ACC

Summary

Gene Symbol: ACC
Description: Acetyl-CoA carboxylase
Alias: A1Z784_DROME, ACoT, CG11198, CG8723, DmACC, Dmel\CG11198, FBgn0043811, dACC, Acetyl-CoA carboxylase, ACC-PA, ACC-PB, ACC-PC, ACC-PE, ACC-PF, ACC-PG, CG11198-PA, CG11198-PB, CG11198-PC, CG11198-PE, CG11198-PF, CG11198-PG, aceto-acetyl-CoA-thiolase, acetyl CoA carboxylase, acetyl coenzyme A carboxylase, acetyl-CoA carboxylase, acetyl-coenzyme A carboxylase
Species: fruit fly
Products:     ACC

Top Publications

  1. Parvy J, Napal L, Rubin T, Poidevin M, Perrin L, Wicker Thomas C, et al. Drosophila melanogaster Acetyl-CoA-carboxylase sustains a fatty acid-dependent remote signal to waterproof the respiratory system. PLoS Genet. 2012;8:e1002925 pubmed publisher
    ..Thus, FA metabolic enzymes are attractive targets for drug therapy. Mouse studies on Acetyl-coenzymeA-carboxylase (ACC), the rate-limiting enzyme for FA synthesis, have highlighted its homeostatic role in liver and adipose tissue...
  2. Havula E, Teesalu M, Hyötyläinen T, Seppälä H, Hasygar K, Auvinen P, et al. Mondo/ChREBP-Mlx-regulated transcriptional network is essential for dietary sugar tolerance in Drosophila. PLoS Genet. 2013;9:e1003438 pubmed publisher
    ..Our data demonstrate that the transcriptional network regulated by Mondo-Mlx is a critical determinant of the healthful dietary spectrum allowing Drosophila to exploit sugar-rich nutrient sources. ..
  3. Rawson R. The SREBP pathway--insights from Insigs and insects. Nat Rev Mol Cell Biol. 2003;4:631-40 pubmed
  4. Kunte A, Matthews K, Rawson R. Fatty acid auxotrophy in Drosophila larvae lacking SREBP. Cell Metab. 2006;3:439-48 pubmed
    ..The role, if any, of dSREBP in adults is not yet apparent. These data indicate that dSREBP deficiency renders Drosophila larvae auxotrophic for fatty acids. ..
  5. Katewa S, Demontis F, Kolipinski M, Hubbard A, Gill M, Perrimon N, et al. Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster. Cell Metab. 2012;16:97-103 pubmed publisher
    ..Together, these results suggest that enhanced fat metabolism in the muscle and physical activity play a key role in the protective effects of DR. ..
  6. Al Anzi B, Sapin V, Waters C, Zinn K, Wyman R, Benzer S. Obesity-blocking neurons in Drosophila. Neuron. 2009;63:329-41 pubmed publisher
    ..Our results show that the fly brain measures fat store levels and can induce changes in food intake and metabolism to maintain them within normal limits. ..
  7. Xun Z, Kaufman T, Clemmer D. Stable isotope labeling and label-free proteomics of Drosophila parkin null mutants. J Proteome Res. 2009;8:4500-10 pubmed publisher
    ..These findings suggest that abnormalities in energy metabolism and protein transporter activity pathways may be associated with the pathogenesis of Parkin-associated AR-JP. ..
  8. Matthews K, Ozdemir C, Rawson R. Activation of sterol regulatory element binding proteins in the absence of Scap in Drosophila melanogaster. Genetics. 2010;185:189-98 pubmed publisher
    ..Thus, dScap and dS2P, essential components of the SREBP activation machinery in mammalian cells, are dispensable in Drosophila owing to different compensatory mechanisms. ..
  9. Stenesen D, Suh J, Seo J, Yu K, Lee K, Kim J, et al. Adenosine nucleotide biosynthesis and AMPK regulate adult life span and mediate the longevity benefit of caloric restriction in flies. Cell Metab. 2013;17:101-12 pubmed publisher

More Information

Publications38

  1. Kim G, Lee Y, Lee G, Cho Y, Lee Y, Jang Y, et al. Overexpression of malic enzyme in the larval stage extends Drosophila lifespan. Biochem Biophys Res Commun. 2015;456:676-82 pubmed publisher
    ..Our results suggest that metabolic changes mediated by Men during development might be related to the control of ROS tolerance and the longevity of Drosophila. ..
  2. Wang B, Chen N, Wei Y, Li J, Sun L, Wu J, et al. Akt signaling-associated metabolic effects of dietary gold nanoparticles in Drosophila. Sci Rep. 2012;2:563 pubmed publisher
    ..This study thus reveals a novel function of AuNPs in influencing animal metabolism and suggests its potential therapeutic applications for metabolic disorders. ..
  3. Di Cara F, Duca E, Dunbar D, Cagney G, Heck M. Invadolysin, a conserved lipid-droplet-associated metalloproteinase, is required for mitochondrial function in Drosophila. J Cell Sci. 2013;126:4769-81 pubmed publisher
    ..As a consequence, invadolysin mutant larvae show lower energetic status and higher oxidative stress. Our data demonstrate an essential role for invadolysin in mitochondrial function that is crucial for normal development and survival. ..
  4. Lim H, Wang W, Wessells R, Ocorr K, Bodmer R. Phospholipid homeostasis regulates lipid metabolism and cardiac function through SREBP signaling in Drosophila. Genes Dev. 2011;25:189-200 pubmed publisher
    ..These findings suggest that dysregulated phospholipid signaling that alters SREBP activity contributes to the progression of impaired heart function in flies and identifies a potential link to lipotoxic cardiac diseases in humans. ..
  5. Matsuda H, Yamada T, Yoshida M, Nishimura T. Flies without trehalose. J Biol Chem. 2015;290:1244-55 pubmed publisher
    ..These diet-dependent phenotypes of Tps1 mutants demonstrate the critical role of trehalose during development in Drosophila and reveal how animals adapt to changes in nutrient availability. ..
  6. Sasamura T, Matsuno K, Fortini M. Disruption of Drosophila melanogaster lipid metabolism genes causes tissue overgrowth associated with altered developmental signaling. PLoS Genet. 2013;9:e1003917 pubmed publisher
    ..Our analysis of the mutants demonstrates genetic links between abnormal lipid metabolism, perturbations in developmental signaling, and aberrant cell proliferation. ..
  7. Mattila J, Havula E, Suominen E, Teesalu M, Surakka I, Hynynen R, et al. Mondo-Mlx Mediates Organismal Sugar Sensing through the Gli-Similar Transcription Factor Sugarbabe. Cell Rep. 2015;13:350-64 pubmed publisher
    ..In sum, Mondo-Mlx is a master regulator of other sugar-responsive pathways essential for adaptation to a high-sugar diet. ..
  8. Buescher J, Musselman L, Wilson C, Lang T, Keleher M, Baranski T, et al. Evidence for transgenerational metabolic programming in Drosophila. Dis Model Mech. 2013;6:1123-32 pubmed publisher
    ..Our data indicate that nutritional programming mechanisms could be highly conserved and support the use of Drosophila as a model for evaluating the underlying genetic and epigenetic contributions to this phenomenon. ..
  9. Bi J, Wang W, Liu Z, Huang X, Jiang Q, Liu G, et al. Seipin promotes adipose tissue fat storage through the ER Ca²?-ATPase SERCA. Cell Metab. 2014;19:861-71 pubmed publisher
    ..Our results reveal that Seipin promotes adipose tissue fat storage by regulating intracellular calcium homeostasis. ..
  10. Dobrosotskaya I, Seegmiller A, Brown M, Goldstein J, Rawson R. Regulation of SREBP processing and membrane lipid production by phospholipids in Drosophila. Science. 2002;296:879-83 pubmed
  11. Bailey A, Koster G, Guillermier C, Hirst E, Macrae J, Lechene C, et al. Antioxidant Role for Lipid Droplets in a Stem Cell Niche of Drosophila. Cell. 2015;163:340-53 pubmed publisher
    ..This study reveals an antioxidant role for lipid droplets that could be relevant in many different biological contexts. ..
  12. Cinnamon E, Makki R, Sawala A, Wickenberg L, Blomquist G, Tittiger C, et al. Drosophila Spidey/Kar Regulates Oenocyte Growth via PI3-Kinase Signaling. PLoS Genet. 2016;12:e1006154 pubmed publisher
    ..Together, the findings in this study show how Spidey/Kar and FarO regulate the balance between the cell growth and lipid storage of larval oenocytes. ..
  13. Matthews K, Kunte A, Tambe Ebot E, Rawson R. Alternative processing of sterol regulatory element binding protein during larval development in Drosophila melanogaster. Genetics. 2009;181:119-28 pubmed publisher
    ..Despite loss of dS2P, dSREBP is processed in mutant larvae. Therefore, larvae have an alternative cleavage mechanism for producing transcriptionally active dSREBP, and this permits survival of dS2P mutants. ..
  14. Banerjee K, Ayyub C, Sengupta S, Kolthur Seetharam U. dSir2 deficiency in the fatbody, but not muscles, affects systemic insulin signaling, fat mobilization and starvation survival in flies. Aging (Albany NY). 2012;4:206-23 pubmed
    ..In conclusion, these findings highlight the central role that fatbody dSir2 plays in linking metabolism to organismal physiology and its importance for survival...
  15. Ozdemir C, Rawson R. Other ways to skin a cat: activating SREBP without Scap. Fly (Austin). 2011;5:3-6 pubmed
    ..We recently characterized the phenotypes of dscap mutants as well. Here, we describe additional details of phenotypes arising from the inability to activate SREBP appropriately. ..
  16. Ciurciu A, Duncalf L, Jonchère V, Lansdale N, Vasieva O, Glenday P, et al. PNUTS/PP1 regulates RNAPII-mediated gene expression and is necessary for developmental growth. PLoS Genet. 2013;9:e1003885 pubmed publisher
    ..Together, these findings shed light on the in vivo role of the PNUTS-PP1 holoenzyme and its contribution to the control of gene expression during early Drosophila development...
  17. Bland M, Lee R, Magallanes J, Foskett J, Birnbaum M. AMPK supports growth in Drosophila by regulating muscle activity and nutrient uptake in the gut. Dev Biol. 2010;344:293-303 pubmed publisher
    ..Furthermore, our data show that in Drosophila, AMPK performs an essential cell-nonautonomous function, serving the needs of the organism by promoting activity of the visceral musculature and, consequently, nutrient intake. ..
  18. Wicker Thomas C, Garrido D, Bontonou G, Napal L, Mazuras N, Denis B, et al. Flexible origin of hydrocarbon/pheromone precursors in Drosophila melanogaster. J Lipid Res. 2015;56:2094-101 pubmed publisher
    ..Our study highlights the importance of environmental and physiological inputs in regulating LCFA synthesis to eventually control sexual communication in a polyphagous animal. ..
  19. Seegmiller A, Dobrosotskaya I, Goldstein J, Ho Y, Brown M, Rawson R. The SREBP pathway in Drosophila: regulation by palmitate, not sterols. Dev Cell. 2002;2:229-38 pubmed
    ..Instead, dSREBP processing is blocked by palmitic acid. These findings suggest that the ancestral SREBP pathway functions to maintain membrane integrity rather than to control cholesterol homeostasis. ..
  20. Katewa S, Akagi K, Bose N, Rakshit K, Camarella T, Zheng X, et al. Peripheral Circadian Clocks Mediate Dietary Restriction-Dependent Changes in Lifespan and Fat Metabolism in Drosophila. Cell Metab. 2016;23:143-54 pubmed publisher
    ..These findings identify a critical role for specific clock genes in modulating the effects of nutrient manipulation on fat metabolism and aging. ..
  21. Okamura T, Shimizu H, Nagao T, Ueda R, Ishii S. ATF-2 regulates fat metabolism in Drosophila. Mol Biol Cell. 2007;18:1519-29 pubmed
    ..Furthermore we showed that dATF-2 positively regulated dPEPCK gene transcription via several CRE half-sites in the PEPCK promoter. Thus, dATF-2 is critical for regulation of fat metabolism. ..
  22. Garrido D, Rubin T, Poidevin M, Maroni B, Le Rouzic A, Parvy J, et al. Fatty acid synthase cooperates with glyoxalase 1 to protect against sugar toxicity. PLoS Genet. 2015;11:e1004995 pubmed publisher
    ..In contrast, FA-synthesis appears to be required to limit a cell-autonomous accumulation of MG-derived-AGEs, supporting the notion that MG is the most deleterious α-oxoaldehyde at the intracellular level. ..
  23. Bauer R, Voelzmann A, Breiden B, Schepers U, Farwanah H, Hahn I, et al. Schlank, a member of the ceramide synthase family controls growth and body fat in Drosophila. EMBO J. 2009;28:3706-16 pubmed publisher
    ..Furthermore, our studies of schlank and the mammalian Lass2 family member suggest a novel role for ceramide synthases in regulating body fat metabolism. ..
  24. Tsuda Sakurai K, Seong K, Horiuchi J, Aigaki T, Tsuda M. Identification of a novel role for Drosophila MESR4 in lipid metabolism. Genes Cells. 2015;20:358-65 pubmed publisher
    ..These results suggest that MESR4 acts as an important upstream regulator of energy homeostasis. ..
  25. Camporeale G, Zempleni J, Eissenberg J. Susceptibility to heat stress and aberrant gene expression patterns in holocarboxylase synthetase-deficient Drosophila melanogaster are caused by decreased biotinylation of histones, not of carboxylases. J Nutr. 2007;137:885-9 pubmed
    ..We conclude that gene expression patterns and phenotypes in HCS-deficient flies in previous studies are caused by decreased biotinylation of histones rather than MCC. ..
  26. Parisi F, Riccardo S, Zola S, Lora C, Grifoni D, Brown L, et al. dMyc expression in the fat body affects DILP2 release and increases the expression of the fat desaturase Desat1 resulting in organismal growth. Dev Biol. 2013;379:64-75 pubmed publisher
    ..accumulation of triglycerides, which correlates with increased levels of Fatty Acid Synthase and Acetyl CoA Carboxylase mRNAs, enzymes responsible for lipid synthesis...
  27. Sassu E, McDermott J, Keys B, Esmaeili M, Keene A, Birnbaum M, et al. Mio/dChREBP coordinately increases fat mass by regulating lipid synthesis and feeding behavior in Drosophila. Biochem Biophys Res Commun. 2012;426:43-8 pubmed publisher
    ..Together, these data implicate a role for Mio in controlling fat accumulation in Drosophila and suggests that it may act as a nutrient sensor in the fat body to coordinate feeding behavior with nutrient availability. ..
  28. Pan D, Hardie D. A homologue of AMP-activated protein kinase in Drosophila melanogaster is sensitive to AMP and is activated by ATP depletion. Biochem J. 2002;367:179-86 pubmed
    ..We also identified a homologue of acetyl-CoA carboxylase (DmACC) in Drosophila and, using a phosphospecific antibody, showed that the site corresponding to the regulatory AMPK ..
  29. Zhao X, Feng D, Wang Q, Abdulla A, Xie X, Zhou J, et al. Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1. J Clin Invest. 2012;122:2417-27 pubmed publisher
    ..Taken together, these results demonstrate that CDK8 and CycC function as evolutionarily conserved components of the insulin signaling pathway in regulating lipid homeostasis. ..