Gene Symbol: sck2
Description: serine/threonine protein kinase Sck2
Alias: serine/threonine protein kinase Sck2
Species: fission yeast
Fujita M, Yamamoto M. S. pombe sck2+, a second homologue of S. cerevisiae SCH9 in fission yeast, encodes a putative protein kinase closely related to PKA in function. Curr Genet. 1998;33:248-54 pubmed
The Schizosaccharomyces pombe sck2 gene, originally identified as SPAC22E12.14c in the genome-sequencing project, encodes a putative protein kinase highly similar to Saccharomyces cerevisiae Sch9p and S...
Roux A, Quissac A, Chartrand P, Ferbeyre G, Rokeach L. Regulation of chronological aging in Schizosaccharomyces pombe by the protein kinases Pka1 and Sck2. Aging Cell. 2006;5:345-57 pubmed
..serine/threonine cAMP-activated protein kinase Pka1 and the second pathway comprises the serine/threonine kinase Sck2, a homologue of Saccharomyces cerevisiae SCH9...
Zuin A, Castellano Esteve D, Ayte J, Hidalgo E. Living on the edge: stress and activation of stress responses promote lifespan extension. Aging (Albany NY). 2010;2:231-7 pubmed
..Importantly enough, the lifespan promotion exerted by deletion of the pka1 or sck2 genes, inactivating the two main nutrient-responsive pathways, is dependent on the presence of a functional Sty1 ..
Wang L, Griffiths K, Zhang Y, Ivey F, Hoffman C. Schizosaccharomyces pombe adenylate cyclase suppressor mutations suggest a role for cAMP phosphodiesterase regulation in feedback control of glucose/cAMP signaling. Genetics. 2005;171:1523-33 pubmed
..These results suggest that PDE activity in S. pombe may be coordinately regulated with adenylate cyclase activity as part of the feedback regulation mechanism to limit the cAMP response to glucose detection. ..
Tanae K, Horiuchi T, Matsuo Y, Katayama S, Kawamukai M. Histone chaperone Asf1 plays an essential role in maintaining genomic stability in fission yeast. PLoS ONE. 2012;7:e30472 pubmed publisher
..Taken together, these results clearly indicate that Asf1 plays an essential role in maintaining genomic stability in S. pombe...
Nakashima A, Otsubo Y, Yamashita A, Sato T, Yamamoto M, Tamanoi F. Psk1, an AGC kinase family member in fission yeast, is directly phosphorylated and controlled by TORC1 and functions as S6 kinase. J Cell Sci. 2012;125:5840-9 pubmed publisher
..Here we report that in fission yeast, three AGC kinase family members, named Psk1, Sck1 and Sck2, which exhibit high homology with human S6K1, are phosphorylated under nutrient-rich conditions and are ..
Becker M, Muller S, Nellen W, Jurkowski T, Jeltsch A, Ehrenhofer Murray A. Pmt1, a Dnmt2 homolog in Schizosaccharomyces pombe, mediates tRNA methylation in response to nutrient signaling. Nucleic Acids Res. 2012;40:11648-58 pubmed publisher
..Furthermore, this induction required the serine/threonine kinase Sck2, but not the kinases Sck1, Pka1 or Tor1 and was independent of glucose signaling...
Kim J, Kim E, López Maury L, BÃ¤hler J, Roe J. A metabolic strategy to enhance long-term survival by Phx1 through stationary phase-specific pyruvate decarboxylases in fission yeast. Aging (Albany NY). 2014;6:587-601 pubmed
..Introduction of Î”phx1 mutation compromised the long-lived phenotypes of Î”pka1 and Î”sck2 mutants that are devoid of pro-aging kinases of nutrient-signalling pathways, and of the Î”pyp1 mutant with ..
Chica N, RozalÃ©n A, PÃ©rez Hidalgo L, Rubio A, Novak B, Moreno S. Nutritional Control of Cell Size by the Greatwall-Endosulfine-PP2AÂ·B55 Pathway. Curr Biol. 2016;26:319-30 pubmed publisher
..Given the conservation of this pathway, it is reasonable to assume that this mechanism operates in higher eukaryotes, as well. ..