Act5C

Summary

Gene Symbol: Act5C
Description: Actin 5C
Alias: A4V404_DROME, ACT, ACT1_DROME, ACT5C, Ac5C, Act, Act-5C, Act5, Act5c, Actin, Actin/BAP47, Actin5C, ArpA, BAP47, Bap47, CG4027, Dmel\CG4027, M32055, T11, act, act 5C, act5C, actin, actin5C, anon-EST:fe2D2, beta-actin, beta-actin/Bap47, chrX:5748184..5748304, cyt5C, l(1)G0009, l(1)G0010, l(1)G0025, l(1)G0079, l(1)G0117, l(1)G0177, l(1)G0245, l(1)G0330, l(1)G0420, l(1)G0486, actin 5C, 5C actin, Act5C-PA, Act5C-PB, Act5C-PC, Act5C-PD, Act5C-PE, CG4027-PA, CG4027-PB, CG4027-PC, CG4027-PD, CG4027-PE, Dm-actin5C, F-actin, G-actin, actin, actin 5 C, actin 5c, actin A1, actin5C, anon-fast-evolving-2D2, beta-actin, cellular cytoskeletal beta-actin
Species: fruit fly
Products:     Act5C

Top Publications

  1. Bahri S, Yang X, Chia W. The Drosophila bifocal gene encodes a novel protein which colocalizes with actin and is necessary for photoreceptor morphogenesis. Mol Cell Biol. 1997;17:5521-9 pubmed
    ..amino acids which is expressed in the embryo and the larval eye imaginal disc in a pattern identical to that of F actin. During pupal development, Bif localizes to the base of the filamentous actin associated with the forming ..
  2. Satoh A, O Tousa J, Ozaki K, Ready D. Rab11 mediates post-Golgi trafficking of rhodopsin to the photosensitive apical membrane of Drosophila photoreceptors. Development. 2005;132:1487-97 pubmed
    ..These results establish a role for Rab11 in the post-Golgi transport of rhodopsin and of other proteins to the rhabdomeric membranes of photoreceptors, and in analogous transport processes in other cells. ..
  3. Adams R, Tavares A, Salzberg A, Bellen H, Glover D. pavarotti encodes a kinesin-like protein required to organize the central spindle and contractile ring for cytokinesis. Genes Dev. 1998;12:1483-94 pubmed
    ..We show that the septin Peanut, actin, and the actin-associated protein Anillin, do not become correctly localized in pav mutants...
  4. Giansanti M, Farkas R, Bonaccorsi S, Lindsley D, Wakimoto B, Fuller M, et al. Genetic dissection of meiotic cytokinesis in Drosophila males. Mol Biol Cell. 2004;15:2509-22 pubmed
    ..Examination of preparations stained for tubulin, anillin, KLP3A, and F-actin revealed discrete defects in the components of the cytokinetic apparatus, suggesting that these genes act at four ..
  5. Padash Barmchi M, Rogers S, Hacker U. DRhoGEF2 regulates actin organization and contractility in the Drosophila blastoderm embryo. J Cell Biol. 2005;168:575-85 pubmed
    Morphogenesis of the Drosophila melanogaster embryo is associated with a dynamic reorganization of the actin cytoskeleton that is mediated by small GTPases of the Rho family...
  6. Andersen R, Li Y, Resseguie M, Brenman J. Calcium/calmodulin-dependent protein kinase II alters structural plasticity and cytoskeletal dynamics in Drosophila. J Neurosci. 2005;25:8878-88 pubmed
    ..Furthermore, general dendrite cytoskeletal compartmentalization is conserved in multipolar neurons. ..
  7. Miyauchi C, Kitazawa D, Ando I, Hayashi D, Inoue Y. Orbit/CLASP is required for germline cyst formation through its developmental control of fusomes and ring canals in Drosophila males. PLoS ONE. 2013;8:e58220 pubmed publisher
    ..Instead, our fluorescence resonance energy transfer experiments suggested that Orbit is closely associated with F-actin, which is abundantly found in fusomes...
  8. Eggert U, Kiger A, Richter C, Perlman Z, Perrimon N, Mitchison T, et al. Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets. PLoS Biol. 2004;2:e379 pubmed
    ..Our study shows that parallel RNA interference and small molecule screening is a generally useful approach to identifying active small molecules and their target pathways...
  9. Roulier E, Panzer S, Beckendorf S. The Tec29 tyrosine kinase is required during Drosophila embryogenesis and interacts with Src64 in ring canal development. Mol Cell. 1998;1:819-29 pubmed
    ..This interaction is similar to that between vertebrate Src and Tec kinases and suggests that Tec29 is an effector of Src64 that modifies ring canal components required for growth. ..

More Information

Publications64

  1. Guarnieri D, Dodson G, Simon M. SRC64 regulates the localization of a Tec-family kinase required for Drosophila ring canal growth. Mol Cell. 1998;1:831-40 pubmed
    ..These data suggest that TEC29 is a downstream target of SRC64, and that regulating TEC29 localization during ring canal growth may be a crucial SRC64 function. ..
  2. Jin P, Duan R, Luo F, Zhang G, Hong S, Chen E. Competition between Blown fuse and WASP for WIP binding regulates the dynamics of WASP-dependent actin polymerization in vivo. Dev Cell. 2011;20:623-38 pubmed publisher
    Dynamic rearrangements of the actin cytoskeleton play a key role in numerous cellular processes...
  3. Riparbelli M, Callaini G, Glover D, Avides M. A requirement for the Abnormal Spindle protein to organise microtubules of the central spindle for cytokinesis in Drosophila. J Cell Sci. 2002;115:913-22 pubmed
    ..Upon fertilisation, Asp is also recruited to the MTOC that nucleates the sperm aster. Asp is required for growth of the microtubules of the sperm aster, which in asp mutants remains diminutive and so prevents migration of the pronuclei. ..
  4. Medina P, Swick L, Andersen R, Blalock Z, Brenman J. A novel forward genetic screen for identifying mutations affecting larval neuronal dendrite development in Drosophila melanogaster. Genetics. 2006;172:2325-35 pubmed
    ..approaches have been used to analyze the latest stages of dendrite development, including the formation of F-actin-rich dendritic filopodia or dendritic spines...
  5. Wills Z, Emerson M, Rusch J, Bikoff J, Baum B, Perrimon N, et al. A Drosophila homolog of cyclase-associated proteins collaborates with the Abl tyrosine kinase to control midline axon pathfinding. Neuron. 2002;36:611-22 pubmed
    ..that Drosophila capulet (capt), a homolog of the adenylyl cyclase-associated protein that binds and regulates actin in yeast, associates with Abl in Drosophila cells, suggesting a functional relationship in vivo...
  6. Fyrberg E, Bond B, Hershey N, Mixter K, Davidson N. The actin genes of Drosophila: protein coding regions are highly conserved but intron positions are not. Cell. 1981;24:107-16 pubmed
    The entire set of six closely related Drosophila actin genes was isolated using recombinant DNA methodology, and the structures of the respective coding regions were characterized by gene mapping techniques and by nucleotide sequencing ..
  7. Ribeiro C, Ebner A, Affolter M. In vivo imaging reveals different cellular functions for FGF and Dpp signaling in tracheal branching morphogenesis. Dev Cell. 2002;2:677-83 pubmed
    ..Bnl/FGF signaling affects the formation of dynamic filopodia, possibly controlling cytoskeletal activity and motility as such, and Dpp controls cellular functions allowing branch morphogenesis and outgrowth. ..
  8. Prokopenko S, Brumby A, O KEEFE L, Prior L, He Y, Saint R, et al. A putative exchange factor for Rho1 GTPase is required for initiation of cytokinesis in Drosophila. Genes Dev. 1999;13:2301-14 pubmed
    ..Our results identify Pbl as a RhoGEF specifically required for cytokinesis and linked through Rho1 activity to the reorganization of the actin cytoskeleton at the cleavage furrow.
  9. Magie C, Pinto Santini D, Parkhurst S. Rho1 interacts with p120ctn and alpha-catenin, and regulates cadherin-based adherens junction components in Drosophila. Development. 2002;129:3771-82 pubmed
    ..Our observations suggest that alpha-catenin and p120(ctn) are key players in a mechanism of recruiting Rho1 to its sites of action. ..
  10. Boutanaev A, Kalmykova A, Shevelyov Y, Nurminsky D. Large clusters of co-expressed genes in the Drosophila genome. Nature. 2002;420:666-9 pubmed
    ..Our data suggest that the prevalent mechanism of transcriptional co-regulation in higher eukaryotes operates with extensive chromatin domains that comprise multiple genes. ..
  11. Mahajan Miklos S, Cooley L. The villin-like protein encoded by the Drosophila quail gene is required for actin bundle assembly during oogenesis. Cell. 1994;78:291-301 pubmed
    ..Nurse cells from quail mutant egg chambers fail to assemble cytoplasmic actin filament bundles correctly...
  12. Sanchez Soriano N, Bottenberg W, Fiala A, Haessler U, Kerassoviti A, Knust E, et al. Are dendrites in Drosophila homologous to vertebrate dendrites?. Dev Biol. 2005;288:126-38 pubmed
    ..Implications of these findings for studies of dendrite development, neuronal polarity, transport and evolution are discussed. ..
  13. Zelhof A, Hardy R, Becker A, Zuker C. Transforming the architecture of compound eyes. Nature. 2006;443:696-9 pubmed
    ..Our results provide a molecular atlas for the construction of microvillar assemblies and illustrate the critical effect of differences in a single structural protein in morphogenesis. ..
  14. D Avino P, Takeda T, Capalbo L, Zhang W, Lilley K, Laue E, et al. Interaction between Anillin and RacGAP50C connects the actomyosin contractile ring with spindle microtubules at the cell division site. J Cell Sci. 2008;121:1151-8 pubmed publisher
    Anillin, one of the first factors recruited to the cleavage site during cytokinesis, interacts with actin, myosin II and septins, and is essential for proper organization of the actomyosin contractile ring...
  15. Gates J, Nowotarski S, Yin H, Mahaffey J, Bridges T, Herrera C, et al. Enabled and Capping protein play important roles in shaping cell behavior during Drosophila oogenesis. Dev Biol. 2009;333:90-107 pubmed publisher
    During development, cells craft an impressive array of actin-based structures, mediating events as diverse as cytokinesis, apical constriction, and cell migration...
  16. Ozdowski E, Gayle S, Bao H, Zhang B, SHERWOOD N. Loss of Drosophila melanogaster p21-activated kinase 3 suppresses defects in synapse structure and function caused by spastin mutations. Genetics. 2011;189:123-35 pubmed publisher
    ..One suppressor region deleted p21-activated kinase 3 (pak3), which encodes a member of the Pak family of actin-regulatory enzymes, but whose in vivo function is unknown...
  17. Ribeiro C, Neumann M, Affolter M. Genetic control of cell intercalation during tracheal morphogenesis in Drosophila. Curr Biol. 2004;14:2197-207 pubmed
    ..Only the combined action of these signaling systems allows efficient branch elongation and the formation of morphologically distinct branches. ..
  18. Wood W, Jacinto A, Grose R, Woolner S, Gale J, Wilson C, et al. Wound healing recapitulates morphogenesis in Drosophila embryos. Nat Cell Biol. 2002;4:907-12 pubmed
    ..expressing green fluorescent protein (GFP) fusion proteins, we show that two cytoskeletal-dependent elements -- an actin cable and dynamic filopodial/lamellipodial protrusions -- are expressed by epithelial cells at the wound edge and ..
  19. Hung R, Pak C, Terman J. Direct redox regulation of F-actin assembly and disassembly by Mical. Science. 2011;334:1710-3 pubmed publisher
    Different types of cell behavior, including growth, motility, and navigation, require actin proteins to assemble into filaments...
  20. Noguchi T, Miller K. A role for actin dynamics in individualization during spermatogenesis in Drosophila melanogaster. Development. 2003;130:1805-16 pubmed
    ..Individualization complexes, which consist of 64 cones of actin that assemble around the sperm nuclei, move to the basal end of the tails, forming a characteristic "cystic ..
  21. Inoue Y, Savoian M, Suzuki T, Mathe E, Yamamoto M, Glover D. Mutations in orbit/mast reveal that the central spindle is comprised of two microtubule populations, those that initiate cleavage and those that propagate furrow ingression. J Cell Biol. 2004;166:49-60 pubmed
    ..orbit mutants have disorganized or incomplete anillin and actin rings, and although cleavage furrows initiate, they ultimately regress...
  22. Smallhorn M, Murray M, Saint R. The epithelial-mesenchymal transition of the Drosophila mesoderm requires the Rho GTP exchange factor Pebble. Development. 2004;131:2641-51 pubmed
    ..Consistent with the dependence of the mesoderm EMT and cytokinesis on actin organisation, the GTP exchange function of the PBL RhoGEF is required for both processes...
  23. Vanoni M, Vitali T, Zucchini D. MICAL, the flavoenzyme participating in cytoskeleton dynamics. Int J Mol Sci. 2013;14:6920-59 pubmed publisher
    ..in transducing the signal initiated by semaphorins interaction with their plexin receptors, which results in local actin cytoskeleton disassembly as part of fundamental processes that include differentiation, migration and cell-cell ..
  24. Lee S, Kolodziej P. The plakin Short Stop and the RhoA GTPase are required for E-cadherin-dependent apical surface remodeling during tracheal tube fusion. Development. 2002;129:1509-20 pubmed
    ..specialized cells at the junction form a new E-cadherin-based contact and assemble an associated track of F-actin and the plakin Short Stop (shot)...
  25. Fyrberg E, Mahaffey J, Bond B, Davidson N. Transcripts of the six Drosophila actin genes accumulate in a stage- and tissue-specific manner. Cell. 1983;33:115-23 pubmed
    ..Two of the genes, act5C and act42A, are expressed in undifferentiated cells and probably encode cytoplasmic actins...
  26. Franke J, Montague R, Kiehart D. Nonmuscle myosin II generates forces that transmit tension and drive contraction in multiple tissues during dorsal closure. Curr Biol. 2005;15:2208-21 pubmed publisher
    ..We demonstrate that MyoII localization is distinct from, but overlaps, F-actin in the supracellular purse string, whereas in the amnioserosa and lateral epidermis each has similar, cortical ..
  27. Kracklauer M, Banks S, Xie X, Wu Y, Fischer J. Drosophila klaroid encodes a SUN domain protein required for Klarsicht localization to the nuclear envelope and nuclear migration in the eye. Fly (Austin). 2007;1:75-85 pubmed
    ..Finally, while perinuclear Klaroid is ubiquitous in the eye, Klarsicht expression is limited to differentiating cells and may be part of the trigger for apical nuclear migration. ..
  28. Major R, Irvine K. Influence of Notch on dorsoventral compartmentalization and actin organization in the Drosophila wing. Development. 2005;132:3823-33 pubmed
    ..at the DV compartment boundary are characterized by a distinct shape, a smooth interface, and an accumulation of F-actin at the adherens junction...
  29. Mermall V, Bonafe N, Jones L, Sellers J, Cooley L, Mooseker M. Drosophila myosin V is required for larval development and spermatid individualization. Dev Biol. 2005;286:238-55 pubmed
    ..molecular motors implicated in vesicular traffic, RNA transport, and mechanochemical coupling of the actin and microtubule-based cytoskeletons...
  30. Matusek T, Djiane A, Jankovics F, Brunner D, Mlodzik M, Mihaly J. The Drosophila formin DAAM regulates the tracheal cuticle pattern through organizing the actin cytoskeleton. Development. 2006;133:957-66 pubmed
    Formins are involved in a wide range of cellular processes that require the remodeling of the actin cytoskeleton. Here, we have analyzed a novel Drosophila formin, belonging to the recently described DAAM subfamily...
  31. Sisson J, Field C, Ventura R, Royou A, Sullivan W. Lava lamp, a novel peripheral golgi protein, is required for Drosophila melanogaster cellularization. J Cell Biol. 2000;151:905-18 pubmed
    ..Our results are consistent with the idea that animal cell cytokinesis depends on both actomyosin-based contraction and Golgi-derived membrane secretion. ..
  32. Jacinto A, Wood W, Balayo T, Turmaine M, Martinez Arias A, Martin P. Dynamic actin-based epithelial adhesion and cell matching during Drosophila dorsal closure. Curr Biol. 2000;10:1420-6 pubmed
    ..Several studies indicate that the actin cytoskeleton plays a critical role in dorsal closure...
  33. Dean S, Rogers S, Stuurman N, Vale R, Spudich J. Distinct pathways control recruitment and maintenance of myosin II at the cleavage furrow during cytokinesis. Proc Natl Acad Sci U S A. 2005;102:13473-8 pubmed
    ..This initial localization mechanism does not require F-actin or the two components of the centralspindlin complex, the mitotic kinesin pavarotti/MKLP1 and racGAP50c/CYK-4...
  34. Afshar K, Stuart B, Wasserman S. Functional analysis of the Drosophila diaphanous FH protein in early embryonic development. Development. 2000;127:1887-97 pubmed
    ..its role in other processes, we generated embryos deficient for Diaphanous and analyzed three cell-cycle-regulated actin-mediated events during embryogenesis: formation of the metaphase furrow, cellularization and formation of the pole ..
  35. Adams J, Kelso R, Cooley L. The kelch repeat superfamily of proteins: propellers of cell function. Trends Cell Biol. 2000;10:17-24 pubmed
    ..In this review, we discuss current information concerning the structural organization of kelch repeat proteins, their biological roles and the molecular basis of their action. ..
  36. Barbosa V, Gatt M, Rebollo E, Gonzalez C, Glover D. Drosophila dd4 mutants reveal that gammaTuRC is required to maintain juxtaposed half spindles in spermatocytes. J Cell Sci. 2003;116:929-41 pubmed
    ..We conclude that spermatocytes do not need astral microtubules nucleated by opposite poles to intersect in order to form a central spindle and a cleavage furrow. ..
  37. Homem C, Peifer M. Exploring the roles of diaphanous and enabled activity in shaping the balance between filopodia and lamellipodia. Mol Biol Cell. 2009;20:5138-55 pubmed publisher
    ..One key challenge is to determine how the toolkit of actin regulators are coordinated to generate these diverse protrusive arrays...
  38. Fulga T, Elson Schwab I, Khurana V, Steinhilb M, Spires T, Hyman B, et al. Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo. Nat Cell Biol. 2007;9:139-48 pubmed
    ..Here, we show that tau-induced neurodegeneration is associated with accumulation of filamentous actin (F-actin) and the formation of actin-rich rods in Drosophila and mouse models of tauopathy...
  39. Pignoni F, Zipursky S. Induction of Drosophila eye development by decapentaplegic. Development. 1997;124:271-8 pubmed
    ..In addition, Dpp positively controls its own expression and suppresses wingless transcription. In contrast to the wing disc, Dpp does not appear to be the principal mediator of Hedgehog function in the eye. ..
  40. Bearer E. Actin in the Drosophila embryo: is there a relationship to developmental cue localization?. Bioessays. 1991;13:199-204 pubmed
    ..The actin-based cytoskeleton is a likely candidate for the formation of a cytomatrix that would allow such distributions and ..
  41. Röper K, Mao Y, Brown N. Contribution of sequence variation in Drosophila actins to their incorporation into actin-based structures in vivo. J Cell Sci. 2005;118:3937-48 pubmed
    b>Actin is a highly conserved protein important for many cellular functions including motility, contraction in muscles and intracellular transport...
  42. LaLonde M, Janssens H, Rosenbaum E, Choi S, Gergen J, Colley N, et al. Regulation of phototransduction responsiveness and retinal degeneration by a phospholipase D-generated signaling lipid. J Cell Biol. 2005;169:471-9 pubmed
    ..Altogether, these findings suggest that Pld facilitates phototransduction by maintaining adequate levels of PIP2 and by protecting the visual system from metarhodopsin-induced, low light degeneration. ..
  43. Fulga T, Rørth P. Invasive cell migration is initiated by guided growth of long cellular extensions. Nat Cell Biol. 2002;4:715-9 pubmed
    ..LCE growth requires directional guidance signals and specific adhesion to the substratum. Interference with actin-myosin interactions allows continued LCE growth while preventing translocation of the cell bodies...
  44. Bucciarelli E, Giansanti M, Bonaccorsi S, Gatti M. Spindle assembly and cytokinesis in the absence of chromosomes during Drosophila male meiosis. J Cell Biol. 2003;160:993-9 pubmed
    ..This suggests that the association of Aurora B with chromosomes is not a prerequisite for its accumulation at the central spindle, or for its function during cytokinesis. ..
  45. Leach T, Mazzeo M, Chotkowski H, Madigan J, Wotring M, Glaser R. Histone H2A.Z is widely but nonrandomly distributed in chromosomes of Drosophila melanogaster. J Biol Chem. 2000;275:23267-72 pubmed
    ..Of the sequences assayed, H2Av was least abundant on 1. 688 satellite sequences and most abundant on the hsp70 genes. Finally, transcription caused, to an equivalent extent, both H2Av and H2A to be less tightly associated with DNA. ..
  46. Tilney L, Derosier D. How to make a curved Drosophila bristle using straight actin bundles. Proc Natl Acad Sci U S A. 2005;102:18785-92 pubmed
    This, our Inaugural Article as Academy Members, is ironically our swan song from the field of the actin cytoskeleton...
  47. Fei X, He B, Adler P. The growth of Drosophila bristles and laterals is not restricted to the tip or base. J Cell Sci. 2002;115:3797-806 pubmed
    ..Extending bristles contain a series of large bundles of actin filaments juxtaposed to the plasma membrane and centrally located microtubules...
  48. Royou A, Field C, Sisson J, Sullivan W, Karess R. Reassessing the role and dynamics of nonmuscle myosin II during furrow formation in early Drosophila embryos. Mol Biol Cell. 2004;15:838-50 pubmed
    ..Both involve actin cytoskeleton rearrangements, and both have myosin II at or near the forming furrow...
  49. Bai J, Hartwig J, Perrimon N. SALS, a WH2-domain-containing protein, promotes sarcomeric actin filament elongation from pointed ends during Drosophila muscle growth. Dev Cell. 2007;13:828-42 pubmed
    Organization of actin filaments into a well-organized sarcomere structure is critical for muscle development and function. However, it is not completely understood how sarcomeric actin/thin filaments attain their stereotyped lengths...
  50. Sens K, Zhang S, Jin P, Duan R, Zhang G, Luo F, et al. An invasive podosome-like structure promotes fusion pore formation during myoblast fusion. J Cell Biol. 2010;191:1013-27 pubmed publisher
    Recent studies in Drosophila have implicated actin cytoskeletal remodeling in myoblast fusion, but the cellular mechanisms underlying this process remain poorly understood...
  51. Chan Y, Naujoks D, Huen D, Russell S. Insect population control by homing endonuclease-based gene drive: an evaluation in Drosophila melanogaster. Genetics. 2011;188:33-44 pubmed publisher
  52. Bonaccorsi S, Giansanti M, Gatti M. Spindle self-organization and cytokinesis during male meiosis in asterless mutants of Drosophila melanogaster. J Cell Biol. 1998;142:751-61 pubmed
    ..In addition, these findings strongly suggest that the asters are not required for signaling cytokinesis. ..
  53. Wagner C, Mahowald A, Miller K. One of the two cytoplasmic actin isoforms in Drosophila is essential. Proc Natl Acad Sci U S A. 2002;99:8037-42 pubmed
    ..We have addressed this question with the cytoplasmic actins in Drosophila, Act5C, and Act42A...
  54. Mathur D, Bost A, Driver I, Ohlstein B. A transient niche regulates the specification of Drosophila intestinal stem cells. Science. 2010;327:210-3 pubmed publisher
    ..Our results demonstrate a paradigm for stem cell-niche biology, where progenitors generate transient niches that determine stem cell fate and may give insights into stem cell specification in other tissues. ..
  55. Verkhusha V, Tsukita S, Oda H. Actin dynamics in lamellipodia of migrating border cells in the Drosophila ovary revealed by a GFP-actin fusion protein. FEBS Lett. 1999;445:395-401 pubmed
    ..In this study, the electron microscopic observation of migrating border cells revealed loose actin bundles in forepart lamellipodia and numerous microvilli extending from nurse cells and providing multiple ..