tsc1

Summary

Gene Symbol: tsc1
Description: hamartin
Alias: hamartin
Species: fission yeast
Products:     tsc1

Top Publications

  1. Matsumoto S, Bandyopadhyay A, Kwiatkowski D, Maitra U, Matsumoto T. Role of the Tsc1-Tsc2 complex in signaling and transport across the cell membrane in the fission yeast Schizosaccharomyces pombe. Genetics. 2002;161:1053-63 pubmed
    Heterozygous inactivation of either human TSC1 or TSC2 causes tuberous sclerosis (TSC), in which development of benign tumors, hamartomas, occurs via a two-hit mechanism...
  2. Weisman R, Roitburg I, Schonbrun M, Harari R, Kupiec M. Opposite effects of tor1 and tor2 on nitrogen starvation responses in fission yeast. Genetics. 2007;175:1153-62 pubmed
    ..b>Tsc1 and Tsc2, the genes mutated in the human tuberous sclerosis complex syndrome, negatively regulate the mammalian TOR ..
  3. van Slegtenhorst M, Mustafa A, Henske E. Pas1, a G1 cyclin, regulates amino acid uptake and rescues a delay in G1 arrest in Tsc1 and Tsc2 mutants in Schizosaccharomyces pombe. Hum Mol Genet. 2005;14:2851-8 pubmed
    Tuberous sclerosis complex is a tumor suppressor syndrome caused by mutations in either the TSC1 or the TSC2 gene...
  4. van Slegtenhorst M, Khabibullin D, Hartman T, Nicolas E, Kruger W, Henske E. The Birt-Hogg-Dube and tuberous sclerosis complex homologs have opposing roles in amino acid homeostasis in Schizosaccharomyces pombe. J Biol Chem. 2007;282:24583-90 pubmed
    ..This "opposite" profile was unexpected, given the overlapping clinical phenotypes. The TSC1/2 proteins inhibit Rheb in mammals, and Tsc1/Tsc2 inhibit Rhb1 in S. pombe...
  5. Cherkasova V, Maury L, Bacikova D, Pridham K, Bahler J, Maraia R. Altered nuclear tRNA metabolism in La-deleted Schizosaccharomyces pombe is accompanied by a nutritional stress response involving Atf1p and Pcr1p that is suppressible by Xpo-t/Los1p. Mol Biol Cell. 2012;23:480-91 pubmed publisher
    ..pombe through its effects on nuclear tRNA processing and probably nuclear export. Finally, the results are discussed in the context of stress response programs in Saccharomyces cerevisiae. ..
  6. Nakase Y, Fukuda K, Chikashige Y, Tsutsumi C, Morita D, Kawamoto S, et al. A defect in protein farnesylation suppresses a loss of Schizosaccharomyces pombe tsc2+, a homolog of the human gene predisposing to tuberous sclerosis complex. Genetics. 2006;173:569-78 pubmed
    Mutations in the human Tsc1 and Tsc2 genes predispose to tuberous sclerosis complex (TSC), a disorder characterized by the wide spread of benign tumors...
  7. Uritani M, Hidaka H, Hotta Y, Ueno M, Ushimaru T, Toda T. Fission yeast Tor2 links nitrogen signals to cell proliferation and acts downstream of the Rheb GTPase. Genes Cells. 2006;11:1367-79 pubmed
    ..We propose that Tor1 and Tor2 are involved in both corroborative and independent roles in nutrient sensing and stress response pathways. ..
  8. Nakase Y, Nakase M, Kashiwazaki J, Murai T, Otsubo Y, Mabuchi I, et al. The fission yeast ?-arrestin-like protein Any1 is involved in TSC-Rheb signaling and the regulation of amino acid transporters. J Cell Sci. 2013;126:3972-81 pubmed publisher
    Rheb GTPase and the Tsc1-Tsc2 protein complex, which serves as a GTPase-activating protein for Rheb, have crucial roles in the regulation of cell growth in response to extracellular conditions...
  9. Sun W, Zhu Y, Wang Z, Zhong Q, Gao F, Lou J, et al. Crystal structure of the yeast TSC1 core domain and implications for tuberous sclerosis pathological mutations. Nat Commun. 2013;4:2135 pubmed publisher
    ..The TSC1 protein, also known as hamartin, has a critical role in controlling mTOR signalling...

More Information

Publications10

  1. Laor D, Cohen A, Pasmanik Chor M, Oron Karni V, Kupiec M, Weisman R. Isp7 is a novel regulator of amino acid uptake in the TOR signaling pathway. Mol Cell Biol. 2014;34:794-806 pubmed publisher
    ..Taken together, our findings suggest a central role for Isp7 in amino acid homeostasis and the presence of isp7(+)-dependent regulatory loops that affect both TORC1 and TORC2. ..