Gene Symbol: swi6
Description: chromodomain protein Swi6
Alias: SPAC824.10c, chromodomain protein Swi6
Species: fission yeast
Products:     swi6

Top Publications

  1. Cam H, Sugiyama T, Chen E, Chen X, FitzGerald P, Grewal S. Comprehensive analysis of heterochromatin- and RNAi-mediated epigenetic control of the fission yeast genome. Nat Genet. 2005;37:809-19 pubmed
    ..In contrast, histone H3 methylated at Lys9 and its interacting protein Swi6/HP1, which define heterochromatin, coated extended domains associated with a variety of repeat elements and small ..
  2. Ekwall K, Nimmo E, Javerzat J, Borgstrøm B, Egel R, Cranston G, et al. Mutations in the fission yeast silencing factors clr4+ and rik1+ disrupt the localisation of the chromo domain protein Swi6p and impair centromere function. J Cell Sci. 1996;109 ( Pt 11):2637-48 pubmed
    ..Mutations in the clr4+, rik1+ and swi6+ genes dramatically reduce silencing at certain centromeric regions and cause elevated chromosome loss rates...
  3. Sugiyama T, Cam H, Verdel A, Moazed D, Grewal S. RNA-dependent RNA polymerase is an essential component of a self-enforcing loop coupling heterochromatin assembly to siRNA production. Proc Natl Acad Sci U S A. 2005;102:152-7 pubmed
    ..depends on components of RITS and Dicer as well as heterochromatin assembly factors including Clr4/Suv39h and Swi6/HP1 proteins...
  4. Jia S, Noma K, Grewal S. RNAi-independent heterochromatin nucleation by the stress-activated ATF/CREB family proteins. Science. 2004;304:1971-6 pubmed
    ..Furthermore, Atf1 and Pcr1 bind to the mating-type region and target histone H3 lysine-9 methylation and the Swi6 protein essential for heterochromatin assembly...
  5. Nakayama J, Rice J, Strahl B, Allis C, Grewal S. Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly. Science. 2001;292:110-3 pubmed
    ..Both the conserved chromo- and SET domains of Clr4 are required for H3 Lys9 methylation in vivo. Localization of Swi6, a homolog of Drosophila HP1, to heterochomatic regions is dependent on H3 Lys9 methylation...
  6. Partridge J, Borgstrøm B, Allshire R. Distinct protein interaction domains and protein spreading in a complex centromere. Genes Dev. 2000;14:783-91 pubmed
    ..b>Swi6 and Chp1 are confined to the flanking outer repeats and Swi6 can spread across at least 3 kb of extraneous ..
  7. Lorentz A, Heim L, Schmidt H. The switching gene swi6 affects recombination and gene expression in the mating-type region of Schizosaccharomyces pombe. Mol Gen Genet. 1992;233:436-42 pubmed
    ..Besides reducing MT switching, the swi6 mutation leads to deletions in the MT region caused by intrachromosomal cross-overs between two paired cassettes...
  8. Ekwall K, Javerzat J, Lorentz A, Schmidt H, Cranston G, Allshire R. The chromodomain protein Swi6: a key component at fission yeast centromeres. Science. 1995;269:1429-31 pubmed
    ..The Swi6 chromodomain protein affects this silencing, and now it is shown that Swi6p localizes with these three chromosomal ..
  9. Bannister A, Zegerman P, Partridge J, Miska E, Thomas J, Allshire R, et al. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature. 2001;410:120-4 pubmed
    ..In the fission yeast Schizosaccharomyces pombe, the correct localization of Swi6 (the HP1 equivalent) depends on Clr4, a homologue of the mammalian SUV39H1 histone methylase...

More Information


  1. Nonaka N, Kitajima T, Yokobayashi S, Xiao G, Yamamoto M, Grewal S, et al. Recruitment of cohesin to heterochromatic regions by Swi6/HP1 in fission yeast. Nat Cell Biol. 2002;4:89-93 pubmed
    ..We find that the preferential localization of cohesins at the centromeric repeats is dependent on Swi6, a conserved heterochromatin protein that is required for proper kinetochore function...
  2. Noma K, Sugiyama T, Cam H, Verdel A, Zofall M, Jia S, et al. RITS acts in cis to promote RNA interference-mediated transcriptional and post-transcriptional silencing. Nat Genet. 2004;36:1174-80 pubmed
    ..entire 20-kb silenced domain, as well as its subsequent maintenance, requires heterochromatin machinery including Swi6 and occurs even in the absence of Dicer...
  3. Keller C, Adaixo R, Stunnenberg R, Woolcock K, Hiller S, Buhler M. HP1(Swi6) mediates the recognition and destruction of heterochromatic RNA transcripts. Mol Cell. 2012;47:215-27 pubmed publisher
    ..Here, we demonstrate by a combination of in vivo and in vitro experiments that the fission yeast HP1(Swi6) protein guarantees tight repression of heterochromatic genes through RNA sequestration and degradation...
  4. Kim H, Choi E, Shin J, Jang Y, Park S. Regulation of Swi6/HP1-dependent heterochromatin assembly by cooperation of components of the mitogen-activated protein kinase pathway and a histone deacetylase Clr6. J Biol Chem. 2004;279:42850-9 pubmed
    ..One is RNA interference-dependent and acts on centromere-homologous repeats (cenH). The other is a stochastic Swi6 (the fission yeast HP1 homolog)-dependent mechanism that is not fully understood...
  5. Braun S, Garcia J, Rowley M, Rougemaille M, Shankar S, Madhani H. The Cul4-Ddb1(Cdt)² ubiquitin ligase inhibits invasion of a boundary-associated antisilencing factor into heterochromatin. Cell. 2011;144:41-54 pubmed publisher
    ..This mechanism acts parallel with phosphorylation of HP1/Swi6 by CK2 to restrict Epe1...
  6. Canzio D, Chang E, Shankar S, Kuchenbecker K, Simon M, Madhani H, et al. Chromodomain-mediated oligomerization of HP1 suggests a nucleosome-bridging mechanism for heterochromatin assembly. Mol Cell. 2011;41:67-81 pubmed publisher
    ..Using the S. pombe HP1 protein, Swi6, we show that recognition of H3K9-methylated chromatin in vitro relies on an interface between two CDs...
  7. Thon G, Verhein Hansen J. Four chromo-domain proteins of Schizosaccharomyces pombe differentially repress transcription at various chromosomal locations. Genetics. 2000;155:551-68 pubmed
    ..The repression involves the chromo-domain proteins Swi6 and Clr4...
  8. Lorentz A, Ostermann K, Fleck O, Schmidt H. Switching gene swi6, involved in repression of silent mating-type loci in fission yeast, encodes a homologue of chromatin-associated proteins from Drosophila and mammals. Gene. 1994;143:139-43 pubmed
    The switching gene swi6 of Schizosaccharomyces pombe is involved in the repression of the silent mating-type loci mat2 and mat3. We have cloned the gene by functional complementation of the switching defect of the swi6-115 mutation...
  9. Ekwall K, Ruusala T. Mutations in rik1, clr2, clr3 and clr4 genes asymmetrically derepress the silent mating-type loci in fission yeast. Genetics. 1994;136:53-64 pubmed
    ..Before this work mutations in two genes, clr1 and swi6, had been shown to allow both expression of the silent loci and recombination in the K region...
  10. Yamada T, Fischle W, Sugiyama T, Allis C, Grewal S. The nucleation and maintenance of heterochromatin by a histone deacetylase in fission yeast. Mol Cell. 2005;20:173-85 pubmed
    ..spreads across the 20 kb silenced domain that requires its own HDAC activity and heterochromatin proteins including Swi6/HP1...
  11. Shimada A, Dohke K, Sadaie M, Shinmyozu K, Nakayama J, Urano T, et al. Phosphorylation of Swi6/HP1 regulates transcriptional gene silencing at heterochromatin. Genes Dev. 2009;23:18-23 pubmed publisher
    ..In fission yeast, a HP1 homolog Swi6 recruits SHREC, Epe1, and cohesin, which are involved in transcriptional gene silencing (TGS), transcriptional ..
  12. Fischer T, Cui B, Dhakshnamoorthy J, Zhou M, Rubin C, Zofall M, et al. Diverse roles of HP1 proteins in heterochromatin assembly and functions in fission yeast. Proc Natl Acad Sci U S A. 2009;106:8998-9003 pubmed publisher
    ..The fission yeast Schizosaccharomyces pombe HP1 family members Chp2 and Swi6 are important for heterochromatin assembly and transcriptional silencing, but their precise roles are not fully ..
  13. Hall I, Shankaranarayana G, Noma K, Ayoub N, Cohen A, Grewal S. Establishment and maintenance of a heterochromatin domain. Science. 2002;297:2232-7 pubmed
    ..We find that, although histone H3 methylated at lysine 9 (H3 Lys9) directly recruits heterochromatin protein Swi6/HP1, the critical determinant for H3 Lys9 methylation to spread in cis and to be inherited through mitosis and ..
  14. Klar A, Bonaduce M. swi6, a gene required for mating-type switching, prohibits meiotic recombination in the mat2-mat3 "cold spot" of fission yeast. Genetics. 1991;129:1033-42 pubmed
    ..swi2 and swi6 switching-deficient mutants possess the normal level of double-strand break at mat1, yet they fail to switch ..
  15. Yamane K, Mizuguchi T, Cui B, Zofall M, Noma K, Grewal S. Asf1/HIRA facilitate global histone deacetylation and associate with HP1 to promote nucleosome occupancy at heterochromatic loci. Mol Cell. 2011;41:56-66 pubmed publisher
    ..In fission yeast, HP1 proteins Chp2 and Swi6, which bind to methylated histone H3 lysine 9, associate with SHREC (Snf2/HDAC repressor complex) and Clr6 histone ..
  16. Bernard P, Maure J, Partridge J, Genier S, Javerzat J, Allshire R. Requirement of heterochromatin for cohesion at centromeres. Science. 2001;294:2539-42 pubmed
    ..It is not known what distinguishes centromere cohesion from arm cohesion. Fission yeast Swi6 (a Heterochromatin protein 1 counterpart) is a component of silent heterochromatin...
  17. Isaac S, Walfridsson J, Zohar T, Lazar D, Kahan T, Ekwall K, et al. Interaction of Epe1 with the heterochromatin assembly pathway in Schizosaccharomyces pombe. Genetics. 2007;175:1549-60 pubmed
    ..We report that Swi6 recruits Epe1 to heterochromatin and that overexpression of epe1+, like mutations in silencing genes or ..
  18. Kato H, Goto D, Martienssen R, Urano T, Furukawa K, Murakami Y. RNA polymerase II is required for RNAi-dependent heterochromatin assembly. Science. 2005;309:467-9 pubmed
    ..This phenotype resembles mutants in RNAi and suggests that RNAPII couples pericentromeric transcription with siRNA processing and heterochromatin assembly. ..
  19. Pidoux A, Uzawa S, Perry P, Cande W, Allshire R. Live analysis of lagging chromosomes during anaphase and their effect on spindle elongation rate in fission yeast. J Cell Sci. 2000;113 Pt 23:4177-91 pubmed
  20. Freeman Cook L, Gómez E, Spedale E, Marlett J, Forsburg S, Pillus L, et al. Conserved locus-specific silencing functions of Schizosaccharomyces pombe sir2+. Genetics. 2005;169:1243-60 pubmed
    ..Enrichment of Sir2p at silenced regions does not require the HP1 homolog Swi6p; instead, Swi6-GFP localization to telomeres depends in part on Sir2p...
  21. Doe C, Wang G, Chow C, Fricker M, Singh P, Mellor E. The fission yeast chromo domain encoding gene chp1(+) is required for chromosome segregation and shows a genetic interaction with alpha-tubulin. Nucleic Acids Res. 1998;26:4222-9 pubmed
    ..Chp1p and Swi6p proteins may be components of the kinetochore which captures and stabilizes the microtubules of the spindle. ..
  22. Sadaie M, Kawaguchi R, Ohtani Y, Arisaka F, Tanaka K, Shirahige K, et al. Balance between distinct HP1 family proteins controls heterochromatin assembly in fission yeast. Mol Cell Biol. 2008;28:6973-88 pubmed publisher
    ..In fission yeast, two HP1 family proteins, Swi6 and Chp2, are involved in transcriptional silencing at heterochromatic regions, but how they function and whether ..
  23. Partridge J, Scott K, Bannister A, Kouzarides T, Allshire R. cis-acting DNA from fission yeast centromeres mediates histone H3 methylation and recruitment of silencing factors and cohesin to an ectopic site. Curr Biol. 2002;12:1652-60 pubmed
    ..by the local de novo methylation of histone H3 on lysine 9, recruitment of known heterochromatin components, Swi6 and Chp1, and the provision of a new strong cohesin binding site...
  24. Li F, Goto D, Zaratiegui M, Tang X, Martienssen R, Cande W. Two novel proteins, dos1 and dos2, interact with rik1 to regulate heterochromatic RNA interference and histone modification. Curr Biol. 2005;15:1448-57 pubmed
    ..In fission yeast, the Heterochromatin Protein 1 homolog Swi6 recognizes H3K9me, silences transcription, and retains cohesin at pericentromeric repeats...
  25. Trewick S, Minc E, Antonelli R, Urano T, Allshire R. The JmjC domain protein Epe1 prevents unregulated assembly and disassembly of heterochromatin. EMBO J. 2007;26:4670-82 pubmed
    ..Thus, Epe1 ensures that heterochromatin is restricted to the domains to which it is targeted by RNAi. ..
  26. Allshire R, Nimmo E, Ekwall K, Javerzat J, Cranston G. Mutations derepressing silent centromeric domains in fission yeast disrupt chromosome segregation. Genes Dev. 1995;9:218-33 pubmed
    ..Strains with lesions at the clr4, rik1, and swi6 loci have highly elevated rates of chromosome loss...
  27. Zofall M, Grewal S. Swi6/HP1 recruits a JmjC domain protein to facilitate transcription of heterochromatic repeats. Mol Cell. 2006;22:681-92 pubmed
    ..Remarkably, Epe1 is recruited to heterochromatic loci by the heterochromatin protein Swi6/HP1...
  28. Bernard P, Hardwick K, Javerzat J. Fission yeast bub1 is a mitotic centromere protein essential for the spindle checkpoint and the preservation of correct ploidy through mitosis. J Cell Biol. 1998;143:1775-87 pubmed
    ..However, unlike its vertebrate counterpart, a pool of Bub1 remains centromere-associated at metaphase and even until telophase. We discuss the possibility of a role for the Bub1 kinase after the metaphase-anaphase transition. ..
  29. Motamedi M, Hong E, Li X, Gerber S, Denison C, Gygi S, et al. HP1 proteins form distinct complexes and mediate heterochromatic gene silencing by nonoverlapping mechanisms. Mol Cell. 2008;32:778-90 pubmed publisher
    ..In fission yeast, two HP1 homologs, Swi6 and Chp2, function in heterochromatic gene silencing, but their relative contribution to silencing remains unknown...
  30. Al Sady B, Madhani H, Narlikar G. Division of labor between the chromodomains of HP1 and Suv39 methylase enables coordination of heterochromatin spread. Mol Cell. 2013;51:80-91 pubmed publisher
    ..3 lysine 9 methylation (H3K9me), requires the chromodomains (CDs) of the H3K9 methylase Suv39/Clr4 and the HP1/Swi6 protein. It is unclear how the actions of these two H3K9me-recognizing CDs are coordinated...
  31. Hayashi A, Ishida M, Kawaguchi R, Urano T, Murakami Y, Nakayama J. Heterochromatin protein 1 homologue Swi6 acts in concert with Ers1 to regulate RNAi-directed heterochromatin assembly. Proc Natl Acad Sci U S A. 2012;109:6159-64 pubmed publisher
    ..Heterochromatin coated with Swi6/Heterochromain Protein 1 is then formed following recruitment of chromatin modification machinery...
  32. Iida T, Nakayama J, Moazed D. siRNA-mediated heterochromatin establishment requires HP1 and is associated with antisense transcription. Mol Cell. 2008;31:178-89 pubmed publisher
    ..These results provide insights into the regulation of siRNA action and reveal roles for cis-dsRNA synthesis and HP1 in siRNA-mediated heterochromatin assembly. ..
  33. Yamagishi Y, Sakuno T, Shimura M, Watanabe Y. Heterochromatin links to centromeric protection by recruiting shugoshin. Nature. 2008;455:251-5 pubmed publisher
    ..in simpler unicellular organisms such as the fission yeast Schizosaccharomyces pombe, the heterochromatin protein Swi6 (HP1 homologue) has several functions at centromeres, including silencing gene expression and recombination, ..
  34. Dolan W, Le A, Schmidt H, Yuan J, Green M, Forsburg S. Fission yeast Hsk1 (Cdc7) kinase is required after replication initiation for induced mutagenesis and proper response to DNA alkylation damage. Genetics. 2010;185:39-53 pubmed publisher
    ..We conclude that Hsk1-Dfp1 kinase functions post-initiation to maintain replication fork stability, an activity potentially mediated by the C terminus of Dfp1. ..
  35. Murakami H, Goto D, Toda T, Chen E, Grewal S, Martienssen R, et al. Ribonuclease activity of Dis3 is required for mitotic progression and provides a possible link between heterochromatin and kinetochore function. PLoS ONE. 2007;2:e317 pubmed
    ..This activity is likely monitored by the mitotic checkpoint, and distinct from that of RNAi-mediated heterochromatin formation directly targeting outer centromeric repeats. ..
  36. Stunnenberg R, Kulasegaran Shylini R, Keller C, Kirschmann M, Gelman L, Bühler M. H3K9 methylation extends across natural boundaries of heterochromatin in the absence of an HP1 protein. EMBO J. 2015;34:2789-803 pubmed publisher
    ..Here, we demonstrate that the fission yeast HP1 protein Swi6 exists as a single highly dynamic population that rapidly exchanges in cis and in trans between different ..
  37. Choi S, McCollum D. A role for metaphase spindle elongation forces in correction of merotelic kinetochore attachments. Curr Biol. 2012;22:225-30 pubmed publisher
  38. Buscaino A, Lejeune E, Audergon P, Hamilton G, Pidoux A, Allshire R. Distinct roles for Sir2 and RNAi in centromeric heterochromatin nucleation, spreading and maintenance. EMBO J. 2013;32:1250-64 pubmed publisher
    ..We demonstrate that the histone deacetylases Sir2 and Clr3 and the chromodomain protein Swi6(HP1) are required for H3K9me spreading from nucleation sites, thus allowing formation of extended ..
  39. Chikashige Y, Tsutsumi C, Okamasa K, Yamane M, Nakayama J, Niwa O, et al. Gene expression and distribution of Swi6 in partial aneuploids of the fission yeast Schizosaccharomyces pombe. Cell Struct Funct. 2007;32:149-61 pubmed
    ..Examining the distribution of the heterochromoatin protein Swi6 using DNA microarray analysis, we found that binding of Swi6 within ~50 kb from the telomere occurred less in ..
  40. Matsuda E, Sugioka Sugiyama R, Mizuguchi T, Mehta S, Cui B, Grewal S. A homolog of male sex-determining factor SRY cooperates with a transposon-derived CENP-B protein to control sex-specific directed recombination. Proc Natl Acad Sci U S A. 2011;108:18754-9 pubmed publisher
  41. Ellermeier C, Higuchi E, Phadnis N, Holm L, Geelhood J, Thon G, et al. RNAi and heterochromatin repress centromeric meiotic recombination. Proc Natl Acad Sci U S A. 2010;107:8701-5 pubmed publisher
  42. Isaac R, Sanulli S, Tibble R, Hornsby M, Ravalin M, Craik C, et al. Biochemical Basis for Distinct Roles of the Heterochromatin Proteins Swi6 and Chp2. J Mol Biol. 2017;429:3666-3677 pubmed publisher
    ..Here, we use the two Schizosaccharomyces pombe HP1 paralogs, Swi6 and Chp2, as model systems to compare and contrast their biophysical properties...
  43. Woolcock K, Gaidatzis D, Punga T, Buhler M. Dicer associates with chromatin to repress genome activity in Schizosaccharomyces pombe. Nat Struct Mol Biol. 2011;18:94-9 pubmed publisher
    ..We anticipate that similar mechanisms could also be operational in other eukaryotes. ..
  44. Wang J, Cohen A, Letian A, Tadeo X, Moresco J, Liu J, et al. The proper connection between shelterin components is required for telomeric heterochromatin assembly. Genes Dev. 2016;30:827-39 pubmed publisher
    ..Thus, subtelomeric heterochromatin assembly requires both the recruitment of CLRC by shelterin to chromosome ends and the proper connection of shelterin components, which allows CLRC to skip telomeric repeats to internal regions. ..
  45. Bernard P, Drogat J, Maure J, Dheur S, Vaur S, Genier S, et al. A screen for cohesion mutants uncovers Ssl3, the fission yeast counterpart of the cohesin loading factor Scc4. Curr Biol. 2006;16:875-81 pubmed
    ..The discovery of a functional homolog of Scc4 indicates that the machinery of cohesin loading is conserved among eukaryotes. ..
  46. Kawashima S, Tsukahara T, Langegger M, Hauf S, Kitajima T, Watanabe Y. Shugoshin enables tension-generating attachment of kinetochores by loading Aurora to centromeres. Genes Dev. 2007;21:420-35 pubmed
    ..The other shugoshin-like protein Sgo2, which requires the heterochromatin protein Swi6/HP1 for full viability, plays a crucial role for proper chromosome segregation at both mitosis and meiosis; however,..
  47. Akamatsu Y, Tsutsui Y, Morishita T, Siddique M, Kurokawa Y, Ikeguchi M, et al. Fission yeast Swi5/Sfr1 and Rhp55/Rhp57 differentially regulate Rhp51-dependent recombination outcomes. EMBO J. 2007;26:1352-62 pubmed
    ..These results suggest that Swi5/Sfr1 functions as an Rhp51 mediator but processes DSBs in a manner different from that of the Rhp55/57 mediator. ..
  48. Bailis J, Bernard P, Antonelli R, Allshire R, Forsburg S. Hsk1-Dfp1 is required for heterochromatin-mediated cohesion at centromeres. Nat Cell Biol. 2003;5:1111-6 pubmed
    ..regulates replication initiation, interacts with and phosphorylates the heterochromatin protein 1 (HP1) equivalent Swi6 (ref. 6)...
  49. Gómez E, Espinosa J, Forsburg S. Schizosaccharomyces pombe mst2+ encodes a MYST family histone acetyltransferase that negatively regulates telomere silencing. Mol Cell Biol. 2005;25:8887-903 pubmed
    ..Although telomere length is normal, meiosis is aberrant in Deltamst2 diploid homozygote mutants, suggesting that telomeric histone acetylation contributes to normal meiotic progression. ..
  50. Reyes C, Serrurier C, Gauthier T, Gachet Y, Tournier S. Aurora B prevents chromosome arm separation defects by promoting telomere dispersion and disjunction. J Cell Biol. 2015;208:713-27 pubmed publisher
    ..Dispersion is promoted by the dissociation of Swi6/HP1 and cohesin Rad21 from telomeres, whereas disjunction occurs at anaphase after the phosphorylation of condensin ..
  51. Dohke K, Miyazaki S, Tanaka K, Urano T, Grewal S, Murakami Y. Fission yeast chromatin assembly factor 1 assists in the replication-coupled maintenance of heterochromatin. Genes Cells. 2008;13:1027-43 pubmed publisher
    ..spCAF1 caused defects in silencing at centromeric and mating locus heterochromatin, accompanied with a decrease in Swi6, the fission yeast HP1 homologue...
  52. Nishibuchi G, Machida S, Osakabe A, Murakoshi H, Hiragami Hamada K, Nakagawa R, et al. N-terminal phosphorylation of HP1α increases its nucleosome-binding specificity. Nucleic Acids Res. 2014;42:12498-511 pubmed publisher
    ..CK2-mediated phosphorylation had a similar effect on the nucleosome-binding specificity of fly HP1a and S. pombe Swi6. These results suggested that HP1 phosphorylation has an evolutionarily conserved role in HP1's recognition of ..
  53. Nakayama Ji -, Allshire R, Klar A, Grewal S. A role for DNA polymerase alpha in epigenetic control of transcriptional silencing in fission yeast. EMBO J. 2001;20:2857-66 pubmed
    ..Specifically, a chromodomain protein Swi6 is believed to be an important determinant of the epigenetic imprint...
  54. Canzio D, Liao M, Naber N, Pate E, Larson A, Wu S, et al. A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly. Nature. 2013;496:377-81 pubmed publisher
    ..Here we show that binding of the key S. pombe HP1 protein, Swi6, to methylated nucleosomes drives a switch from an auto-inhibited state to a spreading-competent state...
  55. Akamatsu Y, Dziadkowiec D, Ikeguchi M, Shinagawa H, Iwasaki H. Two different Swi5-containing protein complexes are involved in mating-type switching and recombination repair in fission yeast. Proc Natl Acad Sci U S A. 2003;100:15770-5 pubmed
    ..suggest that the Swi5-Sfr1-Rhp51 interactions function specifically in DNA recombination repair, whereas the Swi5-Swi2-Rhp51 interactions may function, together with chromodomain protein Swi6 (HP1 homolog), in mating-type switching.
  56. Thon G, Klar A. Directionality of fission yeast mating-type interconversion is controlled by the location of the donor loci. Genetics. 1993;134:1045-54 pubmed
    ..We also present evidence for the involvement of the Swi6 and Swi6-mod trans-acting factors in the donor-choice mechanism...
  57. Singh J, Goel V, Klar A. A novel function of the DNA repair gene rhp6 in mating-type silencing by chromatin remodeling in fission yeast. Mol Cell Biol. 1998;18:5511-22 pubmed
    ..We propose that the effects of the sng1(-)/rhp6(-) mutation on silencing are indirect consequences of changes in chromatin structure. ..
  58. Lawrence R, Volpe T. Msc1 links dynamic Swi6/HP1 binding to cell fate determination. Proc Natl Acad Sci U S A. 2009;106:1163-8 pubmed publisher
    ..pombe. In the absence of Msc1, the in vivo mobility of Swi6 at heterochromatic foci is compromised, and centromere heterochromatin becomes hyperenriched with the ..
  59. Li P, Chretien L, C t J, Kelly T, Forsburg S. S. pombe replication protein Cdc18 (Cdc6) interacts with Swi6 (HP1) heterochromatin protein: region specific effects and replication timing in the centromere. Cell Cycle. 2011;10:323-36 pubmed publisher
    ..We show that the essential DNA replication factor Cdc18 (CDC6) associates with heterochromatin protein 1 (Swi6) in vivo and in vitro...
  60. Kim H, Rhee D, Jang Y. Methylations of histone H3 lysine 9 and lysine 36 are functionally linked to DNA replication checkpoint control in fission yeast. Biochem Biophys Res Commun. 2008;368:419-25 pubmed publisher
    ..Double mutants in Alp13 and Swi6, which can specifically bind to H3-K36 and K9 methylations, exhibited phenotypes similar to those of the clr4-set2 ..
  61. Gómez E, Nugent R, Laria S, Forsburg S. Schizosaccharomyces pombe histone acetyltransferase Mst1 (KAT5) is an essential protein required for damage response and chromosome segregation. Genetics. 2008;179:757-71 pubmed publisher
    ..mst1 mutant sensitivity to hydroxyurea suggests a defect in recovery following HU arrest. We conclude that Mst1 plays essential roles in maintenance of genome stability and recovery from DNA damage...
  62. Dubey R, Nakwal N, Bisht K, Saini A, Haldar S, Singh J. Interaction of APC/C-E3 ligase with Swi6/HP1 and Clr4/Suv39 in heterochromatin assembly in fission yeast. J Biol Chem. 2009;284:7165-76 pubmed publisher
    Heterochromatin assembly in fission yeast is initiated by binding of Swi6/HP1 to the Lys-9-dimethylated H3 followed by spreading via cooperative recruitment of Swi6/HP1...
  63. Egel R, Beach D, Klar A. Genes required for initiation and resolution steps of mating-type switching in fission yeast. Proc Natl Acad Sci U S A. 1984;81:3481-5 pubmed
    ..The data suggest that the switching process can be dissected into genetically distinguishable steps. ..
  64. Lee S, Rozenzhak S, Russell P. ?H2A-binding protein Brc1 affects centromere function in fission yeast. Mol Cell Biol. 2013;33:1410-6 pubmed publisher
  65. Kitajima T, Kawashima S, Watanabe Y. The conserved kinetochore protein shugoshin protects centromeric cohesion during meiosis. Nature. 2004;427:510-7 pubmed
    ..These findings provide insights into the evolution of meiosis and kinetochore regulation during mitosis and meiosis. ..