Adh

Summary

Gene Symbol: Adh
Description: Alcohol dehydrogenase
Alias: ADH, Adh3, BG:DS01486.8, CG32954, CG3481, DM-ADH, DmADH, Dmel\CG3481, Dreg-1, Reg-1, T16, adh, dADH, alcohol dehydrogenase, Adh-PC, Adh-PE, Adh-PF, Adh-PH, Adh-PI, CG3481-PC, CG3481-PE, CG3481-PF, CG3481-PH, CG3481-PI, alcohol dehyrdrogenase, alcoholdehydrogenase, drosophila rhythmically expressed gene 1
Species: fruit fly
Products:     Adh

Top Publications

  1. Bhadra U, Pal Bhadra M, Birchler J. A sex-influenced modifier in Drosophila that affects a broad spectrum of target loci including the histone repeats. Genetics. 1997;146:903-17 pubmed
    ..Thus, Low is a modifier that plays a role in modulating the expression of genes governing various processes including pigment deposition, eye development, chromosomal proteins and position effect variegation. ..
  2. Yang Z, Nielsen R, Goldman N, Pedersen A. Codon-substitution models for heterogeneous selection pressure at amino acid sites. Genetics. 2000;155:431-49 pubmed
    ..However, we encountered difficulties in estimating the precise distribution of omega among sites from real data sets. ..
  3. Sezgin E, Duvernell D, Matzkin L, Duan Y, Zhu C, Verrelli B, et al. Single-locus latitudinal clines and their relationship to temperate adaptation in metabolic genes and derived alleles in Drosophila melanogaster. Genetics. 2004;168:923-31 pubmed
    ..The result, when combined with the overall incidence and pattern of reports for six other genes (Adh, Gpdh, Pgm, G6pd, 6Pgd, Hex-C), presents a picture of latitudinal clines in metabolic genes prevalent around the ..
  4. Papaceit M, Orengo D, Juan E. Sequences upstream of the homologous cis-elements of the Adh adult enhancer of Drosophila are required for maximal levels of Adh gene transcription in adults of Scaptodrosophila lebanonensis. Genetics. 2004;167:289-99 pubmed
    ..All constructs included, as a cotransgene, a modified Adh gene of D. melanogaster (dAdh) in a fixed position and orientation that acted as a chromosomal position control...
  5. Brogna S. Nonsense mutations in the alcohol dehydrogenase gene of Drosophila melanogaster correlate with an abnormal 3' end processing of the corresponding pre-mRNA. RNA. 1999;5:562-73 pubmed
    ..Here, it is reported that mutations in the alcohol dehydrogenase gene (Adh) of Drosophila melanogaster that generate premature termination codons lead to reduced levels of ..
  6. Ayer S, Walker N, Mosammaparast M, Nelson J, Shilo B, Benyajati C. Activation and repression of Drosophila alcohol dehydrogenase distal transcription by two steroid hormone receptor superfamily members binding to a common response element. Nucleic Acids Res. 1993;21:1619-27 pubmed
    Developmental activation of the Drosophila alcohol dehydrogenase (Adh) distal promoter is controlled by the Adh adult enhancer (AAE)...
  7. Leal J, Barbancho M. Aldehyde dehydrogenase (ALDH) activity in Drosophila melanogaster adults: evidence for cytosolic localization. Insect Biochem Mol Biol. 1993;23:543-7 pubmed
    ..2.1.3) enzyme has been studied in nutritionally manipulated Drosophila melanogaster adults from a wild (LRC) and an ADH-null (bAdhn4) strain. ALDH activities from ALDH or ADH (EC 1.1.1...
  8. Abel T, Michelson A, Maniatis T. A Drosophila GATA family member that binds to Adh regulatory sequences is expressed in the developing fat body. Development. 1993;119:623-33 pubmed
    ..a Drosophila transcription factor that binds a sequence element found in the larval promoters of all known alcohol dehydrogenase (Adh) genes...
  9. Benach J, Winberg J, Svendsen J, Atrian S, Gonzalez Duarte R, Ladenstein R. Drosophila alcohol dehydrogenase: acetate-enzyme interactions and novel insights into the effects of electrostatics on catalysis. J Mol Biol. 2005;345:579-98 pubmed
    Drosophila alcohol dehydrogenase (DADH) is an NAD+-dependent enzyme that catalyzes the oxidation of alcohols to aldehydes/ketones and that is also able to further oxidize aldehydes to their corresponding carboxylic acids...
  10. Gatfield D, Unterholzner L, Ciccarelli F, Bork P, Izaurralde E. Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways. EMBO J. 2003;22:3960-70 pubmed
    ..Our findings reveal that despite conservation of the NMD machinery, different mechanisms have evolved to discriminate premature from natural stop codons in metazoa. ..

Detail Information

Publications67

  1. Bhadra U, Pal Bhadra M, Birchler J. A sex-influenced modifier in Drosophila that affects a broad spectrum of target loci including the histone repeats. Genetics. 1997;146:903-17 pubmed
    ..Thus, Low is a modifier that plays a role in modulating the expression of genes governing various processes including pigment deposition, eye development, chromosomal proteins and position effect variegation. ..
  2. Yang Z, Nielsen R, Goldman N, Pedersen A. Codon-substitution models for heterogeneous selection pressure at amino acid sites. Genetics. 2000;155:431-49 pubmed
    ..However, we encountered difficulties in estimating the precise distribution of omega among sites from real data sets. ..
  3. Sezgin E, Duvernell D, Matzkin L, Duan Y, Zhu C, Verrelli B, et al. Single-locus latitudinal clines and their relationship to temperate adaptation in metabolic genes and derived alleles in Drosophila melanogaster. Genetics. 2004;168:923-31 pubmed
    ..The result, when combined with the overall incidence and pattern of reports for six other genes (Adh, Gpdh, Pgm, G6pd, 6Pgd, Hex-C), presents a picture of latitudinal clines in metabolic genes prevalent around the ..
  4. Papaceit M, Orengo D, Juan E. Sequences upstream of the homologous cis-elements of the Adh adult enhancer of Drosophila are required for maximal levels of Adh gene transcription in adults of Scaptodrosophila lebanonensis. Genetics. 2004;167:289-99 pubmed
    ..All constructs included, as a cotransgene, a modified Adh gene of D. melanogaster (dAdh) in a fixed position and orientation that acted as a chromosomal position control...
  5. Brogna S. Nonsense mutations in the alcohol dehydrogenase gene of Drosophila melanogaster correlate with an abnormal 3' end processing of the corresponding pre-mRNA. RNA. 1999;5:562-73 pubmed
    ..Here, it is reported that mutations in the alcohol dehydrogenase gene (Adh) of Drosophila melanogaster that generate premature termination codons lead to reduced levels of ..
  6. Ayer S, Walker N, Mosammaparast M, Nelson J, Shilo B, Benyajati C. Activation and repression of Drosophila alcohol dehydrogenase distal transcription by two steroid hormone receptor superfamily members binding to a common response element. Nucleic Acids Res. 1993;21:1619-27 pubmed
    Developmental activation of the Drosophila alcohol dehydrogenase (Adh) distal promoter is controlled by the Adh adult enhancer (AAE)...
  7. Leal J, Barbancho M. Aldehyde dehydrogenase (ALDH) activity in Drosophila melanogaster adults: evidence for cytosolic localization. Insect Biochem Mol Biol. 1993;23:543-7 pubmed
    ..2.1.3) enzyme has been studied in nutritionally manipulated Drosophila melanogaster adults from a wild (LRC) and an ADH-null (bAdhn4) strain. ALDH activities from ALDH or ADH (EC 1.1.1...
  8. Abel T, Michelson A, Maniatis T. A Drosophila GATA family member that binds to Adh regulatory sequences is expressed in the developing fat body. Development. 1993;119:623-33 pubmed
    ..a Drosophila transcription factor that binds a sequence element found in the larval promoters of all known alcohol dehydrogenase (Adh) genes...
  9. Benach J, Winberg J, Svendsen J, Atrian S, Gonzalez Duarte R, Ladenstein R. Drosophila alcohol dehydrogenase: acetate-enzyme interactions and novel insights into the effects of electrostatics on catalysis. J Mol Biol. 2005;345:579-98 pubmed
    Drosophila alcohol dehydrogenase (DADH) is an NAD+-dependent enzyme that catalyzes the oxidation of alcohols to aldehydes/ketones and that is also able to further oxidize aldehydes to their corresponding carboxylic acids...
  10. Gatfield D, Unterholzner L, Ciccarelli F, Bork P, Izaurralde E. Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways. EMBO J. 2003;22:3960-70 pubmed
    ..Our findings reveal that despite conservation of the NMD machinery, different mechanisms have evolved to discriminate premature from natural stop codons in metazoa. ..
  11. Pal Bhadra M, Bhadra U, Birchler J. RNAi related mechanisms affect both transcriptional and posttranscriptional transgene silencing in Drosophila. Mol Cell. 2002;9:315-27 pubmed
    Two types of transgene silencing were found for the Alcohol dehydrogenase (Adh) transcription unit. Transcriptional gene silencing (TGS) is Polycomb dependent and occurs when Adh is driven by the white eye color gene promoter...
  12. Hansen S, Tjian R. TAFs and TFIIA mediate differential utilization of the tandem Adh promoters. Cell. 1995;82:565-75 pubmed
    The D. melanogaster alcohol dehydrogenase (Adh) gene is transcribed from two tandem promoters that are differentially utilized at various stages during development...
  13. Pal Bhadra M, Bhadra U, Birchler J. Cosuppression of nonhomologous transgenes in Drosophila involves mutually related endogenous sequences. Cell. 1999;99:35-46 pubmed
    ..Here we demonstrate that two nonhomologous reciprocal fusion genes, white-Alcohol dehydrogenase (w-Adh) and Adh-w, exhibit cosuppression using the endogenous Adh sequence as an intermediary...
  14. Thomas R, Hunt J. Phylogenetic relationships in Drosophila: a conflict between molecular and morphological data. Mol Biol Evol. 1993;10:362-74 pubmed publisher
    ..the family Drosophilidae, based on adult morphological characters, is evaluated for those taxa for which alcohol dehydrogenase DNA sequences are also available...
  15. Russo C, Takezaki N, Nei M. Molecular phylogeny and divergence times of drosophilid species. Mol Biol Evol. 1995;12:391-404 pubmed publisher
    ..relationships and divergence times of 39 drosophilid species were studied by using the coding region of the Adh gene...
  16. Fry J, Saweikis M. Aldehyde dehydrogenase is essential for both adult and larval ethanol resistance in Drosophila melanogaster. Genet Res. 2006;87:87-92 pubmed
    ..with some authors arguing that, at least in larvae, acetaldehyde detoxification is carried out mainly by alcohol dehydrogenase (ADH), the enzyme responsible for converting ethanol to acetaldehyde...
  17. Chen Z, Smith K, Batterham P, Robin C. Smg1 nonsense mutations do not abolish nonsense-mediated mRNA decay in Drosophila melanogaster. Genetics. 2005;171:403-6 pubmed
    ..Smg1 is a key component of nonsense-mediated decay (NMD) in Caenorhabditis elegans and mammals. Here we report that two nonsense alleles of the ortholog of Smg1 do not affect NMD in Drosophila melanogaster. ..
  18. Chia W, Savakis C, Karp R, Ashburner M. Adhn4 of Drosophila melanogaster is a nonsense mutation. Nucleic Acids Res. 1987;15:3931 pubmed
  19. Umina P, Weeks A, Kearney M, McKechnie S, Hoffmann A. A rapid shift in a classic clinal pattern in Drosophila reflecting climate change. Science. 2005;308:691-3 pubmed
    ..We show that the classic latitudinal cline in the alcohol dehydrogenase polymorphism of Drosophila melanogaster has shifted over 20 years in eastern coastal Australia...
  20. Jackson J, Benyajati C. DNA-histone interactions are sufficient to position a single nucleosome juxtaposing Drosophila Adh adult enhancer and distal promoter. Nucleic Acids Res. 1993;21:957-67 pubmed
    The alcohol dehydrogenase gene (Adh) of Drosophila melanogaster is transcribed from two tandem promoters in distinct developmental and tissue-specific patterns. Both promoters are regulated by separate upstream enhancer regions...
  21. Bodmer M, Ashburner M. Conservation and change in the DNA sequences coding for alcohol dehydrogenase in sibling species of Drosophila. Nature. 1984;309:425-30 pubmed
    The DNA sequences of the alcohol dehydrogenase (Adh) genes of four very closely related species of Drosophila show that the rates of nucleotide change vary greatly in different functional domains of this gene...
  22. Florea L, Hartzell G, Zhang Z, Rubin G, Miller W. A computer program for aligning a cDNA sequence with a genomic DNA sequence. Genome Res. 1998;8:967-74 pubmed
    ..A freely available computer program, described herein, solves the problem for a 100-kb genomic sequence in a few seconds on a workstation. ..
  23. Pal Bhadra M, Bhadra U, Birchler J. Cosuppression in Drosophila: gene silencing of Alcohol dehydrogenase by white-Adh transgenes is Polycomb dependent. Cell. 1997;90:479-90 pubmed
    When two to six copies of a white promoter-Alcohol dehydrogenase (Adh) reporter fusion gene are introduced into the genome, the expression is progressively reduced both in larvae and adults rather than the expected gene dosage effect...
  24. Cols N, Atrian S, Benach J, Ladenstein R, Gonzalez Duarte R. Drosophila alcohol dehydrogenase: evaluation of Ser139 site-directed mutants. FEBS Lett. 1997;413:191-3 pubmed
    Drosophila alcohol dehydrogenase (DADH) belongs to the large and highly heterogeneous (15-30% residue identity) short-chain dehydrogenase/reductase family (SDR)...
  25. Amador A, Juan E. Nonfixed duplication containing the Adh gene and a truncated form of the Adhr gene in the Drosophila funebris species group: different modes of evolution of Adh relative to Adhr in Drosophila. Mol Biol Evol. 1999;16:1439-56 pubmed publisher
    The sequence of the genomic region that contains the Adh and Adhr genes of Drosophila funebris was used to demonstrate that both genes are present in species of the funebris group. The sequence of this genomic region reveals a 2...
  26. Malherbe Y, Kamping A, van Delden W, van de Zande L. ADH enzyme activity and Adh gene expression in Drosophila melanogaster lines differentially selected for increased alcohol tolerance. J Evol Biol. 2005;18:811-9 pubmed
    In Drosophila melanogaster, alcohol dehydrogenase (ADH) activity is essential for ethanol tolerance, but its role may not be restricted to alcohol metabolism alone...
  27. Chen Z, Jiang J, Lin Z, Lee W, Baker M, Chang S. Site-specific mutagenesis of Drosophila alcohol dehydrogenase: evidence for involvement of tyrosine-152 and lysine-156 in catalysis. Biochemistry. 1993;32:3342-6 pubmed
    Amino acid sequence comparisons reveal that tyrosine-152 and lysine-156 of Drosophila alcohol dehydrogenase (ADH) are conserved in homologous dehydrogenases, suggesting that these residues are important in catalysis...
  28. Reese M, Hartzell G, Harris N, Ohler U, Abril J, Lewis S. Genome annotation assessment in Drosophila melanogaster. Genome Res. 2000;10:483-501 pubmed
    ..genomes of higher organisms, we evaluated their performance on a large, well-characterized sequence contig from the Adh region of Drosophila melanogaster...
  29. Carulli J, Krane D, Hartl D, Ochman H. Compositional heterogeneity and patterns of molecular evolution in the Drosophila genome. Genetics. 1993;134:837-45 pubmed
  30. Heberlein U, England B, Tjian R. Characterization of Drosophila transcription factors that activate the tandem promoters of the alcohol dehydrogenase gene. Cell. 1985;41:965-77 pubmed
    ..of multiple components involved in accurate transcription of both distal and proximal promoters of the alcohol dehydrogenase (Adh) gene...
  31. Ogueta M, Cibik O, Eltrop R, Schneider A, Scholz H. The influence of Adh function on ethanol preference and tolerance in adult Drosophila melanogaster. Chem Senses. 2010;35:813-22 pubmed publisher
    ..whether Drosophila preference, sensitivity and tolerance to ethanol was related to the activity of alcohol dehydrogenase (Adh), the primary ethanol-metabolizing enzyme in D. melanogaster...
  32. Behm Ansmant I, Gatfield D, Rehwinkel J, Hilgers V, Izaurralde E. A conserved role for cytoplasmic poly(A)-binding protein 1 (PABPC1) in nonsense-mediated mRNA decay. EMBO J. 2007;26:1591-601 pubmed
    ..These findings reveal a conserved role for PABPC1 in mRNA surveillance. ..
  33. Cols N, Marfany G, Atrian S, Gonzalez Duarte R. Effect of site-directed mutagenesis on conserved positions of Drosophila alcohol dehydrogenase. FEBS Lett. 1993;319:90-4 pubmed
    Tyr152 and Lys156 may be functionally important residues in Drosophila ADH as they are conserved in the genus and in all short-chain dehydrogenases...
  34. Ludwig A, Loreto E. Evolutionary pattern of the gtwin retrotransposon in the Drosophila melanogaster subgroup. Genetica. 2007;130:161-8 pubmed publisher
    ..melanogaster. The results suggest that the gtwin element may be an infectious retrovirus able to invade the genome of new species, supporting the gtwin evolutionary picture shown in this work...
  35. Posakony J, Fischer J, Maniatis T. Identification of DNA sequences required for the regulation of Drosophila alcohol dehydrogenase gene expression. Cold Spring Harb Symp Quant Biol. 1985;50:515-20 pubmed
  36. Cohn V, Moore G. Organization and evolution of the alcohol dehydrogenase gene in Drosophila. Mol Biol Evol. 1988;5:154-66 pubmed
    The alcohol dehydrogenase (Adh) gene was isolated from Drosophila simulans and D. mauritiana, and the DNA sequence of a 4.6-kb region, containing the structural gene and flanking sequence, was determined for each...
  37. Nurminsky D, Moriyama E, Lozovskaya E, Hartl D. Molecular phylogeny and genome evolution in the Drosophila virilis species group: duplications of the alcohol dehydrogenase gene. Mol Biol Evol. 1996;13:132-49 pubmed
    ..Sequences were determined for 11 Adh genes from 8 species of the D...
  38. McColl G, Hoffmann A, McKechnie S. Response of two heat shock genes to selection for knockdown heat resistance in Drosophila melanogaster. Genetics. 1996;143:1615-27 pubmed
    ..The data indicate that molecular variation in both hsr-omega and.hsp68 contribute to natural heritable variation for hardened heat resistance. ..
  39. Benyajati C, Place A, Powers D, Sofer W. Alcohol dehydrogenase gene of Drosophila melanogaster: relationship of intervening sequences to functional domains in the protein. Proc Natl Acad Sci U S A. 1981;78:2717-21 pubmed
    The gene that codes for Drosophila alcohol dehydrogenase (ADH; alcohol:NAD+ oxidoreductase EC 1.1.1.1) was identified in a bacteriophage lambda library of genomic Drosophila DNA by using ADH cDNA cloned DNA as a probe...
  40. Oppentocht J, van Delden W, van de Zande L. Isolation and characterization of the genomic region from Drosophila kuntzei containing the Adh and Adhr genes. Mol Biol Evol. 2002;19:1026-40 pubmed publisher
    The nucleotide sequences of the Adh and Adhr genes of Drosophila kuntzei were derived from combined overlapping sequences of clones isolated from a genomic library and from cloned PCR and inverse-PCR fragments...
  41. Ren B, Maniatis T. Regulation of Drosophila Adh promoter switching by an initiator-targeted repression mechanism. EMBO J. 1998;17:1076-86 pubmed
    The stage-specific expression of the Drosophila alcohol dehydrogenase (Adh) gene is achieved through the alternate activation of two tandem promoters...
  42. Fischer J, Maniatis T. Drosophila Adh: a promoter element expands the tissue specificity of an enhancer. Cell. 1988;53:451-61 pubmed
    Drosophila alcohol dehydrogenase (Adh) genes are expressed in the fat body and in species-specific sets of other tissues during larval and adult development...
  43. van der Linde K, Houle D, Spicer G, Steppan S. A supermatrix-based molecular phylogeny of the family Drosophilidae. Genet Res (Camb). 2010;92:25-38 pubmed publisher
    ..We argue that these results support a taxonomic revision of the genus Drosophila...
  44. Tatarenkov A, Kwiatowski J, Skarecky D, Barrio E, Ayala F. On the evolution of Dopa decarboxylase (Ddc) and Drosophila systematics. J Mol Evol. 1999;48:445-62 pubmed
    ..phylogeny are resolved by analysis of the Ddc sequences alone or in combination with three other genes, Sod, Adh, and Gpdh...
  45. Albalat R, González Duarte -, Atrian S. Protein engineering of Drosophila alcohol dehydrogenase. The hydroxyl group of Tyr152 is involved in the active site of the enzyme. FEBS Lett. 1992;308:235-9 pubmed
    Drosophila alcohol dehydrogenase is the most studied member of the family of short-chain alcohol dehydrogenases, although its tridimensional structure still remains unknown...
  46. Benyajati C, Ewel A, McKeon J, Chovav M, Juan E. Characterization and purification of Adh distal promoter factor 2, Adf-2, a cell-specific and promoter-specific repressor in Drosophila. Nucleic Acids Res. 1992;20:4481-9 pubmed
    ..in Drosophila tissue culture cells has detected the binding of a non-histone protein at +8 of the distal Adh RNA start site, on a 10-bp direct repeat motif abutting a nucleosome positioned over the inactive Adh distal ..
  47. Abel T, Bhatt R, Maniatis T. A Drosophila CREB/ATF transcriptional activator binds to both fat body- and liver-specific regulatory elements. Genes Dev. 1992;6:466-80 pubmed
    We have identified a Drosophila transcription factor that binds to fat body-specific enhancers of alcohol dehydrogenase (Adh) and yolk protein genes...
  48. Persson B, Krook M, Jornvall H. Characteristics of short-chain alcohol dehydrogenases and related enzymes. Eur J Biochem. 1991;200:537-43 pubmed
    ..Asp64, Tyr152 and Lys156 (in the numbering of Drosophila alcohol dehydrogenase), but no histidine or cysteine residue like in the completely different, classical medium-chain alcohol ..
  49. Corbin V, Maniatis T. The role of specific enhancer-promoter interactions in the Drosophila Adh promoter switch. Genes Dev. 1989;3:2191-20 pubmed
    The Drosophila melanogaster alcohol dehydrogenase (Adh) gene is transcribed from two promoters active at different developmental stages...
  50. England B, Heberlein U, Tjian R. Purified Drosophila transcription factor, Adh distal factor-1 (Adf-1), binds to sites in several Drosophila promoters and activates transcription. J Biol Chem. 1990;265:5086-94 pubmed
    ..Adf-1 binds to upstream recognition elements in each of the two promoters of the Drosophila alcohol dehydrogenase gene (Adh), and binding of Adf-1 to the Adh distal promoter site activates transcription...
  51. Corbin V, Maniatis T. Identification of cis-regulatory elements required for larval expression of the Drosophila melanogaster alcohol dehydrogenase gene. Genetics. 1990;124:637-46 pubmed
    The Alcohol dehydrogenase (Adh) genes of two distantly related species, Drosophila melanogaster and Drosophila mulleri, display similar, but not identical, patterns of tissue-specific expression in larvae and adults...
  52. Maruyama K, Hartl D. Evidence for interspecific transfer of the transposable element mariner between Drosophila and Zaprionus. J Mol Evol. 1991;33:514-24 pubmed
    ..phylogenetic relationship between the genus Zaprionus and the melanogaster species group, we compared the alcohol dehydrogenase (Adh) sequences among these species...
  53. Laurie C, Bridgham J, Choudhary M. Associations between DNA sequence variation and variation in expression of the Adh gene in natural populations of Drosophila melanogaster. Genetics. 1991;129:489-99 pubmed
    A large part of the genetic variation in alcohol dehydrogenase (ADH) activity level in natural populations of Drosophila melanogaster is associated with segregation of an amino acid replacement polymorphism at nucleotide 1490, which ..
  54. Ayer S, Benyajati C. Conserved enhancer and silencer elements responsible for differential Adh transcription in Drosophila cell lines. Mol Cell Biol. 1990;10:3512-23 pubmed
    ..After transfection with an exogenous Adh gene, there was a specific increase in distal alcohol dehydrogenase (ADH) transcripts in ADH-expressing (ADH+) cells above the levels observed in transfected ADH-..
  55. Heinstra P, Geer B, Seykens D, Langevin M. The metabolism of ethanol-derived acetaldehyde by alcohol dehydrogenase (EC 1.1.1.1) and aldehyde dehydrogenase (EC 1.2.1.3) in Drosophila melanogaster larvae. Biochem J. 1989;259:791-7 pubmed
    Both aldehyde dehydrogenase (ALDH, EC 1.2.1.3) and the aldehyde dehydrogenase activity of alcohol dehydrogenase (ADH, EC 1.1.1.1) were found to coexist in Drosophila melanogaster larvae...
  56. Corbin V, Maniatis T. Role of transcriptional interference in the Drosophila melanogaster Adh promoter switch. Nature. 1989;337:279-82 pubmed
    The Drosophilia melanogaster alcohol dehydrogenase (Adh) gene is transcribed from two closely linked promoters, which are regulated by two upstream enhancers...
  57. DeSalle R. The origin and possible time of divergence of the Hawaiian Drosophilidae: evidence from DNA sequences. Mol Biol Evol. 1992;9:905-16 pubmed
    ..In light of fossil evidence, this phylogenetic scenario suggests that the Hawaiian Drosophilidae lineages are no younger than 30 Myr. ..
  58. Lerat E, Bi mont C, Capy P. Codon usage and the origin of P elements. Mol Biol Evol. 2000;17:467-8 pubmed publisher
  59. Siegal M, Hartl D. Transgene Coplacement and high efficiency site-specific recombination with the Cre/loxP system in Drosophila. Genetics. 1996;144:715-26 pubmed
    ..The excision reactions of Cre/loxP and the related FLP/FRT system are used to create Drosophila lines in which transgenes are at exactly allelic sites in homologous chromosomes...
  60. Berry A, Kreitman M. Molecular analysis of an allozyme cline: alcohol dehydrogenase in Drosophila melanogaster on the east coast of North America. Genetics. 1993;134:869-93 pubmed
    ..a latitudinal cline in the frequencies of two common electrophoretically distinguishable alleles at the alcohol dehydrogenase locus (Adh), designated Adh-S and Adh-F...
  61. Bubliy O, Kalabushkin B, Imasheva A. Geographic variation of six allozyme loci in Drosophila melanogaster: an analysis of data from different continents. Hereditas. 1999;130:25-32 pubmed
    ..The analyzed loci were Adh, Odh, Gpdh, G6pd, Pgd, and Est-6, which have been previously reported by other authors to show latitudinal ..
  62. Albalat R, Arenas C, Mestres F. A statistical analysis of nucleotide substitutions in the Drosophila Adh region reflects irregularities in molecular clocks. Genes Genet Syst. 2001;76:209-12 pubmed
    ..To analyze this feature, Ka/Ks ratios have been studied for Alcohol dehydrogenase (Adh) and Alcohol dehydrogenase duplication (Adh-dup) genes in Drosophila species...
  63. Abraham E, Mounier N, Bosquet G. Expression of a Bombyx cytoplasmic actin gene in cultured Drosophila cells: influence of 20-hydroxyecdysone and interference with expression of endogenous cytoplasmic actin genes. Insect Biochem Mol Biol. 1993;23:905-12 pubmed
    ..These results are discussed in terms of competition for transcription and regulatory factors. ..
  64. Pecsenye K, Lefkovitch L, Giles B, Saura A. Differences in environmental temperature, ethanol and sucrose associated with enzyme activity and weight changes in Drosophila melanogaster. Insect Biochem Mol Biol. 1996;26:135-45 pubmed
    Activity changes of three enzymes (ADH, ODH and AOX) of Drosophila melanogaster were followed under different environmental conditions...
  65. Sha K, Choi S, Im J, Lee G, Loeffler F, Park J. Regulation of ethanol-related behavior and ethanol metabolism by the Corazonin neurons and Corazonin receptor in Drosophila melanogaster. PLoS ONE. 2014;9:e87062 pubmed publisher
    ..Key enzymes in ethanol metabolism are alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH); however, neuroendocrine pathways that regulate the activities of ..
  66. Parsons P. Larval responses to environmental ethanol in Drosophila melanogaster: variation within and among populations. Behav Genet. 1980;10:183-90 pubmed
    ..Since ethanol is a resource for D. melanogaster, an approach to the genetics of resource utilization in natural populations via behavior genetics of larval ethanol responses is feasible, using isofemale strains as experimental material. ..