Genomes and Genes
Gene Symbol: alphaTub67C
Description: alpha-Tubulin at 67C
Alias: ALPHA 67C, CG8308, D.m.ALPHA-67C, DTA2, Dmel\CG8308, Fs(3)Kav, Fs(3)Kavar, Fs(3)Sz14, Fs(3)Sz22, Fs(3)Tom, Fs(3)Tomaj, Kavar, Tom, Tub, Tub1E, aTub67C, alpha-Tub, alpha-Tub67C, alpha-tub, alpha-tub67C, alpha-tubulin, alpha-tubulin, alpha4, alpha4-t, alpha4-tubulin, alpha4Tub67C, alpha4t, alpha67C, alphaTUB, alphaTub, alphaTub 67C, alphaTub4, alphaTub[67C], alphatub, alphatub67C, gamma-Tub, mum-tub67C, tub, tub67c, alpha-Tubulin at 67C, CG8308-PA, alpha tubulin, alpha tubulin 67C, alpha-Tubulin, alpha4-tubulin, alphaT, alphaTub67C-PA, alphaTubulin 67C, alphaTubulin67C, alphatubulin, female sterile (3) kavar, kavar, tomaj, tubulin, tubulin at 67C, tubulin67C
Species: fruit fly
- Cullen C, Deak P, Glover D, Ohkura H. mini spindles: A gene encoding a conserved microtubule-associated protein required for the integrity of the mitotic spindle in Drosophila. J Cell Biol. 1999;146:1005-18 pubmed..The absence of centrosomal staining in interphase of the cellularized embryos suggests that the interactions between Msps protein and microtubules or centrosomes may be regulated during the cell cycle. ..
- Bucciarelli E, Pellacani C, Naim V, Palena A, Gatti M, Somma M. Drosophila Dgt6 interacts with Ndc80, Msps/XMAP215, and gamma-tubulin to promote kinetochore-driven MT formation. Curr Biol. 2009;19:1839-45 pubmed publisher..Recent work has suggested that additional spindle MTs can be nucleated by gamma-tubulin ring complexes (gamma-TuRCs) that associate laterally with preexisting spindle MTs, leading to spindle ..
- Kawaguchi S, Zheng Y. Characterization of a Drosophila centrosome protein CP309 that shares homology with Kendrin and CG-NAP. Mol Biol Cell. 2004;15:37-45 pubmed..this novel Drosophila centrosome protein, centrosome protein of 309 kDa (CP309), cofractionates with the gamma-tubulin ring complex and the centrosome-complementing activity...
- Nielsen M, Gadagkar S, Gutzwiller L. Tubulin evolution in insects: gene duplication and subfunctionalization provide specialized isoforms in a functionally constrained gene family. BMC Evol Biol. 2010;10:113 pubmed publisher..Homarus americanus (lobster) outgroup, these were generated through gene duplication events on major beta and alpha tubulin ancestors, followed by subfunctionalization in expression domain...
- Kuchinke U, Grawe F, Knust E. Control of spindle orientation in Drosophila by the Par-3-related PDZ-domain protein Bazooka. Curr Biol. 1998;8:1357-65 pubmed..The PDZ domains of Bazooka provide several protein-protein interfaces, which possibly participate in the assembly of a multiprotein complex at the apical pole. ..
- Venkei Z, Szabad J. The Kavar(D) dominant female-sterile mutations of Drosophila reveal a role for the maternally provided alpha-tubulin4 isoform in cleavage spindle maintenance and elongation. Mol Genet Genomics. 2005;273:283-9 pubmedThe dominant-negative female-sterile Kavar(D) mutations and their revertant kavar(r) alleles identify the alphaTubulin67C gene of Drosophila melanogaster, which codes for the maternally provided alpha-tubulin(4) isoform...
- Endow S, Chandra R, Komma D, Yamamoto A, Salmon E. Mutants of the Drosophila ncd microtubule motor protein cause centrosomal and spindle pole defects in mitosis. J Cell Sci. 1994;107 ( Pt 4):859-67 pubmed..Together with previous work, our findings indicate that ncd is important in maintaining spindle poles in mitosis as well as in meiosis. ..
- Rolls M, Albertson R, Shih H, Lee C, Doe C. Drosophila aPKC regulates cell polarity and cell proliferation in neuroblasts and epithelia. J Cell Biol. 2003;163:1089-98 pubmed
- Natzle J, McCarthy B. Regulation of Drosophila alpha- and beta-tubulin genes during development. Dev Biol. 1984;104:187-98 pubmedBoth the alpha and the beta subunit of tubulin in Drosophila melanogaster are encoded by small multigene families...
- Martinez Campos M, Basto R, Baker J, Kernan M, Raff J. The Drosophila pericentrin-like protein is essential for cilia/flagella function, but appears to be dispensable for mitosis. J Cell Biol. 2004;165:673-83 pubmed..Moreover, the flagella in mutant sperm are nonmotile. Thus, D-PLP is essential for the formation of functional cilia and flagella in flies. ..
- Zheng Y, Wong M, Alberts B, Mitchison T. Nucleation of microtubule assembly by a gamma-tubulin-containing ring complex. Nature. 1995;378:578-83 pubmedThe highly conserved protein gamma-tubulin is required for microtubule nucleation in vivo...
- Moritz M, Braunfeld M, Sedat J, Alberts B, Agard D. Microtubule nucleation by gamma-tubulin-containing rings in the centrosome. Nature. 1995;378:638-40 pubmed..gamma-Tubulin is the only component of the PCM that is so far implicated in microtubule nucleation...
- Komma D, Endow S. Enhancement of the ncdD microtubule motor mutant by mutants of alpha Tub67C. J Cell Sci. 1997;110 ( Pt 2):229-37 pubmed..In tests for interactions with other proteins, we find that mutants of alpha Tub67C, which affect an oocyte- and early embryo-specific alpha-tubulin, enhance meiotic nondisjunction and zygotic ..
- Theurkauf W, Baum H, Bo J, Wensink P. Tissue-specific and constitutive alpha-tubulin genes of Drosophila melanogaster code for structurally distinct proteins. Proc Natl Acad Sci U S A. 1986;83:8477-81 pubmedWe have determined the nucleotide sequences of all four Drosophila alpha-tubulin genes (alpha 1, alpha 2, alpha 3, and alpha 4)...
- Sekelsky J, McKim K, Messina L, French R, Hurley W, Arbel T, et al. Identification of novel Drosophila meiotic genes recovered in a P-element screen. Genetics. 1999;152:529-42 pubmed..Although most of these are alleles of previously undescribed genes, five were in the known genes alphaTubulin67C, CycE, push, and Trl. The five mutations in known genes produce novel phenotypes for those genes.
- Kalfayan L, Wensink P. Developmental regulation of Drosophila alpha-tubulin genes. Cell. 1982;29:91-8 pubmedTranscripts from the four different Drosophila melanogaster alpha-tubulin genes were detected by filter hybridization experiments that used subcloned fragments from each gene as hybridization probes...
- Bucciarelli E, Giansanti M, Bonaccorsi S, Gatti M. Spindle assembly and cytokinesis in the absence of chromosomes during Drosophila male meiosis. J Cell Biol. 2003;160:993-9 pubmed..This suggests that the association of Aurora B with chromosomes is not a prerequisite for its accumulation at the central spindle, or for its function during cytokinesis. ..
- Fuse N, Hisata K, Katzen A, Matsuzaki F. Heterotrimeric G proteins regulate daughter cell size asymmetry in Drosophila neuroblast divisions. Curr Biol. 2003;13:947-54 pubmed..Furthermore, the multiple equal cleavages of G beta mutant neuroblasts accompany neural defects; this finding suggests indispensable roles of eccentric division in assuring the stem cell properties of neuroblasts. ..
- Besse F, López de Quinto S, Marchand V, Trucco A, Ephrussi A. Drosophila PTB promotes formation of high-order RNP particles and represses oskar translation. Genes Dev. 2009;23:195-207 pubmed publisher..Thus, PTB is a key structural component of oskar RNP complexes that dually controls formation of high-order RNP particles and translational silencing. ..
- Theurkauf W, Smiley S, Wong M, Alberts B. Reorganization of the cytoskeleton during Drosophila oogenesis: implications for axis specification and intercellular transport. Development. 1992;115:923-36 pubmed..We believe that actin plays a secondary role in each of these morphogenetic events, based on our parallel studies of actin organization during each of the above stages of oogenesis. ..
- Giunta K, Jang J, Manheim E, Subramanian G, McKim K. subito encodes a kinesin-like protein required for meiotic spindle pole formation in Drosophila melanogaster. Genetics. 2002;160:1489-501 pubmed..sub is also required for the early embryonic divisions but is otherwise dispensable for most mitotic divisions. ..
- Jang J, Rahman T, McKim K. The kinesinlike protein Subito contributes to central spindle assembly and organization of the meiotic spindle in Drosophila oocytes. Mol Biol Cell. 2005;16:4684-94 pubmed..We propose that Subito is required for establishing and/or maintaining the central spindle in Drosophila oocytes, and this substitutes for the role of centrosomes in organizing the bipolar spindle. ..
- Lemos C, Sampaio P, Maiato H, Costa M, Omel yanchuk L, Liberal V, et al. Mast, a conserved microtubule-associated protein required for bipolar mitotic spindle organization. EMBO J. 2000;19:3668-82 pubmed..The defects observed in the mutant alleles and the intracellular localization of the protein suggest that Mast plays an essential role in centrosome separation and organization of the bipolar mitotic spindle. ..
- Moutinho Santos T, Sampaio P, Amorim I, Costa M, Sunkel C. In vivo localisation of the mitotic POLO kinase shows a highly dynamic association with the mitotic apparatus during early embryogenesis in Drosophila. Biol Cell. 1999;91:585-96 pubmed..Furthermore, the wide distribution of the GFP-POLO protein to all compartments of the mitotic apparatus provides a valuable tool for future studies on cell cycle during development. ..
- Matthies H, Messina L, Namba R, Greer K, Walker M, Hawley R. Mutations in the alpha-tubulin 67C gene specifically impair achiasmate segregation in Drosophila melanogaster. J Cell Biol. 1999;147:1137-44 pubmedDrosophila melanogaster oocytes heterozygous for mutations in the alpha-tubulin 67C gene (alphatub67C) display defects in centromere positioning during prometaphase of meiosis I...
- Nielsen M, Caserta J, Kidd S, Phillips C. Functional constraint underlies 60 million year stasis of Dipteran testis-specific beta-tubulin. Evol Dev. 2006;8:23-9 pubmed..find a highly stringent structure/function relationship between the Drosophila melanogaster testis-specific tubulin beta2 and the spermtail axoneme, such that small changes in the beta2 protein render it unable to generate a ..
- Baker J, Theurkauf W, Schubiger G. Dynamic changes in microtubule configuration correlate with nuclear migration in the preblastoderm Drosophila embryo. J Cell Biol. 1993;122:113-21 pubmed..We propose that cortical migration is driven by microtubule-dependent forces that repel adjacent nuclei, leading to an expansion of the nuclear ellipsoid established by axial expansion. ..
- Matthews K, Rees D, Kaufman T. A functionally specialized alpha-tubulin is required for oocyte meiosis and cleavage mitoses in Drosophila. Development. 1993;117:977-91 pubmed..during oogenesis and early embryogenesis in Drosophila melanogaster: alpha TUB84B, alpha TUB84D, and alpha TUB67C. alpha TUB67C is unique in two respects...
- Venkei Z, Gaspar I, Toth G, Szabad J. alpha4-Tubulin is involved in rapid formation of long microtubules to push apart the daughter centrosomes during earlyx Drosophila embryogenesis. J Cell Sci. 2006;119:3238-48 pubmedAlthough alpha4-tubulin comprises only about one-fifth of the alpha-tubulin pool in every Drosophila egg, in the absence of alpha4-tubulin - in eggs of the kavar(0)/- hemizygous females - only a tassel of short microtubules forms with ..
- Gaspar I, Szabad J. In vivo analysis of MT-based vesicle transport by confocal reflection microscopy. Cell Motil Cytoskeleton. 2009;66:68-79 pubmed publisher..e. a motor or a cargo adapter, thus allowing a better understanding of MT-mediated transport and spatiotemporal coordination of the transport machinery. ..
- Goshima G, Nedelec F, Vale R. Mechanisms for focusing mitotic spindle poles by minus end-directed motor proteins. J Cell Biol. 2005;171:229-40 pubmed..From these results and simulations, we propose a model on how two minus end-directed motors cooperate to ensure spindle pole coalescence during mitosis. ..
- Drosopoulou E, Scouras Z. The organization of the alpha-tubulin gene family in the Drosophila montium subgroup of the melanogaster species group. Genome. 1998;41:504-9 pubmedThe alpha 1-, alpha 2-, alpha 3-, and alpha 4-tubulin genes have been mapped by in situ hybridization to the polytene chromosomes of five species representative of the Drosophila montium subgroup geographical distribution...
- Fan S, Marchand V, Ephrussi A. Drosophila Ge-1 promotes P body formation and oskar mRNA localization. PLoS ONE. 2011;6:e20612 pubmed publisher..Our findings suggest an important role of dGe-1 in optimization of the osk mRNA localization process required for patterning the Drosophila embryo. ..
- Galindo M, Pueyo J, Fouix S, Bishop S, Couso J. Peptides encoded by short ORFs control development and define a new eukaryotic gene family. PLoS Biol. 2007;5:e106 pubmed publisher..Our results open a new avenue for the annotation and functional analysis of genes and sequenced genomes, in which thousands of short ORFs are still uncharacterised...
- Ferree P, Sullivan W. A genetic test of the role of the maternal pronucleus in Wolbachia-induced cytoplasmic incompatibility in Drosophila melanogaster. Genetics. 2006;173:839-47 pubmed..We propose that CI occurs instead as the result of either a developmentally incompetent paternal pronucleus or asynchrony between the paternal pronucleus and the cell cycle of the egg cytoplasm. ..
- Yasuda G, Baker J, Schubiger G. Independent roles of centrosomes and DNA in organizing the Drosophila cytoskeleton. Development. 1991;111:379-91 pubmed..We speculate that the principles of cytoskeleton organization in this system may be different from those of the Xenopus "open" mitotic system. ..
- Cook H, Koppetsch B, Wu J, Theurkauf W. The Drosophila SDE3 homolog armitage is required for oskar mRNA silencing and embryonic axis specification. Cell. 2004;116:817-29 pubmed..We conclude that RNA silencing is essential for establishment of the cytoskeletal polarity that initiates embryonic axis specification and for translational control of oskar mRNA. ..
- Szabad J, Mathe E, Puro J. Horka, a dominant mutation of Drosophila, induces nondisjunction and, through paternal effect, chromosome loss and genetic mosaics. Genetics. 1995;139:1585-99 pubmed..Horka is a convenient tool for the generation of gynandromorphs, autosome mosaics and for the study of gene expression in mosaics. ..
- Leismann O, Herzig A, Heidmann S, Lehner C. Degradation of Drosophila PIM regulates sister chromatid separation during mitosis. Genes Dev. 2000;14:2192-205 pubmed..Whereas these securins are known to form a complex with separins, we show that PIM associates in vivo with THR, which does not contain the conserved separin domain. ..
- Stevenson V, Kramer J, Kuhn J, Theurkauf W. Centrosomes and the Scrambled protein coordinate microtubule-independent actin reorganization. Nat Cell Biol. 2001;3:68-75 pubmed..Our results indicate that centrosomes may coordinate assembly of cortical actin caps through a microtubule-independent mechanism, and that Scrambled mediates a second microtubule-independent process that drives mitotic furrow assembly. ..
- Sanchez F, Natzle J, Cleveland D, Kirschner M, McCarthy B. A dispersed multigene family encoding tubulin in Drosophila melanogaster. Cell. 1980;22:845-54 pubmedWe have used cloned chicken cDNA sequences for alpha- and beta-tubulin to investigate tubulin gene organization in Drosophila melanogaster...
- Raff E. Genetics of microtubule systems. J Cell Biol. 1984;99:1-10 pubmedIn most eucaryotes the tubulin genes comprise small multigene families with approximately equal numbers of genes for alpha- and beta-tubulin, the structural proteins of microtubules...
- Verollet C, Colombié N, Daubon T, Bourbon H, Wright M, Raynaud Messina B. Drosophila melanogaster gamma-TuRC is dispensable for targeting gamma-tubulin to the centrosome and microtubule nucleation. J Cell Biol. 2006;172:517-28 pubmedIn metazoans, gamma-tubulin acts within two main complexes, gamma-tubulin small complexes (gamma-TuSCs) and gamma-tubulin ring complexes (gamma-TuRCs)...
- Herzig A, Lehner C, Heidmann S. Proteolytic cleavage of the THR subunit during anaphase limits Drosophila separase function. Genes Dev. 2002;16:2443-54 pubmed
- Zhang G, Breuer M, Förster A, Egger Adam D, Wodarz A. Mars, a Drosophila protein related to vertebrate HURP, is required for the attachment of centrosomes to the mitotic spindle during syncytial nuclear divisions. J Cell Sci. 2009;122:535-45 pubmed publisher..We propose that Mars is an important linker between the spindle and the centrosomes that is required for proper spindle organization during the rapid mitotic cycles in early embryogenesis. ..
- Wei J, Hortsch M, Goode S. Neuroglian stabilizes epithelial structure during Drosophila oogenesis. Dev Dyn. 2004;230:800-8 pubmed..Our data also suggest that Ig superfamily members have significant functional redundancy in maintaining epithelial polarity, with individual members playing subtle, unique roles during epithelial morphogenesis. ..
- Wilson P. BimC motor protein KLP61F cycles between mitotic spindles and fusomes in Drosophila germ cells. Curr Biol. 1999;9:923-6 pubmed..Cytological analyses with antibodies against phosphorylated Eg5 peptide  suggest that cycling of KLP61F might reflect phosphorylation. ..
- Betschinger J, Eisenhaber F, Knoblich J. Phosphorylation-induced autoinhibition regulates the cytoskeletal protein Lethal (2) giant larvae. Curr Biol. 2005;15:276-82 pubmed..Our results suggest that unphosphorylated, active Lgl exists in an open conformation that interacts with the cytoskeleton while phosphorylation changes the protein to an autoinhibited state. ..
- de Carcer G, do Carmo Avides M, Lallena M, Glover D, Gonzalez C. Requirement of Hsp90 for centrosomal function reflects its regulation of Polo kinase stability. EMBO J. 2001;20:2878-84 pubmed
- Lin H, Spradling A. Fusome asymmetry and oocyte determination in Drosophila. Dev Genet. 1995;16:6-12 pubmed..These observations suggest that fusomes help establish a system of directional transport between cystocytes that underlies oocyte determination. ..
- Rodrigues Martins A, Riparbelli M, Callaini G, Glover D, Bettencourt Dias M. Revisiting the role of the mother centriole in centriole biogenesis. Science. 2007;316:1046-50 pubmed..The mother centriole is not a bona fide template but a platform for a set of regulatory molecules that catalyzes and regulates daughter centriole assembly...
- Debec A, Grammont M, Berson G, Dastugue B, Sullivan W, Couderc J. Toucan protein is essential for the assembly of syncytial mitotic spindles in Drosophila melanogaster. Genesis. 2001;31:167-75 pubmed..These results strongly suggest that Toucan represents a factor essential for the assembly and the function of the syncytial mitotic spindles. ..
- Stumpff J, Duncan T, Homola E, Campbell S, Su T. Drosophila Wee1 kinase regulates Cdk1 and mitotic entry during embryogenesis. Curr Biol. 2004;14:2143-8 pubmed..These findings modify previous models about cell cycle regulation in syncytial embryos and demonstrate that Wee1 kinases can regulate mitotic entry in vivo during metazoan development even in cycles that lack a G2 phase. ..
- Wu C, Sakai K, Saito M, Hotta Y. Giant Drosophila neurons differentiated from cytokinesis-arrested embryonic neuroblasts. J Neurobiol. 1990;21:499-507 pubmed..The cells of increased sizes in this culture system are more accessible to physiological and cell biological analyses and could facilitate future studies of the Drosophila nervous system. ..
- Kalfayan L, Loewenberg J, Wensink P. Drosophilia alpha-tubulin genes and their transcription patterns. Cold Spring Harb Symp Quant Biol. 1982;46 Pt 1:185-90 pubmedThere are four different alpha-tubulin genes in D. melanogaster DNA; three of them appear as single copies and the other is present as either one or two copies in the haploid genome. The transcripts of three of these genes were examined...
- Eaton S, Wepf R, Simons K. Roles for Rac1 and Cdc42 in planar polarization and hair outgrowth in the wing of Drosophila. J Cell Biol. 1996;135:1277-89 pubmed..During hair formation, the apical microtubules that point distally elongate and fill the emerging wing hair. As the hair elongates, junctional proteins are reorganized on the proximal and distal edges of each cell. ..
- Brent A, MacQueen A, Hazelrigg T. The Drosophila wispy gene is required for RNA localization and other microtubule-based events of meiosis and early embryogenesis. Genetics. 2000;154:1649-62 pubmed..We propose that the wispy gene product functions directly in several microtubule-based events in meiosis and early embryogenesis and speculate about its possible mode of action. ..
- Delanoue R, Davis I. Dynein anchors its mRNA cargo after apical transport in the Drosophila blastoderm embryo. Cell. 2005;122:97-106 pubmed..We propose a general principle that could also apply to other dynein cargo and to some other molecular motors, whereby cargo transport and anchoring reside in the same molecule. ..
- Heino T, Lahti V, Tirronen M, Roos C. Polytene chromosomes show normal gene activity but some mRNAs are abnormally accumulated in the pseudonurse cell nuclei of Drosophila melanogaster otu mutants. Chromosoma. 1995;104:44-55 pubmed..We suggest that the otu mRNA remains partly attached to the polytene chromosome template after transcription and discuss the effects of this phenomenon on polytenisation of the PNC chromosomes. ..
- Kwon M, Morales Mulia S, Brust Mascher I, Rogers G, Sharp D, Scholey J. The chromokinesin, KLP3A, dives mitotic spindle pole separation during prometaphase and anaphase and facilitates chromatid motility. Mol Biol Cell. 2004;15:219-33 pubmed..We propose that KLP3A acts on MTs associated with chromosome arms and the central spindle to organize ipMT bundles, to drive spindle pole separation and to facilitate chromatid motility. ..
- Courgeon A, Maingourd M, Maisonhaute C, Montmory C, Rollet E, Tanguay R, et al. Effect of hydrogen peroxide on cytoskeletal proteins of Drosophila cells: comparison with heat shock and other stresses. Exp Cell Res. 1993;204:30-7 pubmed..The synthesis of two cytoskeletal proteins, tubulin and a 46-kDa insoluble protein of the intermediate filament fraction, was also slightly increased by H2O2 in ..
- Endow S, Komma D. Assembly and dynamics of an anastral:astral spindle: the meiosis II spindle of Drosophila oocytes. J Cell Sci. 1998;111 ( Pt 17):2487-95 pubmed..gamma-Tubulin transiently localizes to the central spindle pole body, implying that the body acts as a microtubule nucleating ..
- Huynh J, Shulman J, Benton R, St Johnston D. PAR-1 is required for the maintenance of oocyte fate in Drosophila. Development. 2001;128:1201-9 pubmed..Finally, we show that PAR-1 localises on the fusome, and provides a link between the asymmetry of the fusome and the selection of the oocyte. ..
- Mathe E, Inoue Y, Palframan W, Brown G, Glover D. Orbit/Mast, the CLASP orthologue of Drosophila, is required for asymmetric stem cell and cystocyte divisions and development of the polarised microtubule network that interconnects oocyte and nurse cells during oogenesis. Development. 2003;130:901-15 pubmed..The localisation of CLIP-190 to such microtubules and to the fusome is dependent upon Orbit/Mast to which it is complexed. ..
- Röper K, Brown N. A spectraplakin is enriched on the fusome and organizes microtubules during oocyte specification in Drosophila. Curr Biol. 2004;14:99-110 pubmed..Shot associates with the fusome and is required for microtubule organization. We suggest that it does this directly, via its microtubule binding GAS2 domain. ..
- Ben Yaacov S, Le Borgne R, Abramson I, Schweisguth F, Schejter E. Wasp, the Drosophila Wiskott-Aldrich syndrome gene homologue, is required for cell fate decisions mediated by Notch signaling. J Cell Biol. 2001;152:1-13 pubmed..The nature of the Wsp mutant phenotypes, coupled with genetic interaction studies, identifies an essential role for Wsp in lineage decisions mediated by the Notch signaling pathway. ..
- Mollinari C, Lange B, Gonzalez C. Miranda, a protein involved in neuroblast asymmetric division, is associated with embryonic centrosomes of Drosophila melanogaster. Biol Cell. 2002;94:1-13 pubmed..on purified syncytial centrosomes shows that Miranda is located on the pericentriolar material along with gamma-tubulin. Taken all together, our data indicate for the first time that Miranda belongs to a growing class of proteins ..
- Izumi Y, Ohta N, Itoh Furuya A, Fuse N, Matsuzaki F. Differential functions of G protein and Baz-aPKC signaling pathways in Drosophila neuroblast asymmetric division. J Cell Biol. 2004;164:729-38 pubmed..We thus suggest that the two apical signaling pathways have overlapping but different roles in asymmetric NB division. ..
- Siegrist S, Doe C. Microtubule-induced Pins/Galphai cortical polarity in Drosophila neuroblasts. Cell. 2005;123:1323-35 pubmed..These results identify a role for microtubules in polarizing the neuroblast cortex, a fundamental step for generating cell diversity through asymmetric cell division. ..
- Zhang Y, Rai M, Wang C, Gonzalez C, Wang H. Prefoldin and Pins synergistically regulate asymmetric division and suppress dedifferentiation. Sci Rep. 2016;6:23735 pubmed publisherPrefoldin is a molecular chaperone complex that regulates tubulin function in mitosis. Here, we show that Prefoldin depletion results in disruption of neuroblast polarity, leading to neuroblast overgrowth in Drosophila larval brains...
- Sakaguchi A, Steward R. Aberrant monomethylation of histone H4 lysine 20 activates the DNA damage checkpoint in Drosophila melanogaster. J Cell Biol. 2007;176:155-62 pubmed..We therefore propose that monomethylated H4K20 is involved in the maintenance of proper higher order structure of DNA and is consequently essential for chromosome condensation. ..