Gene Symbol: Act42A
Description: Actin 42A
Alias: 42A, ACT2_DROME, AFFX-Dros-ACTIN_M_r_at, Act, Act42, Act42a, Actin, Actin/BAP47, ArpB, BAP47, CG12051, Dmel\CG12051, act 42A, act42A, actin, actin 42A, 42A actin, Act42A-PA, Actin-42A, CG12051-PA, F-actin, actin, actin42a
Species: fruit fly

Top Publications

  1. Riparbelli M, Callaini G, Glover D, Avides M. A requirement for the Abnormal Spindle protein to organise microtubules of the central spindle for cytokinesis in Drosophila. J Cell Sci. 2002;115:913-22 pubmed
    ..Upon fertilisation, Asp is also recruited to the MTOC that nucleates the sperm aster. Asp is required for growth of the microtubules of the sperm aster, which in asp mutants remains diminutive and so prevents migration of the pronuclei. ..
  2. Royou A, Field C, Sisson J, Sullivan W, Karess R. Reassessing the role and dynamics of nonmuscle myosin II during furrow formation in early Drosophila embryos. Mol Biol Cell. 2004;15:838-50 pubmed
    ..Both involve actin cytoskeleton rearrangements, and both have myosin II at or near the forming furrow...
  3. Sisson J, Field C, Ventura R, Royou A, Sullivan W. Lava lamp, a novel peripheral golgi protein, is required for Drosophila melanogaster cellularization. J Cell Biol. 2000;151:905-18 pubmed
    ..Our results are consistent with the idea that animal cell cytokinesis depends on both actomyosin-based contraction and Golgi-derived membrane secretion. ..
  4. Inoue Y, Savoian M, Suzuki T, Mathe E, Yamamoto M, Glover D. Mutations in orbit/mast reveal that the central spindle is comprised of two microtubule populations, those that initiate cleavage and those that propagate furrow ingression. J Cell Biol. 2004;166:49-60 pubmed
    ..orbit mutants have disorganized or incomplete anillin and actin rings, and although cleavage furrows initiate, they ultimately regress...
  5. Padash Barmchi M, Rogers S, Hacker U. DRhoGEF2 regulates actin organization and contractility in the Drosophila blastoderm embryo. J Cell Biol. 2005;168:575-85 pubmed
    Morphogenesis of the Drosophila melanogaster embryo is associated with a dynamic reorganization of the actin cytoskeleton that is mediated by small GTPases of the Rho family...
  6. LaLonde M, Janssens H, Rosenbaum E, Choi S, Gergen J, Colley N, et al. Regulation of phototransduction responsiveness and retinal degeneration by a phospholipase D-generated signaling lipid. J Cell Biol. 2005;169:471-9 pubmed
    ..Altogether, these findings suggest that Pld facilitates phototransduction by maintaining adequate levels of PIP2 and by protecting the visual system from metarhodopsin-induced, low light degeneration. ..
  7. Bonaccorsi S, Giansanti M, Gatti M. Spindle self-organization and cytokinesis during male meiosis in asterless mutants of Drosophila melanogaster. J Cell Biol. 1998;142:751-61 pubmed
    ..In addition, these findings strongly suggest that the asters are not required for signaling cytokinesis. ..
  8. Barbosa V, Gatt M, Rebollo E, Gonzalez C, Glover D. Drosophila dd4 mutants reveal that gammaTuRC is required to maintain juxtaposed half spindles in spermatocytes. J Cell Sci. 2003;116:929-41 pubmed
    ..We conclude that spermatocytes do not need astral microtubules nucleated by opposite poles to intersect in order to form a central spindle and a cleavage furrow. ..
  9. Giansanti M, Farkas R, Bonaccorsi S, Lindsley D, Wakimoto B, Fuller M, et al. Genetic dissection of meiotic cytokinesis in Drosophila males. Mol Biol Cell. 2004;15:2509-22 pubmed
    ..Examination of preparations stained for tubulin, anillin, KLP3A, and F-actin revealed discrete defects in the components of the cytokinetic apparatus, suggesting that these genes act at four ..

More Information


  1. Bahri S, Yang X, Chia W. The Drosophila bifocal gene encodes a novel protein which colocalizes with actin and is necessary for photoreceptor morphogenesis. Mol Cell Biol. 1997;17:5521-9 pubmed
    ..amino acids which is expressed in the embryo and the larval eye imaginal disc in a pattern identical to that of F actin. During pupal development, Bif localizes to the base of the filamentous actin associated with the forming ..
  2. Adams R, Tavares A, Salzberg A, Bellen H, Glover D. pavarotti encodes a kinesin-like protein required to organize the central spindle and contractile ring for cytokinesis. Genes Dev. 1998;12:1483-94 pubmed
    ..We show that the septin Peanut, actin, and the actin-associated protein Anillin, do not become correctly localized in pav mutants...
  3. Prokopenko S, Brumby A, O KEEFE L, Prior L, He Y, Saint R, et al. A putative exchange factor for Rho1 GTPase is required for initiation of cytokinesis in Drosophila. Genes Dev. 1999;13:2301-14 pubmed
    ..Our results identify Pbl as a RhoGEF specifically required for cytokinesis and linked through Rho1 activity to the reorganization of the actin cytoskeleton at the cleavage furrow.
  4. Bucciarelli E, Giansanti M, Bonaccorsi S, Gatti M. Spindle assembly and cytokinesis in the absence of chromosomes during Drosophila male meiosis. J Cell Biol. 2003;160:993-9 pubmed
    ..This suggests that the association of Aurora B with chromosomes is not a prerequisite for its accumulation at the central spindle, or for its function during cytokinesis. ..
  5. Afshar K, Stuart B, Wasserman S. Functional analysis of the Drosophila diaphanous FH protein in early embryonic development. Development. 2000;127:1887-97 pubmed
    ..its role in other processes, we generated embryos deficient for Diaphanous and analyzed three cell-cycle-regulated actin-mediated events during embryogenesis: formation of the metaphase furrow, cellularization and formation of the pole ..
  6. Major R, Irvine K. Influence of Notch on dorsoventral compartmentalization and actin organization in the Drosophila wing. Development. 2005;132:3823-33 pubmed the DV compartment boundary are characterized by a distinct shape, a smooth interface, and an accumulation of F-actin at the adherens junction...
  7. Eltsov M, Dubé N, Yu Z, Pasakarnis L, Haselmann Weiss U, Brunner D, et al. Quantitative analysis of cytoskeletal reorganization during epithelial tissue sealing by large-volume electron tomography. Nat Cell Biol. 2015;17:605-14 pubmed publisher
    ..After establishing contact through actin-driven exploratory filopodia, cells use a single lamella to generate 'roof tile'-like overlaps...
  8. Jankovics F, Sinka R, Lukacsovich T, Erdelyi M. MOESIN crosslinks actin and cell membrane in Drosophila oocytes and is required for OSKAR anchoring. Curr Biol. 2002;12:2060-5 pubmed
    ..To date, only a single actin binding protein (TropomyosinII) has been identified with a putative role in osk mRNA and protein anchoring...
  9. Earl J, Britt S. Expression of Drosophila rhodopsins during photoreceptor cell differentiation: insights into R7 and R8 cell subtype commitment. Gene Expr Patterns. 2006;6:687-94 pubmed
    ..This sequence mimics the model for how R7 and R8 photoreceptor cells are specified, and defines the timing of photoreceptor cell fate decisions with respect to other events in eye development. ..
  10. Ponton F, Chapuis M, Pernice M, Sword G, Simpson S. Evaluation of potential reference genes for reverse transcription-qPCR studies of physiological responses in Drosophila melanogaster. J Insect Physiol. 2011;57:840-50 pubmed publisher
    ..melanogaster studies are lacking. We analyzed the expression levels of seven candidate reference genes (Actin, EF1, Mnf, Rps20, Rpl32, Tubulin and 18S) in flies that were injured, heat-stressed, or fed different diets...
  11. Grosshans J, Müller H, Wieschaus E. Control of cleavage cycles in Drosophila embryos by frühstart. Dev Cell. 2003;5:285-94 pubmed
    ..Furthermore, the expression of frs is delayed in haploid embryos and requires activity of the maternal checkpoint gene grapes. We propose that zygotic frs expression is involved in linking the N/C and the pause of cleavage cycle. ..
  12. Miller K. A role for moesin in polarity. Trends Cell Biol. 2003;13:165-8 pubmed
    ..Previously, studies in cultured mammalian cells suggested that ERM proteins are important for actin-membrane associations...
  13. Bai J, Binari R, Ni J, Vijayakanthan M, Li H, Perrimon N. RNA interference screening in Drosophila primary cells for genes involved in muscle assembly and maintenance. Development. 2008;135:1439-49 pubmed publisher
    ..We find that Fermitin 1 and Fermitin 2, which are involved in integrin-containing adhesion structures, act in a partially redundant manner to maintain muscle integrity...
  14. Lo S. Focal adhesions: what's new inside. Dev Biol. 2006;294:280-91 pubmed
    ..adhesions is comprised of large molecular complexes that link transmembrane receptors, such as integrins, to the actin cytoskeleton and mediate signals modulating cell attachment, migration, proliferation, differentiation, and gene ..
  15. McCartney B, Price M, Webb R, Hayden M, Holot L, Zhou M, et al. Testing hypotheses for the functions of APC family proteins using null and truncation alleles in Drosophila. Development. 2006;133:2407-18 pubmed
    ..Two mutant proteins have dominant effects on cytoskeletal regulation, affecting Wnt-independent nuclear retention in syncytial embryos. However, they do not have dominant-negative effects on Wnt signaling. ..
  16. Bogdan S, Klämbt C. Kette regulates actin dynamics and genetically interacts with Wave and Wasp. Development. 2003;130:4427-37 pubmed
    ..well as in tissue culture models most of the Kette protein is found in the cytoplasm where it colocalizes with F-actin to which it can bind via its N-terminal domain...
  17. Hernández G, Vazquez Pianzola P, Zurbriggen A, Altmann M, Sierra J, Rivera Pomar R. Two functionally redundant isoforms of Drosophila melanogaster eukaryotic initiation factor 4B are involved in cap-dependent translation, cell survival, and proliferation. Eur J Biochem. 2004;271:2923-36 pubmed
    ..Overexpression of eIF4B in Drosophila cells in culture and in developing eye imaginal discs promotes cell proliferation. ..
  18. Zelhof A, Hardy R, Becker A, Zuker C. Transforming the architecture of compound eyes. Nature. 2006;443:696-9 pubmed
    ..Our results provide a molecular atlas for the construction of microvillar assemblies and illustrate the critical effect of differences in a single structural protein in morphogenesis. ..
  19. Moser M, Campbell G. Generating and interpreting the Brinker gradient in the Drosophila wing. Dev Biol. 2005;286:647-58 pubmed
    ..This Brk negative autoregulation appears to increase the sensitivity of the cells to Dpp/pMad and should also function to stabilize the brk gradient. ..
  20. Schmitz S, Clayton J, Nongthomba U, Prinz H, Veigel C, Geeves M, et al. Drosophila ACT88F indirect flight muscle-specific actin is not N-terminally acetylated: a mutation in N-terminal processing affects actin function. J Mol Biol. 2000;295:1201-10 pubmed
    ..In class II actins, which include muscle actins, the common primary sequence of Met-Cys-Asp-actin is processed to acetyl-Asp-actin. The functional significance of this in vivo is unknown...
  21. Guarnieri D, Dodson G, Simon M. SRC64 regulates the localization of a Tec-family kinase required for Drosophila ring canal growth. Mol Cell. 1998;1:831-40 pubmed
    ..These data suggest that TEC29 is a downstream target of SRC64, and that regulating TEC29 localization during ring canal growth may be a crucial SRC64 function. ..
  22. Mounier N, Sparrow J. Muscle actin genes in insects. Comp Biochem Physiol B. 1993;105:231-8 pubmed
  23. Caussinus E, Gonzalez C. Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster. Nat Genet. 2005;37:1125-9 pubmed
  24. Collier S, Chan H, Toda T, McKimmie C, Johnson G, Adler P, et al. The Drosophila embargoed gene is required for larval progression and encodes the functional homolog of schizosaccharomyces Crm1. Genetics. 2000;155:1799-807 pubmed
    ..We see a nuclear accumulation of endogenous actin in the intestinal epithelial cells of the emb mutant larvae, consistent with a role for the emb gene product in ..
  25. Schober M, Rebay I, Perrimon N. Function of the ETS transcription factor Yan in border cell migration. Development. 2005;132:3493-504 pubmed
    ..Our results suggest that Yan acts as a pivotal link between signal transduction, cell adhesion and invasive cell migration in Drosophila border cells. ..
  26. Delanoue R, Davis I. Dynein anchors its mRNA cargo after apical transport in the Drosophila blastoderm embryo. Cell. 2005;122:97-106 pubmed
    ..One class of cargo is localized mRNAs, which are transported by myosin on actin filaments or by kinesin and dynein on microtubules...
  27. Cavey M, Rauzi M, Lenne P, Lecuit T. A two-tiered mechanism for stabilization and immobilization of E-cadherin. Nature. 2008;453:751-6 pubmed publisher
    ..adhesion mediated by E-cadherin, in particular its trans-association in homophilic complexes supported by actin filaments through beta- and alpha-catenin...
  28. Hongo S, Jacobs Lorena M. Translational discrimination of ribosomal protein mRNAs in the early Drosophila embryo. Dev Biol. 1991;145:338-43 pubmed
    ..No evidence for involvement of reversibly binding trans-acting factors was obtained, although there are limitations in the interpretation of the latter experiments. ..
  29. Lu X, Li Y. Drosophila Src42A is a negative regulator of RTK signaling. Dev Biol. 1999;208:233-43 pubmed
    ..Our study provides the first evidence that Src42A defines a negative regulatory pathway parallel to Ras1 in the RTK signaling cascade. A possible model for Src42A function is discussed. ..
  30. McCartney B, Peifer M. Stem cells in the news: CNN and APC make headlines. Dev Cell. 2003;5:532-4 pubmed
    ..provide new insights into the factors that control this process in the male germline of Drosophila, identifying roles for the centrosomal protein Centrosomin and tumor suppressor homologs of the APC family. ..
  31. Swank D, Bartoo M, Knowles A, Iliffe C, Bernstein S, Molloy J, et al. Alternative exon-encoded regions of Drosophila myosin heavy chain modulate ATPase rates and actin sliding velocity. J Biol Chem. 2001;276:15117-24 pubmed
    ..The in vitro actin sliding velocity on the flight muscle isoform (6...
  32. Razzaq A, Schmitz S, Veigel C, Molloy J, Geeves M, Sparrow J. Actin residue glu(93) is identified as an amino acid affecting myosin binding. J Biol Chem. 1999;274:28321-8 pubmed
    Many mutants have been described that affect the function of the actin encoded by the Drosophila melanogaster indirect flight muscle-specific actin gene, Act88F...
  33. Frankel S, Mooseker M. The actin-related proteins. Curr Opin Cell Biol. 1996;8:30-7 pubmed
    A family of proteins has been discovered over the past three years whose members have clear sequence homology to actin but are distinguished from actin by their structural and functional diversity...
  34. Wasser M, Chia W. The EAST protein of drosophila controls an expandable nuclear endoskeleton. Nat Cell Biol. 2000;2:268-75 pubmed
    ..Moreover, EAST functions to promote the preferential accumulation of the proteins CP60 and actin in extrachromosomal regions of the nucleus...
  35. McEwen D, Peifer M. Puckered, a Drosophila MAPK phosphatase, ensures cell viability by antagonizing JNK-induced apoptosis. Development. 2005;132:3935-46 pubmed
    ..However, if cell death is prevented, JNK activation can trigger tissue overgrowth. Thus, MKPs are key regulators of the delicate balance between proliferation, differentiation and apoptosis during development. ..
  36. Salminen T, Vesala L, Laiho A, Merisalo M, Hoikkala A, Kankare M. Seasonal gene expression kinetics between diapause phases in Drosophila virilis group species and overwintering differences between diapausing and non-diapausing females. Sci Rep. 2015;5:11197 pubmed publisher
    ..littoralis and D. ezoana. The present study helps to achieve a better understanding of the genetic regulation of diapause and of the plasticity of seasonal responses in general. ..
  37. Naim V, Imarisio S, Di Cunto F, Gatti M, Bonaccorsi S. Drosophila citron kinase is required for the final steps of cytokinesis. Mol Biol Cell. 2004;15:5053-63 pubmed
    ..However late telophases of both cell types displayed persistent midbodies associated with disorganized F actin and anillin structures...
  38. Courgeon A, Maingourd M, Maisonhaute C, Montmory C, Rollet E, Tanguay R, et al. Effect of hydrogen peroxide on cytoskeletal proteins of Drosophila cells: comparison with heat shock and other stresses. Exp Cell Res. 1993;204:30-7 pubmed the promoter of heat-shock genes of Drosophila cells, has also been reported to enhance the synthesis of actin. We show here that very short and transient H2O2 treatments, from 1 s to 2 min, are sufficient to induce an ..
  39. Mannervik M. Target genes of homeodomain proteins. Bioessays. 1999;21:267-70 pubmed
    ..An alternative view, that most genes are only indirectly affected by homeodomain proteins is also discussed. ..
  40. Muller U, Littlewood Evans A. Mechanisms that regulate mechanosensory hair cell differentiation. Trends Cell Biol. 2001;11:334-42 pubmed
    ..The studies have also provided new insights into the function of receptors such as integrins and protocadherins, and cytoplasmic proteins such as Rho-type GTPases and unconventional myosins, in organizing the actin cytoskeleton.
  41. Jaiswal M, Agrawal N, Sinha P. Fat and Wingless signaling oppositely regulate epithelial cell-cell adhesion and distal wing development in Drosophila. Development. 2006;133:925-35 pubmed
    ..Finally, we show that Ft intersects Wnt/Wg signaling, downstream of the Wg ligand. Fat and Wg signaling thus exert opposing regulation to coordinate cell-cell adhesion and patterning along the PD axis of Drosophila wing. ..
  42. Laplante C, Nilson L. Differential expression of the adhesion molecule Echinoid drives epithelial morphogenesis in Drosophila. Development. 2006;133:3255-64 pubmed
    Epithelial morphogenesis requires cell movements and cell shape changes coordinated by modulation of the actin cytoskeleton...
  43. Clark D, Sabl J, Henikoff S. Repetitive arrays containing a housekeeping gene have altered polytene chromosome morphology in Drosophila. Chromosoma. 1998;107:96-104 pubmed
    ..Because this unique structure is distinct from bands, interbands, puffs, and the chromocenter, which comprise polytene chromosomes, we suggest that it is composed of an altered form of chromatin. ..
  44. Frankel S, Heintzelman M, Artavanis Tsakonas S, Mooseker M. Identification of a divergent actin-related protein in Drosophila. J Mol Biol. 1994;235:1351-6 pubmed
    The actin-related proteins (ARPs) have primary sequence homology to actin, have no homology to other proteins and, unlike the conventional actins, are clearly divergent...
  45. Li M, Serr M, Newman E, Hays T. The Drosophila tctex-1 light chain is dispensable for essential cytoplasmic dynein functions but is required during spermatid differentiation. Mol Biol Cell. 2004;15:3005-14 pubmed
    ..Our results provide evidence that the function of the 14-kDa light chain in Drosophila is distinct from other dynein subunits and is not required for any essential functions in early development or in the adult organism. ..
  46. Bai J, Hartwig J, Perrimon N. SALS, a WH2-domain-containing protein, promotes sarcomeric actin filament elongation from pointed ends during Drosophila muscle growth. Dev Cell. 2007;13:828-42 pubmed
    Organization of actin filaments into a well-organized sarcomere structure is critical for muscle development and function. However, it is not completely understood how sarcomeric actin/thin filaments attain their stereotyped lengths...
  47. Tobin S, Cook P, Burn T. Transcripts of individual Drosophila actin genes are differentially distributed during embryogenesis. Dev Genet. 1990;11:15-26 pubmed
    ..The 5C and 42A actin genes are cytoplasmic actin genes, with transcripts distributed in all cells and tissues of the developing ..
  48. Nongthomba U, Pasalodos Sanchez S, Clark S, Clayton J, Sparrow J. Expression and function of the Drosophila ACT88F actin isoform is not restricted to the indirect flight muscles. J Muscle Res Cell Motil. 2001;22:111-9 pubmed
    Most higher eukaryotic genomes contain multiple actin genes, yet the sequence differences between isoforms are few...
  49. Mohrmann L, Langenberg K, Krijgsveld J, Kal A, Heck A, Verrijzer C. Differential targeting of two distinct SWI/SNF-related Drosophila chromatin-remodeling complexes. Mol Cell Biol. 2004;24:3077-88 pubmed
    ..Our results support a close reciprocity of chromatin regulation by ATP-dependent remodelers and histone-modifying enzymes. ..
  50. Gervais L, Casanova J. The Drosophila homologue of SRF acts as a boosting mechanism to sustain FGF-induced terminal branching in the tracheal system. Development. 2011;138:1269-74 pubmed publisher
    ..Our results indicate that DSRF acts as an amplifying step to sustain the progression of terminal branch elongation even in the wild-type conditions of FGF signalling. ..
  51. Stowe S, Davis D. Anti-actin immunoreactivity is retained in rhabdoms of Drosophila ninaC photoreceptors. Cell Tissue Res. 1990;260:431-4 pubmed
    ..Using post-embedding immunogold labelling of LR White-embedded eyes, we show that several alleles of this mutation retain positive anti-actin immunoreactivity in the rhabdomeres, comparable to that of wild-type flies.
  52. Oshima K, Takeda M, Kuranaga E, Ueda R, Aigaki T, Miura M, et al. IKK epsilon regulates F actin assembly and interacts with Drosophila IAP1 in cellular morphogenesis. Curr Biol. 2006;16:1531-7 pubmed
    ..Drosophila IKK epsilon was localized to the ruffling membrane of cultured cells and was required for F actin turnover at the cell margin...
  53. Biggin M. To bind or not to bind. Nat Genet. 2001;28:303-4 pubmed
    ..Genome-wide surveys of DNA binding by transcription factors in vivo are beginning to provide some answers. ..
  54. Strickland L, Burgess D. Pathways for membrane trafficking during cytokinesis. Trends Cell Biol. 2004;14:115-8 pubmed
    ..Furthermore, new work reveals that vesicles derived from the Rab11 recycling endosome (RE) promote actin remodeling at the furrow.
  55. Adams J, Kelso R, Cooley L. The kelch repeat superfamily of proteins: propellers of cell function. Trends Cell Biol. 2000;10:17-24 pubmed
    ..In this review, we discuss current information concerning the structural organization of kelch repeat proteins, their biological roles and the molecular basis of their action. ..
  56. Alexandre C, Lecourtois M, Vincent J. Wingless and Hedgehog pattern Drosophila denticle belts by regulating the production of short-range signals. Development. 1999;126:5689-98 pubmed
    ..Attributes of a morphogen can be ascribed to Hedgehog in this system. However, no single morphogen organises the whole denticle pattern. ..
  57. Harden N, Ricos M, Yee K, Sanny J, Langmann C, Yu H, et al. Drac1 and Crumbs participate in amnioserosa morphogenesis during dorsal closure in Drosophila. J Cell Sci. 2002;115:2119-29 pubmed
    ..their effects on the amnioserosa cytoskeleton, as constitutively active Drac1 causes increased staining for F-actin and myosin, whereas dominant-negative Drac1 reduces F-actin levels...
  58. Lu H, Bilder D. Endocytic control of epithelial polarity and proliferation in Drosophila. Nat Cell Biol. 2005;7:1232-9 pubmed
    ..Our findings reveal a critical and specific role for endocytic traffic in the control of both apico-basal polarity and cell proliferation. ..
  59. Wills Z, Emerson M, Rusch J, Bikoff J, Baum B, Perrimon N, et al. A Drosophila homolog of cyclase-associated proteins collaborates with the Abl tyrosine kinase to control midline axon pathfinding. Neuron. 2002;36:611-22 pubmed
    ..that Drosophila capulet (capt), a homolog of the adenylyl cyclase-associated protein that binds and regulates actin in yeast, associates with Abl in Drosophila cells, suggesting a functional relationship in vivo...
  60. Fyrberg E, Bond B, Hershey N, Mixter K, Davidson N. The actin genes of Drosophila: protein coding regions are highly conserved but intron positions are not. Cell. 1981;24:107-16 pubmed
    The entire set of six closely related Drosophila actin genes was isolated using recombinant DNA methodology, and the structures of the respective coding regions were characterized by gene mapping techniques and by nucleotide sequencing ..
  61. Laayouni H, Santos M, Fontdevila A. Toward a physical map of Drosophila buzzatii. Use of randomly amplified polymorphic dna polymorphisms and sequence-tagged site landmarks. Genetics. 2000;156:1797-816 pubmed
    ..Further prospects toward obtaining a more developed genetic map than the one currently available for D. buzzatii are discussed...
  62. Labuhn M, Brack C. Age-related changes in the mRNA expression of actin isoforms in Drosophila melanogaster. Gerontology. 1997;43:261-7 pubmed
    ..Here we have examined age-related changes in the mRNA levels of the gene family encoding the six Drosophila actin genes...
  63. Brodu V, Casanova J. The RhoGAP crossveinless-c links trachealess and EGFR signaling to cell shape remodeling in Drosophila tracheal invagination. Genes Dev. 2006;20:1817-28 pubmed
    ..Our results identify a developmental pathway linking cell fate genes and cell signaling pathways to intracellular modifications during tracheal cell invagination. ..
  64. Davis J, Luchici A, Mosis F, Thackery J, Salazar J, Mao Y, et al. Inter-cellular forces orchestrate contact inhibition of locomotion. Cell. 2015;161:361-73 pubmed publisher
    ..Tracking actin retrograde flow within hemocytes in vivo reveals synchronous reorganization of colliding actin networks through ..
  65. Ruddell A, Jacobs Lorena M. Biphasic pattern of histone gene expression during Drosophila oogenesis. Proc Natl Acad Sci U S A. 1985;82:3316-9 pubmed
    ..of histone genes during Drosophila oogenesis was compared to periods of DNA synthesis as well as to the pattern of actin gene expression. Accumulation of histone mRNAs was measured by RNA blot hybridization...
  66. Zhang C, Rothwell W, Sullivan W, Hsieh T. Discontinuous actin hexagon, a protein essential for cortical furrow formation in Drosophila, is membrane associated and hyperphosphorylated. Mol Biol Cell. 2000;11:1011-22 pubmed
    discontinuous actin hexagon (dah) is a maternal-effect gene essential for the formation of cortical furrows during Drosophila embryogenesis, and DAH protein colocalizes with actin in these furrows...
  67. Chittaranjan S, Xu J, Kuzyk M, Dullat H, Wilton J, Devorkin L, et al. The Drosophila TIPE family member Sigmar interacts with the Ste20-like kinase Misshapen and modulates JNK signaling, cytoskeletal remodeling and autophagy. Biol Open. 2015;4:672-84 pubmed publisher
    ..Together, these findings link Sigmar to the JNK pathway, cytoskeletal remodeling and autophagy activity during salivary gland development, and provide new insights into TIPE family member function. ..
  68. Cela C, Llimargas M. Egfr is essential for maintaining epithelial integrity during tracheal remodelling in Drosophila. Development. 2006;133:3115-25 pubmed
    ..This finding establishes a link between a developmental pathway governing tracheal formation and cell adhesiveness. ..
  69. Todi S, Franke J, Kiehart D, Eberl D. Myosin VIIA defects, which underlie the Usher 1B syndrome in humans, lead to deafness in Drosophila. Curr Biol. 2005;15:862-8 pubmed
  70. Brault V, Sauder U, Reedy M, Aebi U, Schoenenberger C. Differential epitope tagging of actin in transformed Drosophila produces distinct effects on myofibril assembly and function of the indirect flight muscle. Mol Biol Cell. 1999;10:135-49 pubmed
    We have tested the impact of tags on the structure and function of indirect flight muscle (IFM)-specific Act88F actin by transforming mutant Drosophila melanogaster, which do not express endogenous actin in their IFMs, with tagged Act88F ..
  71. Lenartowska M, Isaji M, Miller K. A pre-embedding immunogold approach reveals localization of myosin VI at the ultrastructural level in the actin cones that mediate Drosophila spermatid individualization. Protoplasma. 2012;249:337-46 pubmed publisher
    Stable actin structures play important roles in the development and specialization of differentiated cells. How these structures form, are organized, and are used to mediate physiological processes is not well understood in most cases...
  72. Zeitler J, Hsu C, Dionne H, Bilder D. Domains controlling cell polarity and proliferation in the Drosophila tumor suppressor Scribble. J Cell Biol. 2004;167:1137-46 pubmed
    ..We suggest a model in which Scrib, via the activity of the LRR, governs proliferation primarily by regulating apicobasal polarity. ..
  73. Vereshchagina N, Bennett D, Szoor B, Kirchner J, Gross S, Vissi E, et al. The essential role of PP1beta in Drosophila is to regulate nonmuscle myosin. Mol Biol Cell. 2004;15:4395-405 pubmed
    ..regulatory light chain (MRLC) is a key regulatory mechanism controlling myosin activity and thus regulating the actin/myosin cytoskeleton...
  74. Baehrecke E. Caspase activation finds fertile ground. Dev Cell. 2003;4:608-9 pubmed
    ..Recent work demonstrates that cytochrome c and caspases function in Drosophila sperm cell differentiation and indicates that caspase activity can be regulated in a subcellular manner in cells that live. ..
  75. Mounier N, Gouy M, Mouchiroud D, Prudhomme J. Insect muscle actins differ distinctly from invertebrate and vertebrate cytoplasmic actins. J Mol Evol. 1992;34:406-15 pubmed
    ..However, Bombyx and Drosophila have actin genes specifically expressed in muscles...
  76. He M, Haymer D. Codon bias in actin multigene families and effects on the reconstruction of phylogenetic relationships. J Mol Evol. 1995;41:141-9 pubmed
    Codon usage patterns and phylogenetic relationships in the actin multigene family have been analyzed for three dipteran species--Drosophila melanogaster, Bactrocera dorsalis, and Ceratitis capitata...
  77. Fyrberg E, Fyrberg C, Biggs J, Saville D, Beall C, Ketchum A. Functional nonequivalence of Drosophila actin isoforms. Biochem Genet. 1998;36:271-87 pubmed
    We show that different Drosophila actin isoforms are not interchangeable. We sequenced the six genes that encode conventional Drosophila actins and found that they specify amino acid replacements in 27 of 376 positions...
  78. Cooley L. Drosophila ring canal growth requires Src and Tec kinases. Cell. 1998;93:913-5 pubmed
  79. Brennan C, Ashburner M, Moses K. Ecdysone pathway is required for furrow progression in the developing Drosophila eye. Development. 1998;125:2653-64 pubmed
    ..These results suggest that, in the morphogenetic furrow, temporal hormonal signals are integrated into genetic pathways specifying spatial pattern. ..
  80. Mermall V, Bonafe N, Jones L, Sellers J, Cooley L, Mooseker M. Drosophila myosin V is required for larval development and spermatid individualization. Dev Biol. 2005;286:238-55 pubmed
    ..molecular motors implicated in vesicular traffic, RNA transport, and mechanochemical coupling of the actin and microtubule-based cytoskeletons...
  81. Chandrasekaran V, Beckendorf S. Tec29 controls actin remodeling and endoreplication during invagination of the Drosophila embryonic salivary glands. Development. 2005;132:3515-24 pubmed
    ..We show that actin reorganization and control of endocycle entry are crucial for normal invagination of the salivary placodes...
  82. Jaiswal R, Stepanik V, Rankova A, Molinar O, Goode B, McCartney B. Drosophila homologues of adenomatous polyposis coli (APC) and the formin diaphanous collaborate by a conserved mechanism to stimulate actin filament assembly. J Biol Chem. 2013;288:13897-905 pubmed publisher
    Vertebrate APC collaborates with Dia through its Basic domain to assemble actin filaments...
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    ..N, but not Dl, formed a specific complex with DEcad in vivo. Finally, our results suggest that juxtacrine signaling in epithelia generally depends on the apicobasally polarized structure of epithelial cells. ..
  84. Fernandes I, Schöck F. The nebulin repeat protein Lasp regulates I-band architecture and filament spacing in myofibrils. J Cell Biol. 2014;206:559-72 pubmed publisher
    Mutations in nebulin, a giant muscle protein with 185 actin-binding nebulin repeats, are the major cause of nemaline myopathy in humans...
  85. He Y, Fang X, Emoto K, Jan Y, Adler P. The tricornered Ser/Thr protein kinase is regulated by phosphorylation and interacts with furry during Drosophila wing hair development. Mol Biol Cell. 2005;16:689-700 pubmed
    ..Our data suggest a feedback mechanism involving Trc activity regulates the accumulation of Fry in developing hairs. ..
  86. Taylor M. A novel Drosophila, mef2-regulated muscle gene isolated in a subtractive hybridization-based molecular screen using small amounts of zygotic mutant RNA. Dev Biol. 2000;220:37-52 pubmed
    ..The tin-independent and Dmef2-independent expression of Dmeso18E indicates that it either occupies a link between twi and genes like tin and Dmef2 or it lies in a parallel pathway of gene activation. ..
  87. Röper K, Brown N. Maintaining epithelial integrity: a function for gigantic spectraplakin isoforms in adherens junctions. J Cell Biol. 2003;162:1305-15 pubmed
    ..Previously characterized Shot isoforms are similar to spectrin and dystrophin, with an actin-binding domain followed by spectrin repeats...
  88. Quinn L, Herr A, McGarry T, Richardson H. The Drosophila Geminin homolog: roles for Geminin in limiting DNA replication, in anaphase and in neurogenesis. Genes Dev. 2001;15:2741-54 pubmed
    ..In a partially female-sterile Dm geminin mutant, excessive DNA amplification in the ovarian follicle cells is observed. Our data suggest roles for Dm Geminin in limiting DNA replication, in anaphase and in neural differentiation. ..