Gene Symbol: rhp23
Description: UV excision repair protein rhp23
Alias: UV excision repair protein rhp23
Species: fission yeast

Top Publications

  1. Wilkinson C, Seeger M, Hartmann Petersen R, Stone M, Wallace M, Semple C, et al. Proteins containing the UBA domain are able to bind to multi-ubiquitin chains. Nat Cell Biol. 2001;3:939-43 pubmed
    ..These two proteins are implicated, along with the fission-yeast Pus1(S5a/Rpn10) subunit of the 26 S proteasome, in the recognition and turnover of substrates by this proteolytic complex. ..
  2. Elder R, Song X, Chen M, Hopkins K, Lieberman H, Zhao Y. Involvement of rhp23, a Schizosaccharomyces pombe homolog of the human HHR23A and Saccharomyces cerevisiae RAD23 nucleotide excision repair genes, in cell cycle control and protein ubiquitination. Nucleic Acids Res. 2002;30:581-91 pubmed
    A functional homolog (rhp23) of human HHR23A and Saccharomyces cerevisiae RAD23 was cloned from the fission yeast Schizosaccharomyces pombe and characterized...
  3. Seeger M, Hartmann Petersen R, Wilkinson C, Wallace M, Samejima I, Taylor M, et al. Interaction of the anaphase-promoting complex/cyclosome and proteasome protein complexes with multiubiquitin chain-binding proteins. J Biol Chem. 2003;278:16791-6 pubmed
    Fission yeast Rhp23 and Pus1 represent two families of multiubiquitin chain-binding proteins that associate with the proteasome. We show that both proteins bind to different regions of the proteasome subunit Mts4...
  4. Hartmann Petersen R, Semple C, Ponting C, Hendil K, Gordon C. UBA domain containing proteins in fission yeast. Int J Biochem Cell Biol. 2003;35:629-36 pubmed
    ..The proteins display remarkable differences in their domain organisation, indicating that these potential ubiquitin binding proteins are involved in various cell activities. ..
  5. Lombaerts M, Goeloe J, den Dulk H, Brandsma J, Brouwer J. Identification and characterization of the rhp23(+) DNA repair gene in Schizosaccharomyces pombe. Biochem Biophys Res Commun. 2000;268:210-5 pubmed
    We have identified rhp23(+), the ortholog of the Saccharomyces cerevisiae RAD23 and human HHR23A and HHR23B genes, in Schizosaccharomyces pombe and examined its role in cell survival and DNA repair. In S...
  6. Fukumoto Y, Hiyama H, Yokoi M, Nakaseko Y, Yanagida M, Hanaoka F. Two budding yeast RAD4 homologs in fission yeast play different roles in the repair of UV-induced DNA damage. DNA Repair (Amst). 2002;1:833-45 pubmed
    ..Rhp4B in contrast acts as an accessory protein in non-transcribed strand (NTS) repair. ..
  7. Hartmann Petersen R, Hendil K, Gordon C. Ubiquitin binding proteins protect ubiquitin conjugates from disassembly. FEBS Lett. 2003;535:77-81 pubmed
    ..Here we report that three ubiquitin binding proteins, Rhp23, Dph1 and Pus1, from fission yeast can protect multiubiquitin conjugates against deubiquitination...
  8. Andersen K, Semple C, Hartmann Petersen R. Characterisation of the nascent polypeptide-associated complex in fission yeast. Mol Biol Rep. 2007;34:275-81 pubmed
    ..However, they displayed resistance to the amino acid analogue canavanine, in accordance with the idea that NAC is involved in protein quality control. ..
  9. Latypov V, Tubbs J, Watson A, Marriott A, McGown G, Thorncroft M, et al. Atl1 regulates choice between global genome and transcription-coupled repair of O(6)-alkylguanines. Mol Cell. 2012;47:50-60 pubmed publisher

More Information


  1. Medina B, Paraskevopoulos K, Boehringer J, Sznajder A, Robertson M, Endicott J, et al. The ubiquitin-associated (UBA) 1 domain of Schizosaccharomyces pombe Rhp23 is essential for the recognition of ubiquitin-proteasome system substrates both in vitro and in vivo. J Biol Chem. 2012;287:42344-51 pubmed publisher
    ..One of these shuttle factors, Schizosaccharomyces pombe Rhp23, has an unusual domain architecture...
  2. Paraskevopoulos K, Kriegenburg F, Tatham M, Rösner H, Medina B, Larsen I, et al. Dss1 is a 26S proteasome ubiquitin receptor. Mol Cell. 2014;56:453-61 pubmed publisher
    ..Mutations in the ubiquitin-binding site of Dss1 cause growth defects and accumulation of ubiquitylated proteins. ..
  3. Li G, Elder R, Dubrovsky L, Liang D, Pushkarsky T, Chiu K, et al. HIV-1 replication through hHR23A-mediated interaction of Vpr with 26S proteasome. PLoS ONE. 2010;5:e11371 pubmed publisher
    ..These findings suggest that Vpr-proteasome interaction might counteract certain host restriction factor(s) to stimulate viral replication in non-dividing cells. ..