analogous component of the coatomer (COPI) ..
  4. Jullien Flores V, Mahe Y, Mirey G, Leprince C, Meunier Bisceuil B, Sorkin A, et al. RLIP76, an effector of the GTPase Ral, interacts with the AP2 complex: involvement of the Ral pathway in receptor endocytosis. J Cell Sci. 2000;113 ( Pt 16):2837-44 pubmed
    ..Furthermore, RLIP76 differentiates AP2 from AP1 in vivo as RLIP76 differentiates mu2 from mu1 in vitro and in two hybrid assays...
  5. Boehm M, Bonifacino J. Genetic analyses of adaptin function from yeast to mammals. Gene. 2002;286:175-86 pubmed
    ..Here, we review recent progress in the genetic analysis of the function of AP complexes, focusing on studies that make use of targeted interference or naturally-occurring mutations in various model organisms. ..
  6. Christis C, Munro S. The small G protein Arl1 directs the trans-Golgi-specific targeting of the Arf1 exchange factors BIG1 and BIG2. J Cell Biol. 2012;196:327-35 pubmed publisher
    ..We show that in mammalian cells, Arl1 is necessary for Golgi recruitment of BIG1 and BIG2 but not GBF1. Thus, Arl1 acts to direct a trans-Golgi-specific Arf1 GEF, and hence active Arf1, to the trans side of the Golgi. ..
  7. Kametaka S, Kametaka A, Yonekura S, Haruta M, Takenoshita S, Goto S, et al. AP-1 clathrin adaptor and CG8538/Aftiphilin are involved in Notch signaling during eye development in Drosophila melanogaster. J Cell Sci. 2012;125:634-48 pubmed publisher
    ..These results suggest that AP-1 and Aftiphilin are cooperatively involved in the intracellular trafficking of Notch during eye development in Drosophila. ..