Gene Symbol: Acsl
Description: Acyl-CoA synthetase long-chain
Alias: 7447, CG8732, Dmel\CG8732, FACS, FCS, anon-WO0172774.173, dAcsl, dFAC, l(2)05847, l(2)44DEa, l(2)7447, l(2)SH0465, l(2)SH2 0465, l(2)k05304, Acyl-CoA synthetase long-chain, Acsl-PA, Acsl-PB, Acsl-PC, Acsl-PD, Acsl-PE, Acsl-PF, Acsl-PG, Acsl-PH, Acsl-PI, Acsl-PJ, CG8732-PA, CG8732-PB, CG8732-PC, CG8732-PD, CG8732-PE, CG8732-PF, CG8732-PG, CG8732-PH, CG8732-PI, CG8732-PJ, Long-chain acyl-CoA synthetase, fatty acyl CoA synthetase, fatty acyl coenzyme A (CoA) synthetase, fatty acyl-CoA synthetase, lethal (2) 44DEa, lethal (2) SH0465
Species: fruit fly

Top Publications

  1. Liu Z, Huang Y, Zhang Y, Chen D, Zhang Y. Drosophila Acyl-CoA synthetase long-chain family member 4 regulates axonal transport of synaptic vesicles and is required for synaptic development and transmission. J Neurosci. 2011;31:2052-63 pubmed publisher
    ..Mutations in ACSL4 cause nonsyndromic X-linked mental retardation. We previously demonstrated that Drosophila dAcsl is functionally homologous to human ACSL4, and is required for axonal targeting in the brain...
  2. Zhang Y, Chen D, Wang Z. Analyses of mental dysfunction-related ACSl4 in Drosophila reveal its requirement for Dpp/BMP production and visual wiring in the brain. Hum Mol Genet. 2009;18:3894-905 pubmed publisher
    ..The Drosophila ACSL-like protein is highly homologous to human ACSL3 and ACSL4, and we designate it as dAcsl. In this study, we demonstrate that dAcsl and ACSL4 are highly conserved in terms of ACSL4's ability to substitute ..
  3. Dockendorff T, Robertson S, Faulkner D, Jongens T. Genetic characterization of the 44D-45B region of the Drosophila melanogaster genome based on an F2 lethal screen. Mol Gen Genet. 2000;263:137-43 pubmed
    ..This screen may have uncovered mutant alleles of these genes. The results of complementation tests with previously identified genes in 44D-45B suggests that over half of the complementation groups identified in this screen may be novel. ..
  4. Sala A, Toto M, Pinello L, Gabriele A, Di Benedetto V, Ingrassia A, et al. Genome-wide characterization of chromatin binding and nucleosome spacing activity of the nucleosome remodelling ATPase ISWI. EMBO J. 2011;30:1766-77 pubmed publisher
    ..Our study shows how in higher eukaryotes the activity of the evolutionarily conserved nucleosome remodelling factor ISWI regulates gene expression and chromosome organization genome-wide. ..
  5. Zhang Y, Zhang Y, Gao Y, Zhao X, Wang Z. Drosophila long-chain acyl-CoA synthetase acts like a gap gene in embryonic segmentation. Dev Biol. 2011;353:259-65 pubmed publisher
    ..b>dAcsl is the Drosophila homolog of human ACSL4 and their functions are highly conserved in the processes ranging from ..
  6. Montooth K, Siebenthall K, Clark A. Membrane lipid physiology and toxin catabolism underlie ethanol and acetic acid tolerance in Drosophila melanogaster. J Exp Biol. 2006;209:3837-50 pubmed
  7. Seegmiller A, Dobrosotskaya I, Goldstein J, Ho Y, Brown M, Rawson R. The SREBP pathway in Drosophila: regulation by palmitate, not sterols. Dev Cell. 2002;2:229-38 pubmed
    ..Instead, dSREBP processing is blocked by palmitic acid. These findings suggest that the ancestral SREBP pathway functions to maintain membrane integrity rather than to control cholesterol homeostasis. ..
  8. Chambers M, Song K, Schneider D. Listeria monocytogenes infection causes metabolic shifts in Drosophila melanogaster. PLoS ONE. 2012;7:e50679 pubmed publisher
    ..Free amino acid levels also change during infection, including a drop in tyrosine levels which may be due to robust L. monocytogenes induced melanization. ..
  9. Liu Z, Huang Y, Hu W, Huang S, Wang Q, Han J, et al. dAcsl, the Drosophila ortholog of acyl-CoA synthetase long-chain family member 3 and 4, inhibits synapse growth by attenuating bone morphogenetic protein signaling via endocytic recycling. J Neurosci. 2014;34:2785-96 pubmed publisher
    ..We report here that dAcsl, the Drosophila ortholog of ACSL4 and ACSL3, inhibits synaptic growth by attenuating BMP signaling, a major growth-..

More Information


  1. Oba Y, Sato M, Ojika M, Inouye S. Enzymatic and genetic characterization of firefly luciferase and Drosophila CG6178 as a fatty acyl-CoA synthetase. Biosci Biotechnol Biochem. 2005;69:819-28 pubmed
    ..These results suggest that insects have a novel type of fatty acyl-CoA synthetase. ..
  2. Rawson R. The SREBP pathway--insights from Insigs and insects. Nat Rev Mol Cell Biol. 2003;4:631-40 pubmed
  3. Li Y, Zhang Z, Robinson G, Palli S. Identification and characterization of a juvenile hormone response element and its binding proteins. J Biol Chem. 2007;282:37605-17 pubmed
  4. Bauer R, Voelzmann A, Breiden B, Schepers U, Farwanah H, Hahn I, et al. Schlank, a member of the ceramide synthase family controls growth and body fat in Drosophila. EMBO J. 2009;28:3706-16 pubmed publisher
    ..Furthermore, our studies of schlank and the mammalian Lass2 family member suggest a novel role for ceramide synthases in regulating body fat metabolism. ..
  5. Mohr S, Boswell R. Genetic analysis of Drosophila melanogaster polytene chromosome region 44D-45F: loci required for viability and fertility. Genetics. 2002;160:1503-10 pubmed
    ..Mutations in sine prole disrupt spermatogenesis at or before individualization of spermatozoa and cause multiple defects in oogenesis, including inappropriate division of the germline cyst and arrest of oogenesis at stage 4. ..
  6. O Sullivan N, Jahn T, Reid E, O Kane C. Reticulon-like-1, the Drosophila orthologue of the hereditary spastic paraplegia gene reticulon 2, is required for organization of endoplasmic reticulum and of distal motor axons. Hum Mol Genet. 2012;21:3356-65 pubmed publisher
    ..Our data provide a route to further understanding of both the role of the SER in axons and the pathological consequences of the impairment of this compartment. ..
  7. Lee H, Peng Y, Guo Y. Analysis of lipid droplet dynamics and functions in Drosophila melanogaster. Methods Cell Biol. 2013;116:53-69 pubmed publisher
  8. Röttgen G, Wagner T, Hinz U. A genetic screen for elements of the network that regulates neurogenesis in Drosophila. Mol Gen Genet. 1998;257:442-51 pubmed
    ..Besides mutations in genes expected to modify the phenotype, we have isolated mutations in six genes not known so far to be involved in neurogenesis. ..
  9. Huang Y, Huang S, Lam S, Liu Z, Shui G, Zhang Y. Acsl, the Drosophila ortholog of intellectual-disability-related ACSL4, inhibits synaptic growth by altered lipids. J Cell Sci. 2016;129:4034-4045 pubmed
    ..We previously reported that Acsl, the Drosophila ortholog of mammalian ACSL3 and ACSL4, inhibits neuromuscular synapse growth by suppressing bone ..
  10. Dobrosotskaya I, Seegmiller A, Brown M, Goldstein J, Rawson R. Regulation of SREBP processing and membrane lipid production by phospholipids in Drosophila. Science. 2002;296:879-83 pubmed