Gene Symbol: Act57B
Description: Actin 57B
Alias: Act57, Act57A, Act57b, Actin, ArpE, BEST:RE38067, CG10067, CG30294, Dmel\CG10067, T10, act 57A, act57A, act57B, act57b, actin, anon-EST:CL2c12, chr2R:16452771..16452966, actin 57B, Act57B-PA, CG10067-PA, F-actin, actin, actin57B
Species: fruit fly
Products:     Act57B

Top Publications

  1. Röper K, Mao Y, Brown N. Contribution of sequence variation in Drosophila actins to their incorporation into actin-based structures in vivo. J Cell Sci. 2005;118:3937-48 pubmed
    b>Actin is a highly conserved protein important for many cellular functions including motility, contraction in muscles and intracellular transport...
  2. Riparbelli M, Callaini G, Glover D, Avides M. A requirement for the Abnormal Spindle protein to organise microtubules of the central spindle for cytokinesis in Drosophila. J Cell Sci. 2002;115:913-22 pubmed
    ..Upon fertilisation, Asp is also recruited to the MTOC that nucleates the sperm aster. Asp is required for growth of the microtubules of the sperm aster, which in asp mutants remains diminutive and so prevents migration of the pronuclei. ..
  3. Bai J, Binari R, Ni J, Vijayakanthan M, Li H, Perrimon N. RNA interference screening in Drosophila primary cells for genes involved in muscle assembly and maintenance. Development. 2008;135:1439-49 pubmed publisher
    ..Finally, we discuss how Drosophila primary cells can be manipulated to develop cell-based assays to model human diseases for RNAi and small-molecule screens. ..
  4. Bai J, Hartwig J, Perrimon N. SALS, a WH2-domain-containing protein, promotes sarcomeric actin filament elongation from pointed ends during Drosophila muscle growth. Dev Cell. 2007;13:828-42 pubmed
    Organization of actin filaments into a well-organized sarcomere structure is critical for muscle development and function. However, it is not completely understood how sarcomeric actin/thin filaments attain their stereotyped lengths...
  5. Barbosa V, Gatt M, Rebollo E, Gonzalez C, Glover D. Drosophila dd4 mutants reveal that gammaTuRC is required to maintain juxtaposed half spindles in spermatocytes. J Cell Sci. 2003;116:929-41 pubmed
    ..We conclude that spermatocytes do not need astral microtubules nucleated by opposite poles to intersect in order to form a central spindle and a cleavage furrow. ..
  6. Kelly K, Meadows S, Cripps R. Drosophila MEF2 is a direct regulator of Actin57B transcription in cardiac, skeletal, and visceral muscle lineages. Mech Dev. 2002;110:39-50 pubmed
    ..during myogenesis, we characterized the transcriptional regulation of a Drosophila melanogaster actin gene, Actin 57B. Act57B transcription is first detected in visceral muscle precursors and is detectable in all embryonic muscles ..
  7. Mounier N, Sparrow J. Muscle actin genes in insects. Comp Biochem Physiol B. 1993;105:231-8 pubmed
  8. Labuhn M, Brack C. Age-related changes in the mRNA expression of actin isoforms in Drosophila melanogaster. Gerontology. 1997;43:261-7 pubmed
    ..Here we have examined age-related changes in the mRNA levels of the gene family encoding the six Drosophila actin genes...
  9. Casal J, Leptin M. Identification of novel genes in Drosophila reveals the complex regulation of early gene activity in the mesoderm. Proc Natl Acad Sci U S A. 1996;93:10327-32 pubmed
    ..These novel genes show a variety of expression patterns and also differ in their dependence on twist and snail functions. This indicates that the regulation of early gene activity in the mesoderm is more complex than previously thought. ..

More Information


  1. He M, Haymer D. Codon bias in actin multigene families and effects on the reconstruction of phylogenetic relationships. J Mol Evol. 1995;41:141-9 pubmed
    Codon usage patterns and phylogenetic relationships in the actin multigene family have been analyzed for three dipteran species--Drosophila melanogaster, Bactrocera dorsalis, and Ceratitis capitata...
  2. Kroeger P, Rowe T. Analysis of topoisomerase I and II cleavage sites on the Drosophila actin and Hsp70 heat shock genes. Biochemistry. 1992;31:2492-501 pubmed
    We have compared topoisomerase I and II cleavage sites on the actin 5C and 57A genes and the hsp70 genes in Drosophila Kc cells using the inhibitors camptothecin (topoisomerase I specific) and VM-26 (topoisomerase II specific) to assess ..
  3. Davis J, Luchici A, Mosis F, Thackery J, Salazar J, Mao Y, et al. Inter-cellular forces orchestrate contact inhibition of locomotion. Cell. 2015;161:361-73 pubmed publisher
    ..Tracking actin retrograde flow within hemocytes in vivo reveals synchronous reorganization of colliding actin networks through ..
  4. Frankel S, Heintzelman M, Artavanis Tsakonas S, Mooseker M. Identification of a divergent actin-related protein in Drosophila. J Mol Biol. 1994;235:1351-6 pubmed
    The actin-related proteins (ARPs) have primary sequence homology to actin, have no homology to other proteins and, unlike the conventional actins, are clearly divergent...
  5. Nongthomba U, Pasalodos Sanchez S, Clark S, Clayton J, Sparrow J. Expression and function of the Drosophila ACT88F actin isoform is not restricted to the indirect flight muscles. J Muscle Res Cell Motil. 2001;22:111-9 pubmed
    Most higher eukaryotic genomes contain multiple actin genes, yet the sequence differences between isoforms are few...
  6. Gaertner B, Johnston J, Chen K, Wallaschek N, Paulson A, Garruss A, et al. Poised RNA polymerase II changes over developmental time and prepares genes for future expression. Cell Rep. 2012;2:1670-83 pubmed publisher
    ..We compare our data with findings in mammalian embryonic stem cells and discuss a framework for predicting developmental programs on the basis of the chromatin state. ..
  7. Elgar S, Han J, Taylor M. mef2 activity levels differentially affect gene expression during Drosophila muscle development. Proc Natl Acad Sci U S A. 2008;105:918-23 pubmed publisher
    ..This suggests a route by which mef2 can orchestrate the muscle differentiation program and contribute to the stringent regulation of gene expression during myogenesis. ..
  8. Fyrberg E, Davidson N, Kindle K. The actin genes of Drosophila: a dispersed multigene family. Cell. 1980;19:365-78 pubmed
    We have initiated a study of the organization and expression of the actin genes of D. melanogaster...
  9. Akimana C, Al Khodor S, Abu Kwaik Y. Host factors required for modulation of phagosome biogenesis and proliferation of Francisella tularensis within the cytosol. PLoS ONE. 2010;5:e11025 pubmed publisher
    ..tularensis. Our data will facilitate deciphering molecular ecology, patho-adaptation of F. tularensis to the arthropod vector and its role in bacterial ecology and patho-evolution to infect mammals. ..
  10. Baehrecke E. Caspase activation finds fertile ground. Dev Cell. 2003;4:608-9 pubmed
    ..Recent work demonstrates that cytochrome c and caspases function in Drosophila sperm cell differentiation and indicates that caspase activity can be regulated in a subcellular manner in cells that live. ..
  11. García Zaragoza E, Mas J, Vivar J, Arredondo J, Cervera M. CF2 activity and enhancer integration are required for proper muscle gene expression in Drosophila. Mech Dev. 2008;125:617-30 pubmed publisher
    ..However, it may also be a more general mechanism to control the correct levels of gene expression during development in each cell type. ..
  12. Drosopoulou E, Tsiafouli M, Mavragani Tsipidou P, Scouras Z. The glutamate dehydrogenase, E74 and putative actin gene loci in the Drosophila montium subgroup. Chromosomal homologies among the montium species and D. melanogaster. Chromosoma. 1997;106:20-8 pubmed
    ..from an enzyme-coding gene (glutamate dehydrogenase, gdh), a regulatory protein-coding gene (E74) and genes of the actin family were mapped by in situ hybridization on the polytene chromosomes of six species representative of the ..
  13. Zeitler J, Hsu C, Dionne H, Bilder D. Domains controlling cell polarity and proliferation in the Drosophila tumor suppressor Scribble. J Cell Biol. 2004;167:1137-46 pubmed
    ..We suggest a model in which Scrib, via the activity of the LRR, governs proliferation primarily by regulating apicobasal polarity. ..
  14. Beltran S, Angulo M, Pignatelli M, Serras F, Corominas M. Functional dissection of the ash2 and ash1 transcriptomes provides insights into the transcriptional basis of wing phenotypes and reveals conserved protein interactions. Genome Biol. 2007;8:R67 pubmed
    ..Like in humans, both ASH2 and Sin3A bind HCF. Finally, the reduction of H3K4 trimethylation in ash2 mutants is the first evidence in Drosophila regarding the molecular function of this trxG gene. ..
  15. Lichter J, Storti R. In vitro transcription analysis of the Drosophila tropomyosin and other muscle genes. Biochim Biophys Acta. 1991;1088:419-24 pubmed
    ..The embryonic extract did, however, contain developmental-specific proteins that bound to the muscle enhancer regulatory region of the Tropomyosin I gene. ..
  16. Miller K. A role for moesin in polarity. Trends Cell Biol. 2003;13:165-8 pubmed
    ..Previously, studies in cultured mammalian cells suggested that ERM proteins are important for actin-membrane associations...
  17. Inoue Y, Savoian M, Suzuki T, Mathe E, Yamamoto M, Glover D. Mutations in orbit/mast reveal that the central spindle is comprised of two microtubule populations, those that initiate cleavage and those that propagate furrow ingression. J Cell Biol. 2004;166:49-60 pubmed
    ..orbit mutants have disorganized or incomplete anillin and actin rings, and although cleavage furrows initiate, they ultimately regress...
  18. Gwack Y, Srikanth S, Feske S, Cruz Guilloty F, Oh Hora M, Neems D, et al. Biochemical and functional characterization of Orai proteins. J Biol Chem. 2007;282:16232-43 pubmed
    ..Together, these data establish Orai1 as a predominant mediator of store-operated calcium entry, proliferation, and cytokine production in T cells. ..
  19. Schmitz S, Clayton J, Nongthomba U, Prinz H, Veigel C, Geeves M, et al. Drosophila ACT88F indirect flight muscle-specific actin is not N-terminally acetylated: a mutation in N-terminal processing affects actin function. J Mol Biol. 2000;295:1201-10 pubmed
    ..In class II actins, which include muscle actins, the common primary sequence of Met-Cys-Asp-actin is processed to acetyl-Asp-actin. The functional significance of this in vivo is unknown...
  20. Jaiswal R, Stepanik V, Rankova A, Molinar O, Goode B, McCartney B. Drosophila homologues of adenomatous polyposis coli (APC) and the formin diaphanous collaborate by a conserved mechanism to stimulate actin filament assembly. J Biol Chem. 2013;288:13897-905 pubmed publisher
    Vertebrate APC collaborates with Dia through its Basic domain to assemble actin filaments...
  21. Rui Y, Bai J, Perrimon N. Sarcomere formation occurs by the assembly of multiple latent protein complexes. PLoS Genet. 2010;6:e1001208 pubmed publisher
    ..Thus, sarcomere formation occurs by the coordinated assembly of multiple latent protein complexes, as opposed to sequential assembly. ..
  22. Tanaka K, Bryantsev A, Cripps R. Myocyte enhancer factor 2 and chorion factor 2 collaborate in activation of the myogenic program in Drosophila. Mol Cell Biol. 2008;28:1616-29 pubmed
    ..individually activate actin gene expression, we demonstrate that these two factors collaborate in regulating the Actin57B target gene in vitro and in vivo...
  23. Wang H, Lai D, Yuan M, Xu H. Growth inhibition and differences in protein profiles in azadirachtin-treated Drosophila melanogaster larvae. Electrophoresis. 2014;35:1122-9 pubmed publisher
    ..Protein network analysis reveals heat shock protein 23 to be a potential target of azadirachtin. These results provide new insights into understanding the mechanism of growth inhibition in insects in response to azadirachtin. ..
  24. Snyder M, Hunkapiller M, Yuen D, Silvert D, Fristrom J, Davidson N. Cuticle protein genes of Drosophila: structure, organization and evolution of four clustered genes. Cell. 1982;29:1027-40 pubmed
    ..We discuss the structure, organization and evolution of these cuticle genes as a model small gene family. ..
  25. Razzaq A, Schmitz S, Veigel C, Molloy J, Geeves M, Sparrow J. Actin residue glu(93) is identified as an amino acid affecting myosin binding. J Biol Chem. 1999;274:28321-8 pubmed
    Many mutants have been described that affect the function of the actin encoded by the Drosophila melanogaster indirect flight muscle-specific actin gene, Act88F...
  26. Adams J, Kelso R, Cooley L. The kelch repeat superfamily of proteins: propellers of cell function. Trends Cell Biol. 2000;10:17-24 pubmed
    ..In this review, we discuss current information concerning the structural organization of kelch repeat proteins, their biological roles and the molecular basis of their action. ..
  27. Deng H, Hughes S, Bell J, Simmonds A. Alternative requirements for Vestigial, Scalloped, and Dmef2 during muscle differentiation in Drosophila melanogaster. Mol Biol Cell. 2009;20:256-69 pubmed publisher
    ..Thus, the muscle-specific phenotypes we have associated with Vg or Sd may be a consequence of alternative binding of Vg and/or Sd to Dmef2 forming alternative protein complexes that modify Dmef2 activity. ..
  28. Tobin S, Cook P, Burn T. Transcripts of individual Drosophila actin genes are differentially distributed during embryogenesis. Dev Genet. 1990;11:15-26 pubmed
    The temporal and spatial patterns of accumulation of transcripts from individual actin genes during Drosophila embryogenesis have been determined by in situ hybridization...
  29. Fyrberg E, Fyrberg C, Biggs J, Saville D, Beall C, Ketchum A. Functional nonequivalence of Drosophila actin isoforms. Biochem Genet. 1998;36:271-87 pubmed
    We show that different Drosophila actin isoforms are not interchangeable. We sequenced the six genes that encode conventional Drosophila actins and found that they specify amino acid replacements in 27 of 376 positions...
  30. Viswanathan M, Blice Baum A, Schmidt W, Foster D, Cammarato A. Pseudo-acetylation of K326 and K328 of actin disrupts Drosophila melanogaster indirect flight muscle structure and performance. Front Physiol. 2015;6:116 pubmed publisher
    In striated muscle tropomyosin (Tm) extends along the length of F-actin-containing thin filaments. Its location governs access of myosin binding sites on actin and, hence, force production...
  31. Lo S. Focal adhesions: what's new inside. Dev Biol. 2006;294:280-91 pubmed
    ..adhesions is comprised of large molecular complexes that link transmembrane receptors, such as integrins, to the actin cytoskeleton and mediate signals modulating cell attachment, migration, proliferation, differentiation, and gene ..
  32. Biggin M. To bind or not to bind. Nat Genet. 2001;28:303-4 pubmed
    ..Genome-wide surveys of DNA binding by transcription factors in vivo are beginning to provide some answers. ..
  33. Padash Barmchi M, Rogers S, Hacker U. DRhoGEF2 regulates actin organization and contractility in the Drosophila blastoderm embryo. J Cell Biol. 2005;168:575-85 pubmed
    Morphogenesis of the Drosophila melanogaster embryo is associated with a dynamic reorganization of the actin cytoskeleton that is mediated by small GTPases of the Rho family...
  34. Texada M, Simonette R, Deery W, Beckingham K. Tropomyosin is an interaction partner of the Drosophila coiled coil protein yuri gagarin. Exp Cell Res. 2011;317:474-87 pubmed publisher
    ..studies indicate that one of the large isoform classes (Yuri-65) is required for formation of specialized F-actin-containing structures generated during spermatogenesis, including the so-called actin "cones" that ..
  35. Lenartowska M, Isaji M, Miller K. A pre-embedding immunogold approach reveals localization of myosin VI at the ultrastructural level in the actin cones that mediate Drosophila spermatid individualization. Protoplasma. 2012;249:337-46 pubmed publisher
    Stable actin structures play important roles in the development and specialization of differentiated cells. How these structures form, are organized, and are used to mediate physiological processes is not well understood in most cases...
  36. Eggert U, Kiger A, Richter C, Perlman Z, Perrimon N, Mitchison T, et al. Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets. PLoS Biol. 2004;2:e379 pubmed
    ..Our study shows that parallel RNA interference and small molecule screening is a generally useful approach to identifying active small molecules and their target pathways...
  37. Xu N, Bagumian G, Galiano M, Myat M. Rho GTPase controls Drosophila salivary gland lumen size through regulation of the actin cytoskeleton and Moesin. Development. 2011;138:5415-27 pubmed publisher
    ..We show that Rho1 controls cell rearrangement and apical domain elongation by promoting actin polymerization and regulating F-actin distribution at the apical and basolateral membranes through Rho kinase...
  38. Tobin S, Zulauf E, Sanchez F, Craig E, McCarthy B. Multiple actin-related sequences in the Drosophila melanogaster genome. Cell. 1980;19:121-31 pubmed
    ..melanogaster chromosomal DNA fragment (K1) which contains nucleotide sequences complementary to D. melanogaster actin mRNA. Plasmid K1 was identified using a Dictyostelium actin cDNA plasmid, B1, as a probe. D...
  39. Bryantsev A, Cripps R. Purification of cardiac cells from Drosophila embryos. Methods. 2012;56:44-9 pubmed publisher
    ..In the future, this approach can be used to describe the cardiac transcriptome of Drosophila at distinct stages of embryonic development. ..
  40. Tilney L, Derosier D. How to make a curved Drosophila bristle using straight actin bundles. Proc Natl Acad Sci U S A. 2005;102:18785-92 pubmed
    This, our Inaugural Article as Academy Members, is ironically our swan song from the field of the actin cytoskeleton...
  41. Bahadorani S, Bahadorani P, Marcon E, Walker D, Hilliker A. A Drosophila model of Menkes disease reveals a role for DmATP7 in copper absorption and neurodevelopment. Dis Model Mech. 2010;3:84-91 pubmed publisher
    ..Taken together, these results highlight the role of DmATP7-mediated copper uptake in the neurodevelopment of Drosophila melanogaster and provide a framework for the analysis of potential gene interactions influencing Menkes disease. ..
  42. Vierstraete E, Verleyen P, Baggerman G, D Hertog W, Van den Bergh G, Arckens L, et al. A proteomic approach for the analysis of instantly released wound and immune proteins in Drosophila melanogaster hemolymph. Proc Natl Acad Sci U S A. 2004;101:470-5 pubmed
    ..Determining the function of all of these immune-induced proteins represents an exciting challenge for increasing our knowledge of insect immunity. ..
  43. Baum B. Winging it--actin on the fly. Dev Cell. 2002;2:125-6 pubmed
    How actin dynamics might be regulated to generate specific cellular structures during development remains something of a mystery...
  44. Baker P, Tanaka K, Klitgord N, Cripps R. Adult myogenesis in Drosophila melanogaster can proceed independently of myocyte enhancer factor-2. Genetics. 2005;170:1747-59 pubmed
    ..Using quantitative polymerase chain reaction, we determined that expression of the MEF2-regulated actin gene Act57B was severely reduced in these animals...
  45. Wilson I. Glycosylation of proteins in plants and invertebrates. Curr Opin Struct Biol. 2002;12:569-77 pubmed
    ..Whereas the forms of O-linked glycans in plants are unlike those in animals, studies on invertebrate O-glycosylation often yield information relevant to mammalian systems. ..
  46. Bearer E. Actin in the Drosophila embryo: is there a relationship to developmental cue localization?. Bioessays. 1991;13:199-204 pubmed
    ..The actin-based cytoskeleton is a likely candidate for the formation of a cytomatrix that would allow such distributions and ..
  47. Fernandes I, Schöck F. The nebulin repeat protein Lasp regulates I-band architecture and filament spacing in myofibrils. J Cell Biol. 2014;206:559-72 pubmed publisher
    Mutations in nebulin, a giant muscle protein with 185 actin-binding nebulin repeats, are the major cause of nemaline myopathy in humans...
  48. Mounier N, Gouy M, Mouchiroud D, Prudhomme J. Insect muscle actins differ distinctly from invertebrate and vertebrate cytoplasmic actins. J Mol Evol. 1992;34:406-15 pubmed
    ..However, Bombyx and Drosophila have actin genes specifically expressed in muscles...
  49. Shah A, Nongthomba U, Kelly Tanaka K, Denton M, Meadows S, Bancroft N, et al. Cardiac remodeling in Drosophila arises from changes in actin gene expression and from a contribution of lymph gland-like cells to the heart musculature. Mech Dev. 2011;128:222-33 pubmed publisher
    ..In addition, expression of the Actin87E actin gene is initiated in the remodeling cardiac tube, but not in the longitudinal fibers, and we have identified an ..
  50. Davis R, Tavsanli B, Dittrich C, Walldorf U, Mardon G. Drosophila retinal homeobox (drx) is not required for establishment of the visual system, but is required for brain and clypeus development. Dev Biol. 2003;259:272-87 pubmed
    ..We propose that differences in insect and vertebrate eye development may be explained by changes in gene regulation and/or the tissue of origin for eye precursor cells. ..
  51. Adame V, Chapapas H, Cisneros M, Deaton C, Deichmann S, Gadek C, et al. An undergraduate laboratory class using CRISPR/Cas9 technology to mutate drosophila genes. Biochem Mol Biol Educ. 2016;44:263-75 pubmed publisher
    ..2016 by The International Union of Biochemistry and Molecular Biology, 44:263-275, 2016. ..
  52. Jaiswal M, Agrawal N, Sinha P. Fat and Wingless signaling oppositely regulate epithelial cell-cell adhesion and distal wing development in Drosophila. Development. 2006;133:925-35 pubmed
    ..Finally, we show that Ft intersects Wnt/Wg signaling, downstream of the Wg ligand. Fat and Wg signaling thus exert opposing regulation to coordinate cell-cell adhesion and patterning along the PD axis of Drosophila wing. ..
  53. Palsson A, Wesolowska N, Reynisdóttir S, Ludwig M, Kreitman M. Naturally occurring deletions of hunchback binding sites in the even-skipped stripe 3+7 enhancer. PLoS ONE. 2014;9:e91924 pubmed publisher
    ..The data reveal segregating variation in regulatory elements, which may reflect evolutionary turnover of characterized TFBS due to drift or co-evolution. ..
  54. Fyrberg E, Bond B, Hershey N, Mixter K, Davidson N. The actin genes of Drosophila: protein coding regions are highly conserved but intron positions are not. Cell. 1981;24:107-16 pubmed
    The entire set of six closely related Drosophila actin genes was isolated using recombinant DNA methodology, and the structures of the respective coding regions were characterized by gene mapping techniques and by nucleotide sequencing ..
  55. Lovato T, Adams M, Baker P, Cripps R. A molecular mechanism of temperature sensitivity for mutations affecting the Drosophila muscle regulator Myocyte enhancer factor-2. Genetics. 2009;183:107-17 pubmed publisher
    ..These findings will provide new insight and guidance into the functions of dimeric proteins and how they might be engineered to generate TS combinations. ..
  56. Keller C, Erickson M, Abmayr S. Misexpression of nautilus induces myogenesis in cardioblasts and alters the pattern of somatic muscle fibers. Dev Biol. 1997;181:197-212 pubmed
    ..Moreover, many cardioblasts express increased levels of muscle-specific genes such as myosin, actin 57B, and Mlp60A, a protein that is restricted to the somatic, visceral, and pharyngeal muscles...
  57. Fyrberg E, Mahaffey J, Bond B, Davidson N. Transcripts of the six Drosophila actin genes accumulate in a stage- and tissue-specific manner. Cell. 1983;33:115-23 pubmed
    ..b>Act57A and act87E are expressed predominantly in larval, pupal, and adult intersegmental muscles; act88F in muscles of ..
  58. Williams J, Boin N, Valera J, Johnson A. Noncanonical roles for Tropomyosin during myogenesis. Development. 2015;142:3440-52 pubmed publisher
    ..Tm2 overexpression rescued the hoip myogenic phenotype by promoting F-actin assembly at the myotube leading edge, by restoring the expression of additional sarcomeric RNAs, and by promoting ..
  59. Laayouni H, Santos M, Fontdevila A. Toward a physical map of Drosophila buzzatii. Use of randomly amplified polymorphic dna polymorphisms and sequence-tagged site landmarks. Genetics. 2000;156:1797-816 pubmed
    ..Further prospects toward obtaining a more developed genetic map than the one currently available for D. buzzatii are discussed...
  60. Bucciarelli E, Giansanti M, Bonaccorsi S, Gatti M. Spindle assembly and cytokinesis in the absence of chromosomes during Drosophila male meiosis. J Cell Biol. 2003;160:993-9 pubmed
    ..This suggests that the association of Aurora B with chromosomes is not a prerequisite for its accumulation at the central spindle, or for its function during cytokinesis. ..
  61. Röper K, Brown N. Maintaining epithelial integrity: a function for gigantic spectraplakin isoforms in adherens junctions. J Cell Biol. 2003;162:1305-15 pubmed
    ..Previously characterized Shot isoforms are similar to spectrin and dystrophin, with an actin-binding domain followed by spectrin repeats...
  62. Hongo S, Jacobs Lorena M. Translational discrimination of ribosomal protein mRNAs in the early Drosophila embryo. Dev Biol. 1991;145:338-43 pubmed
    ..No evidence for involvement of reversibly binding trans-acting factors was obtained, although there are limitations in the interpretation of the latter experiments. ..
  63. Eltsov M, Dubé N, Yu Z, Pasakarnis L, Haselmann Weiss U, Brunner D, et al. Quantitative analysis of cytoskeletal reorganization during epithelial tissue sealing by large-volume electron tomography. Nat Cell Biol. 2015;17:605-14 pubmed publisher
    ..After establishing contact through actin-driven exploratory filopodia, cells use a single lamella to generate 'roof tile'-like overlaps...
  64. Bulchand S, Menon S, George S, Chia W. Muscle wasted: a novel component of the Drosophila histone locus body required for muscle integrity. J Cell Sci. 2010;123:2697-707 pubmed publisher
    ..We speculate that mute regulates terminal muscle differentiation possibly through heterochromatic reorganisation. ..
  65. D Avino P, Takeda T, Capalbo L, Zhang W, Lilley K, Laue E, et al. Interaction between Anillin and RacGAP50C connects the actomyosin contractile ring with spindle microtubules at the cell division site. J Cell Sci. 2008;121:1151-8 pubmed publisher
    Anillin, one of the first factors recruited to the cleavage site during cytokinesis, interacts with actin, myosin II and septins, and is essential for proper organization of the actomyosin contractile ring...
  66. Strickland L, Burgess D. Pathways for membrane trafficking during cytokinesis. Trends Cell Biol. 2004;14:115-8 pubmed
    ..Furthermore, new work reveals that vesicles derived from the Rab11 recycling endosome (RE) promote actin remodeling at the furrow.
  67. Blunk A, Akbergenova Y, Cho R, Lee J, Walldorf U, Xu K, et al. Postsynaptic actin regulates active zone spacing and glutamate receptor apposition at the Drosophila neuromuscular junction. Mol Cell Neurosci. 2014;61:241-54 pubmed publisher
    ..From this screen we identified a mutation in Actin 57B that disrupted synaptic morphology and presynaptic active zone organization...
  68. Meisen N, Baars S, Jimenez F. Isolation of mesoderm-specific genes expressed in the Drosophila embryo. Gene. 1988;74:457-64 pubmed
    ..No neural-specific genes were identified using this approach, most probably because of the low sensitivity of detection methods which combine filter hybridization techniques with the use of complex probes. ..
  69. Leptin M. twist and snail as positive and negative regulators during Drosophila mesoderm development. Genes Dev. 1991;5:1568-76 pubmed
    ..twist is also required for the full expression of snail and for the maintenance of its own expression. Only the absence of both twist and snail results in the complete loss of all mesodermal characteristics. ..