Gene Symbol: 5-HT1A
Description: 5-hydroxytryptamine (serotonin) receptor 1A
Alias: 5-HT-dro2A, 5-HT1ADro, 5-HT[1A]Dro, 5-HT[[1ADro]], 5-HT[[1A]], 5-HT[[1A]]DRO, 5HT-R2A, 5HT-dro2A, 5HT-drp[[2A]], 5HT1A, 5HT[[1ADro]], 5htdro2a, CG16720, DRO2A, Dm5HTdro2A, Dmel\CG16720, HT1A, d5-HT1A, 5-hydroxytryptamine (serotonin) receptor 1A, 5-HT1A-PB, CG16720-PB, serotonin receptor 1A, serotonin receptor 2A, serotonin-receptor-2A
Species: fruit fly
Products:     5-HT1A

Top Publications

  1. Tierney A. Structure and function of invertebrate 5-HT receptors: a review. Comp Biochem Physiol A Mol Integr Physiol. 2001;128:791-804 pubmed
    ..This review summarizes information on the pharmacological and transductional properties of cloned invertebrate 5-HT receptors, and considers recent studies of endogenous receptors in the light of this new data. ..
  2. Yuan Q, Joiner W, Sehgal A. A sleep-promoting role for the Drosophila serotonin receptor 1A. Curr Biol. 2006;16:1051-62 pubmed
    ..or obtained flies with genetically altered expression of each of three Drosophila serotonin receptor subtypes (d5-HT1A, d5-HT1B, and d5-HT2) and assayed them for baseline sleep phenotypes...
  3. Hen R. Structural and functional conservation of serotonin receptors throughout evolution. EXS. 1993;63:266-78 pubmed
    ..A widespread distribution of 5-HT receptors might explain how serotonin can modulate the multiple neuronal circuits which underlie complex behaviors. ..
  4. Rodriguez Moncalvo V, Campos A. Role of serotonergic neurons in the Drosophila larval response to light. BMC Neurosci. 2009;10:66 pubmed publisher
    ..Finally, pan-neural over-expression of 5-HT1A Dro receptors, but not of any other 5-HT receptor subtype, causes a significant decrease in the response to light ..
  5. Saudou F, Boschert U, Amlaiky N, Plassat J, Hen R. A family of Drosophila serotonin receptors with distinct intracellular signalling properties and expression patterns. EMBO J. 1992;11:7-17 pubmed
    ..The 5HT-dro1 receptor stimulates adenylate cyclase while the 5HT-dro2A and the 5HT-dro2B receptors inhibit adenylate cyclase and activate phospholipase C...
  6. Dierick H, Greenspan R. Serotonin and neuropeptide F have opposite modulatory effects on fly aggression. Nat Genet. 2007;39:678-82 pubmed
    ..Moreover, this neuropeptide F effect seems to be independent of 5-HT. The implication of these two modulatory systems in fly and mouse aggression suggest a marked degree of conservation and a deep molecular root for this behavior. ..
  7. Luo J, Becnel J, Nichols C, Nassel D. Insulin-producing cells in the brain of adult Drosophila are regulated by the serotonin 5-HT1A receptor. Cell Mol Life Sci. 2012;69:471-84 pubmed publisher
    ..Thus, we have identified a second inhibitory pathway regulating IPC activity in the Drosophila brain. ..
  8. Johnson O, Becnel J, Nichols C. Serotonin 5-HT(2) and 5-HT(1A)-like receptors differentially modulate aggressive behaviors in Drosophila melanogaster. Neuroscience. 2009;158:1292-300 pubmed publisher
  9. Blenau W, Baumann A. Molecular and pharmacological properties of insect biogenic amine receptors: lessons from Drosophila melanogaster and Apis mellifera. Arch Insect Biochem Physiol. 2001;48:13-38 pubmed
    ..In this review, the present knowledge on the biochemical, molecular, and pharmacological properties of biogenic amine receptors from Drosophila and Apis will be summarized. Arch...

More Information


  1. Han K, Millar N, Davis R. A novel octopamine receptor with preferential expression in Drosophila mushroom bodies. J Neurosci. 1998;18:3650-8 pubmed
    ..The preferential expression of OAMB in mushroom bodies and its capacity to produce cAMP accumulation suggest an important role in synaptic modulation underlying behavioral plasticity. ..
  2. Feng G, Hannan F, Reale V, Hon Y, Kousky C, Evans P, et al. Cloning and functional characterization of a novel dopamine receptor from Drosophila melanogaster. J Neurosci. 1996;16:3925-33 pubmed
    ..Because DopR99B is the second dopamine receptor cloned from Drosophila, this work establishes dopamine receptor diversity in a system amenable to genetic dissection. ..
  3. Majeed Z, Abdeljaber E, Soveland R, Cornwell K, Bankemper A, Koch F, et al. Modulatory Action by the Serotonergic System: Behavior and Neurophysiology in Drosophila melanogaster. Neural Plast. 2016;2016:7291438 pubmed publisher
    ..5-HT2 receptor activation mediates a modulatory role in a sensory-motor circuit, and the activation of 5-HT neurons can suppress the neural circuit activity, while fluoxetine can significantly decrease the sensory-motor activity. ..
  4. Guven Ozkan T, Davis R. Functional neuroanatomy of Drosophila olfactory memory formation. Learn Mem. 2014;21:519-26 pubmed publisher
    ..Despite this progress, a complete and unified model that details the pathway from acquisition to memory expression remains elusive. ..
  5. Silva B, Goles N, Varas R, Campusano J. Serotonin receptors expressed in Drosophila mushroom bodies differentially modulate larval locomotion. PLoS ONE. 2014;9:e89641 pubmed publisher
    ..Thus, our data suggest that CNS 5HT systems are involved in motor control, and that 5HT receptors expressed in MB differentially modulate motor programs in fly larvae. ..
  6. Hong K, Park Y, Suh H. Sleep-promoting effects of a GABA/5-HTP mixture: Behavioral changes and neuromodulation in an invertebrate model. Life Sci. 2016;150:42-9 pubmed publisher
    ..003). These results related to transcript levels of the GABAB receptor (GABAB-R1) and serotonin receptor (5-HT1A), compared to the control group...
  7. Pebusque M, Coulier F, Birnbaum D, Pontarotti P. Ancient large-scale genome duplications: phylogenetic and linkage analyses shed light on chordate genome evolution. Mol Biol Evol. 1998;15:1145-59 pubmed
    ..Linkage of some of these genes can be found in the Drosophila melanogaster and Caenorhabditis elegans genomes, suggesting that they were linked in the triploblast Metazoa ancestor. ..
  8. Johnson O, Becnel J, Nichols C. Serotonin receptor activity is necessary for olfactory learning and memory in Drosophila melanogaster. Neuroscience. 2011;192:372-81 pubmed publisher
  9. Bjordal M, Arquier N, Kniazeff J, Pin J, Leopold P. Sensing of amino acids in a dopaminergic circuitry promotes rejection of an incomplete diet in Drosophila. Cell. 2014;156:510-21 pubmed publisher
    ..Taken together, these data identify a central amino-acid-sensing mechanism operating in specific DA neurons and controlling food intake. ..
  10. Singh K, Ju J, Walsh M, Diiorio M, Hart A. Deep conservation of genes required for both Drosphila melanogaster and Caenorhabditis elegans sleep includes a role for dopaminergic signaling. Sleep. 2014;37:1439-51 pubmed publisher
    ..Quantitative analysis of various components of quiescence suggests that interdependent or identical cellular and molecular mechanisms are likely to regulate both arousal and sleep entry. ..
  11. Merlet I, Ryvlin P, Costes N, Dufournel D, Isnard J, Faillenot I, et al. Statistical parametric mapping of 5-HT1A receptor binding in temporal lobe epilepsy with hippocampal ictal onset on intracranial EEG. Neuroimage. 2004;22:886-96 pubmed
    ..Further studies are warranted to evaluate the clinical usefulness of [(18)F]MPPF-PET as compared to other established PET tracers in drug resistant TLE. ..
  12. Alekseyenko O, Kravitz E. Serotonin and the search for the anatomical substrate of aggression. Fly (Austin). 2014;8:200-5 pubmed publisher
    ..We found anatomical target areas within the brain where these neurons appear to form synaptic contacts with 5HT1A receptor-expressing neurons, and then confirmed the likelihood of those connections on a functional level...
  13. Curran K, Chalasani S. Serotonin circuits and anxiety: what can invertebrates teach us?. Invert Neurosci. 2012;12:81-92 pubmed publisher
    ..These model systems possess well-defined neuroanatomies and robust serotonin-mediated behavior and should reveal insights into how serotonin can modulate human cognitive functions...
  14. Wu W, Cooper R. Serotonin and synaptic transmission at invertebrate neuromuscular junctions. Exp Neurobiol. 2012;21:101-12 pubmed publisher
    ..In this review we highlight some of the key findings of 5-HT actions and receptor types associated at NMJs in a variety of invertebrate preparations in hopes that future studies will build on this knowledge base. ..
  15. Bryson Richardson R, Logan D, Currie P, Jackson I. Large-scale analysis of gene structure in rhodopsin-like GPCRs: evidence for widespread loss of an ancient intron. Gene. 2004;338:15-23 pubmed
    ..Together, these two lines of evidence provide compelling evidence for the widespread loss of introns during the evolution of the mammalian GPCR-A family. ..
  16. Williams M, Goergen P, Phad G, Fredriksson R, Schioth H. The Drosophila Kctd-family homologue Kctd12-like modulates male aggression and mating behaviour. Eur J Neurosci. 2014;40:2513-26 pubmed publisher
    ..was shown that Ktl is in a complex with the Drosophila 5-HT receptor 5-HT7, and we observed that both Ktl and the 5-HT1A receptor are required in insulin-producing cells (IPCs) for proper adult male behaviour, as well as for ..
  17. Alekseyenko O, Chan Y, Fernández M, Bülow T, Pankratz M, Kravitz E. Single serotonergic neurons that modulate aggression in Drosophila. Curr Biol. 2014;24:2700-7 pubmed publisher
    ..GFP reconstitution across synaptic partners (GRASP) analyses suggest that 5HT-PLP neurons form contacts with 5HT1A receptor-expressing neurons in two distinct anatomical regions of the brain...
  18. Mohammad F, Aryal S, Ho J, Stewart J, Norman N, Tan T, et al. Ancient Anxiety Pathways Influence Drosophila Defense Behaviors. Curr Biol. 2016;26:981-6 pubmed publisher
    ..The presence of conserved neurogenetic pathways in the insect brain identifies Drosophila as an attractive genetic model for the study of anxiety and anxiety-related disorders, complementing existing rodent systems. ..
  19. Liu Y, Luo J, Carlsson M, Nässel D. Serotonin and insulin-like peptides modulate leucokinin-producing neurons that affect feeding and water homeostasis in Drosophila. J Comp Neurol. 2015;523:1840-63 pubmed publisher
    ..Our results suggest that serotonin via 5-HT1B diminishes activity in the LK neurons and thereby modulates functions regulated by LK peptide, but the action of the dInR in these neurons remains less clear. ..
  20. Gnerer J, Venken K, Dierick H. Gene-specific cell labeling using MiMIC transposons. Nucleic Acids Res. 2015;43:e56 pubmed publisher
    ..We show the efficacy and broad applicability of these new tools by dissecting the cellular expression patterns of the Drosophila serotonin receptor gene family. ..
  21. Nikoh N, Duty A, Gibson G. Effects of population structure and sex on association between serotonin receptors and Drosophila heart rate. Genetics. 2004;168:1963-74 pubmed
    ..Thirteen kilobases of DNA including the complete coding regions of 5-HT1A, 5-HT1B, and 5-HT2 were sequenced in 216 highly inbred lines extracted from two North American populations in ..
  22. Kerr M, Davies S, Dow J. Cell-specific manipulation of second messengers; a toolbox for integrative physiology in Drosophila. Curr Biol. 2004;14:1468-74 pubmed
    ..The results uncovered a new role for cGMP signaling in tubule and also demonstrate the utility of the tubule as a possible in vivo test bed for novel receptors, ligands, or agonists/antagonists. ..
  23. Shim K, Blake K, Jack J, Krasnow M. The Drosophila ribbon gene encodes a nuclear BTB domain protein that promotes epithelial migration and morphogenesis. Development. 2001;128:4923-33 pubmed
    ..We propose that Rib is a key regulator of epithelial morphogenesis that promotes migration and morphogenesis of the tracheal cell bodies and apical surface and other morphogenetic movements. ..
  24. Hita M, Poirie M, Leblanc N, Lemeunier F, Lutcher F, Frey F, et al. Genetic localization of a Drosophila melanogaster resistance gene to a parasitoid wasp and physical mapping of the region. Genome Res. 1999;9:471-81 pubmed
    ..Using single and double digests, cross hybridization of restriction fragments, and location of genetically mapped genes and STSs, a complete, five-enzyme restriction map of this 830-kb region was obtained. ..
  25. Luo J, Lushchak O, Goergen P, Williams M, Nassel D. Drosophila insulin-producing cells are differentially modulated by serotonin and octopamine receptors and affect social behavior. PLoS ONE. 2014;9:e99732 pubmed publisher
    ..Two monoamine receptors, the octopamine receptor OAMB and the serotonin receptor 5-HT1A, are expressed by the IPCs. These receptors may act antagonistically on adenylate cyclase...
  26. Lee P, Lin H, Chang Y, Fu T, Dubnau J, Hirsh J, et al. Serotonin-mushroom body circuit modulating the formation of anesthesia-resistant memory in Drosophila. Proc Natl Acad Sci U S A. 2011;108:13794-9 pubmed publisher
    ..Thus, in addition to the Amnesiac peptide required for anesthesia-sensitive memory formation, the two DPM neurons also release 5HT acting on MB neurons for ARM formation...
  27. Gasque G, Conway S, Huang J, Rao Y, Vosshall L. Small molecule drug screening in Drosophila identifies the 5HT2A receptor as a feeding modulation target. Sci Rep. 2013;3:srep02120 pubmed publisher
    ..These results highlight the conservation of molecular mechanisms controlling appetite and provide a method for unbiased whole-organism drug screens to identify novel drugs and molecular pathways modulating food intake. ..