Gene Symbol: srw1
Description: CDK inhibitor Srw1
Alias: ste9, CDK inhibitor Srw1
Species: fission yeast

Top Publications

  1. Izawa D, Goto M, Yamashita A, Yamano H, Yamamoto M. Fission yeast Mes1p ensures the onset of meiosis II by blocking degradation of cyclin Cdc13p. Nature. 2005;434:529-33 pubmed
    ..We therefore propose that Mes1p has a key function in saving a sufficient level of MPF (M-phase-promoting factor) activity required for the execution of MII. ..
  2. Blanco M, Sanchez Diaz A, de Prada J, Moreno S. APC(ste9/srw1) promotes degradation of mitotic cyclins in G(1) and is inhibited by cdc2 phosphorylation. EMBO J. 2000;19:3945-55 pubmed
    Fission yeast ste9/srw1 is a WD-repeat protein highly homologous to budding yeast Hct1/Cdh1 and Drosophila Fizzy-related that are involved in activating APC/C (anaphase-promoting complex/cyclosome)...
  3. Yamada H, Matsumoto S, Matsumoto T. High dosage expression of a zinc finger protein, Grt1, suppresses a mutant of fission yeast slp1(+), a homolog of CDC20/p55CDC/Fizzy. J Cell Sci. 2000;113 ( Pt 22):3989-99 pubmed
    ..Slp1, a WD-repeat protein, is a putative activator for APC in fission yeast. With another WD- repeat protein, Ste9/Srw1, it is thought to promote the proteolysis in a substrate-specific manner...
  4. Alvarez B, Blanco M, Moreno S. The fission yeast APC activator Ste9 is regulated by mRNA decay. Cell Cycle. 2006;5:865-8 pubmed
    Fission yeast Ste9/Srw1 is a family member of the Fizzy-related APC activators that promote the ubiquitination and degradation of mitotic cyclins and other substrates at the end of mitosis and G1...
  5. Aono T, Yanai H, Miki F, Davey J, Shimoda C. Mating pheromone-induced expression of the mat1-Pm gene of Schizosaccharomyces pombe: identification of signalling components and characterization of upstream controlling elements. Yeast. 1994;10:757-70 pubmed
    ..Point mutations in the TR-box motif abolished the expression of mat1-Pm/lacZ. Almost no expression of mat1-Pm was detected in a ste11 deletion mutant, whereas overproduction of Ste11 greatly increased the expression. ..
  6. Kitamura K, Maekawa H, Shimoda C. Fission yeast Ste9, a homolog of Hct1/Cdh1 and Fizzy-related, is a novel negative regulator of cell cycle progression during G1-phase. Mol Biol Cell. 1998;9:1065-80 pubmed
    ..The role of ste9(+) in the cell cycle progression was investigated...
  7. Kominami K, Seth Smith H, Toda T. Apc10 and Ste9/Srw1, two regulators of the APC-cyclosome, as well as the CDK inhibitor Rum1 are required for G1 cell-cycle arrest in fission yeast. EMBO J. 1998;17:5388-99 pubmed
    ..Three loci (apc10, ste9/srw1 and rum1) were identified...
  8. Sakai T. Cdk inhibitor ste9p/srw1p is involved in response to protein synthesis inhibition in fission yeast. Biochem Biophys Res Commun. 2004;315:984-90 pubmed
    ..It is suggested that cell cycle be positively controlled in an ste9-dependent manner before essential factors for viability and other important functions are exhausted when protein ..
  9. Alvarez B, Moreno S. Fission yeast Tor2 promotes cell growth and represses cell differentiation. J Cell Sci. 2006;119:4475-85 pubmed
    ..Thus, our data reveal a unique regulatory function of the Tor pathway - ensuring that growth and cell differentiation become mutually exclusive and that the choice between them depends on environmental conditions. ..

More Information


  1. Trickey M, Fujimitsu K, Yamano H. Anaphase-promoting complex/cyclosome-mediated proteolysis of Ams2 in the G1 phase ensures the coupling of histone gene expression to DNA replication in fission yeast. J Biol Chem. 2013;288:928-37 pubmed publisher
    ..Ubiquitylation and destruction of Ams2 is dependent upon a coactivator Cdh1/Ste9 and the KEN box in the C terminus of Ams2...
  2. Sipiczki M. The role of sterility genes (ste and aff) in the initiation of sexual development in Schizosaccharomyces pombe. Mol Gen Genet. 1988;213:529-34 pubmed
    ..Those defective in genes ste1 to ste4 and ste7 to ste9 are also deficient in meiosis and sporulation...
  3. Yamaguchi S, Okayama H, Nurse P. Fission yeast Fizzy-related protein srw1p is a G(1)-specific promoter of mitotic cyclin B degradation. EMBO J. 2000;19:3968-77 pubmed
    ..We propose that this phosphorylation targets srw1p for proteolysis and inhibits its activity to promote cdc13p turnover. ..
  4. Kimata Y, Kitamura K, Fenner N, Yamano H. Mes1 controls the meiosis I to meiosis II transition by distinctly regulating the anaphase-promoting complex/cyclosome coactivators Fzr1/Mfr1 and Slp1 in fission yeast. Mol Biol Cell. 2011;22:1486-94 pubmed publisher
    ..Thus Mes1 interacts with two coactivators in a different way to control the activity of the APC/C required for the meiosis I/meiosis II transition...
  5. Yamaguchi S, Murakami H, Okayama H. A WD repeat protein controls the cell cycle and differentiation by negatively regulating Cdc2/B-type cyclin complexes. Mol Biol Cell. 1997;8:2475-86 pubmed
    ..We recently isolated a new gene named srw1(+), capable of encoding a WD repeat protein, as a multicopy suppressor of hyperactivated p34(cdc2)...
  6. Chu Z, Eshaghi M, Poon S, Liu J. A Cds1-mediated checkpoint protects the MBF activator Rep2 from ubiquitination by anaphase-promoting complex/cyclosome-Ste9 at S-phase arrest in fission yeast. Mol Cell Biol. 2009;29:4959-70 pubmed publisher
    ..b>Ste9 can be phosphorylated by the checkpoint kinase Cds1 in vitro, and its inhibition/phosphorylation at S-phase arrest ..
  7. Rodr guez S nchez L, Rodr guez L pez M, Garc a Z, Tenorio G mez M, Schvartzman J, Krimer D, et al. The fission yeast rDNA-binding protein Reb1 regulates G1 phase under nutritional stress. J Cell Sci. 2011;124:25-34 pubmed publisher
    ..We found that Schizosaccharomyces pombe Reb1 also upregulates transcription of the ste9(+) gene that is required for nitrogen-starvation-induced growth arrest with a G1 DNA content and sexual ..