ana1

Summary

Gene Symbol: ana1
Description: anastral spindle 1
Alias: Ana 1, Ana-1, Ana1, CG6631, Dmel\CG6631, mecB, anastral spindle 1, CG6631-PA, CG6631-PC, ana1-PA, ana1-PC, anastral spindle phenotype 1, mechanosensory B, mechanosensory mutant B
Species: fruit fly

Top Publications

  1. Stevens N, Dobbelaere J, Brunk K, Franz A, Raff J. Drosophila Ana2 is a conserved centriole duplication factor. J Cell Biol. 2010;188:313-23 pubmed publisher
    ..We propose that members of the SAS-5/Ana2/STIL family of proteins are key conserved components of the centriole duplication machinery. ..
  2. Conduit P, Brunk K, Dobbelaere J, Dix C, Lucas E, Raff J. Centrioles regulate centrosome size by controlling the rate of Cnn incorporation into the PCM. Curr Biol. 2010;20:2178-86 pubmed publisher
    ..This mechanism can explain how centrosome size is regulated during the cell cycle and also allows mother and daughter centrioles to set centrosome size independently of one another. ..
  3. Gopalakrishnan J, Mennella V, Blachon S, Zhai B, Smith A, Megraw T, et al. Sas-4 provides a scaffold for cytoplasmic complexes and tethers them in a centrosome. Nat Commun. 2011;2:359 pubmed publisher
    ..In summary, PCM assembly begins in the cytosol where Sas-4 provides a scaffold for pre-assembled cytoplasmic complexes before tethering of the complexes in a centrosome. ..
  4. Blachon S, Gopalakrishnan J, Omori Y, Polyanovsky A, Church A, Nicastro D, et al. Drosophila asterless and vertebrate Cep152 Are orthologs essential for centriole duplication. Genetics. 2008;180:2081-94 pubmed publisher
    ..The clear absence of several centriolar markers in mecD mutants suggests that Asl is critical early in centriole duplication...
  5. Blachon S, Cai X, Roberts K, Yang K, Polyanovsky A, Church A, et al. A proximal centriole-like structure is present in Drosophila spermatids and can serve as a model to study centriole duplication. Genetics. 2009;182:133-44 pubmed publisher
    ..First, a single PCL forms near the proximal segment of the older centriole. Second, the centriolar proteins SAS-6, Ana1, and Bld10p/Cep135 are in the PCL. Third, PCL formation depends on SAK/PLK4 and SAS-6...
  6. Mottier Pavie V, Megraw T. Drosophila bld10 is a centriolar protein that regulates centriole, basal body, and motile cilium assembly. Mol Biol Cell. 2009;20:2605-14 pubmed publisher
    ..These results show that Drosophila Bld10 is required for centriole and axoneme assembly to confer cilium motility. ..
  7. Stevens N, Dobbelaere J, Wainman A, Gergely F, Raff J. Ana3 is a conserved protein required for the structural integrity of centrioles and basal bodies. J Cell Biol. 2009;187:355-63 pubmed publisher
    ..Thus, Ana3 defines a conserved family of centriolar proteins and plays an important part in ensuring the structural integrity of centrioles and basal bodies. ..
  8. Gopalakrishnan J, Chim Y, Ha A, Basiri M, Lerit D, Rusan N, et al. Tubulin nucleotide status controls Sas-4-dependent pericentriolar material recruitment. Nat Cell Biol. 2012;14:865-73 pubmed publisher
    ..On the basis of its guanine-bound state, tubulin can act as a molecular switch in PCM recruitment. ..
  9. Blachon S, Khire A, Avidor Reiss T. The origin of the second centriole in the zygote of Drosophila melanogaster. Genetics. 2014;197:199-205 pubmed publisher
    ..These observations demonstrate that the PCL is the origin for the second centriole in the Drosophila zygote and that a paternal centriole precursor, without centriolar proteins, is transmitted to the egg during fertilization. ..

More Information

Publications17

  1. Galletta B, Jacobs K, Fagerstrom C, Rusan N. Asterless is required for centriole length control and sperm development. J Cell Biol. 2016;213:435-50 pubmed publisher
    ..Insights into the role of Asl/Cep152 beyond centriole duplication could help shed light on how Cep152 mutations lead to the development of microcephaly. ..
  2. Chen J, Kao L, Jana S, Sivan Loukianova E, Mendonça S, Cabrera O, et al. Rootletin organizes the ciliary rootlet to achieve neuron sensory function in Drosophila. J Cell Biol. 2015;211:435-53 pubmed publisher
    ..Ectopically expressed Root resides at the base of mother centrioles in spermatocytes and localizes asymmetrically to mother centrosomes in neuroblasts, both requiring Bld10, a basal body protein with varied functions. ..
  3. Fu J, Lipinszki Z, Rangone H, Min M, Mykura C, Chao Chu J, et al. Conserved molecular interactions in centriole-to-centrosome conversion. Nat Cell Biol. 2016;18:87-99 pubmed publisher
    ..Here we show that centriole-to-centrosome conversion requires sequential loading of Cep135, Ana1 (Cep295) and Asterless (Cep152) onto daughter centrioles during mitotic progression in both Drosophila melanogaster ..
  4. Galletta B, Fagerstrom C, Schoborg T, McLamarrah T, Ryniawec J, Buster D, et al. A centrosome interactome provides insight into organelle assembly and reveals a non-duplication role for Plk4. Nat Commun. 2016;7:12476 pubmed publisher
    ..We show that Plk4 phosphorylates Cep135 to properly position the essential centriole component Asterless. This interaction landscape affords a critical framework for research of normal and aberrant centrosomes. ..
  5. Saurya S, Roque H, Novak Z, Wainman A, Aydogan M, Volanakis A, et al. Drosophila Ana1 is required for centrosome assembly and centriole elongation. J Cell Sci. 2016;129:2514-25 pubmed publisher
    ..In flies, the centriole protein Ana1 is required for the assembly of functional centrosomes and cilia...
  6. Franz A, Roque H, Saurya S, Dobbelaere J, Raff J. CP110 exhibits novel regulatory activities during centriole assembly in Drosophila. J Cell Biol. 2013;203:785-99 pubmed publisher
    ..Finally, and unexpectedly, CP110 suppresses centriole overduplication induced by the overexpression of centriole duplication proteins. These studies identify novel and surprising functions for CP110 in vivo in flies. ..
  7. Basiri M, Ha A, Chadha A, Clark N, Polyanovsky A, Cook B, et al. A migrating ciliary gate compartmentalizes the site of axoneme assembly in Drosophila spermatids. Curr Biol. 2014;24:2622-31 pubmed publisher
  8. Riparbelli M, Gottardo M, Glover D, Callaini G. Inhibition of Polo kinase by BI2536 affects centriole separation during Drosophila male meiosis. Cell Cycle. 2014;13:2064-72 pubmed publisher
    ..Despite these defects spermatid differentiation proceeds, leading to axoneme formation. ..