Abl

Summary

Gene Symbol: Abl
Description: Abl tyrosine kinase
Alias: 4674, ABL, Abl1, AblK, Ableson, Am ABL, C-abl, CG4032, D-Abl, D-abl, D-ash, DAbl, DROTKABL3, Dabl, Dash, Ddash/abl, Dmel\CG4032, Dsrc7, abl, abl1, c-abl, cAbl, dAbl, l(3)04674, l(3)73Ba, l(3)c-abl, Abl tyrosine kinase, Abl oncogene, Abl-PA, Abl-PB, Abl-PC, Abl-PD, Abl-PE, Abl-PF, Abl-PG, Abl-PH, Abl-PI, Abl-PJ, CG4032-PA, CG4032-PB, CG4032-PC, CG4032-PD, CG4032-PE, CG4032-PF, CG4032-PG, CG4032-PH, CG4032-PI, CG4032-PJ, D-abelson, abelson, abelson kinase, abelson tyrosine kinase, abl kinase
Species: fruit fly

Top Publications

  1. Baum B, Perrimon N. Spatial control of the actin cytoskeleton in Drosophila epithelial cells. Nat Cell Biol. 2001;3:883-90 pubmed
    ..The Abl tyrosine kinase also collaborates in this process...
  2. Wills Z, Bateman J, Korey C, Comer A, Van Vactor D. The tyrosine kinase Abl and its substrate enabled collaborate with the receptor phosphatase Dlar to control motor axon guidance. Neuron. 1999;22:301-12 pubmed
    ..We now demonstrate that the Drosophila Abl tyrosine kinase functions in the intersegmental nerve b (ISNb) motor choice point pathway as an antagonist of the RPTP Dlar...
  3. Kunes S. Stop or go in the target zone. Neuron. 1999;22:639-40 pubmed
  4. Van Etten R. Cycling, stressed-out and nervous: cellular functions of c-Abl. Trends Cell Biol. 1999;9:179-86 pubmed
    ..biochemical and genetic approaches have converged to shed new light on the mechanism of regulation of c-Abl kinase activity and the multiple roles of c-Abl in cellular physiology...
  5. Liebl E, Forsthoefel D, Franco L, Sample S, Hess J, Cowger J, et al. Dosage-sensitive, reciprocal genetic interactions between the Abl tyrosine kinase and the putative GEF trio reveal trio's role in axon pathfinding. Neuron. 2000;26:107-18 pubmed
    The Abelson tyrosine kinase (Abl) is integrated into signal transduction networks regulating axon outgrowth. We have identified the Drosophila trio gene through a mutation that exacerbates the Abl mutant phenotype...
  6. Crowner D, Le Gall M, Gates M, Giniger E. Notch steers Drosophila ISNb motor axons by regulating the Abl signaling pathway. Curr Biol. 2003;13:967-72 pubmed
    ..Notch interacts genetically with multiple components of a signal transduction pathway that includes the Abl tyrosine kinase and its affiliated accessory proteins...
  7. Gertler F, Doctor J, Hoffmann F. Genetic suppression of mutations in the Drosophila abl proto-oncogene homolog. Science. 1990;248:857-60 pubmed
    The Drosophila abelson (abl) gene encodes the homolog of the mammalian c-abl cytoplasmic tyrosine kinase and is an essential gene for the development of viable adult flies...
  8. Comer A, Ahern Djamali S, Juang J, Jackson P, Hoffmann F. Phosphorylation of Enabled by the Drosophila Abelson tyrosine kinase regulates the in vivo function and protein-protein interactions of Enabled. Mol Cell Biol. 1998;18:152-60 pubmed
    ..Mutations in Drosophila ena were discovered as dominant genetic suppressors of mutations in the Abelson tyrosine kinase (Abl), suggesting that Ena and Abl function in the same pathway or process...
  9. Wills Z, Marr L, Zinn K, Goodman C, Van Vactor D. Profilin and the Abl tyrosine kinase are required for motor axon outgrowth in the Drosophila embryo. Neuron. 1999;22:291-9 pubmed
    ..Profilin associates with members of the Enabled family of proteins, suggesting that Profilin might link Abl function to the cytoskeleton...

More Information

Publications71

  1. Singh J, Yanfeng W, Grumolato L, Aaronson S, Mlodzik M. Abelson family kinases regulate Frizzled planar cell polarity signaling via Dsh phosphorylation. Genes Dev. 2010;24:2157-68 pubmed publisher
    b>Abelson (Abl) family tyrosine kinases have been implicated in cell morphogenesis, adhesion, motility, and oncogenesis...
  2. Kuzina I, Song J, Giniger E. How Notch establishes longitudinal axon connections between successive segments of the Drosophila CNS. Development. 2011;138:1839-49 pubmed publisher
    ..non-canonical signaling pathway in the pioneer growth cones themselves, promoting their motility by suppressing Abl signaling to stimulate filopodial growth while presumably reducing substratum adhesion...
  3. Andrews G, Tanglao S, Farmer W, Morin S, Brotman S, Berberoglu M, et al. Dscam guides embryonic axons by Netrin-dependent and -independent functions. Development. 2008;135:3839-48 pubmed publisher
    ..These functions in axon guidance have implications for the pathogenesis of Down Syndrome. ..
  4. Grevengoed E, Loureiro J, Jesse T, Peifer M. Abelson kinase regulates epithelial morphogenesis in Drosophila. J Cell Biol. 2001;155:1185-98 pubmed
    Activation of the nonreceptor tyrosine kinase Abelson (Abl) contributes to the development of leukemia, but the complex roles of Abl in normal development are not fully understood...
  5. Lowery L, Lee H, Lu C, Murphy R, Obar R, Zhai B, et al. Parallel genetic and proteomic screens identify Msps as a CLASP-Abl pathway interactor in Drosophila. Genetics. 2010;185:1311-25 pubmed publisher
    ..Here, we report that Msps is a strong modifier of CLASP and Abl in the retina...
  6. Wills Z, Emerson M, Rusch J, Bikoff J, Baum B, Perrimon N, et al. A Drosophila homolog of cyclase-associated proteins collaborates with the Abl tyrosine kinase to control midline axon pathfinding. Neuron. 2002;36:611-22 pubmed
    ..a homolog of the adenylyl cyclase-associated protein that binds and regulates actin in yeast, associates with Abl in Drosophila cells, suggesting a functional relationship in vivo...
  7. Song J, Giniger E, Desai C. The receptor protein tyrosine phosphatase PTP69D antagonizes Abl tyrosine kinase to guide axons in Drosophila. Mech Dev. 2008;125:247-56 pubmed
    During Drosophila embryogenesis, both the cytoplasmic Abelson tyrosine kinase (Abl) and the membrane bound tyrosine phosphatase PTP69D are required for proper guidance of CNS and motor axons...
  8. Li W, Li Y, Gao F. Abelson, enabled, and p120 catenin exert distinct effects on dendritic morphogenesis in Drosophila. Dev Dyn. 2005;234:512-22 pubmed
    ..both loss-of-function and gain-of-function analyses in vivo, we show here that the nonreceptor tyrosine kinase Abelson (Abl), an important regulator of cytoskeleton dynamics, inhibits dendritic branching of dendritic arborization (..
  9. Giniger E. A role for Abl in Notch signaling. Neuron. 1998;20:667-81 pubmed
    b>Abl is an axonal tyrosine kinase that has yet to be clearly linked to a receptor; Notch is a receptor for which the signaling pathway remains incompletely understood...
  10. Huang C, Lin T, Pan R, Juang J. The involvement of Abl and PTP61F in the regulation of Abi protein localization and stability and lamella formation in Drosophila S2 cells. J Biol Chem. 2007;282:32442-52 pubmed
    ..Abi (Abl interactor protein) functions as a substrate adaptor protein for Abl and a core member of the WAVE complex, ..
  11. Lin T, Huang C, Kao H, Liou G, Yeh S, Cheng C, et al. Abi plays an opposing role to Abl in Drosophila axonogenesis and synaptogenesis. Development. 2009;136:3099-107 pubmed publisher
    b>Abl tyrosine kinase (Abl) regulates axon guidance by modulating actin dynamics...
  12. Hsouna A, Kim Y, VanBerkum M. Abelson tyrosine kinase is required to transduce midline repulsive cues. J Neurobiol. 2003;57:15-30 pubmed
    ..The cytoplasmic Abelson tyrosine kinase participate in several signaling pathways that orchestrate both growth cone advance and steering in ..
  13. Stevens T, Rogers E, Koontz L, Fox D, Homem C, Nowotarski S, et al. Using Bcr-Abl to examine mechanisms by which abl kinase regulates morphogenesis in Drosophila. Mol Biol Cell. 2008;19:378-93 pubmed
    ..Here, we explore the role of regulation of Abl kinase activity during development...
  14. Dorsten J, Kolodziej P, VanBerkum M. Frazzled regulation of myosin II activity in the Drosophila embryonic CNS. Dev Biol. 2007;308:120-32 pubmed
    ..b>Abelson tyrosine kinase may also help regulate myosin II activity...
  15. Hu S, Sonnenfeld M, Stahl S, Crews S. Midline Fasciclin: a Drosophila Fasciclin-I-related membrane protein localized to the CNS midline cells and trachea. J Neurobiol. 1998;35:77-93 pubmed
    ..However, embryos mutant for both midline fasciclin and the abelson nonreceptor tyrosine kinase, show more severe defects in axonogenesis that resemble fasciclin I abelson double ..
  16. Loureiro J, Peifer M. Roles of Armadillo, a Drosophila catenin, during central nervous system development. Curr Biol. 1998;8:622-32 pubmed
    ..Mutations in the gene encoding the Drosophila tyrosine kinase Abelson substantially enhanced the severity of the CNS phenotype of armadillo mutations, consistent with these proteins ..
  17. Fogerty F, Juang J, Petersen J, Clark M, Hoffmann F, Mosher D. Dominant effects of the bcr-abl oncogene on Drosophila morphogenesis. Oncogene. 1999;18:219-32 pubmed
    ..Enabled, previously identified as a suppressor of the abl mutant phenotype and substrate for Drosophila Abl kinase, had markedly increased phosphotyrosine levels in Bcr-Abl expressing Drosophila, indicating that it is a ..
  18. Woodring P, Litwack E, O Leary D, Lucero G, Wang J, Hunter T. Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension. J Cell Biol. 2002;156:879-92 pubmed
    ..Purified c-Abl tyrosine kinase is inhibited by F-actin, and this inhibition can be relieved through mutation of its FABD...
  19. Liebl E, Rowe R, Forsthoefel D, Stammler A, Schmidt E, Turski M, et al. Interactions between the secreted protein Amalgam, its transmembrane receptor Neurotactin and the Abelson tyrosine kinase affect axon pathfinding. Development. 2003;130:3217-26 pubmed
    Two novel dosage-sensitive modifiers of the Abelson tyrosine kinase (Abl) mutant phenotype have been identified...
  20. Forsthoefel D, Liebl E, Kolodziej P, Seeger M. The Abelson tyrosine kinase, the Trio GEF and Enabled interact with the Netrin receptor Frazzled in Drosophila. Development. 2005;132:1983-94 pubmed
    The attractive Netrin receptor Frazzled (Fra), and the signaling molecules Abelson tyrosine kinase (Abl), the guanine nucleotide-exchange factor Trio, and the Abl substrate Enabled (Ena), all regulate axon pathfinding at the Drosophila ..
  21. Fox D, Peifer M. Abelson kinase (Abl) and RhoGEF2 regulate actin organization during cell constriction in Drosophila. Development. 2007;134:567-78 pubmed
    ..Here, we report the identification of Abelson kinase (Abl) as a novel ventral furrow regulator...
  22. Dorsten J, Varughese B, Karmo S, Seeger M, VanBerkum M. In the absence of frazzled over-expression of Abelson tyrosine kinase disrupts commissure formation and causes axons to leave the embryonic CNS. PLoS ONE. 2010;5:e9822 pubmed publisher
    ..nerve cord, the formation of commissures require both the chemoattractive Netrin receptor Frazzled (Fra) and the Abelson (Abl) cytoplasmic tyrosine kinase...
  23. Henkemeyer M, West S, Gertler F, Hoffmann F. A novel tyrosine kinase-independent function of Drosophila abl correlates with proper subcellular localization. Cell. 1990;63:949-60 pubmed
  24. Gates J, Nowotarski S, Yin H, Mahaffey J, Bridges T, Herrera C, et al. Enabled and Capping protein play important roles in shaping cell behavior during Drosophila oogenesis. Dev Biol. 2009;333:90-107 pubmed publisher
    ..Enabled appears to be negatively regulated during oogenesis by Abelson kinase. We also explored the function of Capping protein...
  25. Henkemeyer M, Gertler F, Goodman W, Hoffmann F. The Drosophila Abelson proto-oncogene homolog: identification of mutant alleles that have pleiotropic effects late in development. Cell. 1987;51:821-8 pubmed
    The Abelson gene in Drosophila (abl) consists of ten exons extending over 26 kb of genomic DNA...
  26. Elkins T, Zinn K, McAllister L, Hoffmann F, Goodman C. Genetic analysis of a Drosophila neural cell adhesion molecule: interaction of fasciclin I and Abelson tyrosine kinase mutations. Cell. 1990;60:565-75 pubmed
    ..The Drosophila Abelson (abl) proto-oncogene homolog encodes a cytoplasmic tyrosine kinase that is expressed during embryogenesis ..
  27. Rørth P, Szabo K, Bailey A, Laverty T, Rehm J, Rubin G, et al. Systematic gain-of-function genetics in Drosophila. Development. 1998;125:1049-57 pubmed
    ..These studies demonstrate the ability of the modular misexpression system to identify developmentally important genes and suggest that it will be generally useful for genetic interaction screens. ..
  28. Gertler F, Bennett R, Clark M, Hoffmann F. Drosophila abl tyrosine kinase in embryonic CNS axons: a role in axonogenesis is revealed through dosage-sensitive interactions with disabled. Cell. 1989;58:103-13 pubmed
    During Drosophila embryogenesis, the Abelson tyrosine kinase (abl) is localized in the axons of the central nervous system (CNS)...
  29. Al Anzi B, Wyman R. The Drosophila immunoglobulin gene turtle encodes guidance molecules involved in axon pathfinding. Neural Dev. 2009;4:31 pubmed publisher
    ..The latter two capabilities are required by migrating axons to explore densely packed targets. ..
  30. Song J, Kannan R, Merdes G, Singh J, Mlodzik M, Giniger E. Disabled is a bona fide component of the Abl signaling network. Development. 2010;137:3719-27 pubmed publisher
    b>Abl is an essential regulator of cell migration and morphogenesis in both vertebrates and invertebrates...
  31. Leyssen M, Ayaz D, Hébert S, Reeve S, De Strooper B, Hassan B. Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain. EMBO J. 2005;24:2944-55 pubmed
    ..arborization, which depends critically on a conserved motif in the C-terminus and requires interaction with the Abelson (Abl) tyrosine kinase...
  32. Soldano A, Okray Z, Janovská P, Tmejová K, Reynaud E, Claeys A, et al. The Drosophila homologue of the amyloid precursor protein is a conserved modulator of Wnt PCP signaling. PLoS Biol. 2013;11:e1001562 pubmed publisher
    ..PCP pathway activation by modulating the phosphorylation of the Wnt adaptor protein Dishevelled (Dsh) by Abelson kinase (Abl)...
  33. Grevengoed E, Fox D, Gates J, Peifer M. Balancing different types of actin polymerization at distinct sites: roles for Abelson kinase and Enabled. J Cell Biol. 2003;163:1267-79 pubmed
    The proto-oncogenic kinase Abelson (Abl) regulates actin in response to cell signaling. Drosophila Abl is required in the nervous system, and also in epithelial cells, where it regulates adherens junction stability and actin organization...
  34. Ahern Djamali S, Bachmann C, Hua P, Reddy S, Kastenmeier A, Walter U, et al. Identification of profilin and src homology 3 domains as binding partners for Drosophila enabled. Proc Natl Acad Sci U S A. 1999;96:4977-82 pubmed
    Drosophila Enabled (Ena) was first identified as a genetic suppressor of mutations in the Abelson tyrosine kinase and subsequently was shown to be a member of the Ena/vasodilator-stimulated phosphoprotein family of proteins...
  35. Gertler F, Comer A, Juang J, Ahern S, Clark M, Liebl E, et al. enabled, a dosage-sensitive suppressor of mutations in the Drosophila Abl tyrosine kinase, encodes an Abl substrate with SH3 domain-binding properties. Genes Dev. 1995;9:521-33 pubmed
    ..ena protein contains proline-rich motifs and binds to Abl and Src SH3 domains, ena is also a substrate for the Abl kinase; tyrosine phosphorylation of ena is increased when it is coexpressed in cells with human or Drosophila Abl and ..
  36. Bashaw G, Kidd T, Murray D, Pawson T, Goodman C. Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor. Cell. 2000;101:703-15 pubmed
    ..Here, we present genetic and biochemical evidence that the Abelson (Abl) tyrosine kinase and its substrate Enabled (Ena) play direct and opposing roles in Robo signal transduction...
  37. Chang Y, Lin S, Liang S, Pan K, Chou C, Chen C, et al. Tyrosine phosphoproteomics and identification of substrates of protein tyrosine phosphatase dPTP61F in Drosophila S2 cells by mass spectrometry-based substrate trapping strategy. J Proteome Res. 2008;7:1055-66 pubmed publisher
    ..were confirmed as tyrosine phosphorylated proteins, including a receptor PTK PDGF/VEGF receptor, a cytosolic PTK Abl, and several components of SCAR/WAVE complex, which may work in coordination to control actin dynamics...
  38. Bennett R, Hoffmann F. Increased levels of the Drosophila Abelson tyrosine kinase in nerves and muscles: subcellular localization and mutant phenotypes imply a role in cell-cell interactions. Development. 1992;116:953-66 pubmed
    Mutations in the Drosophila Abelson tyrosine kinase have pleiotropic effects late in development that lead to pupal lethality or adults with a reduced life span, reduced fecundity and rough eyes...
  39. Gates J, Mahaffey J, Rogers S, Emerson M, Rogers E, Sottile S, et al. Enabled plays key roles in embryonic epithelial morphogenesis in Drosophila. Development. 2007;134:2027-39 pubmed
    ..We also explored filopodial regulation in cultured Drosophila cells and embryos. These data provide new insights into developmental and mechanistic roles of this important actin regulator. ..
  40. Tamada M, Farrell D, Zallen J. Abl regulates planar polarized junctional dynamics through ?-catenin tyrosine phosphorylation. Dev Cell. 2012;22:309-19 pubmed publisher
    ..The Abl tyrosine kinase is concentrated at specific planar junctions and is necessary for polarized ?-catenin localization and ..
  41. Henkemeyer M, Bennett R, Gertler F, Hoffmann F. DNA sequence, structure, and tyrosine kinase activity of the Drosophila melanogaster Abelson proto-oncogene homolog. Mol Cell Biol. 1988;8:843-53 pubmed
    We report our molecular characterization of the Drosophila melanogaster Abelson gene (abl), a gene in which recessive loss-of-function mutations result in lethality at the pupal stage of development...
  42. Hill K, Bedian V, Juang J, Hoffmann F. Genetic interactions between the Drosophila Abelson (Abl) tyrosine kinase and failed axon connections (fax), a novel protein in axon bundles. Genetics. 1995;141:595-606 pubmed
    Mutations in the failed axon connections (fax) gene have been identified as dominant genetic enhancers of the Abl mutant phenotype. These mutations in fax all result in defective or absent protein product...
  43. Wang J. Abl tyrosine kinase in signal transduction and cell-cycle regulation. Curr Opin Genet Dev. 1993;3:35-43 pubmed
    Although the biological function of the c-Abl tyrosine kinase remains unsolved, potentially productive avenues towards the elucidation of that function have been identified by recent progress...
  44. Ku H, Wu C, Rabinow L, Chen G, Meng T. Organization of F-actin via concerted regulation of Kette by PTP61F and dAbl. Mol Cell Biol. 2009;29:3623-32 pubmed publisher
    ..of actin polymerization, as a substrate for Drosophila protein tyrosine phosphatase PTP61F, as well as for dAbl tyrosine kinase. We further show that dAbl is a direct substrate for PTP61F...
  45. Singh J, Aaronson S, Mlodzik M. Drosophila Abelson kinase mediates cell invasion and proliferation through two distinct MAPK pathways. Oncogene. 2010;29:4033-45 pubmed publisher
    The Abelson (Abl) family of non-receptor tyrosine kinases has an important role in cell morphogenesis, motility, and proliferation...
  46. Jhaveri D, Saharan S, Sen A, Rodrigues V. Positioning sensory terminals in the olfactory lobe of Drosophila by Robo signaling. Development. 2004;131:1903-12 pubmed
    ..The location of sensory arbors at distinct positions within the lobe allows short-range interactions with projection neurons leading to formation of the glomeruli. ..
  47. Ahern Djamali S, Comer A, Bachmann C, Kastenmeier A, Reddy S, Beckerle M, et al. Mutations in Drosophila enabled and rescue by human vasodilator-stimulated phosphoprotein (VASP) indicate important functional roles for Ena/VASP homology domain 1 (EVH1) and EVH2 domains. Mol Biol Cell. 1998;9:2157-71 pubmed
    Drosophila Enabled (Ena) was initially identified as a dominant genetic suppressor of mutations in the Abelson tyrosine kinase and, more recently, as a member of the Ena/human vasodilator-stimulated phosphoprotein (VASP) family of ..
  48. Gertler F, Hill K, Clark M, Hoffmann F. Dosage-sensitive modifiers of Drosophila abl tyrosine kinase function: prospero, a regulator of axonal outgrowth, and disabled, a novel tyrosine kinase substrate. Genes Dev. 1993;7:441-53 pubmed
    In the absence of the Drosophila abl protein-tyrosine kinase (PTK), loss-of-function mutations in either disabled or prospero have dominant phenotypic effects on embryonic development...
  49. Shivalkar M, Giniger E. Control of dendritic morphogenesis by Trio in Drosophila melanogaster. PLoS ONE. 2012;7:e33737 pubmed publisher
    b>Abl tyrosine kinase and its effectors among the Rho family of GTPases each act to control dendritic morphogenesis in Drosophila...
  50. O Donnell M, Bashaw G. Distinct functional domains of the Abelson tyrosine kinase control axon guidance responses to Netrin and Slit to regulate the assembly of neural circuits. Development. 2013;140:2724-33 pubmed publisher
    ..These receptors must link to intracellular signaling cascades to direct axon pathfinding decisions. The Abelson tyrosine kinase (Abl) plays a crucial role in multiple Drosophila axon guidance pathways during development, though the ..
  51. Tchankouo Nguetcheu S, Udinotti M, Durand M, Meng T, Taouis M, Rabinow L. Negative regulation of MAP kinase signaling in Drosophila by Ptp61F/PTP1B. Mol Genet Genomics. 2014;289:795-806 pubmed publisher
    ..Our results validate recent data showing that the activity of insulin and Abl kinase signaling is increased in Ptp61F mutants and RNA interference lines...
  52. Schug M, Mackay T, Aquadro C. Low mutation rates of microsatellite loci in Drosophila melanogaster. Nat Genet. 1997;15:99-102 pubmed
    ..3 x 10(-6), a mutation rate considerably lower than reported for various mammals. We propose that the comparatively low mutation rate is primarily a function of short microsatellite repeat lengths in the D. melanogaster genome. ..
  53. Belote J, Hoffmann F, McKeown M, Chorsky R, Baker B. Cytogenetic analysis of chromosome region 73AD of Drosophila melanogaster. Genetics. 1990;125:783-93 pubmed
    ..One of the newly identified lethal complementation groups corresponds to the molecularly identified abl locus, and another gene is defined by mutant alleles that exhibit an interaction with the abl mutants...
  54. Simon M, Kornberg T, Bishop J. Three loci related to the src oncogene and tyrosine-specific protein kinase activity in Drosophila. Nature. 1983;302:837-9 pubmed
    ..It should now be possible to identify the precise locus that encodes a src-specific protein kinase in Drosophila, and to explore the role of c-src in the growth and development of D. melanogaster. ..
  55. Oliva C, Sierralta J. Regulation of axonal development by the nuclear protein hindsight (pebbled) in the Drosophila visual system. Dev Biol. 2010;344:911-21 pubmed publisher
    ..Based on genetic interaction experiments we show that part of HNT function in axonal development is exerted through the regulation of genes involved in the dynamics of the actin cytoskeleton. ..
  56. Bothwell M, Giniger E. Alzheimer's disease: neurodevelopment converges with neurodegeneration. Cell. 2000;102:271-3 pubmed
  57. Quan F, Wolfgang W, Forte M. A Drosophila G-protein alpha subunit, Gf alpha, expressed in a spatially and temporally restricted pattern during Drosophila development. Proc Natl Acad Sci U S A. 1993;90:4236-40 pubmed
    ..The Gf alpha gene has been characterized and mapped to position 73B of the Drosophila genome. ..
  58. Fu C, Whitfield C. Genes associated with honey bee behavioral maturation affect clock-dependent and -independent aspects of daily rhythmic activity in fruit flies. PLoS ONE. 2012;7:e29157 pubmed publisher
    ..CAH1 affected overall inactivity. The remaining gene, abl, affected peak activity levels but was not clearly time-of-day-specific...
  59. Lapidus D, Duka V, Stonkus V, Czaplewski C, Liwo A, Ventura S, et al. Multiple ?-sheet molecular dynamics of amyloid formation from two ABl-SH3 domain peptides. Biopolymers. 2012;98:557-66 pubmed publisher
    ..of six 10-strand antiparallel ?-sheets for two peptides corresponding to the diverging turn of two homologous Abl-SH3 domains...
  60. Wemmer T, Klämbt C. A genetic analysis of the Drosophila closely linked interacting genes bulge, argos and soba. Genetics. 1995;140:629-41 pubmed
    ..In addition, we have identified one allele of a new gene, clown, which like soba suppresses the eye phenotypes associated with hs-argos and bulgeDominant. clown maps on chromosome 3 at the cytological position 68CD. ..
  61. Lin H, Lin T, Juang J. Abl deregulates Cdk5 kinase activity and subcellular localization in Drosophila neurodegeneration. Cell Death Differ. 2007;14:607-15 pubmed
    ..We found that beta-amyloid (Abeta42) initiated Abl kinase activity and that blockade of Abl kinase rescued both Drosophila and mammalian neuronal cells from cell death...
  62. Broadie K, Sink H, Van Vactor D, Fambrough D, Whitington P, Bate M, et al. From growth cone to synapse: the life history of the RP3 motor neuron. Dev Suppl. 1993;:227-38 pubmed
    ..Genetic analysis has revealed mutations in a number of different genes which affect specific aspects of RP3 development from axon outgrowth to synapse formation. ..