Gene Symbol: ALiX
Description: ALG-2 interacting protein X
Alias: AIP1, ALIX, Aip1, Alix, CG12876, DAIP1, Dmel\CG12876, Snf7, alix, ALG-2 interacting protein X, ALG-2 interacting protein 1, ALiX-PA, CG12876-PA, apoptosis linked gene 2 interacting X
Species: fruit fly

Top Publications

  1. Tsuda M, Seong K, Aigaki T. POSH, a scaffold protein for JNK signaling, binds to ALG-2 and ALIX in Drosophila. FEBS Lett. 2006;580:3296-300 pubmed
    ..Here, we show that POSH forms a complex with Apoptosis-linked gene-2 (ALG-2) and ALG-2-interacting protein (ALIX/AIP1) in a calcium-dependent manner...
  2. Michelet X, Djeddi A, Legouis R. Developmental and cellular functions of the ESCRT machinery in pluricellular organisms. Biol Cell. 2010;102:191-202 pubmed publisher
    ..The present review summarizes recent research on the developmental and cellular functions of the ESCRT in Caenorhabditis elegans, Drosophila melanogaster, Mus musculus or Arabidopsis thaliana. ..
  3. Parchure A, Vyas N, Ferguson C, Parton R, Mayor S. Oligomerization and endocytosis of Hedgehog is necessary for its efficient exovesicular secretion. Mol Biol Cell. 2015;26:4700-17 pubmed publisher
    ..These results provide evidence that nanoscale organization of Hh regulates the secretion of Hh on ESCRT-derived exovesicles, which in turn act as a vehicle for long-range signaling. ..
  4. Quan J, Saaem I, Tang N, Ma S, Negre N, Gong H, et al. Parallel on-chip gene synthesis and application to optimization of protein expression. Nat Biotechnol. 2011;29:449-52 pubmed publisher
    ..This technology may facilitate systematic investigation of the molecular mechanisms of protein translation and the design, construction and evolution of macromolecular machines, metabolic networks and synthetic cells. ..
  5. Pirooznia S, Sarthi J, Johnson A, Toth M, Chiu K, Koduri S, et al. Tip60 HAT activity mediates APP induced lethality and apoptotic cell death in the CNS of a Drosophila Alzheimer's disease model. PLoS ONE. 2012;7:e41776 pubmed publisher
  6. Gradilla A, González E, Seijo I, Andrés G, Bischoff M, González Mendez L, et al. Exosomes as Hedgehog carriers in cytoneme-mediated transport and secretion. Nat Commun. 2014;5:5649 pubmed publisher
    ..We propose Hh transport via exosomes along cytonemes as a significant mechanism for the restricted distribution of a lipid-modified morphogen. ..
  7. Loncle N, Agromayor M, Martin Serrano J, Williams D. An ESCRT module is required for neuron pruning. Sci Rep. 2015;5:8461 pubmed publisher
    ..Furthermore we show that this ESCRT module requires a direct, in vivo, interaction between Shrub/CHMP4B and the accessory protein Myopic/HD-PTP. ..
  8. Valzania L, Romani P, Tian L, Li S, Cavaliere V, Pennacchio F, et al. A polydnavirus ANK protein acts as virulence factor by disrupting the function of prothoracic gland steroidogenic cells. PLoS ONE. 2014;9:e95104 pubmed publisher
    ..The localization of the TnBVANK1 is restricted to the cytoplasm where it interacts with Hrs and Alix marked endosomes...
  9. Matusek T, Wendler F, Polès S, Pizette S, D Angelo G, Fürthauer M, et al. The ESCRT machinery regulates the secretion and long-range activity of Hedgehog. Nature. 2014;516:99-103 pubmed publisher

More Information


  1. Eikenes Ã, Malerød L, Christensen A, Steen C, Mathieu J, Nezis I, et al. ALIX and ESCRT-III coordinately control cytokinetic abscission during germline stem cell division in vivo. PLoS Genet. 2015;11:e1004904 pubmed publisher
    ..The mechanisms of abscission in living metazoan tissues are however not well understood. Here we show that ALIX and the ESCRT-III component Shrub are required for completion of abscission during Drosophila female germline stem ..
  2. van Eeden F, Palacios I, Petronczki M, Weston M, St Johnston D. Barentsz is essential for the posterior localization of oskar mRNA and colocalizes with it to the posterior pole. J Cell Biol. 2001;154:511-23 pubmed
    ..Thus, Barentsz is essential for the posterior localization of oskar mRNA and behaves as a specific component of the oskar RNA transport complex. ..
  3. Corrigan L, Redhai S, Leiblich A, Fan S, Perera S, Patel R, et al. BMP-regulated exosomes from Drosophila male reproductive glands reprogram female behavior. J Cell Biol. 2014;206:671-88 pubmed publisher
    ..These results demonstrate a new function for the MVB-exosome pathway in the reproductive tract that appears to be conserved across evolution. ..
  4. Bischoff M, Gradilla A, Seijo I, Andrés G, Rodríguez Navas C, González Méndez L, et al. Cytonemes are required for the establishment of a normal Hedgehog morphogen gradient in Drosophila epithelia. Nat Cell Biol. 2013;15:1269-81 pubmed publisher
    ..Indeed, mutant conditions that affect cytoneme formation reduce both cytoneme length and Hh gradient length. Our results suggest that cytoneme-mediated Hh transport is the mechanistic basis for Hh gradient formation. ..