Genomes and Genes
Gene Symbol: rpn10
Description: 19S proteasome regulatory subunit Rpn10
Alias: pus1, 19S proteasome regulatory subunit Rpn10
Species: fission yeast
- Sha Z, Yen H, Scheel H, Suo J, Hofmann K, Chang E. Isolation of the Schizosaccharomyces pombe proteasome subunit Rpn7 and a structure-function study of the proteasome-COP9-initiation factor domain. J Biol Chem. 2007;282:32414-23 pubmed..Disruption of such an arrangement in the PCI domain may substantially inactivate many PCI proteins and block their binding to other proteins. ..
- Paraskevopoulos K, Kriegenburg F, Tatham M, RÃ¶sner H, Medina B, Larsen I, et al. Dss1 is a 26S proteasome ubiquitin receptor. Mol Cell. 2014;56:453-61 pubmed publisher..The proteasome subunits Rpn10 and Rpn13 are known to bind ubiquitin, but genetic and biochemical data suggest the existence of at least one ..
- Hartmann Petersen R, Wallace M, Hofmann K, Koch G, Johnsen A, Hendil K, et al. The Ubx2 and Ubx3 cofactors direct Cdc48 activity to proteolytic and nonproteolytic ubiquitin-dependent processes. Curr Biol. 2004;14:824-8 pubmed..Our genetic analyses revealed that Ubx3/p47 functionally parallels a substrate receptor of the 26S proteasome, Pus1/Rpn10, indicating that the Cdc48-Ubx3 complex is involved in delivering substrates to the 26S proteasome.
- Boehringer J, Riedinger C, Paraskevopoulos K, Johnson E, Lowe E, Khoudian C, et al. Structural and functional characterization of Rpn12 identifies residues required for Rpn10 proteasome incorporation. Biochem J. 2012;448:55-65 pubmed publisher..essential component of the 19S regulatory particle and plays a role in recruiting the extrinsic ubiquitin receptor Rpn10. In the present paper we report the crystal structure of Rpn12, a proteasomal PCI-domain-containing protein...