Gene Symbol: alpha-Est7
Description: alpha-Esterase-7
Alias: Ali, Alpha-Est7, CG1112, DmalphaE7, Dmel\CG1112, EST23, Est-23, Est23, Mce, aE7, ali, alphaE7, alphaest-7, alpha-Esterase-7, CG1112-PA, aliesterase, aliesteraseless, alpha-Est7-PA, carboxylesterase 23, esterase 23, fragment H, malathion carboxylesterase
Species: fruit fly

Top Publications

  1. Heidari R, Devonshire A, Campbell B, Dorrian S, Oakeshott J, Russell R. Hydrolysis of pyrethroids by carboxylesterases from Lucilia cuprina and Drosophila melanogaster with active sites modified by in vitro mutagenesis. Insect Biochem Mol Biol. 2005;35:597-609 pubmed
    ..The results are discussed in relation to likely steric effects on enzyme-substrate interactions, cross-resistance between pyrethroids and malathion, and the potential for bioremediation of pyrethroid residues. ..
  2. Hooven L, Sherman K, Butcher S, Giebultowicz J. Does the clock make the poison? Circadian variation in response to pesticides. PLoS ONE. 2009;4:e6469 pubmed publisher
    ..Time of day of chemical exposure should be an important consideration in experimental design, use of pesticides, and human risk assessment. ..
  3. Campbell P, de Q Robin G, Court L, Dorrian S, Russell R, Oakeshott J. Developmental expression and gene/enzyme identifications in the alpha esterase gene cluster of Drosophila melanogaster. Insect Mol Biol. 2003;12:459-71 pubmed
    ..and in vitro gene expression we have also shown that two of the genes encode the isozymes EST9 (formerly ESTC) and EST23. EST9 is the major 'alpha staining' esterase in zymograms of gut tissues in feeding stages while orthologues of ..
  4. Healy M, Dumancic M, Oakeshott J. Biochemical and physiological studies of soluble esterases from Drosophila melanogaster. Biochem Genet. 1991;29:365-88 pubmed
    ..Carboxylesterases are distributed across a wide range of tissues, but subclass 1 cholinesterases are generally associated with neural or neurosecretory tissues and subclass 2 cholinesterases with digestive tissues. ..
  5. Oakeshott J, van Papenrecht E, Boyce T, Healy M, Russell R. Evolutionary genetics of Drosophila esterases. Genetica. 1993;90:239-68 pubmed
    ..melanogaster. These polymorphisms are associated with differences in substrate interactions in vitro and demographic data indicate that the alternative forms are not selectively equivalent in vivo...
  6. Russell R, Robin G, Kostakos P, Newcomb R, Boyce T, Medveczky K, et al. Molecular cloning of an alpha-esterase gene cluster on chromosome 3r of Drosophila melanogaster. Insect Biochem Mol Biol. 1996;26:235-47 pubmed
    ..It probably also includes the genes encoding the EST23, MCE and ALI esterases that have previously been mapped to 84D3-E2...
  7. de Q Robin G, Claudianos C, Russell R, Oakeshott J. Reconstructing the diversification of alpha-esterases: comparing the gene clusters of Drosophila buzzatii and D. melanogaster. J Mol Evol. 2000;51:149-60 pubmed
  8. Beaver L, Hooven L, Butcher S, Krishnan N, Sherman K, Chow E, et al. Circadian clock regulates response to pesticides in Drosophila via conserved Pdp1 pathway. Toxicol Sci. 2010;115:513-20 pubmed publisher
    ..Taken together, our data uncover a pathway from the positive arm of the circadian clock through Pdp1 to detoxification effector genes, demonstrating a conserved role of the circadian system in modulating xenobiotic toxicity. ..
  9. Robin C, Russell R, Medveczky K, Oakeshott J. Duplication and divergence of the genes of the alpha-esterase cluster of Drosophila melanogaster. J Mol Evol. 1996;43:241-52 pubmed
    ..The distribution of indels also suggests a deeper node in the gene phylogeny that separates six genes at the two ends of the cluster from a block of five in the middle. ..

More Information


  1. Oakeshott J, Claudianos C, Russell R, Robin G. Carboxyl/cholinesterases: a case study of the evolution of a successful multigene family. Bioessays. 1999;21:1031-42 pubmed
    ..Furthermore, we postulate that the versatility of the substrate binding motifs underpins the recruitment of several family members to additional noncatalytic signal transduction functions. ..
  2. Robin G, Russell R, Cutler D, Oakeshott J. The evolution of an alpha-esterase pseudogene inactivated in the Drosophila melanogaster lineage. Mol Biol Evol. 2000;17:563-75 pubmed publisher
    ..We argue that the original alphaE4a gene had a function which it has lost since the divergence of the D. melanogaster and D. simulans lineages...
  3. Birner Gruenberger R, Bickmeyer I, Lange J, Hehlert P, Hermetter A, Kollroser M, et al. Functional fat body proteomics and gene targeting reveal in vivo functions of Drosophila melanogaster ?-Esterase-7. Insect Biochem Mol Biol. 2012;42:220-9 pubmed publisher
    ..It also offers an entry point for in vivo structure-function analyses of ?-Esterase-7, which is of central importance for naturally occurring insecticide resistance in wild populations of various dipteran insect species. ..
  4. Wang S, Hu X, Meng Q, Muhammad S, Chen R, Li F, et al. The involvement of several enzymes in methanol detoxification in Drosophila melanogaster adults. Comp Biochem Physiol B Biochem Mol Biol. 2013;166:7-14 pubmed publisher
    ..It seems that there are some differences in methanol metabolism between larvae and adults, but not between female and male adults. ..
  5. Hamby K, Kwok R, Zalom F, Chiu J. Integrating circadian activity and gene expression profiles to predict chronotoxicity of Drosophila suzukii response to insecticides. PLoS ONE. 2013;8:e68472 pubmed publisher
    ..However, field research is necessary for extrapolation to agricultural settings. ..
  6. Spackman M, Oakeshott J, Smyth K, Medveczky K, Russell R. A cluster of esterase genes on chromosome 3R of Drosophila melanogaster includes homologues of esterase genes conferring insecticide resistance in Lucilia cuprina. Biochem Genet. 1994;32:39-62 pubmed EST 9 (formerly EST C), ali-esterase activity, defined by the hydrolysis of methyl butyrate, and malathion carboxylesterase activity, defined by hydrolysis of the organophosphate malathion...