Genomes and Genes
Gene Symbol: AcCoAS
Description: Acetyl Coenzyme A synthase
Alias: ACS, AcCoAs, BEST:GH28401, CG9390, Dmel\CG9390, dACS, acetyl coenzyme A synthase, Ac CoA synthase, AcCoA synthetase, AcCoAS-PA, AcCoAS-PB, AcCoAS-PD, Acetyl-CoA synthase, Acetyl-CoA sythase, AcetylCoA synthase, CG9390-PA, CG9390-PB, CG9390-PD, acetate-coenzyme A ligase, acetyl CoA synthase, acetyl CoA synthetase, acetyl-CoA synthetase, acetyl-coenzyme A synthase
Species: fruit fly
- Montooth K, Siebenthall K, Clark A. Membrane lipid physiology and toxin catabolism underlie ethanol and acetic acid tolerance in Drosophila melanogaster. J Exp Biol. 2006;209:3837-50 pubmed
- Oba Y, Ojika M, Inouye S. Characterization of CG6178 gene product with high sequence similarity to firefly luciferase in Drosophila melanogaster. Gene. 2004;329:137-45 pubmed..Further, phylogenic analyses strongly suggest that the firefly luciferase gene may have evolved from a fatty acyl-CoA synthetase gene as a common ancestral gene. ..
- Ashburner M. Speculations on the subject of alcohol dehydrogenase and its properties in Drosophila and other flies. Bioessays. 1998;20:949-54 pubmed publisher..I also hint that the ADH enzymes of other flies (e.g., the tephritid fruit flies) may have evolved independently of those of Drosophila, but from a common ancestral gene...
- Kunte A, Matthews K, Rawson R. Fatty acid auxotrophy in Drosophila larvae lacking SREBP. Cell Metab. 2006;3:439-48 pubmed..The role, if any, of dSREBP in adults is not yet apparent. These data indicate that dSREBP deficiency renders Drosophila larvae auxotrophic for fatty acids. ..
- Rawson R. The SREBP pathway--insights from Insigs and insects. Nat Rev Mol Cell Biol. 2003;4:631-40 pubmed
- Seegmiller A, Dobrosotskaya I, Goldstein J, Ho Y, Brown M, Rawson R. The SREBP pathway in Drosophila: regulation by palmitate, not sterols. Dev Cell. 2002;2:229-38 pubmed..Instead, dSREBP processing is blocked by palmitic acid. These findings suggest that the ancestral SREBP pathway functions to maintain membrane integrity rather than to control cholesterol homeostasis. ..
- Kong E, Allouche L, Chapot P, Vranizan K, Moore M, Heberlein U, et al. Ethanol-regulated genes that contribute to ethanol sensitivity and rapid tolerance in Drosophila. Alcohol Clin Exp Res. 2010;34:302-16 pubmed publisher..Our findings implicate novel roles for these genes in regulating ethanol behavioral responses. ..
- Matthews K, Ozdemir C, Rawson R. Activation of sterol regulatory element binding proteins in the absence of Scap in Drosophila melanogaster. Genetics. 2010;185:189-98 pubmed publisher..Thus, dScap and dS2P, essential components of the SREBP activation machinery in mammalian cells, are dispensable in Drosophila owing to different compensatory mechanisms. ..
- Yampolsky L, Glazko G, Fry J. Evolution of gene expression and expression plasticity in long-term experimental populations of Drosophila melanogaster maintained under constant and variable ethanol stress. Mol Ecol. 2012;21:4287-99 pubmed publisher..The results give evidence that expression plasticity evolves considerably more slowly than mean expression. ..
- Eisenberg T, Schroeder S, Andryushkova A, Pendl T, Kuttner V, Bhukel A, et al. Nucleocytosolic depletion of the energy metabolite acetyl-coenzyme a stimulates autophagy and prolongs lifespan. Cell Metab. 2014;19:431-44 pubmed publisher..Brain-specific knockdown of Drosophila AcCoA synthetase was sufficient to enhance autophagic protein clearance and prolong lifespan...
- Bi J, Wang W, Liu Z, Huang X, Jiang Q, Liu G, et al. Seipin promotes adipose tissue fat storage through the ER Ca²?-ATPase SERCA. Cell Metab. 2014;19:861-71 pubmed publisher..Our results reveal that Seipin promotes adipose tissue fat storage by regulating intracellular calcium homeostasis. ..
- Bauer R, Voelzmann A, Breiden B, Schepers U, Farwanah H, Hahn I, et al. Schlank, a member of the ceramide synthase family controls growth and body fat in Drosophila. EMBO J. 2009;28:3706-16 pubmed publisher..Furthermore, our studies of schlank and the mammalian Lass2 family member suggest a novel role for ceramide synthases in regulating body fat metabolism. ..
- Kim G, Lee Y, Lee G, Cho Y, Lee Y, Jang Y, et al. Overexpression of malic enzyme in the larval stage extends Drosophila lifespan. Biochem Biophys Res Commun. 2015;456:676-82 pubmed publisher..Our results suggest that metabolic changes mediated by Men during development might be related to the control of ROS tolerance and the longevity of Drosophila. ..