Gene Symbol: ste11
Description: transcription factor Ste11
Alias: aff1, stex, transcription factor Ste11
Species: fission yeast

Top Publications

  1. Sipiczki M. The role of sterility genes (ste and aff) in the initiation of sexual development in Schizosaccharomyces pombe. Mol Gen Genet. 1988;213:529-34 pubmed
    ..A new gene, aff1, whose defective allele suppresses the pat1-114-provoked haploid sporulation and arrest of vegetative growth is ..
  2. Kato T, Okazaki K, Murakami H, Stettler S, Fantes P, Okayama H. Stress signal, mediated by a Hog1-like MAP kinase, controls sexual development in fission yeast. FEBS Lett. 1996;378:207-12 pubmed
    ..In phh1 disruptant, nitrogen starvation-induced expression of ste11+, a key controller of sexual differentiation, is markedly diminished...
  3. Oowatari Y, Jeong H, Tanae K, Nakagawa T, Kawamukai M. Regulation and role of an RNA-binding protein Msa2 in controlling the sexual differentiation of fission yeast. Curr Genet. 2011;57:191-200 pubmed publisher
    ..that negatively regulates sexual differentiation of fission yeast Schizosaccharomyces pombe by repressing the Ste11-regulated genes...
  4. Li P, McLeod M. Molecular mimicry in development: identification of ste11+ as a substrate and mei3+ as a pseudosubstrate inhibitor of ran1+ kinase. Cell. 1996;87:869-80 pubmed
    ..Here, we show that the ste11+ transcription factor is a substrate for ran1+ in vitro and that this reaction is directly inhibited by mei3+...
  5. Alvarez B, Moreno S. Fission yeast Tor2 promotes cell growth and represses cell differentiation. J Cell Sci. 2006;119:4475-85 pubmed
    ..This newly revealed function of Tor2 appears to operate by interfering with the functions of the transcription factor Ste11 and the meiosis-promoting RNA-binding protein Mei2...
  6. Mata J, Bahler J. Global roles of Ste11p, cell type, and pheromone in the control of gene expression during early sexual differentiation in fission yeast. Proc Natl Acad Sci U S A. 2006;103:15517-22 pubmed
    ..Given the divergent mechanisms regulating cell type-specific gene expression, our results highlight the plasticity of regulatory circuits, which evolve to allow adaptation to changing environments and lifestyles. ..
  7. Kunitomo H, Higuchi T, Iino Y, Yamamoto M. A zinc-finger protein, Rst2p, regulates transcription of the fission yeast ste11(+) gene, which encodes a pivotal transcription factor for sexual development. Mol Biol Cell. 2000;11:3205-17 pubmed
    Schizosaccharomyces pombe ste11 encodes a high-mobility group family transcriptional activator that is pivotal in sexual development...
  8. Valbuena N, Moreno S. TOR and PKA pathways synergize at the level of the Ste11 transcription factor to prevent mating and meiosis in fission yeast. PLoS ONE. 2010;5:e11514 pubmed publisher
    ..operate coordinately to negatively regulate sexual differentiation by inhibiting the nuclear accumulation of the Ste11 transcription factor...
  9. Kjaerulff S, Andersen N, Borup M, Nielsen O. Cdk phosphorylation of the Ste11 transcription factor constrains differentiation-specific transcription to G1. Genes Dev. 2007;21:347-59 pubmed
    ..In fission yeast, induction of the transcription factor Ste11 triggers sexual differentiation. We find that Ste11 is only active in G(1) when Cdk activity is low...

More Information


  1. Kitamura K, Katayama S, Dhut S, Sato M, Watanabe Y, Yamamoto M, et al. Phosphorylation of Mei2 and Ste11 by Pat1 kinase inhibits sexual differentiation via ubiquitin proteolysis and 14-3-3 protein in fission yeast. Dev Cell. 2001;1:389-99 pubmed
    ..yeast Pat1 kinase inhibits sexual differentiation by phosphorylating the meiotic inducer Mei2 and the transcription factor Ste11. Here, we show how Pat1 downregulates these proteins...
  2. Sugimoto A, Iino Y, Maeda T, Watanabe Y, Yamamoto M. Schizosaccharomyces pombe ste11+ encodes a transcription factor with an HMG motif that is a critical regulator of sexual development. Genes Dev. 1991;5:1990-9 pubmed
    Schizosaccharomyces pombe ste11 encodes a member of the family of HMG-box proteins. Its transcript is induced in response to nitrogen starvation and a concomitant decrease of the intracellular cAMP level...
  3. Sukegawa Y, Yamashita A, Yamamoto M. The fission yeast stress-responsive MAPK pathway promotes meiosis via the phosphorylation of Pol II CTD in response to environmental and feedback cues. PLoS Genet. 2011;7:e1002387 pubmed publisher
    ..Phosphorylation of CTD Ser-2 is essential to enable the robust transcription of ste11, which encodes an HMG-type transcription factor that regulates the expression of mei2 and other genes necessary ..
  4. Kjaerulff S, Lautrup Larsen I, Truelsen S, Pedersen M, Nielsen O. Constitutive activation of the fission yeast pheromone-responsive pathway induces ectopic meiosis and reveals ste11 as a mitogen-activated protein kinase target. Mol Cell Biol. 2005;25:2045-59 pubmed
    ..We find that the Ste11 transcription factor becomes constitutively expressed in these cells and that the expression of pheromone-..
  5. Fukushima K, Tanaka Y, Nabeshima K, Yoneki T, Tougan T, Tanaka S, et al. Dmc1 of Schizosaccharomyces pombe plays a role in meiotic recombination. Nucleic Acids Res. 2000;28:2709-16 pubmed
    ..Induction of the bicistronic transcript is under the control of a meiosis-specific transcription factor, Ste11. Disruption of both dmc1(+) and rad24(+) had no effect on mitosis or spore formation, and dmc1Delta cells ..
  6. van Beest M, Dooijes D, van de Wetering M, Kjaerulff S, Bonvin A, Nielsen O, et al. Sequence-specific high mobility group box factors recognize 10-12-base pair minor groove motifs. J Biol Chem. 2000;275:27266-73 pubmed
    ..However, alignment of promoter elements controlled by the yeast genes ste11 and Rox1 has indicated strict conservation of a larger DNA motif...
  7. Gupta D, Paul S, Oowatari Y, Matsuo Y, Kawamukai M. Multistep regulation of protein kinase A in its localization, phosphorylation and binding with a regulatory subunit in fission yeast. Curr Genet. 2011;57:353-65 pubmed publisher
    ..Rst2 and Ste11 proteins were induced and localized to the nucleus of sam5 and sam7 mutants even under rich glucose conditions, ..
  8. Nakase Y, Fukuda K, Chikashige Y, Tsutsumi C, Morita D, Kawamoto S, et al. A defect in protein farnesylation suppresses a loss of Schizosaccharomyces pombe tsc2+, a homolog of the human gene predisposing to tuberous sclerosis complex. Genetics. 2006;173:569-78 pubmed
    ..On the basis of these results, we discuss TSC pathology and possible improvement in chemotherapy for TSC. ..
  9. Shinozaki Yabana S, Watanabe Y, Yamamoto M. Novel WD-repeat protein Mip1p facilitates function of the meiotic regulator Mei2p in fission yeast. Mol Cell Biol. 2000;20:1234-42 pubmed
    ..These results suggest that Mip1p assists functional expression of a number of proteins required for proliferation and sexual development in fission yeast. ..
  10. Sugiyama T, Sugioka Sugiyama R, Hada K, Niwa R. Rhn1, a nuclear protein, is required for suppression of meiotic mRNAs in mitotically dividing fission yeast. PLoS ONE. 2012;7:e42962 pubmed publisher
  11. Helmlinger D, Marguerat S, Villen J, Gygi S, Bahler J, Winston F. The S. pombe SAGA complex controls the switch from proliferation to sexual differentiation through the opposing roles of its subunits Gcn5 and Spt8. Genes Dev. 2008;22:3184-95 pubmed publisher
    ..First, in nutrient-rich conditions, the SAGA histone acetyltransferase Gcn5 represses ste11(+), which encodes the master regulator of the mating pathway...
  12. Kim L, Hoe K, Yu Y, Yeon J, Maeng P. The fission yeast GATA factor, Gaf1, modulates sexual development via direct down-regulation of ste11+ expression in response to nitrogen starvation. PLoS ONE. 2012;7:e42409 pubmed publisher
    ..Here, we report that Gaf1 functions as a negatively acting transcription factor of ste11(+), delaying the entrance of cells exposed to transient nitrogen starvation into the meiotic cycle...
  13. Matia González A, Sotelo J, Rodríguez Gabriel M. The RNA binding protein Csx1 promotes sexual differentiation in Schizosaccharomyces pombe. PLoS ONE. 2012;7:e30067 pubmed publisher
    ..One of the key regulatory proteins in fission yeast sexual differentiation is the transcription factor Ste11. Ste11 regulates the transcription of many genes required for the initial steps of conjugation and ..
  14. Materne P, Vazquez E, Sanchez M, Yague Sanz C, Anandhakumar J, Migeot V, et al. Histone H2B ubiquitylation represses gametogenesis by opposing RSC-dependent chromatin remodeling at the ste11 master regulator locus. elife. 2016;5: pubmed publisher
    In fission yeast, the ste11 gene encodes the master regulator initiating the switch from vegetative growth to gametogenesis...
  15. Pereira P, Jones N. The RGS domain-containing fission yeast protein, Rgs1p, regulates pheromone signalling and is required for mating. Genes Cells. 2001;6:789-802 pubmed
    ..The Ste11 protein is a key regulator of this differentiation pathway, activating the transcription of mating and meiotic ..
  16. Anandhakumar J, Fauquenoy S, Materne P, Migeot V, Hermand D. Regulation of entry into gametogenesis by Ste11: the endless game. Biochem Soc Trans. 2013;41:1673-8 pubmed publisher
    ..The ste11 gene was isolated more than 20 years ago by the Yamamoto laboratory as a suppressor of the uncontrolled meiosis ..
  17. Aono T, Yanai H, Miki F, Davey J, Shimoda C. Mating pheromone-induced expression of the mat1-Pm gene of Schizosaccharomyces pombe: identification of signalling components and characterization of upstream controlling elements. Yeast. 1994;10:757-70 pubmed
    ..of a TATA-like box and contains a TR-box (TTCTTTGTTY) motif which is the recognition site of a putative transcription factor Ste11. Point mutations in the TR-box motif abolished the expression of mat1-Pm/lacZ...
  18. Kjaerulff S, Dooijes D, Clevers H, Nielsen O. Cell differentiation by interaction of two HMG-box proteins: Mat1-Mc activates M cell-specific genes in S.pombe by recruiting the ubiquitous transcription factor Ste11 to weak binding sites. EMBO J. 1997;16:4021-33 pubmed
    ..This regulation requires two HMG-box proteins: the ubiquitous Ste11 transcription factor and the M cell-controlling protein Mat1-Mc...
  19. Szilagyi Z, Grallert A, Nemeth N, Sipiczki M. The Schizosaccharomyces pombe genes sep10 and sep11 encode putative general transcriptional regulators involved in multiple cellular processes. Mol Genet Genomics. 2002;268:553-62 pubmed
    ..Overexpression of aff1/ste11, a pivotal regulator of sexual development, suppresses the sterility of sep10 (-) cells, which suggests that sep10 ..
  20. Styrkarsdottir U, Egel R, Nielsen O. Functional conservation between Schizosaccharomyces pombe ste8 and Saccharomyces cerevisiae STE11 protein kinases in yeast signal transduction. Mol Gen Genet. 1992;235:122-30 pubmed
    ..Furthermore, ste8+ is highly homologous to the Saccharomyces cerevisiae STE11 gene, which functions in signal transduction in budding yeast. Expression of the S. cerevisiae STE11 gene in S...
  21. Valbuena N, Moreno S. AMPK phosphorylation by Ssp1 is required for proper sexual differentiation in fission yeast. J Cell Sci. 2012;125:2655-64 pubmed publisher
    ..We also show that AMPK is important in the promotion of the nuclear localization and accumulation of the Ste11 transcription factor...
  22. Kjaerulff S, Davey J, Nielsen O. Analysis of the structural genes encoding M-factor in the fission yeast Schizosaccharomyces pombe: identification of a third gene, mfm3. Mol Cell Biol. 1994;14:3895-905 pubmed
    ..Their transcription is limited to M cells and requires the mat1-Mc and ste11 gene products...
  23. Christensen P, Davey J, Nielsen O. The Schizosaccharomyces pombe mam1 gene encodes an ABC transporter mediating secretion of M-factor. Mol Gen Genet. 1997;255:226-36 pubmed
    ..We show that STE6 can also mediate secretion of M-factor in S. pombe...