Gene Symbol: AdoR
Description: Adenosine receptor
Alias: CG9753, DmAdoR, Dmel\CG9753, adoR, anon-WO0170980.109, anon-WO0170980.110, dADOR, dAdoR, adenosine receptor, Ado receptor, AdoR-PA, AdoR-PB, CG9753-PA, CG9753-PB
Species: fruit fly

Top Publications

  1. McPartland J, Di Marzo V, De Petrocellis L, Mercer A, Glass M. Cannabinoid receptors are absent in insects. J Comp Neurol. 2001;436:423-9 pubmed
  2. Wu M, Ho K, Crocker A, Yue Z, Koh K, Sehgal A. The effects of caffeine on sleep in Drosophila require PKA activity, but not the adenosine receptor. J Neurosci. 2009;29:11029-37 pubmed publisher
    ..identify the mechanisms underlying these effects of caffeine, we first generated mutants of the only known adenosine receptor in flies (dAdoR), which by sequence is most similar to the mammalian A2A receptor...
  3. Liu S, Lamaze A, Liu Q, Tabuchi M, Yang Y, Fowler M, et al. WIDE AWAKE mediates the circadian timing of sleep onset. Neuron. 2014;82:151-66 pubmed publisher
    ..We propose that WAKE acts as a clock output molecule specifically for sleep, inhibiting LNvs at dusk to promote the transition from wake to sleep. ..
  4. Sidorov R, Kucerova L, Kiss I, Zurovec M. Mutation in the Drosophila melanogaster adenosine receptor gene selectively decreases the mosaic hyperplastic epithelial outgrowth rates in wts or dco heterozygous flies. Purinergic Signal. 2015;11:95-105 pubmed publisher
    ..Ado signaling is mediated by Ado receptors (AdoR) and proteins modulating its concentration, including nucleoside transporters and Ado deaminases...
  5. Dolezal T, Dolezelova E, Zurovec M, Bryant P. A role for adenosine deaminase in Drosophila larval development. PLoS Biol. 2005;3:e201 pubmed
    ..The block of pupariation appears to involve signaling through the adenosine receptor (AdoR), but fat body disintegration, which is promoted by action of the hemocytes, seems to be independent ..
  6. Knight D, Harvey P, Iliadi K, Klose M, Iliadi N, Dolezelova E, et al. Equilibrative nucleoside transporter 2 regulates associative learning and synaptic function in Drosophila. J Neurosci. 2010;30:5047-57 pubmed publisher
    ..observed in calcium influx and transmitter release probability at the NMJ were rescued by introducing an adenosine receptor mutant allele (AdoR(1)) into the ent2 mutant background...
  7. Bhaskara S, Chandrasekharan M, Ganguly R. Caffeine induction of Cyp6a2 and Cyp6a8 genes of Drosophila melanogaster is modulated by cAMP and D-JUN protein levels. Gene. 2008;415:49-59 pubmed publisher
    ..Since caffeine antagonizes adenosine receptor (AdoR) and inhibits cAMP phosphodiesterase (PDE), we used luciferase reporter gene to examine whether in SL-..
  8. Kucerova L, Broz V, Fleischmannova J, Santruckova E, Sidorov R, Dolezal V, et al. Characterization of the Drosophila adenosine receptor: the effect of adenosine analogs on cAMP signaling in Drosophila cells and their utility for in vivo experiments. J Neurochem. 2012;121:383-95 pubmed publisher
    ..We have shown previously that the Drosophila adenosine receptor (DmAdoR) evokes an increase in cAMP and calcium concentration in heterologous cells...
  9. Zuberova M, Fenckova M, Simek P, Janeckova L, Dolezal T. Increased extracellular adenosine in Drosophila that are deficient in adenosine deaminase activates a release of energy stores leading to wasting and death. Dis Model Mech. 2010;3:773-84 pubmed publisher
    ..The adenosine works in this regard through the adenosine receptor as an anti-insulin hormone in parallel to adipokinetic hormone, a glucagon counterpart in flies...

More Information


  1. Zemanova M, Stašková T, Kodrik D. Role of adipokinetic hormone and adenosine in the anti-stress response in Drosophila melanogaster. J Insect Physiol. 2016;91-92:39-47 pubmed publisher
    ..was studied in Drosophila melanogaster larvae and adults carrying a mutation in the Akh gene (Akh(1)), the adenosine receptor gene (AdoR(1)), or in both of these genes (Akh(1) AdoR(1) double mutant)...
  2. McPartland J, Matias I, Di Marzo V, Glass M. Evolutionary origins of the endocannabinoid system. Gene. 2006;370:64-74 pubmed
    ..Our methods identified fewer orthologs than did automated annotation systems, such as HomoloGene. Phylogenetic profiles, nonorthologous gene displacement, functional convergence, and coevolution are discussed. ..
  3. Celotto A, Frank A, Seigle J, Palladino M. Drosophila model of human inherited triosephosphate isomerase deficiency glycolytic enzymopathy. Genetics. 2006;174:1237-46 pubmed
    ..Biochemical studies demonstrate that mutation of this glycolytic enzyme gene does not result in a bioenergetic deficit, suggesting an alternate cause of enzymopathy associated with TPI impairment. ..
  4. Bajgar A, Kucerova K, Jonatova L, Tomcala A, Schneedorferová I, Okrouhlík J, et al. Extracellular adenosine mediates a systemic metabolic switch during immune response. PLoS Biol. 2015;13:e1002135 pubmed publisher
    ..Preventing adenosine transport from immune cells or blocking adenosine receptor precludes the metabolic switch and the deceleration of development, dramatically reducing host resistance...
  5. Dolezelova E, Nothacker H, Civelli O, Bryant P, Zurovec M. A Drosophila adenosine receptor activates cAMP and calcium signaling. Insect Biochem Mol Biol. 2007;37:318-29 pubmed
    ..Here we report the first characterization of an insect AdoR, encoded by the Drosophila gene CG9753. Adenosine stimulation of Chinese hamster ovary cells carrying transiently expressed CG9753 led to a dose-..
  6. Mondal B, Mukherjee T, Mandal L, Evans C, Sinenko S, Martinez Agosto J, et al. Interaction between differentiating cell- and niche-derived signals in hematopoietic progenitor maintenance. Cell. 2011;147:1589-600 pubmed publisher
    ..Similar homeostatic mechanisms are likely to be utilized in other systems that maintain relatively large numbers of progenitors that are not all in direct contact with the cells of the niche...
  7. Fleischmannova J, Kucerova L, Sandova K, Steinbauerová V, Broz V, Simek P, et al. Differential response of Drosophila cell lines to extracellular adenosine. Insect Biochem Mol Biol. 2012;42:321-31 pubmed publisher
    ..Our results show that different types of Drosophila cell lines use different pathways for Ado conversion and suggest that such differences may be an important part of complex mechanisms maintaining energy homeostasis in the body. ..