AP-1gamma

Summary

Gene Symbol: AP-1gamma
Description: Adaptor Protein complex 1, gamma subunit
Alias: AP-1, AP-1 gamma, AP-1[gamma], AP1gamma, AP1gamma1, Ap-1, CG9113, Dmel\CG9113, apl4, cg9113, dgamma, gamma, gamma-Ada, adaptor protein complex 1, gamma subunit, AP-1gamma-PA, AP-1gamma-PB, AP-1gamma-PC, AP-1gamma-PD, AP-1gamma-PE, AP-1gamma-PF, AP-1gamma-PG, AP-1gamma-PH, AP-1gamma-PI, CG9113-PA, CG9113-PB, CG9113-PC, CG9113-PD, CG9113-PE, CG9113-PF, CG9113-PG, CG9113-PH, CG9113-PI, gamma subunit of AP-1 clathrin, gamma-adaptin
Species: fruit fly

Top Publications

  1. Boehm M, Bonifacino J. Adaptins: the final recount. Mol Biol Cell. 2001;12:2907-20 pubmed
    ..Finally, we extend our survey to adaptin-related proteins such as the GGAs and stonins, which contain domains homologous to the adaptins. ..
  2. Peng Y, Yang W, Lin W, Lai T, Chien C. Nak regulates Dlg basal localization in Drosophila salivary gland cells. Biochem Biophys Res Commun. 2009;382:108-13 pubmed publisher
    ..Therefore, Nak regulates the transition of Dlg distribution likely through endocytosis of Dlg from the apical membrane domain and transcytosis of Dlg to the basolateral membrane domain during the maturation of SGs development. ..
  3. Hirst J, Sahlender D, Choma M, Sinka R, Harbour M, Parkinson M, et al. Spatial and functional relationship of GGAs and AP-1 in Drosophila and HeLa cells. Traffic. 2009;10:1696-710 pubmed
    The GGAs [Golgi-localised, gamma-ear containing, ARF (ADP ribosylation factor)-binding proteins] and the AP-1 (adaptor protein-1) complex are both adaptors for clathrin-mediated intracellular trafficking, but their relationship to each ..
  4. Benhra N, Lallet S, Cotton M, Le Bras S, Dussert A, Le Borgne R. AP-1 controls the trafficking of Notch and Sanpodo toward E-cadherin junctions in sensory organ precursors. Curr Biol. 2011;21:87-95 pubmed publisher
    ..Because AP-1 does not prevent endocytosis and recycling of the Notch ligand Delta, our data indicate that the DE-cadherin junctional domain may act as a launching pad through which endocytosed Notch ligand is trafficked for signaling. ..
  5. Burgess J, Jauregui M, Tan J, Rollins J, Lallet S, Leventis P, et al. AP-1 and clathrin are essential for secretory granule biogenesis in Drosophila. Mol Biol Cell. 2011;22:2094-105 pubmed publisher
    ..Finally, loss of clathrin or AP-1 leads to a profound block in secretory granule formation. These findings establish a novel role for AP-1- and clathrin-dependent trafficking in the biogenesis of mucin-containing secretory granules. ..
  6. Chen G, Li W, Zhang Q, Regulski M, Sinha N, Barditch J, et al. Identification of synaptic targets of Drosophila pumilio. PLoS Comput Biol. 2008;4:e1000026 pubmed publisher
    ..Finally, we show that the endogenous dlg1 mRNA can be regulated by Pumilio in a neuronal context, the adult mushroom bodies (MB), which is an anatomical site of memory storage. ..
  7. Szul T, Burgess J, Jeon M, Zinn K, Marques G, Brill J, et al. The Garz Sec7 domain guanine nucleotide exchange factor for Arf regulates salivary gland development in Drosophila. Cell Logist. 2011;1:69-76 pubmed
    ..Our findings suggest that Garz is essential for establishment of epithelial structures and demonstrate an absolute requirement for Garz during Drosophila development. ..
  8. Christis C, Munro S. The small G protein Arl1 directs the trans-Golgi-specific targeting of the Arf1 exchange factors BIG1 and BIG2. J Cell Biol. 2012;196:327-35 pubmed publisher
    ..We show that in mammalian cells, Arl1 is necessary for Golgi recruitment of BIG1 and BIG2 but not GBF1. Thus, Arl1 acts to direct a trans-Golgi-specific Arf1 GEF, and hence active Arf1, to the trans side of the Golgi. ..
  9. Peterson S, Krasnow M. Subcellular trafficking of FGF controls tracheal invasion of Drosophila flight muscle. Cell. 2015;160:313-23 pubmed publisher
    ..We propose that tracheal invasion is controlled by an AP-1-dependent switch in FGF trafficking. Thus, subcellular targeting of a chemoattractant can direct outgrowth to specific domains, including inside the cell. ..

More Information

Publications18

  1. Burgess J, Del Bel L, Ma C, Barylko B, Polevoy G, Rollins J, et al. Type II phosphatidylinositol 4-kinase regulates trafficking of secretory granule proteins in Drosophila. Development. 2012;139:3040-50 pubmed publisher
    ..Our genetic analysis of PI4KII in flies thus reveals a novel role for PI4KII in regulating the fidelity of granule protein trafficking in secretory tissues. ..
  2. Giagtzoglou N, Li T, Yamamoto S, Bellen H. Drosophila EHBP1 regulates Scabrous secretion during Notch-mediated lateral inhibition. J Cell Sci. 2013;126:3686-96 pubmed publisher
    ..In conclusion, dEHBP1 provides developmental versatility of intercellular signaling by regulating the trafficking of distinct Notch signaling components. ..
  3. Boehm M, Bonifacino J. Genetic analyses of adaptin function from yeast to mammals. Gene. 2002;286:175-86 pubmed
    ..Here, we review recent progress in the genetic analysis of the function of AP complexes, focusing on studies that make use of targeted interference or naturally-occurring mutations in various model organisms. ..
  4. Davie K, Jacobs J, Atkins M, Potier D, Christiaens V, Halder G, et al. Discovery of transcription factors and regulatory regions driving in vivo tumor development by ATAC-seq and FAIRE-seq open chromatin profiling. PLoS Genet. 2015;11:e1004994 pubmed publisher
  5. Hirst J, Carmichael J. A potential role for the clathrin adaptor GGA in Drosophila spermatogenesis. BMC Cell Biol. 2011;12:22 pubmed publisher
  6. Torres I, Rosa Ferreira C, Munro S. The Arf family G protein Arl1 is required for secretory granule biogenesis in Drosophila. J Cell Sci. 2014;127:2151-60 pubmed publisher
    ..Arl1 does not appear to be required for AP-1 recruitment in all tissues, suggesting that it is crucially required to enhance Arf1 activation at the trans-Golgi in particular tissues. ..
  7. Kametaka S, Kametaka A, Yonekura S, Haruta M, Takenoshita S, Goto S, et al. AP-1 clathrin adaptor and CG8538/Aftiphilin are involved in Notch signaling during eye development in Drosophila melanogaster. J Cell Sci. 2012;125:634-48 pubmed publisher
    ..These results suggest that AP-1 and Aftiphilin are cooperatively involved in the intracellular trafficking of Notch during eye development in Drosophila. ..
  8. Cotton M, Benhra N, Le Borgne R. Numb inhibits the recycling of Sanpodo in Drosophila sensory organ precursor. Curr Biol. 2013;23:581-7 pubmed publisher
    ..In numb mutant organs, Spdo is efficiently internalized and recycled back to the plasma membrane. We propose that Numb acts in concert with AP-1 to control the endocytic recycling of Spdo to regulate binary-fate decisions. ..
  9. Jiang K, Liu Y, Fan J, Zhang J, Li X, Evers B, et al. PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail. PLoS Biol. 2016;14:e1002375 pubmed publisher