Gene Symbol: ubr1
Description: N-end-recognizing protein Ubr1
Alias: SPBC32F12.14, N-end-recognizing protein Ubr1
Species: fission yeast
Penney M, Samejima I, Wilkinson C, McInerny C, Mathiassen S, Wallace M, et al
. Fission yeast 26S proteasome mutants are multi-drug resistant due to stabilization of the Pap1 transcription factor. PLoS ONE. 2012;7:e50796 pubmed publisher
..that the ubiquitylation and ultimately the degradation of Pap1 depend on the Rhp6/Ubc2 E2 ubiquitin conjugating enzyme and the Ubr1 E3 ubiquitin-protein ligase. Accordingly, mutants lacking Rhp6 or Ubr1 display drug-resistant phenotypes.
Fujiwara H, Tanaka N, Yamashita I, Kitamura K. Essential role of Ubr11, but not Ubr1, as an N-end rule ubiquitin ligase in Schizosaccharomyces pombe. Yeast. 2013;30:1-11 pubmed publisher
..Schizosaccharomyces pombe has two similar Ubr proteins, Ubr1 and Ubr11...
Kitamura K, Katayama S, Dhut S, Sato M, Watanabe Y, Yamamoto M, et al
. Phosphorylation of Mei2 and Ste11 by Pat1 kinase inhibits sexual differentiation via ubiquitin proteolysis and 14-3-3 protein in fission yeast. Dev Cell. 2001;1:389-99 pubmed
..Mei2 is degraded via a ubiquitin-proteasome pathway in a phosphorylation-dependent fashion. The E2 Ubc2 and the E3 Ubr1 are required for this proteolysis...
Takeda K, Yanagida M. Regulation of nuclear proteasome by Rhp6/Ubc2 through ubiquitination and destruction of the sensor and anchor Cut8. Cell. 2005;122:393-405 pubmed
..Here we show that the fission yeast ubiquitin-conjugating Rhp6/Ubc2/Rad6 and ligating enzymes Ubr1 are responsible for nuclear enrichment of proteasome through the function of Cut8, a nuclear envelope protein...
Dodgson J, Avula H, Hoe K, Kim D, Park H, Hayles J, et al
. Functional genomics of adhesion, invasion, and mycelial formation in Schizosaccharomyces pombe. Eukaryot Cell. 2009;8:1298-306 pubmed publisher
..We show that galactose-dependent cell adhesion and actin assembly are both required for mycelial formation and mutants lacking a range of genes controlling cell polarity all produce mycelia but with radically altered morphology. ..
Kriegenburg F, Jakopec V, Poulsen E, Nielsen S, Roguev A, Krogan N, et al
. A chaperone-assisted degradation pathway targets kinetochore proteins to ensure genome stability. PLoS Genet. 2014;10:e1004140 pubmed publisher
Lee C, Yeh T, Hughes B, Espenshade P. Regulation of the Sre1 hypoxic transcription factor by oxygen-dependent control of DNA binding. Mol Cell. 2011;44:225-34 pubmed publisher
..In contrast to the HIF system, where proline hydroxylation is essential for regulation, Ofd1 inhibition of Sre1N does not require hydroxylation and, thus, defines a new mechanism for hypoxic gene regulation. ..
Kitamura K, Taki M, Tanaka N, Yamashita I. Fission yeast Ubr1 ubiquitin ligase influences the oxidative stress response via degradation of active Pap1 bZIP transcription factor in the nucleus. Mol Microbiol. 2011;80:739-55 pubmed publisher
..We report here an additional regulatory mechanism that Ubr1 ubiquitin ligase-dependent degradation lowered the Pap1 protein levels...