Gene Symbol: abo
Description: abnormal oocyte
Alias: Abo, CG6093, Dmel\CG6093, abnormal oocyte, CG6093-PA, abo-PA
Species: fruit fly

Top Publications

  1. Gigliotti S, Cavaliere V, Manzi A, Tino A, Graziani F, Malva C. A membrane guanylate cyclase Drosophila homolog gene exhibits maternal and zygotic expression. Dev Biol. 1993;159:450-61 pubmed
    ..The putative maternal transcript can be seen in very early embryos and reappears later as a product of zygotic gene expression. ..
  2. Berloco M, Fanti L, Breiling A, Orlando V, Pimpinelli S. The maternal effect gene, abnormal oocyte (abo), of Drosophila melanogaster encodes a specific negative regulator of histones. Proc Natl Acad Sci U S A. 2001;98:12126-31 pubmed
    The abnormal oocyte (abo) gene of Drosophila melanogaster is a peculiar maternal effect gene whose mutations cause a maternal-effect lethality that can be rescued by specific regions of heterochromatin during early embryogenesis...
  3. Malva C, Graziani F, Gargiulo G, Manzi A. Cell functions in Drosophila oogenesis. Genetica. 1994;94:115-26 pubmed
    ..Some (hold up, wavoid-like and abnormal oocyte) have been isolated by L...
  4. Sandler L. Evidence for a set of closely linked autosomal genes that interact with sex-chromosome heterochromatin in Drosophila melanogaster. Genetics. 1977;86:567-82 pubmed
    ..The nature of this interaction and possible reasons for the existence of the cluster of autosomal genes are discussed. ..
  5. Sinclair D, Ruddell A, Brock J, Clegg N, Lloyd V, Grigliatti T. A cytogenetic and genetic characterization of a group of closely linked second chromosome mutations that suppress position-effect variegation in Drosophila melanogaster. Genetics. 1992;130:333-44 pubmed
    ..We also report that two previously isolated mutants located in 31E and 31F-32A act as recessive suppressors of PEV. ..
  6. Pimpinelli S, Sullivan W, Prout M, Sandler L. On biological functions mapping to the heterochromatin of Drosophila melanogaster. Genetics. 1985;109:701-24 pubmed
    We examined the behavior of an autosomal recessive maternal-effect mutation, abnormal-oocyte (abo), that is located in the euchromatin of the left arm of chromosome 2...
  7. Graziani F, Vicari L, Boncinelli E, Malva C, Manzi A, Mariani C. Selective replication of ribosomal DNA repeats after loss of the abnormal oocyte phenotype in Drosophila melanogaster. Proc Natl Acad Sci U S A. 1981;78:7662-4 pubmed
    Drosophila melanogaster females homozygous for the abnormal oocyte mutation produce a large excess of female offspring when crossed with XY/0 males...
  8. Sandler L. The Regulation of Sex Chromosome Heterochromatic Activity by an Autosomal Gene in DROSOPHILA MELANOGASTER. Genetics. 1970;64:481-93 pubmed
  9. Marcand S, Gasser S, Gilson E. Chromatin: a sticky silence. Curr Biol. 1996;6:1222-5 pubmed

More Information


  1. Moore D, Miyazaki W, Tomkiel J, Orr Weaver T. Double or nothing: a Drosophila mutation affecting meiotic chromosome segregation in both females and males. Genetics. 1994;136:953-64 pubmed
    ..Dub results in nondisjunction of all chromosomes in meiosis I of males, although the levels are lower than in females. When homozygous, Dub is a conditional lethal allele and exhibits phenotypes consistent with cell death. ..
  2. Krider H, Levine B. Studies on the mutation abnormal oocyte and its interaction with the ribosomal DNA of Drosophila melanogaster. Genetics. 1975;81:501-13 pubmed
    Sandler (1970) suggested that mutation, abnormal oocyte (abo:2-38), may influence the function of the ribosomal RNA cistrons. We have examined the abo mutation and its interaction with the ribosomal DNA of Drosophila melanogaster...
  3. Sandler L. Studies on the genetic control of heterochromatin in Drosophila melanogaster. Elizabeth Goldschmidt Memorial Lecture. Isr J Med Sci. 1975;11:1124-34 pubmed
  4. Tomkiel J, Pimpinelli S, Sandler L. Rescue from the abnormal oocyte maternal-effect lethality by ABO heterochromatin in Drosophila melanogaster. Genetics. 1991;128:583-94 pubmed
    The euchromatic maternal-effect mutation abnormal oocyte (abo), of Drosophila melanogaster interacts with regions of heterochromatin known as ABO, which reside on the X, Y and second chromosomes...
  5. Malva C, Labella T, Manzi A, Salzano G, Lavorgna G, De Ponti L, et al. Maternal and Zygotic Interactions between the Abnormal Oocyte Mutation and the Scute Inversion in DROSOPHILA MELANOGASTER. Genetics. 1985;111:487-94 pubmed
    The authors have studied the interaction between the abnormal oocyte mutation and an inversion of the X chromosome, In( 1)sc(4), which has a proximal breakpoint in or near the heterochromatic region (ABO) that maternally interacts with ..
  6. Cohen S, Agmon N, Yacobi K, Mislovati M, Segal D. Evidence for rolling circle replication of tandem genes in Drosophila. Nucleic Acids Res. 2005;33:4519-26 pubmed
    ..RCIs are detected throughout the life cycle of Drosophila and in cultured fly cells. These structures are found regardless of the expression of the replicated gene or of its chromosomal copy number. ..
  7. Malva C, Graziani F, Cavaliere V, Manzi A, Tino A. Genetic and molecular analysis of maternal information in region 32 of Drosophila melanogaster. Mol Reprod Dev. 1991;28:307-17 pubmed
  8. Weiler K, Wakimoto B. Heterochromatin and gene expression in Drosophila. Annu Rev Genet. 1995;29:577-605 pubmed
  9. Cavaliere V, Graziani F, Andone S, Manzi A, Malva C. Complete reversion of the abo phenotype in D. melanogaster occurs only when the blood transposon is lost from region 32E. Mol Gen Genet. 1991;230:433-41 pubmed
    The abnormal oocyte phenotype is characterized by instability, as shown by the loss and reappearance of the abo maternal effect under specific genetic conditions...
  10. Gigliotti S, Callaini G, Andone S, Riparbelli M, Pernas Alonso R, Hoffmann G, et al. Nup154, a new Drosophila gene essential for male and female gametogenesis is related to the nup155 vertebrate nucleoporin gene. J Cell Biol. 1998;142:1195-207 pubmed
    ..Finally, the multiplicity of phenotypes observed in Nup154 mutant alleles suggests that this gene plays a crucial role in cell physiology. ..
  11. Gatti M, Pimpinelli S. Functional elements in Drosophila melanogaster heterochromatin. Annu Rev Genet. 1992;26:239-75 pubmed
  12. Lavorgna G, Malva C, Manzi A, Gigliotti S, Graziani F. The abnormal oocyte phenotype is correlated with the presence of blood transposon in Drosophila melanogaster. Genetics. 1989;123:485-94 pubmed
    The abnormal oocyte mutation (2;44) originates in the wild: it confers no visible phenotype on homozygous abo males or females, but homozygous abo females produce defective eggs and the probability of their developing into adults is much ..
  13. Tomkiel J, Fanti L, Berloco M, Spinelli L, Tamkun J, Wakimoto B, et al. Developmental genetical analysis and molecular cloning of the abnormal oocyte gene of Drosophila melanogaster. Genetics. 1995;140:615-27 pubmed
    Studies of the abnormal oocyte (abo) gene of Drosophila melanogaster have previously been limited to the analysis of a single mutant allele, abnormal oocyte1 (abo1)...
  14. Carpenter A, Sandler L. On recombination-defective meiotic mutants in Drosophila melanogaster. Genetics. 1974;76:453-75 pubmed
  15. Sullivan W, Pimpinelli S. The genetic factors altered in homozygous abo stocks of Drosophila melanogaster. Genetics. 1986;114:885-95 pubmed
    Females homozygous for the maternal-effect mutation abo (2-44.0) produce a large fraction of eggs which arrest during embryogenesis...
  16. Onfelt A, Magnusson J, Wikén M. Ageing before mating and quinacrine ameliorate the expression of abnormal oocyte (abo) in homozygous Drosophila melanogaster females. Hereditas. 1993;118:21-33 pubmed
    Several studies have shown that the characteristically skewed sex ratio among the progeny of abo homozygous females, derived from heterozygous stocks and mated to attached XY males, can be modified during homozygous stock-keeping...
  17. Palumbo G, Berloco M, Fanti L, Bozzetti M, Massari S, Caizzi R, et al. Interaction systems between heterochromatin and euchromatin in Drosophila melanogaster. Genetica. 1994;94:267-74 pubmed
    ..and euchromatic genetic elements are known: the Segregation Distortion, the crystal-Stellate and the abo-ABO systems...
  18. Pardue M, Hennig W. Heterochromatin: junk or collectors item?. Chromosoma. 1990;100:3-7 pubmed
  19. Mange A, Sandler L. A note on the maternal effect mutants daughterless and abnormal oocyte in Drosophila melanogaster. Genetics. 1973;73:73-86 pubmed
    ..Their properties were studied with respect to both da and the linked maternal effect mutant, "abnormal oocyte" (abo), with the following conclusions...