5-HT2B

Summary

Gene Symbol: 5-HT2B
Description: 5-hydroxytryptamine (serotonin) receptor 2B
Alias: 5-HT[[2B]], CG42796, CG7994, CG8007, Dmel\CG42796, Dmel_CG7994, Dmel_CG8007, anon-WO0170980.94, anon-WO0170980.95, anon-WO0170980.97, anon-WO0170980.98, d5-HT2B, 5-hydroxytryptamine (serotonin) receptor 2B, 5-HT2B-PD, 5-HT2B-PE, 5-HT2B-PF, CG42796-PD, CG42796-PE, CG42796-PF
Species: fruit fly
Products:     5-HT2B

Top Publications

  1. Stotz S, Clapham D. Anion-sensitive fluorophore identifies the Drosophila swell-activated chloride channel in a genome-wide RNA interference screen. PLoS ONE. 2012;7:e46865 pubmed publisher
    ..dBest1 is an anion channel clearly responsive to swell; this activation depends upon its N-terminus. ..
  2. Gasque G, Conway S, Huang J, Rao Y, Vosshall L. Small molecule drug screening in Drosophila identifies the 5HT2A receptor as a feeding modulation target. Sci Rep. 2013;3:srep02120 pubmed publisher
    ..These results highlight the conservation of molecular mechanisms controlling appetite and provide a method for unbiased whole-organism drug screens to identify novel drugs and molecular pathways modulating food intake. ..
  3. Gnerer J, Venken K, Dierick H. Gene-specific cell labeling using MiMIC transposons. Nucleic Acids Res. 2015;43:e56 pubmed publisher
    ..We show the efficacy and broad applicability of these new tools by dissecting the cellular expression patterns of the Drosophila serotonin receptor gene family. ..
  4. Mohammad F, Aryal S, Ho J, Stewart J, Norman N, Tan T, et al. Ancient Anxiety Pathways Influence Drosophila Defense Behaviors. Curr Biol. 2016;26:981-6 pubmed publisher
    ..The presence of conserved neurogenetic pathways in the insect brain identifies Drosophila as an attractive genetic model for the study of anxiety and anxiety-related disorders, complementing existing rodent systems. ..
  5. Majeed Z, Stacy A, Cooper R. Pharmacological and genetic identification of serotonin receptor subtypes on Drosophila larval heart and aorta. J Comp Physiol B. 2014;184:205-19 pubmed publisher
    ..Given these results, we conclude that these 5-HT2 receptor subtypes are involved in the action of 5-HT on the heart rate in the larval stage. ..
  6. Qi Y, Huang J, Li M, Wu Y, Xia R, Ye G. Serotonin modulates insect hemocyte phagocytosis via two different serotonin receptors. elife. 2016;5: pubmed publisher