Gene Symbol: 5-HT2A
Description: 5-hydroxytryptamine (serotonin) receptor 2A
Alias: 5-HT2, 5-HT2Dro, 5-HT[2]Dro, 5-HT[[2Dro]], 5-HT[[2]], 5-HT[[2]]Dro, 5-ht2Dro, 5HT-R82A, 5HT-dro[[1]], 5HT2, 5HT2-Dro, 5HT2Dro, 5HT[[2Dro]], CG1056, Dm5HT2, Dmel\CG1056, d5-HT2, d5-HT2A, l(3)82CDb, 5-hydroxytryptamine (serotonin) receptor 2A, 5-HT2A-PA, 5-HT2A-PB, 5-HT2A-PD, 5-HT2A-PF, 5-HT2A-PH, 5-HT[[2]]Dro receptor, CG1056-PA, CG1056-PB, CG1056-PD, CG1056-PF, CG1056-PH, lethal (3) 82CDb, serotonin receptor 2
Species: fruit fly
Products:     5-HT2A

Top Publications

  1. Rodriguez Moncalvo V, Campos A. Role of serotonergic neurons in the Drosophila larval response to light. BMC Neurosci. 2009;10:66 pubmed publisher
    ..These findings provide new insights into the function of 5-HT neurons in Drosophila larval behavior as well as into the mechanisms underlying regulation of larval response to light. ..
  2. Colas J, Launay J, Maroteaux L. Maternal and zygotic control of serotonin biosynthesis are both necessary for Drosophila germband extension. Mech Dev. 1999;87:67-76 pubmed
    ..Together, these findings provide additional support for the notion that serotonin, acting through the 5-HT(2Dro) receptor, is necessary for proper gastrulation. ..
  3. Colas J, Launay J, Kellermann O, Rosay P, Maroteaux L. Drosophila 5-HT2 serotonin receptor: coexpression with fushi-tarazu during segmentation. Proc Natl Acad Sci U S A. 1995;92:5441-5 pubmed
    ..Simultaneously with this pair-rule expression, the complete machinery of serotonin synthesis is present and leads to a peak of ligand concomitant with a peak of 5-HT2-specific receptor sites in blastoderm embryos. ..
  4. Yuan Q, Joiner W, Sehgal A. A sleep-promoting role for the Drosophila serotonin receptor 1A. Curr Biol. 2006;16:1051-62 pubmed
    ..These data show that serotonin promotes baseline sleep in Drosophila. They also link the regulation of sleep behavior by serotonin to a specific receptor in a distinct region of the fly brain. ..
  5. Hen R. Structural and functional conservation of serotonin receptors throughout evolution. EXS. 1993;63:266-78 pubmed
    ..A widespread distribution of 5-HT receptors might explain how serotonin can modulate the multiple neuronal circuits which underlie complex behaviors. ..
  6. Colas J, Launay J, Vonesch J, Hickel P, Maroteaux L. Serotonin synchronises convergent extension of ectoderm with morphogenetic gastrulation movements in Drosophila. Mech Dev. 1999;87:77-91 pubmed
  7. Tierney A. Structure and function of invertebrate 5-HT receptors: a review. Comp Biochem Physiol A Mol Integr Physiol. 2001;128:791-804 pubmed
    ..This review summarizes information on the pharmacological and transductional properties of cloned invertebrate 5-HT receptors, and considers recent studies of endogenous receptors in the light of this new data. ..
  8. Johnson O, Becnel J, Nichols C. Serotonin 5-HT(2) and 5-HT(1A)-like receptors differentially modulate aggressive behaviors in Drosophila melanogaster. Neuroscience. 2009;158:1292-300 pubmed publisher
  9. Dierick H, Greenspan R. Serotonin and neuropeptide F have opposite modulatory effects on fly aggression. Nat Genet. 2007;39:678-82 pubmed
    ..Moreover, this neuropeptide F effect seems to be independent of 5-HT. The implication of these two modulatory systems in fly and mouse aggression suggest a marked degree of conservation and a deep molecular root for this behavior. ..

More Information


  1. Nichols C. 5-HT2 receptors in Drosophila are expressed in the brain and modulate aspects of circadian behaviors. Dev Neurobiol. 2007;67:752-63 pubmed
  2. Blenau W, Baumann A. Molecular and pharmacological properties of insect biogenic amine receptors: lessons from Drosophila melanogaster and Apis mellifera. Arch Insect Biochem Physiol. 2001;48:13-38 pubmed
    ..In this review, the present knowledge on the biochemical, molecular, and pharmacological properties of biogenic amine receptors from Drosophila and Apis will be summarized. Arch...
  3. Silva B, Goles N, Varas R, Campusano J. Serotonin receptors expressed in Drosophila mushroom bodies differentially modulate larval locomotion. PLoS ONE. 2014;9:e89641 pubmed publisher
    ..Thus, our data suggest that CNS 5HT systems are involved in motor control, and that 5HT receptors expressed in MB differentially modulate motor programs in fly larvae. ..
  4. Miller W, Nagel A, Bachmann J, Bachmann L. Evolutionary dynamics of the SGM transposon family in the Drosophila obscura species group. Mol Biol Evol. 2000;17:1597-609 pubmed publisher
  5. Mohammad F, Aryal S, Ho J, Stewart J, Norman N, Tan T, et al. Ancient Anxiety Pathways Influence Drosophila Defense Behaviors. Curr Biol. 2016;26:981-6 pubmed publisher
    ..The presence of conserved neurogenetic pathways in the insect brain identifies Drosophila as an attractive genetic model for the study of anxiety and anxiety-related disorders, complementing existing rodent systems. ..
  6. Johnson O, Becnel J, Nichols C. Serotonin receptor activity is necessary for olfactory learning and memory in Drosophila melanogaster. Neuroscience. 2011;192:372-81 pubmed publisher
  7. Majeed Z, Stacy A, Cooper R. Pharmacological and genetic identification of serotonin receptor subtypes on Drosophila larval heart and aorta. J Comp Physiol B. 2014;184:205-19 pubmed publisher
    ..Given these results, we conclude that these 5-HT2 receptor subtypes are involved in the action of 5-HT on the heart rate in the larval stage. ..
  8. Shen W, Kwon Y, Adegbola A, Luo J, Chess A, Montell C. Function of rhodopsin in temperature discrimination in Drosophila. Science. 2011;331:1333-6 pubmed publisher
    ..We propose that rhodopsins represent a class of evolutionarily conserved GPCRs that are required for initiating thermosensory signaling cascades. ..
  9. Majeed Z, Abdeljaber E, Soveland R, Cornwell K, Bankemper A, Koch F, et al. Modulatory Action by the Serotonergic System: Behavior and Neurophysiology in Drosophila melanogaster. Neural Plast. 2016;2016:7291438 pubmed publisher
    ..5-HT2 receptor activation mediates a modulatory role in a sensory-motor circuit, and the activation of 5-HT neurons can suppress the neural circuit activity, while fluoxetine can significantly decrease the sensory-motor activity. ..
  10. Curran K, Chalasani S. Serotonin circuits and anxiety: what can invertebrates teach us?. Invert Neurosci. 2012;12:81-92 pubmed publisher
    ..These model systems possess well-defined neuroanatomies and robust serotonin-mediated behavior and should reveal insights into how serotonin can modulate human cognitive functions...
  11. Nikoh N, Duty A, Gibson G. Effects of population structure and sex on association between serotonin receptors and Drosophila heart rate. Genetics. 2004;168:1963-74 pubmed
  12. Pebusque M, Coulier F, Birnbaum D, Pontarotti P. Ancient large-scale genome duplications: phylogenetic and linkage analyses shed light on chordate genome evolution. Mol Biol Evol. 1998;15:1145-59 pubmed
    ..Linkage of some of these genes can be found in the Drosophila melanogaster and Caenorhabditis elegans genomes, suggesting that they were linked in the triploblast Metazoa ancestor. ..
  13. Gasque G, Conway S, Huang J, Rao Y, Vosshall L. Small molecule drug screening in Drosophila identifies the 5HT2A receptor as a feeding modulation target. Sci Rep. 2013;3:srep02120 pubmed publisher
    ..These results highlight the conservation of molecular mechanisms controlling appetite and provide a method for unbiased whole-organism drug screens to identify novel drugs and molecular pathways modulating food intake. ..
  14. Tomson K, Vaht M, Laas K, Veidebaum T, Harro J. Effect of a human serotonin 5-HT2A receptor gene polymorphism on impulsivity: Dependence on cholesterol levels. J Affect Disord. 2016;206:23-30 pubmed publisher
    ..This suggests that future studies on impulsivity need to consider the interaction of serotonergic measures with the whole range of cholesterol levels. ..
  15. Zwarts L, Versteven M, Callaerts P. Genetics and neurobiology of aggression in Drosophila. Fly (Austin). 2012;6:35-48 pubmed publisher
    ..The state of the art on aggression in Drosophila and the many opportunities provided by this model organism to unravel the genetic and neurobiological basis of aggression are reviewed. ..
  16. Xu H, Guan J, Yi H, Yin S. A systematic review and meta-analysis of the association between serotonergic gene polymorphisms and obstructive sleep apnea syndrome. PLoS ONE. 2014;9:e86460 pubmed publisher
    ..The A allele of the 1438G/A gene polymorphism is predominantly distributed in males and increased the OSAS risk significantly. ..
  17. Gnerer J, Venken K, Dierick H. Gene-specific cell labeling using MiMIC transposons. Nucleic Acids Res. 2015;43:e56 pubmed publisher
    ..We show the efficacy and broad applicability of these new tools by dissecting the cellular expression patterns of the Drosophila serotonin receptor gene family. ..
  18. Schaerlinger B, Launay J, Vonesch J, Maroteaux L. Gain of affinity point mutation in the serotonin receptor gene 5-HT2Dro accelerates germband extension movements during Drosophila gastrulation. Dev Dyn. 2007;236:991-9 pubmed
  19. Tsubouchi A, Caldwell J, Tracey W. Dendritic filopodia, Ripped Pocket, NOMPC, and NMDARs contribute to the sense of touch in Drosophila larvae. Curr Biol. 2012;22:2124-34 pubmed publisher
    ..These cells show physiological responses to force. Ion channels in several force-sensing gene families are required for behavioral sensitivity to touch and for the formation of the actin-rich sensory filopodia. ..
  20. Wu W, Cooper R. Serotonin and synaptic transmission at invertebrate neuromuscular junctions. Exp Neurobiol. 2012;21:101-12 pubmed publisher
    ..In this review we highlight some of the key findings of 5-HT actions and receptor types associated at NMJs in a variety of invertebrate preparations in hopes that future studies will build on this knowledge base. ..
  21. Hou H, Heffer A, Anderson W, Liu J, Bowler T, Pick L. Stripy Ftz target genes are coordinately regulated by Ftz-F1. Dev Biol. 2009;335:442-53 pubmed publisher