Gene Symbol: uch2
Description: ubiquitin hydrolase Uch2
Alias: ubiquitin hydrolase Uch2
Species: fission yeast

Top Publications

  1. Stone M, Hartmann Petersen R, Seeger M, Bech Otschir D, Wallace M, Gordon C. Uch2/Uch37 is the major deubiquitinating enzyme associated with the 26S proteasome in fission yeast. J Mol Biol. 2004;344:697-706 pubmed
    ..Here, we characterise fission yeast Uch2 and Ubp6, two proteasome associated deubiquitinating enzymes...
  2. Kampmeyer C, Karakostova A, Schenstrøm S, Abildgaard A, Lauridsen A, Jourdain I, et al. The exocyst subunit Sec3 is regulated by a protein quality control pathway. J Biol Chem. 2017;292:15240-15253 pubmed publisher
    ..In conclusion, our results suggest that a cytosolic protein quality control pathway monitors folding and proteasome-dependent turnover of an exocyst subunit and, thereby, controls exocytosis in fission yeast. ..
  3. Li T, Naqvi N, Yang H, Teo T. Identification of a 26S proteasome-associated UCH in fission yeast. Biochem Biophys Res Commun. 2000;272:270-5 pubmed
    ..The gene (designated uch2+) encodes a protein containing a UCH catalytic domain at its N-terminus and a short extension at its C-terminus...
  4. Jossé L, Harley M, Pires I, Hughes D. Fission yeast Dss1 associates with the proteasome and is required for efficient ubiquitin-dependent proteolysis. Biochem J. 2006;393:303-9 pubmed
    ..These findings show that DSS1 has an evolutionarily conserved role as a regulator of proteasome function and suggest that DSS1 may provide a link between BRCA2 and ubiquitin-mediated proteolysis in human cells. ..
  5. O Donoghue J, Bech Otschir D, Larsen I, Wallace M, Hartmann Petersen R, Gordon C. Nedd8 processing enzymes in Schizosaccharomyces pombe. BMC Biochem. 2013;14:8 pubmed publisher
    ..Instead it appears that deubiquitylating enzymes can efficiently process the Nedd8 precursor in vivo. Several enzymes contribute to Nedd8 precursor processing including a number of deubiquitylating enzymes...