Gene Symbol: rhb1
Description: Rheb GTPase Rhb1
Alias: Rheb GTPase Rhb1
Species: fission yeast

Top Publications

  1. van Slegtenhorst M, Mustafa A, Henske E. Pas1, a G1 cyclin, regulates amino acid uptake and rescues a delay in G1 arrest in Tsc1 and Tsc2 mutants in Schizosaccharomyces pombe. Hum Mol Genet. 2005;14:2851-8 pubmed
    ..In a second screen, we identified a novel G63D/S165 N mutant of the small GTPase Rhb1, the target of the Tsc1/Tsc2 protein complex...
  2. Urano J, Comiso M, Guo L, Aspuria P, Deniskin R, Tabancay A, et al. Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast. Mol Microbiol. 2005;58:1074-86 pubmed
    ..of the Rheb pathway, we sought to identify hyperactivating mutations in the Schizosaccharomyces pombe Rheb, Rhb1. Hyperactive forms of Rhb1 were found to result from single amino acid changes at valine-17, serine-21, lysine-120 ..
  3. Murai T, Nakase Y, Fukuda K, Chikashige Y, Tsutsumi C, Hiraoka Y, et al. Distinctive responses to nitrogen starvation in the dominant active mutants of the fission yeast Rheb GTPase. Genetics. 2009;183:517-27 pubmed publisher
    ..b>Rhb1 (a fission yeast homolog of Rheb) regulates amino acid uptake as well as response to nitrogen starvation...
  4. Yang W, Urano J, Tamanoi F. Protein farnesylation is critical for maintaining normal cell morphology and canavanine resistance in Schizosaccharomyces pombe. J Biol Chem. 2000;275:429-38 pubmed
    ..These results demonstrate that protein farnesylation is critical for maintaining normal cell morphology through Ras1 and canavanine resistance through SpRheb. ..
  5. Mach K, Furge K, Albright C. Loss of Rhb1, a Rheb-related GTPase in fission yeast, causes growth arrest with a terminal phenotype similar to that caused by nitrogen starvation. Genetics. 2000;155:611-22 pubmed
    ..A likely fission yeast homologue of mammalian Rheb, which we designated Rhb1, was identified by genome sequencing...
  6. Aspuria P, Tamanoi F. The Tsc/Rheb signaling pathway controls basic amino acid uptake via the Cat1 permease in fission yeast. Mol Genet Genomics. 2008;279:441-50 pubmed publisher
    ..These results provide a crucial link between Tsc/Rheb signaling and the regulation of the basic amino acid permease in fission yeast. ..
  7. Tabancay A, Gau C, Machado I, Uhlmann E, Gutmann D, Guo L, et al. Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K. J Biol Chem. 2003;278:39921-30 pubmed
    ..In addition, Rheb1D60K and Rheb1D60V mutants blocked nutrient- or serum-induced activation of p70S6K. This provides critical evidence that Rheb plays a role in the mTOR/S6K pathway in mammalian cells. ..
  8. van Slegtenhorst M, Carr E, Stoyanova R, Kruger W, Henske E. Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe. J Biol Chem. 2004;279:12706-13 pubmed
    ..the defect in arginine uptake in cells lacking tsc2+ is rescued by the expression of a dominant negative form of rhb1+, the Rheb homolog in S. pombe, but not by expressing wild-type rhb1+...
  9. Uritani M, Hidaka H, Hotta Y, Ueno M, Ushimaru T, Toda T. Fission yeast Tor2 links nitrogen signals to cell proliferation and acts downstream of the Rheb GTPase. Genes Cells. 2006;11:1367-79 pubmed
    ..Tor2 physically interacts with the conserved Rhb1/GTPase...

More Information


  1. Urano J, Sato T, Matsuo T, Otsubo Y, Yamamoto M, Tamanoi F. Point mutations in TOR confer Rheb-independent growth in fission yeast and nutrient-independent mammalian TOR signaling in mammalian cells. Proc Natl Acad Sci U S A. 2007;104:3514-9 pubmed
    ..In fission yeast, Rheb is encoded by the rhb1 gene. Rhb1p is essential for growth and directly interacts with Tor2p...
  2. Laor D, Cohen A, Pasmanik Chor M, Oron Karni V, Kupiec M, Weisman R. Isp7 is a novel regulator of amino acid uptake in the TOR signaling pathway. Mol Cell Biol. 2014;34:794-806 pubmed publisher
    ..Taken together, our findings suggest a central role for Isp7 in amino acid homeostasis and the presence of isp7(+)-dependent regulatory loops that affect both TORC1 and TORC2. ..