ubc13

Summary

Gene Symbol: ubc13
Description: ubiquitin-conjugating enzyme Ubc13
Alias: spu13, ubiquitin-conjugating enzyme Ubc13
Species: fission yeast

Top Publications

  1. Brown M, Zhu Y, Hemmingsen S, Xiao W. Structural and functional conservation of error-free DNA postreplication repair in Schizosaccharomyces pombe. DNA Repair (Amst). 2002;1:869-80 pubmed
    ..yeast two-hybrid screen, we identified a fission yeast cDNA homologous to UBC13 from various species and named it spu13(+)...
  2. Frampton J, Irmisch A, Green C, Neiss A, Trickey M, Ulrich H, et al. Postreplication repair and PCNA modification in Schizosaccharomyces pombe. Mol Biol Cell. 2006;17:2976-85 pubmed
    ..We show that PCNA modification and cell cycle checkpoints represent two independent signals in response to DNA damage. Finally, we unexpectedly find that PCNA is ubiquitinated in response to DNA damage when cells are arrested in G2. ..
  3. Liu X, Sun L, Hu W, Ding Y, Dong M, Du L. ESCRTs Cooperate with a Selective Autophagy Receptor to Mediate Vacuolar Targeting of Soluble Cargos. Mol Cell. 2015;59:1035-42 pubmed publisher
    ..Our findings demonstrate the ability of ESCRTs to mediate highly selective autophagy of soluble cargos, and suggest an unexpected mechanistic versatility of autophagy receptors. ..
  4. Onishi M, Nakamura Y, Koga T, Takegawa K, Fukui Y. Isolation of suppressor mutants of phosphatidylinositol 3-phosphate 5-kinase deficient cells in Schizosaccharomyces pombe. Biosci Biotechnol Biochem. 2003;67:1772-9 pubmed
    ..They included genes coding for proteins with domains homologous to calcium transporters, casein kinase II, UBC13, AMSH, Vps23p, and Vps27p of Saccharomyces cerevisiae...
  5. Vejrup Hansen R, Mizuno K, Miyabe I, Fleck O, Holmberg C, Murray J, et al. Schizosaccharomyces pombe Mms1 channels repair of perturbed replication into Rhp51 independent homologous recombination. DNA Repair (Amst). 2011;10:283-95 pubmed publisher
    ..These observations suggest that Mms1 acts to channel repair of perturbed replication into a particular sub-pathway of homologous recombination. ..
  6. Gatti L, Hoe K, Hayles J, Righetti S, Carenini N, Bo L, et al. Ubiquitin-proteasome genes as targets for modulation of cisplatin sensitivity in fission yeast. BMC Genomics. 2011;12:44 pubmed publisher
    ..Using this approach, we identified three Ub-proteasome mutants exhibiting hypersensitivity to cisplatin (ubp16, ubc13 and pmt3) and ten mutants (including ufd2, beta7 20S, rpt6/let1) resistant to the drug...
  7. Groocock L, Prudden J, Perry J, Boddy M. The RecQ4 orthologue Hrq1 is critical for DNA interstrand cross-link repair and genome stability in fission yeast. Mol Cell Biol. 2012;32:276-87 pubmed publisher
    ..Genetic epistasis analyses reveal that Hrq1 acts parallel to the PCNA/Ubc13/Mms2-dependent postreplication repair (PRR) pathway...
  8. Olsen S, Lima C. Structure of a ubiquitin E1-E2 complex: insights to E1-E2 thioester transfer. Mol Cell. 2013;49:884-96 pubmed publisher
    ..Comparison to a Ub E1/Ub/ATP·Mg structure reveals conformational changes in the E1 that bring the E1 and E2 active sites together...
  9. Ranatunga N, Forsburg S. Characterization of a Novel MMS-Sensitive Allele of Schizosaccharomyces pombe mcm4. G3 (Bethesda). 2016;6:3049-3063 pubmed publisher
    ..Surprisingly, we found that the deletion of rif1+ suppressed the MMS-sensitive phenotype without affecting temperature sensitivity. Together, these data suggest that mcm4-c106 destabilizes replisome structure. ..

More Information

Publications15

  1. Dolan W, Le A, Schmidt H, Yuan J, Green M, Forsburg S. Fission yeast Hsk1 (Cdc7) kinase is required after replication initiation for induced mutagenesis and proper response to DNA alkylation damage. Genetics. 2010;185:39-53 pubmed publisher
    ..We conclude that Hsk1-Dfp1 kinase functions post-initiation to maintain replication fork stability, an activity potentially mediated by the C terminus of Dfp1. ..
  2. Køhler J, Jørgensen M, Beinoraité G, Thorsen M, Thon G. Concerted action of the ubiquitin-fusion degradation protein 1 (Ufd1) and Sumo-targeted ubiquitin ligases (STUbLs) in the DNA-damage response. PLoS ONE. 2013;8:e80442 pubmed publisher
    ..Broader functional relationships between Ufd1 and STUbLs conceivably affect numerous cellular processes beyond the DDR...
  3. Tapia Alveal C, Lin S, Yeoh A, Jabado O, O Connell M. H2A.Z-dependent regulation of cohesin dynamics on chromosome arms. Mol Cell Biol. 2014;34:2092-104 pubmed publisher
    ..Z suppress the mitotic defects conferred by Smc5/6 dysfunction. Together, H2A.Z and the SMC complexes ensure genome integrity through accurate chromosome segregation. ..
  4. Mastro T, Forsburg S. Increased meiotic crossovers and reduced genome stability in absence of Schizosaccharomyces pombe Rad16 (XPF). Genetics. 2014;198:1457-72 pubmed publisher
    ..Thus, the XPF/XPA module of the nucleotide excision repair pathway is incorporated into multiple aspects of genome maintenance even in the absence of external DNA damage. ..
  5. Lv Z, Rickman K, Yuan L, Williams K, Selvam S, Woosley A, et al. S. pombe Uba1-Ubc15 Structure Reveals a Novel Regulatory Mechanism of Ubiquitin E2 Activity. Mol Cell. 2017;65:699-714.e6 pubmed publisher
  6. Yadav R, Jablonowski C, Fernandez A, Lowe B, Henry R, Finkelstein D, et al. Histone H3G34R mutation causes replication stress, homologous recombination defects and genomic instability in S. pombe. elife. 2017;6: pubmed publisher
    ..This analysis of H3-G34R mutant fission yeast provides mechanistic insight into how G34R mutation may promote genomic instability in glioma. ..