Gene Symbol: sty1
Description: MAP kinase Sty1
Alias: phh1, spc1, MAP kinase Sty1
Species: fission yeast

Top Publications

  1. Wang L, Shimada K, Morishita M, Shiozaki K. Response of fission yeast to toxic cations involves cooperative action of the stress-activated protein kinase Spc1/Sty1 and the Hal4 protein kinase. Mol Cell Biol. 2005;25:3945-55 pubmed
    ..Here we report a novel physiological role of the fission yeast Spc1 SAPK in cellular resistance to certain cations, such as Na(+), Li(+), and Ca(2+)...
  2. Soto T, Beltrán F, Paredes V, Madrid M, Millar J, Vicente Soler J, et al. Cold induces stress-activated protein kinase-mediated response in the fission yeast Schizosaccharomyces pombe. Eur J Biochem. 2002;269:5056-65 pubmed
  3. Millar J, Buck V, Wilkinson M. Pyp1 and Pyp2 PTPases dephosphorylate an osmosensing MAP kinase controlling cell size at division in fission yeast. Genes Dev. 1995;9:2117-30 pubmed
    ..mutations that bypass the requirement for pyp1 and pyp2 and reside in two complementation groups were isolated, sty1 and sty2. sty1- and sty2- mutant cells are substantially delayed in the timing of mitotic initiation...
  4. Davidson M, Shandilya H, Hirota K, Ohta K, Wahls W. Atf1-Pcr1-M26 complex links stress-activated MAPK and cAMP-dependent protein kinase pathways via chromatin remodeling of cgs2+. J Biol Chem. 2004;279:50857-63 pubmed
    ..Here signals from the fission yeast stress-activated MAPK Spc1 are shown to regulate Cgs2, a negative regulator of the cAMP-dependent protein kinase (protein kinase A) pathway...
  5. Gaits F, Degols G, Shiozaki K, Russell P. Phosphorylation and association with the transcription factor Atf1 regulate localization of Spc1/Sty1 stress-activated kinase in fission yeast. Genes Dev. 1998;12:1464-73 pubmed
    ..Herein are reported subcellular localization studies of fission yeast Spc1, a homolog of human p38 and budding yeast Hog1p SAPKs. Stress induces transient nuclear localization of Spc1...
  6. Toone W, Kuge S, Samuels M, Morgan B, Toda T, Jones N. Regulation of the fission yeast transcription factor Pap1 by oxidative stress: requirement for the nuclear export factor Crm1 (Exportin) and the stress-activated MAP kinase Sty1/Spc1. Genes Dev. 1998;12:1453-63 pubmed
    The fission yeast Sty1 stress-activated MAP kinase is crucial for the cellular response to a variety of stress conditions...
  7. Shieh J, Wilkinson M, Buck V, Morgan B, Makino K, Millar J. The Mcs4 response regulator coordinately controls the stress-activated Wak1-Wis1-Sty1 MAP kinase pathway and fission yeast cell cycle. Genes Dev. 1997;11:1008-22 pubmed
    The fission yeast Sty1 MAP kinase is required for cell cycle control, initiation of sexual differentiation, and protection against cellular stress...
  8. Degols G, Shiozaki K, Russell P. Activation and regulation of the Spc1 stress-activated protein kinase in Schizosaccharomyces pombe. Mol Cell Biol. 1996;16:2870-7 pubmed
    b>Spc1, an osmotic-stress-stimulated mitogen-activated protein kinase (MAPK) homolog in the fission yeast Schizosaccharomyces pombe, is required for the induction of mitosis and survival in high-osmolarity conditions...
  9. Kato T, Okazaki K, Murakami H, Stettler S, Fantes P, Okayama H. Stress signal, mediated by a Hog1-like MAP kinase, controls sexual development in fission yeast. FEBS Lett. 1996;378:207-12 pubmed
    We identified the phh1+ gene that encodes a MAP kinase as the effector of Wis1 MAP kinase kinase in fission yeast, which is highly homologous with HOG1 of S. cerevisiae...

More Information


  1. Zuin A, Vivancos A, Sansó M, Takatsume Y, Ayte J, Inoue Y, et al. The glycolytic metabolite methylglyoxal activates Pap1 and Sty1 stress responses in Schizosaccharomyces pombe. J Biol Chem. 2005;280:36708-13 pubmed
    ..Here we have shown that the two principal oxidative stress response pathways of Schizosaccharomyces pombe, Sty1 and Pap1, are involved in the response to methylglyoxal toxicity...
  2. Dunand Sauthier I, Walker C, Narasimhan J, Pearce A, Wek R, Humphrey T. Stress-activated protein kinase pathway functions to support protein synthesis and translational adaptation in response to environmental stress in fission yeast. Eukaryot Cell. 2005;4:1785-93 pubmed
    ..the SAPK pathway, including the mitogen-activated protein kinase Wis1 or the mitogen-activated protein kinase Spc1/Sty1, suggesting a role for these stress response factors in this translational control...
  3. Paredes V, Franco A, Madrid M, Soto T, Vicente Soler J, Gacto M, et al. Transcriptional and post-translational regulation of neutral trehalase in Schizosaccharomyces pombe during thermal stress. Yeast. 2004;21:593-603 pubmed
    ..Unlike what happens under osmostress or oxidative treatments, Sty1p has no role in the post-translational activation of neutral trehalase induced by heat shock in the fission yeast. ..
  4. Zhou X, Ma Y, Sugiura R, Kobayashi D, Suzuki M, Deng L, et al. MAP kinase kinase kinase (MAPKKK)-dependent and -independent activation of Sty1 stress MAPK in fission yeast. J Biol Chem. 2010;285:32818-23 pubmed publisher
    In fission yeast, the Sty1/Spc1/Phh1 mitogen-activated protein kinase (MAPK) pathway is known to be involved in multiple-stress responses...
  5. Kon N, Schroeder S, Krawchuk M, Wahls W. Regulation of the Mts1-Mts2-dependent ade6-M26 meiotic recombination hot spot and developmental decisions by the Spc1 mitogen-activated protein kinase of fission yeast. Mol Cell Biol. 1998;18:7575-83 pubmed
    ..The first class (osmoregulation, spore viability, and spore quiescence) requires the Spc1 MAP kinase and the Mts1 protein but does not require the Mts2 protein...
  6. Wilkinson M, Samuels M, Takeda T, Toone W, Shieh J, Toda T, et al. The Atf1 transcription factor is a target for the Sty1 stress-activated MAP kinase pathway in fission yeast. Genes Dev. 1996;10:2289-301 pubmed
    ..We show here that the fission yeast Atf1 factor is also regulated by a stress-activated kinase, Sty1. The Sty1 kinase is stimulated by a variety of different stress conditions including osmotic and oxidative stress ..
  7. Bellini A, Girard P, Lambert S, Tessier L, Sage E, Francesconi S. Stress activated protein kinase pathway modulates homologous recombination in fission yeast. PLoS ONE. 2012;7:e47987 pubmed publisher
    ..Indeed, cells lacking Sty1, the major fission yeast MAP kinase of the SAPK pathway, do not display Rad52 phosphorylation and have UVA induced ..
  8. Sansó M, Vargas Pérez I, Garcia P, Ayte J, Hidalgo E. Nuclear roles and regulation of chromatin structure by the stress-dependent MAP kinase Sty1 of Schizosaccharomyces pombe. Mol Microbiol. 2011;82:542-54 pubmed publisher
    ..The MAP kinase Sty1 and its substrate, the transcription factor Atf1, regulate diverse processes mainly at the nucleus...
  9. Tatebe H, Shiozaki K. Identification of Cdc37 as a novel regulator of the stress-responsive mitogen-activated protein kinase. Mol Cell Biol. 2003;23:5132-42 pubmed
    ..Here we report that Cdc37, an evolutionarily conserved kinase-specific chaperone, is a positive regulator of Spc1 SAPK in the fission yeast Schizosaccharomyces pombe...
  10. Buck V, Quinn J, Soto Pino T, Martin H, Saldanha J, Makino K, et al. Peroxide sensors for the fission yeast stress-activated mitogen-activated protein kinase pathway. Mol Biol Cell. 2001;12:407-19 pubmed
    ..We conclude that the transcriptional response to free radical attack is initiated by at least two distinct phospho-relay pathways in fission yeast. ..
  11. Reiter W, Watt S, Dawson K, Lawrence C, Bahler J, Jones N, et al. Fission yeast MAP kinase Sty1 is recruited to stress-induced genes. J Biol Chem. 2008;283:9945-56 pubmed publisher
    The stress-induced expression of many fission yeast genes is dependent upon the Sty1 mitogen-activated protein kinase (MAPK) and Atf1 transcription factor...
  12. Petersen J, Hagan I. Polo kinase links the stress pathway to cell cycle control and tip growth in fission yeast. Nature. 2005;435:507-12 pubmed
  13. Udagawa T, Nemoto N, Wilkinson C, Narashimhan J, Jiang L, Watt S, et al. Int6/eIF3e promotes general translation and Atf1 abundance to modulate Sty1 MAPK-dependent stress response in fission yeast. J Biol Chem. 2008;283:22063-75 pubmed publisher
    ..In agreement with this, Sty1 MAPK and its target transcription factor Atf1, which signal the CESR, are required for overcoming 3AT-induced ..
  14. Gao J, Davidson M, Wahls W. Phosphorylation-independent regulation of Atf1-promoted meiotic recombination by stress-activated, p38 kinase Spc1 of fission yeast. PLoS ONE. 2009;4:e5533 pubmed publisher
    ..Atf1 is phosphorylated by the conserved, p38-family kinase Spc1 (Sty1, Phh1) and is required for many Spc1-dependent stress responses, efficient sexual differentiation, and activation of ..
  15. Shiozaki K, Russell P. Cell-cycle control linked to extracellular environment by MAP kinase pathway in fission yeast. Nature. 1995;378:739-43 pubmed
    ..Fission yeast spc1- mutants have a G2 delay that is greatly exacerbated by growth in high osmolarity media and nutrient limitation...
  16. Yamada T, Mizuno K, Hirota K, Kon N, Wahls W, Hartsuiker E, et al. Roles of histone acetylation and chromatin remodeling factor in a meiotic recombination hotspot. EMBO J. 2004;23:1792-803 pubmed
    ..These results suggest that HATs and ADCRs cooperatively alter local chromatin structure, as in selective transcription activation, to activate meiotic recombination at M26 in a site-specific manner. ..
  17. Sansó M, Gogol M, Ayte J, Seidel C, Hidalgo E. Transcription factors Pcr1 and Atf1 have distinct roles in stress- and Sty1-dependent gene regulation. Eukaryot Cell. 2008;7:826-35 pubmed publisher
    The mitogen-activated protein kinase Sty1 is essential for the regulation of transcriptional responses that promote cell survival in response to different types of environmental stimuli in Schizosaccharomyces pombe...
  18. Gaits F, Russell P. Active nucleocytoplasmic shuttling required for function and regulation of stress-activated kinase Spc1/StyI in fission yeast. Mol Biol Cell. 1999;10:1395-407 pubmed
    ..In the fission yeast Schizosaccharomyces pombe, nuclear accumulation of the SAPK Spc1 (also known as StyI) requires activating phosphorylation catalyzed by the SAPK kinase Wis1; however, it is unknown ..
  19. Rodríguez Gabriel M, Russell P. Distinct signaling pathways respond to arsenite and reactive oxygen species in Schizosaccharomyces pombe. Eukaryot Cell. 2005;4:1396-402 pubmed
    ..A strain that lacks the transcription factor Zip1 has the opposite relationship. Spc1 (Sty1) mitogen-activated protein kinase (MAPK), a homologue of mammalian p38 MAPK, and the upstream MAPK kinase (MAPKK) ..
  20. Day A, Veal E. Hydrogen peroxide-sensitive cysteines in the Sty1 MAPK regulate the transcriptional response to oxidative stress. J Biol Chem. 2010;285:7505-16 pubmed publisher
    ..In the fission yeast Schizosaccharomyces pombe, the Sty1 MAPK is crucial for changes in gene expression that allow adaptation to many forms of environmental stress...
  21. Tatebe H, Shimada K, Uzawa S, Morigasaki S, Shiozaki K. Wsh3/Tea4 is a novel cell-end factor essential for bipolar distribution of Tea1 and protects cell polarity under environmental stress in S. pombe. Curr Biol. 2005;15:1006-15 pubmed
    ..In addition to its role in bipolar growth during the normal cell cycle, the Wsh3-Tea1 complex, together with the stress-signaling MAPK cascade, contributes to cell-polarity maintenance under stress conditions. ..
  22. Nguyen A, Lee A, Place W, Shiozaki K. Multistep phosphorelay proteins transmit oxidative stress signals to the fission yeast stress-activated protein kinase. Mol Biol Cell. 2000;11:1169-81 pubmed
    ..Here we present evidence that oxidative stress stimuli are transmitted by a multistep phosphorelay system to the Spc1/Sty1 stress-activated protein kinase in the fission yeast Schizosaccharomyces pombe...
  23. Nguyen A, Shiozaki K. Heat-shock-induced activation of stress MAP kinase is regulated by threonine- and tyrosine-specific phosphatases. Genes Dev. 1999;13:1653-63 pubmed
    ..Here, we report the heat shock regulation of the fission yeast Spc1 SAPK, a homolog of human p38 and budding yeast Hog1p...
  24. Shiozaki K, Russell P. Stress-activated protein kinase pathway in cell cycle control of fission yeast. Methods Enzymol. 1997;283:506-20 pubmed
  25. Degols G, Russell P. Discrete roles of the Spc1 kinase and the Atf1 transcription factor in the UV response of Schizosaccharomyces pombe. Mol Cell Biol. 1997;17:3356-63 pubmed
    ..In fission yeast cells, UV irradiation induces activation of Spc1 stress-activated protein kinase, which in turn phosphorylates the Atf1 bZIP transcription factor...
  26. Samejima I, Mackie S, Warbrick E, Weisman R, Fantes P. The fission yeast mitotic regulator win1+ encodes an MAP kinase kinase kinase that phosphorylates and activates Wis1 MAP kinase kinase in response to high osmolarity. Mol Biol Cell. 1998;9:2325-35 pubmed
    ..We discuss the cell cycle phenotype of the win1-1 cdc25-22 wee1-50 mutant and its suppression by wis genes. ..
  27. Shiozaki K, Russell P. Conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast. Genes Dev. 1996;10:2276-88 pubmed
    The stress-activated Wis1-Spc1 protein kinase cascade links mitotic control with environmental signals in Schizosaccharomyces pombe...
  28. Shieh J, Wilkinson M, Millar J. The Win1 mitotic regulator is a component of the fission yeast stress-activated Sty1 MAPK pathway. Mol Biol Cell. 1998;9:311-22 pubmed
    The fission yeast Sty1 mitogen-activated protein (MAP) kinase (MAPK) and its activator the Wis1 MAP kinase kinase (MAPKK) are required for cell cycle control, initiation of sexual differentiation, and protection against cellular stress...
  29. Cadou A, Couturier A, Le Goff C, Xie L, Paulson J, Le Goff X. The Kin1 kinase and the calcineurin phosphatase cooperate to link actin ring assembly and septum synthesis in fission yeast. Biol Cell. 2013;105:129-48 pubmed publisher
    ..We conclude that calcineurin and Kin1 activities must be tightly coordinated to link actomyosin ring assembly with septum synthesis and membrane closure and to ensure separation of the daughter cells. ..
  30. Opalko H, Moseley J. Dynamic regulation of Cdr1 kinase localization and phosphorylation during osmotic stress. J Biol Chem. 2017;292:18457-18468 pubmed publisher
    ..stress-induced hyperphosphorylation required both Cdr1 autophosphorylation and the stress-activated protein kinase Sty1. During osmotic stress, Cdr1 exited cortical nodes and localized in the cytoplasm...
  31. Yoshida J, Tani T. Hsp16p is required for thermotolerance in nuclear mRNA export in fission yeast Schizosaccharomyces pombe. Cell Struct Funct. 2005;29:125-38 pubmed
    ..We also found that Hsp16p, the expression of which is controlled by Atf1p, is involved in acquisition of thermotolerance in mRNA export in S. pombe. ..
  32. Calvo I, Gabrielli N, Iglesias Baena I, García Santamarina S, Hoe K, Kim D, et al. Genome-wide screen of genes required for caffeine tolerance in fission yeast. PLoS ONE. 2009;4:e6619 pubmed publisher these sensitive clones were involved in a number of cellular roles including the H(2)O(2)-induced Pap1 and Sty1 stress pathways, the integrity and calcineurin pathways, cell morphology and chromatin remodeling...
  33. Chung K, Won M, Lee S, Jang Y, Hoe K, Kim D, et al. Isolation of a novel gene from Schizosaccharomyces pombe: stm1+ encoding a seven-transmembrane loop protein that may couple with the heterotrimeric Galpha 2 protein, Gpa2. J Biol Chem. 2001;276:40190-201 pubmed
    ..factor, by Stm1 overexpression was enhanced in gpa2-deleted cells but was absent in a deletion mutant of sty1, a key protein kinase that links mitotic control with environmental signals and induces stress-responsive genes...
  34. Morigasaki S, Ikner A, Tatebe H, Shiozaki K. Response regulator-mediated MAPKKK heteromer promotes stress signaling to the Spc1 MAPK in fission yeast. Mol Biol Cell. 2013;24:1083-92 pubmed publisher
    The Spc1 mitogen-activated protein kinase (MAPK) cascade in fission yeast is activated by two MAPK kinase kinase (MAPKKK) paralogues, Wis4 and Win1, in response to multiple forms of environmental stress...
  35. Jara M, Vivancos A, Calvo I, Moldón A, Sansó M, Hidalgo E. The peroxiredoxin Tpx1 is essential as a H2O2 scavenger during aerobic growth in fission yeast. Mol Biol Cell. 2007;18:2288-95 pubmed
    ..C169S, lacking the resolving cysteine, can sustain aerobic growth, and we show that small reductants can modulate the activity of the mutant protein in vitro, probably by supplying a thiol group to substitute for cysteine 169. ..
  36. Rupes I, Jia Z, Young P. Ssp1 promotes actin depolymerization and is involved in stress response and new end take-off control in fission yeast. Mol Biol Cell. 1999;10:1495-510 pubmed
    ..ssp1 deletion causes stress sensitivity, reminiscent of defects in the stress-activated MAP kinase, Spc1; however, the two protein kinases do not act through the same pathway...
  37. Quinn J, Malakasi P, Smith D, Cheetham J, Buck V, Millar J, et al. Two-component mediated peroxide sensing and signal transduction in fission yeast. Antioxid Redox Signal. 2011;15:153-65 pubmed publisher
    ..For example, the peroxide-sensing Mak2 and Mak3 histidine kinases regulate H(2)O(2)-induced activation of the Sty1 stress-activated protein kinase pathway, and the Skn7-related response regulator transcription factor, Prr1, is ..
  38. Smith D, Toone W, Chen D, Bahler J, Jones N, Morgan B, et al. The Srk1 protein kinase is a target for the Sty1 stress-activated MAPK in fission yeast. J Biol Chem. 2002;277:33411-21 pubmed
    The fission yeast stress-activated Sty1/Spc1 MAPK pathway responds to a similar range of stresses as do the mammalian p38 and SAPK/JNK MAPK pathways...
  39. Navarro F, Nurse P. A systematic screen reveals new elements acting at the G2/M cell cycle control. Genome Biol. 2012;13:R36 pubmed publisher
    ..Despite extensive investigation of the G2/M control, our work has revealed new components of characterized pathways that regulate CDK Tyr15 phosphorylation and new components of novel mechanisms controlling mitotic entry. ..
  40. Stiefel J, Wang L, Kelly D, Janoo R, Seitz J, Whitehall S, et al. Suppressors of an adenylate cyclase deletion in the fission yeast Schizosaccharomyces pombe. Eukaryot Cell. 2004;3:610-9 pubmed
    ..triggers a cyclic AMP signal to activate protein kinase A (PKA), while glucose or nitrogen starvation activates the Spc1/Sty1 stress-activated protein kinase (SAPK)...
  41. Jang Y, Won M, Yoo H. Phosphorylations of Sds23/Psp1/Moc1 by stress-activated kinase and cAMP-dependent kinase are essential for regulating cell viability in prolonged stationary phase. Yeast. 2013;30:379-94 pubmed publisher
    ..We showed here that Sds23/Psp1/Moc1 was phosphorylated by both cAMP-dependent kinase and stress-activated MAP kinase Sty1 upon entry into stationary phase...
  42. Duncan C, Mata J. Cotranslational protein-RNA associations predict protein-protein interactions. BMC Genomics. 2014;15:298 pubmed publisher
    ..Similarly, we show that the cotranslational interaction between the Sty1 MAP kinase and the cip2 mRNA, which encodes an RNA-binding protein, predicts a complex between Sty1 and Cip2...
  43. Humphrey T, Enoch T. Sum1, a highly conserved WD-repeat protein, suppresses S-M checkpoint mutants and inhibits the osmotic stress cell cycle response in fission yeast. Genetics. 1998;148:1731-42 pubmed
    ..These results suggest that Suml interacts with the stress-activated MAP kinase pathway and raise the possibility that environmental conditions may influence the checkpoint response in fission yeast. ..
  44. Hálová L, Petersen J. Aurora promotes cell division during recovery from TOR-mediated cell cycle arrest by driving spindle pole body recruitment of Polo. J Cell Sci. 2011;124:3441-9 pubmed publisher
    ..Interestingly, the use of Ark1 to phosphorylate Plo1 and promote mitotic entry is dependent on the environment. ..
  45. Asp E, Sunnerhagen P. Mkp1 and Mkp2, two MAPKAP-kinase homologues in Schizosaccharomyces pombe, interact with the MAP kinase Sty1. Mol Genet Genomics. 2003;268:585-97 pubmed
    ..The Mkp1 protein is readily co-immunoprecipitated with Sty1 from S. pombe extracts; Mkp2 shows a weaker interaction with Sty1...
  46. Jeong H, Ozoe F, Tanaka K, Nakagawa T, Matsuda H, Kawamukai M. A novel gene, msa1, inhibits sexual differentiation in Schizosaccharomyces pombe. Genetics. 2004;167:77-91 pubmed
    ..Therefore, we suggest that the primary function of Msa1 is to negatively regulate sexual differentiation by controlling the expression of Ste11-regulated genes, possibly through the pheromone-signaling pathway. ..
  47. Sanchez Piris M, Posas F, Alemany V, Winge I, Hidalgo E, Bachs O, et al. The serine/threonine kinase Cmk2 is required for oxidative stress response in fission yeast. J Biol Chem. 2002;277:17722-7 pubmed
    ..Upon stress, Cmk2 was phosphorylated in vivo, and this phosphorylation was dependent on the stress-activated MAPK Sty1/Spc1. Co-precipitation assays demonstrated that Cmk2 binds Sty1...
  48. Bozonet S, Findlay V, Day A, Cameron J, Veal E, Morgan B. Oxidation of a eukaryotic 2-Cys peroxiredoxin is a molecular switch controlling the transcriptional response to increasing levels of hydrogen peroxide. J Biol Chem. 2005;280:23319-27 pubmed
    ..Indeed, in contrast to the previously described role for Tpx1 in the activation of the Sty1 stress-activated protein kinase by peroxide, we find that both catalytic cysteines of Tpx1 are required for Pap1 ..
  49. Alao J, Olesch J, Sunnerhagen P. Inhibition of type I histone deacetylase increases resistance of checkpoint-deficient cells to genotoxic agents through mitotic delay. Mol Cancer Ther. 2009;8:2606-15 pubmed publisher
    ..Effective use of these agents as chemosensitizers and radiosensitizers may require specific treatment schedules that circumvent their inhibition of cell cycle progression. ..
  50. Veal E, Findlay V, Day A, Bozonet S, Evans J, Quinn J, et al. A 2-Cys peroxiredoxin regulates peroxide-induced oxidation and activation of a stress-activated MAP kinase. Mol Cell. 2004;15:129-39 pubmed
    ..2-Cys Prx in Schizosaccharomyces pombe, is required for the peroxide-induced activation of the p38/JNK homolog, Sty1. Tpx1 activates Sty1, downstream of previously identified redox sensors, by a mechanism that involves formation of ..
  51. Bellini A, Girard P, Tessier L, Sage E, Francesconi S. Fission yeast Rad52 phosphorylation restrains error prone recombination pathways. PLoS ONE. 2014;9:e95788 pubmed publisher
    ..We have previously reported that fission yeast Rad52 is phosphorylated in a Sty1 dependent manner upon oxidative stress and in cells where the early step of HR is impaired because of lack of Rad51...
  52. Kim M, Lee W, Park J, Kim J, Jang Y, Seong R, et al. The stress-activated MAP kinase Sty1/Spc1 and a 3'-regulatory element mediate UV-induced expression of the uvi15(+) gene at the post-transcriptional level. Nucleic Acids Res. 2000;28:3392-402 pubmed
    ..Transcription run-on assays revealed that the rate of uvi15(+) transcription was increased 1.8-fold regardless of Sty1 when cells were UV irradiated. The half-life of uvi15(+) mRNA was also increased 1...
  53. Asp E, Nilsson D, Sunnerhagen P. Fission yeast mitogen-activated protein kinase Sty1 interacts with translation factors. Eukaryot Cell. 2008;7:328-38 pubmed
    ..We have investigated the stress-activated MAPK from fission yeast, Sty1, and its downstream protein kinase, Mkp1/Srk1, for physically associated proteins using tandem affinity ..
  54. Schonbrun M, Laor D, López Maury L, Bahler J, Kupiec M, Weisman R. TOR complex 2 controls gene silencing, telomere length maintenance, and survival under DNA-damaging conditions. Mol Cell Biol. 2009;29:4584-94 pubmed publisher
    ..These data place TOR proteins in line with other PIKK members, such as ATM and ATR, as guardians of genome stability. ..
  55. Zuin A, Castellano Esteve D, Ayte J, Hidalgo E. Living on the edge: stress and activation of stress responses promote lifespan extension. Aging (Albany NY). 2010;2:231-7 pubmed
    ..Studies in Schizosaccharomyces pombe have recently showed that the Sty1 MAP kinase, known to be activated by hydrogen peroxide and other cellular stressors, plays a pivotal role in ..
  56. Berlanga J, Rivero D, Martin R, Herrero S, Moreno S, de Haro C. Role of mitogen-activated protein kinase Sty1 in regulation of eukaryotic initiation factor 2alpha kinases in response to environmental stress in Schizosaccharomyces pombe. Eukaryot Cell. 2010;9:194-207 pubmed publisher
    The mitogen-activated protein kinase (MAPK) Sty1 is essential for the regulation of transcriptional responses that promote cell survival in response to different types of environmental stimuli in Schizosaccharomyces pombe...
  57. Karagiannis J, Saleki R, Young P. The pub1 E3 ubiquitin ligase negatively regulates leucine uptake in response to NH(4)(+) in fission yeast. Curr Genet. 1999;35:593-601 pubmed
    ..and the inactivating effect of NH(4)(+) on leucine transport, seen in pub1-1 point mutants, becomes as complete as seen in pub1Delta backgrounds when cells have concomitantly lost the function of the spc1 stress-activated MAPK.
  58. Chung K, Won M, Lee J, Ahn J, Hoe K, Kim D, et al. Yeast-based screening to identify modulators of G-protein signaling using uncontrolled cell division cycle by overexpression of Stm1. J Biotechnol. 2007;129:547-54 pubmed
    ..b>Sty1 and Gpa2 seem to play important roles for Stm1 to deliver starvation signal to induce downstream function...
  59. Vázquez B, Soto T, del Dedo J, Franco A, Vicente J, Hidalgo E, et al. Distinct biological activity of threonine monophosphorylated MAPK isoforms during the stress response in fission yeast. Cell Signal. 2015;27:2534-42 pubmed publisher
    ..In the fission yeast Schizosaccharomyces pombe MAPKs Sty1 and Pmk1 control multiple aspects of fission yeast life cycle, including morphogenesis, cell cycle, and cellular ..
  60. Rodríguez Gabriel M, Burns G, McDonald W, Martin V, Yates J, Bahler J, et al. RNA-binding protein Csx1 mediates global control of gene expression in response to oxidative stress. EMBO J. 2003;22:6256-66 pubmed
    Fission yeast Spc1 (Sty1), a stress-activated mitogen-activated protein kinase (MAPK) homologous to human p38, orchestrates global changes in gene expression in response to diverse forms of cytotoxic stress...
  61. Grimard V, Massier J, Richter D, Schwudke D, Kalaidzidis Y, Fava E, et al. siRNA screening reveals JNK2 as an evolutionary conserved regulator of triglyceride homeostasis. J Lipid Res. 2008;49:2427-40 pubmed publisher
    ..Similar control of the level of TGs and lipid droplets was observed for its Schizosaccharomyces pombe homolog, Sty1, suggesting an evolutionary conserved function of mitogen-activated protein kinases in the regulation of lipid ..
  62. López Avilés S, Lambea E, Moldón A, Grande M, Fajardo A, Rodríguez Gabriel M, et al. Activation of Srk1 by the mitogen-activated protein kinase Sty1/Spc1 precedes its dissociation from the kinase and signals its degradation. Mol Biol Cell. 2008;19:1670-9 pubmed publisher
    ..The Schizosaccharomyces pombe SAPK Sty1/Spc1 orchestrates general changes in gene expression in response to diverse forms of cytotoxic stress...
  63. Kawasaki Y, Nagao K, Nakamura T, Yanagida M. Fission yeast MAP kinase is required for the increased securin-separase interaction that rescues separase mutants under stresses. Cell Cycle. 2006;5:1831-9 pubmed
    ..The stresses caused a temporal arrest in the cell number increase, and this arrest was dependent on Spc1/Sty1 but not Rad3 and Mad2...
  64. Kjaerulff S, Lautrup Larsen I, Truelsen S, Pedersen M, Nielsen O. Constitutive activation of the fission yeast pheromone-responsive pathway induces ectopic meiosis and reveals ste11 as a mitogen-activated protein kinase target. Mol Cell Biol. 2005;25:2045-59 pubmed
  65. Mutavchiev D, Leda M, Sawin K. Remodeling of the Fission Yeast Cdc42 Cell-Polarity Module via the Sty1 p38 Stress-Activated Protein Kinase Pathway. Curr Biol. 2016;26:2921-2928 pubmed publisher
    ..Our results place MAP kinase Sty1 as an important physiological regulator of the Cdc42 polarity module.
  66. Sengar A, Markley N, Marini N, Young D. Mkh1, a MEK kinase required for cell wall integrity and proper response to osmotic and temperature stress in Schizosaccharomyces pombe. Mol Cell Biol. 1997;17:3508-19 pubmed
    ..Our results also suggest that Mkh1 and Pck2 act independently to maintain cell wall integrity, cell morphology, and salt resistance but act in opposition to regulate filamentous growth. ..
  67. Zhou X, Ma Y, Kato T, Kuno T. A measurable activation of the bZIP transcription factor Atf1 in a fission yeast strain devoid of stress-activated and cell integrity mitogen-activated protein kinase (MAPK) activities. J Biol Chem. 2012;287:23434-9 pubmed publisher
    In Schizosaccharomyces pombe, the stress-activated Sty1 MAPK pathway is essential for cell survival under stress conditions...