Gene Symbol: uch2
Description: ubiquitin hydrolase Uch2
Alias: ubiquitin hydrolase Uch2
Species: fission yeast
Stone M, Hartmann Petersen R, Seeger M, Bech Otschir D, Wallace M, Gordon C. Uch2/Uch37 is the major deubiquitinating enzyme associated with the 26S proteasome in fission yeast. J Mol Biol. 2004;344:697-706 pubmed
..Here, we characterise fission yeast Uch2 and Ubp6, two proteasome associated deubiquitinating enzymes...
Kampmeyer C, Karakostova A, Schenstrøm S, Abildgaard A, Lauridsen A, Jourdain I, et al
. The exocyst subunit Sec3 is regulated by a protein quality control pathway. J Biol Chem. 2017;292:15240-15253 pubmed publisher
..In conclusion, our results suggest that a cytosolic protein quality control pathway monitors folding and proteasome-dependent turnover of an exocyst subunit and, thereby, controls exocytosis in fission yeast. ..
Li T, Naqvi N, Yang H, Teo T. Identification of a 26S proteasome-associated UCH in fission yeast. Biochem Biophys Res Commun. 2000;272:270-5 pubmed
..The gene (designated uch2+) encodes a protein containing a UCH catalytic domain at its N-terminus and a short extension at its C-terminus...
Jossé L, Harley M, Pires I, Hughes D. Fission yeast Dss1 associates with the proteasome and is required for efficient ubiquitin-dependent proteolysis. Biochem J. 2006;393:303-9 pubmed
..These findings show that DSS1 has an evolutionarily conserved role as a regulator of proteasome function and suggest that DSS1 may provide a link between BRCA2 and ubiquitin-mediated proteolysis in human cells. ..
O Donoghue J, Bech Otschir D, Larsen I, Wallace M, Hartmann Petersen R, Gordon C. Nedd8 processing enzymes in Schizosaccharomyces pombe. BMC Biochem. 2013;14:8 pubmed publisher
..Instead it appears that deubiquitylating enzymes can efficiently process the Nedd8 precursor in vivo.
Several enzymes contribute to Nedd8 precursor processing including a number of deubiquitylating enzymes...