Gene Symbol: AcCoAS
Description: Acetyl Coenzyme A synthase
Alias: ACS, AcCoAs, BEST:GH28401, CG9390, Dmel\CG9390, dACS, acetyl coenzyme A synthase, Ac CoA synthase, AcCoA synthetase, AcCoAS-PA, AcCoAS-PB, AcCoAS-PD, Acetyl-CoA synthase, Acetyl-CoA sythase, AcetylCoA synthase, CG9390-PA, CG9390-PB, CG9390-PD, acetate-coenzyme A ligase, acetyl CoA synthase, acetyl CoA synthetase, acetyl-CoA synthetase, acetyl-coenzyme A synthase
Species: fruit fly

Top Publications

  1. Karan D, Lesbats M, David J, Capy P. Evolution of the AMP-forming acetyl-CoA synthetase gene in the Drosophilidae family. J Mol Evol. 2003;57 Suppl 1:S297-303 pubmed
    Analysis of the AMP-forming ACS gene was performed in 12 species of the Drosophilidae family...
  2. Teleman A, Chen Y, Cohen S. Drosophila Melted modulates FOXO and TOR activity. Dev Cell. 2005;9:271-81 pubmed
    ..We provide evidence that in the melted mutant, TOR activity is reduced and FOXO is activated. The melted mutant condition mimics the effects of nutrient deprivation in a normal animal, producing an animal with 40% less fat than normal. ..
  3. Dobrosotskaya I, Seegmiller A, Brown M, Goldstein J, Rawson R. Regulation of SREBP processing and membrane lipid production by phospholipids in Drosophila. Science. 2002;296:879-83 pubmed
  4. Oba Y, Sato M, Ojika M, Inouye S. Enzymatic and genetic characterization of firefly luciferase and Drosophila CG6178 as a fatty acyl-CoA synthetase. Biosci Biotechnol Biochem. 2005;69:819-28 pubmed
    ..These results suggest that insects have a novel type of fatty acyl-CoA synthetase. ..
  5. Zinke I, Kirchner C, Chao L, Tetzlaff M, Pankratz M. Suppression of food intake and growth by amino acids in Drosophila: the role of pumpless, a fat body expressed gene with homology to vertebrate glycine cleavage system. Development. 1999;126:5275-84 pubmed
    ..This signaling system may also mediate growth transition from larval to the pupal stage during Drosophila development. ..
  6. Zhao X, Feng D, Wang Q, Abdulla A, Xie X, Zhou J, et al. Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1. J Clin Invest. 2012;122:2417-27 pubmed publisher
    ..Taken together, these results demonstrate that CDK8 and CycC function as evolutionarily conserved components of the insulin signaling pathway in regulating lipid homeostasis. ..
  7. Inouye S. Firefly luciferase: an adenylate-forming enzyme for multicatalytic functions. Cell Mol Life Sci. 2010;67:387-404 pubmed publisher
    ..Further, we succeeded in converting the fatty acyl-CoA synthetase of non-luminous insects into functional luciferase showing luminescence activity by site-directed mutagenesis. ..
  8. Matthews K, Kunte A, Tambe Ebot E, Rawson R. Alternative processing of sterol regulatory element binding protein during larval development in Drosophila melanogaster. Genetics. 2009;181:119-28 pubmed publisher
    ..Despite loss of dS2P, dSREBP is processed in mutant larvae. Therefore, larvae have an alternative cleavage mechanism for producing transcriptionally active dSREBP, and this permits survival of dS2P mutants. ..
  9. Okamura T, Shimizu H, Nagao T, Ueda R, Ishii S. ATF-2 regulates fat metabolism in Drosophila. Mol Biol Cell. 2007;18:1519-29 pubmed
    ..Furthermore we showed that dATF-2 positively regulated dPEPCK gene transcription via several CRE half-sites in the PEPCK promoter. Thus, dATF-2 is critical for regulation of fat metabolism. ..

More Information


  1. Montooth K, Siebenthall K, Clark A. Membrane lipid physiology and toxin catabolism underlie ethanol and acetic acid tolerance in Drosophila melanogaster. J Exp Biol. 2006;209:3837-50 pubmed
  2. Oba Y, Ojika M, Inouye S. Characterization of CG6178 gene product with high sequence similarity to firefly luciferase in Drosophila melanogaster. Gene. 2004;329:137-45 pubmed
    ..Further, phylogenic analyses strongly suggest that the firefly luciferase gene may have evolved from a fatty acyl-CoA synthetase gene as a common ancestral gene. ..
  3. Ashburner M. Speculations on the subject of alcohol dehydrogenase and its properties in Drosophila and other flies. Bioessays. 1998;20:949-54 pubmed publisher
    ..I also hint that the ADH enzymes of other flies (e.g., the tephritid fruit flies) may have evolved independently of those of Drosophila, but from a common ancestral gene...
  4. Kunte A, Matthews K, Rawson R. Fatty acid auxotrophy in Drosophila larvae lacking SREBP. Cell Metab. 2006;3:439-48 pubmed
    ..The role, if any, of dSREBP in adults is not yet apparent. These data indicate that dSREBP deficiency renders Drosophila larvae auxotrophic for fatty acids. ..
  5. Rawson R. The SREBP pathway--insights from Insigs and insects. Nat Rev Mol Cell Biol. 2003;4:631-40 pubmed
  6. Seegmiller A, Dobrosotskaya I, Goldstein J, Ho Y, Brown M, Rawson R. The SREBP pathway in Drosophila: regulation by palmitate, not sterols. Dev Cell. 2002;2:229-38 pubmed
    ..Instead, dSREBP processing is blocked by palmitic acid. These findings suggest that the ancestral SREBP pathway functions to maintain membrane integrity rather than to control cholesterol homeostasis. ..
  7. Kong E, Allouche L, Chapot P, Vranizan K, Moore M, Heberlein U, et al. Ethanol-regulated genes that contribute to ethanol sensitivity and rapid tolerance in Drosophila. Alcohol Clin Exp Res. 2010;34:302-16 pubmed publisher
    ..Our findings implicate novel roles for these genes in regulating ethanol behavioral responses. ..
  8. Matthews K, Ozdemir C, Rawson R. Activation of sterol regulatory element binding proteins in the absence of Scap in Drosophila melanogaster. Genetics. 2010;185:189-98 pubmed publisher
    ..Thus, dScap and dS2P, essential components of the SREBP activation machinery in mammalian cells, are dispensable in Drosophila owing to different compensatory mechanisms. ..
  9. Yampolsky L, Glazko G, Fry J. Evolution of gene expression and expression plasticity in long-term experimental populations of Drosophila melanogaster maintained under constant and variable ethanol stress. Mol Ecol. 2012;21:4287-99 pubmed publisher
    ..The results give evidence that expression plasticity evolves considerably more slowly than mean expression. ..
  10. Eisenberg T, Schroeder S, Andryushkova A, Pendl T, Kuttner V, Bhukel A, et al. Nucleocytosolic depletion of the energy metabolite acetyl-coenzyme a stimulates autophagy and prolongs lifespan. Cell Metab. 2014;19:431-44 pubmed publisher
    ..Brain-specific knockdown of Drosophila AcCoA synthetase was sufficient to enhance autophagic protein clearance and prolong lifespan...
  11. Bi J, Wang W, Liu Z, Huang X, Jiang Q, Liu G, et al. Seipin promotes adipose tissue fat storage through the ER Ca²?-ATPase SERCA. Cell Metab. 2014;19:861-71 pubmed publisher
    ..Our results reveal that Seipin promotes adipose tissue fat storage by regulating intracellular calcium homeostasis. ..
  12. Bauer R, Voelzmann A, Breiden B, Schepers U, Farwanah H, Hahn I, et al. Schlank, a member of the ceramide synthase family controls growth and body fat in Drosophila. EMBO J. 2009;28:3706-16 pubmed publisher
    ..Furthermore, our studies of schlank and the mammalian Lass2 family member suggest a novel role for ceramide synthases in regulating body fat metabolism. ..
  13. Kim G, Lee Y, Lee G, Cho Y, Lee Y, Jang Y, et al. Overexpression of malic enzyme in the larval stage extends Drosophila lifespan. Biochem Biophys Res Commun. 2015;456:676-82 pubmed publisher
    ..Our results suggest that metabolic changes mediated by Men during development might be related to the control of ROS tolerance and the longevity of Drosophila. ..