Gene Symbol: stc1
Description: LIM-like protein Stc1
Alias: LIM-like protein Stc1
Species: fission yeast
Bayne E, White S, Kagansky A, Bijos D, Sanchez Pulido L, Hoe K, et al
. Stc1: a critical link between RNAi and chromatin modification required for heterochromatin integrity. Cell. 2010;140:666-77 pubmed publisher
..We have identified a LIM domain protein, Stc1, that is required for centromeric heterochromatin integrity...
Buscaino A, White S, Houston D, Lejeune E, Simmer F, de Lima Alves F, et al
. Raf1 Is a DCAF for the Rik1 DDB1-like protein and has separable roles in siRNA generation and chromatin modification. PLoS Genet. 2012;8:e1002499 pubmed publisher
..Thus the association of a DCAF, Raf1, with its adaptor, Rik1, is required for histone methylation and to allow RNAi to signal to chromatin. ..
Mata J, Lyne R, Burns G, Bahler J. The transcriptional program of meiosis and sporulation in fission yeast. Nat Genet. 2002;32:143-7 pubmed
Reddy B, Wang Y, Niu L, Higuchi E, Marguerat S, B hler J, et al
. Elimination of a specific histone H3K14 acetyltransferase complex bypasses the RNAi pathway to regulate pericentric heterochromatin functions. Genes Dev. 2011;25:214-9 pubmed publisher
..We further reveal that reducing RNA polymerase II recruitment to pericentric regions is essential for maintaining heterochromatin in the absence of RNAi...
Rougemaille M, Braun S, Coyle S, Dumesic P, Garcia J, Isaac R, et al
. Ers1 links HP1 to RNAi. Proc Natl Acad Sci U S A. 2012;109:11258-63 pubmed publisher
..Through the interactions described here, Ers1 may promote RNAi by tethering the corresponding enzyme complexes to HP1-coated chromatin, thereby placing them in proximity to the nascent noncoding RNA substrate...
He C, Pillai S, Taglini F, Li F, Ruan K, Zhang J, et al
. Structural analysis of Stc1 provides insights into the coupling of RNAi and chromatin modification. Proc Natl Acad Sci U S A. 2013;110:E1879-88 pubmed publisher
..A key question is how the RNAi and chromatin modification machineries are connected. Stc1 is a small protein recently shown to associate with both Ago1 and CLRC and to play a pivotal role in mediating the ..
Kuscu C, Zaratiegui M, Kim H, Wah D, Martienssen R, Schalch T, et al
. CRL4-like Clr4 complex in Schizosaccharomyces pombe depends on an exposed surface of Dos1 for heterochromatin silencing. Proc Natl Acad Sci U S A. 2014;111:1795-800 pubmed publisher
..Dos2 and Stc1 have been proposed to be part of the complex but do not bear similarity to canonical ubiquitin ligase components...