Gene Symbol: res1
Description: MBF transcription factor complex subunit Res1
Alias: sct1, MBF transcription factor complex subunit Res1
Species: fission yeast

Top Publications

  1. Ayte J, Leis J, Herrera A, Tang E, Yang H, DeCaprio J. The Schizosaccharomyces pombe MBF complex requires heterodimerization for entry into S phase. Mol Cell Biol. 1995;15:2589-99 pubmed
    ..The MBF complex contains both p85cdc10 and p72res1/sct1. To obtain a better understanding of how the MBF complex regulates gene expression at the G1/S transition, we have ..
  2. Miyamoto M, Tanaka K, Okayama H. res2+, a new member of the cdc10+/SWI4 family, controls the 'start' of mitotic and meiotic cycles in fission yeast. EMBO J. 1994;13:1873-80 pubmed
    In the fission yeast Schizosaccharomyces pombe, the cdc10+ and res1+ genes play a crucial role in the start of mitotic and meiotic cycles...
  3. Aligianni S, Lackner D, Klier S, Rustici G, Wilhelm B, Marguerat S, et al. The fission yeast homeodomain protein Yox1p binds to MBF and confines MBF-dependent cell-cycle transcription to G1-S via negative feedback. PLoS Genet. 2009;5:e1000626 pubmed publisher
    ..Compared to the orthologous budding yeast Yox1p, which indirectly functions in a negative feedback loop for cell-cycle transcription, similarities but also notable differences in the wiring of the regulatory circuits are evident. ..
  4. Caligiuri M, Beach D. Sct1 functions in partnership with Cdc10 in a transcription complex that activates cell cycle START and inhibits differentiation. Cell. 1993;72:607-19 pubmed
    A fission yeast cell cycle START gene has been identified, sct1. Loss of sct1 function results in cell cycle arrest at START and simultaneously in derepression of the mating pathway...
  5. Ayte J, Schweitzer C, Zarzov P, Nurse P, DeCaprio J. Feedback regulation of the MBF transcription factor by cyclin Cig2. Nat Cell Biol. 2001;3:1043-50 pubmed
    ..Cig2p can bind to Res2p, promote the phosphorylation of Res1p and inhibit MBF-dependent gene transcription. Cig2p thus forms an autoregulating feedback-inhibition loop with MBF which is important for normal regulation of the cell cycle. ..
  6. Tahara S, Tanaka K, Yuasa Y, Okayama H. Functional domains of rep2, a transcriptional activator subunit for Res2-Cdc10, controlling the cell cycle "start". Mol Biol Cell. 1998;9:1577-88 pubmed
    ..from G1 to S-phase requires the execution of the transcriptional factor complex that consists of the Cdc10 and Res1/2 molecules...
  7. Nakashima N, Tanaka K, Sturm S, Okayama H. Fission yeast Rep2 is a putative transcriptional activator subunit for the cell cycle 'start' function of Res2-Cdc10. EMBO J. 1995;14:4794-802 pubmed
    ..Fission yeast possess two such overlapping systems, Res1-Cdc10 and Res2-Cdc10, both of which act to start the mitotic and meiotic cycles...
  8. Gómez Escoda B, Ivanova T, Calvo I, Alves Rodrigues I, Hidalgo E, Ayte J. Yox1 links MBF-dependent transcription to completion of DNA synthesis. EMBO Rep. 2011;12:84-9 pubmed publisher
    ..When the DNA synthesis checkpoint is activated, Yox1 is phosphorylated, which abrogates its binding to MBF. MBF-dependent transcription therefore remains active until cells are able to overcome this challenge. ..
  9. Tanaka K, Okazaki K, Okazaki N, Ueda T, Sugiyama A, Nojima H, et al. A new cdc gene required for S phase entry of Schizosaccharomyces pombe encodes a protein similar to the cdc 10+ and SWI4 gene products. EMBO J. 1992;11:4923-32 pubmed
    We have isolated a new cell division cycle gene (res1+) required for entry into S phase, as a multicopy dual suppressor of the pat1 and cdc10 mutants of the fission yeast Schizosaccharomyces pombe...

More Information


  1. Obara Ishihara T, Okayama H. A B-type cyclin negatively regulates conjugation via interacting with cell cycle 'start' genes in fission yeast. EMBO J. 1994;13:1863-72 pubmed
    ..b>res1+ and res2+ are the newly identified members of this family and encode putative association partners of the Cdc10 ..
  2. Zhu Y, Takeda T, Whitehall S, Peat N, Jones N. Functional characterization of the fission yeast Start-specific transcription factor Res2. EMBO J. 1997;16:1023-34 pubmed
    ..Two such complexes have been identified; both contain the Cdc10 protein in partnership with either the Res1 or Res2 protein...
  3. Whitehall S, Stacey P, Dawson K, Jones N. Cell cycle-regulated transcription in fission yeast: Cdc10-Res protein interactions during the cell cycle and domains required for regulated transcription. Mol Biol Cell. 1999;10:3705-15 pubmed Start and is composed of a common subunit called Cdc10 in combination with two alternative DNA-binding partners, Res1 and Res2...
  4. Marks J, Fankhauser C, Reymond A, Simanis V. Cytoskeletal and DNA structure abnormalities result from bypass of requirement for the cdc10 start gene in the fission yeast Schizosaccharomyces pombe. J Cell Sci. 1992;101 ( Pt 3):517-28 pubmed
    ..A single gene, sct1+ (suppressor of cdc ten), has been identified, mutation of which suppresses all conditional alleles and a null ..
  5. Ivanova T, Alves Rodrigues I, Gómez Escoda B, Dutta C, DeCaprio J, Rhind N, et al. The DNA damage and the DNA replication checkpoints converge at the MBF transcription factor. Mol Biol Cell. 2013;24:3350-7 pubmed publisher
    ..Thus Yox1 and Cdc10 couple normal cell cycle regulation in unperturbed conditions and the DNA replication and DNA damage checkpoints into a single transcriptional complex. ..
  6. Aranda A, Proudfoot N. Transcriptional termination factors for RNA polymerase II in yeast. Mol Cell. 2001;7:1003-11 pubmed
    ..Deletion of res2 in both fission and budding yeast results in a defect in 3' end formation. This raises the possibility that RNAP II transcriptional termination may in some situations be integrated with cell cycle events. ..
  7. Tournier S, Millar J. A role for the START gene-specific transcription factor complex in the inactivation of cyclin B and Cut2 destruction. Mol Biol Cell. 2000;11:3411-24 pubmed
    ..Mutation of either Cdc10 or Res1 also deregulates MBF-dependent transcription and causes a G2 delay...
  8. Sturm S, Okayama H. Domains determining the functional distinction of the fission yeast cell cycle "start" molecules Res1 and Res2. Mol Biol Cell. 1996;7:1967-76 pubmed
    ..quot;start" of the cell cycle is regulated by two parallel, functionally overlapping complexes composed of Res1-Cdc10 and Res2-Cdc10...
  9. Jackson W, Martin G. Transcription of the Schizosaccharomyces pombe gene cdc18+: roles of MCB elements and the DSC1 complex. Gene. 2006;369:100-8 pubmed
    ..elements known as MluI Cell-cycle Boxes, or MCBs, and by a family of transcription factors, including Cdc10, Res1, Res2 and Rep2...
  10. Ayte J, Leis J, DeCaprio J. The fission yeast protein p73res2 is an essential component of the mitotic MBF complex and a master regulator of meiosis. Mol Cell Biol. 1997;17:6246-54 pubmed
    ..These observations suggest that p73res2 plays a pivotal role at Start and constitutes an example of a transcription factor involved in the control of both mitotic and meiotic progression. ..
  11. Cohen A, Kupiec M, Weisman R. Gad8 Protein Is Found in the Nucleus Where It Interacts with the MluI Cell Cycle Box-binding Factor (MBF) Transcriptional Complex to Regulate the Response to DNA Replication Stress. J Biol Chem. 2016;291:9371-81 pubmed publisher
    ..Taken together, our findings highlight critical functions of TORC2 in the nucleus and suggest a role in surviving DNA replication stress via transcriptional regulation of MBF target genes. ..