Gene Symbol: ana3
Description: anastral spindle 3
Alias: Ana3, CG13162, Dmel\CG13162, l(2)SH0558, anastral spindle 3, CG13162-PA, ana3-PA, anastral spindle phenotype 3, lethal (2) SH0558
Species: fruit fly
Stevens N, Dobbelaere J, Wainman A, Gergely F, Raff J. Ana3 is a conserved protein required for the structural integrity of centrioles and basal bodies. J Cell Biol. 2009;187:355-63 pubmed publisher
..In this study, we investigate the function of one of these proteins, Drosophila melanogaster Ana3. We show that Ana3 is present in centrioles and basal bodies, but its behavior is distinct from that of the core ..
Conduit P, Brunk K, Dobbelaere J, Dix C, Lucas E, Raff J. Centrioles regulate centrosome size by controlling the rate of Cnn incorporation into the PCM. Curr Biol. 2010;20:2178-86 pubmed publisher
..This mechanism can explain how centrosome size is regulated during the cell cycle and also allows mother and daughter centrioles to set centrosome size independently of one another. ..
Gopalakrishnan J, Mennella V, Blachon S, Zhai B, Smith A, Megraw T, et al
. Sas-4 provides a scaffold for cytoplasmic complexes and tethers them in a centrosome. Nat Commun. 2011;2:359 pubmed publisher
..In summary, PCM assembly begins in the cytosol where Sas-4 provides a scaffold for pre-assembled cytoplasmic complexes before tethering of the complexes in a centrosome. ..
Galletta B, Fagerstrom C, Schoborg T, McLamarrah T, Ryniawec J, Buster D, et al
. A centrosome interactome provides insight into organelle assembly and reveals a non-duplication role for Plk4. Nat Commun. 2016;7:12476 pubmed publisher
..We show that Plk4 phosphorylates Cep135 to properly position the essential centriole component Asterless. This interaction landscape affords a critical framework for research of normal and aberrant centrosomes. ..
Taylor C, Winther A, Siviter R, Shirras A, Isaac R, Nassel D. Identification of a proctolin preprohormone gene (Proct) of Drosophila melanogaster: expression and predicted prohormone processing. J Neurobiol. 2004;58:379-91 pubmed
..The distribution of proctolin suggests roles as a neuromodulator in motoneurons and interneurons, and as a neurohormone that could be released from brain neurosecretory cells with terminations in the ring gland. ..
Stevens N, Dobbelaere J, Brunk K, Franz A, Raff J. Drosophila Ana2 is a conserved centriole duplication factor. J Cell Biol. 2010;188:313-23 pubmed publisher
..We propose that members of the SAS-5/Ana2/STIL family of proteins are key conserved components of the centriole duplication machinery. ..