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Genomes and Genes | ran1SummaryGene Symbol: ran1 Description: serine/threonine protein kinase Ran1 Alias: pat1, serine/threonine protein kinase Ran1 Species: fission yeast Top Publications
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Publications
- Obara Ishihara T, Okayama H. A B-type cyclin negatively regulates conjugation via interacting with cell cycle 'start' genes in fission yeast. EMBO J. 1994;13:1863-72 pubmed..The Pat1 kinase plays a pivotal role in switching between vegetative growth and sexual development, and its inactivation in ..
- Stettler S, Warbrick E, Prochnik S, Mackie S, Fantes P. The wis1 signal transduction pathway is required for expression of cAMP-repressed genes in fission yeast. J Cell Sci. 1996;109 ( Pt 7):1927-35 pubmed..loss of wis1 function leads to defective conjugation, and to suppression of the hyperconjugation phenotype of the pat1-114 mutation...
- Yamamoto A, Hiraoka Y. Monopolar spindle attachment of sister chromatids is ensured by two distinct mechanisms at the first meiotic division in fission yeast. EMBO J. 2003;22:2284-96 pubmed..This monopolar attachment requires both mating pheromone signaling and inactivation of Pat1 kinase (a key negative regulator of meiosis)...
- McLeod M, Shor B, Caporaso A, Wang W, Chen H, Hu L. Cpc2, a fission yeast homologue of mammalian RACK1 protein, interacts with Ran1 (Pat1) kinase To regulate cell cycle progression and meiotic development. Mol Cell Biol. 2000;20:4016-27 pubmedThe Schizosaccharomyces pombe ran1/pat1 gene regulates the transition between mitosis and meiosis. Inactivation of Ran1 (Pat1) kinase is necessary and sufficient for cells to exit the cell cycle and undergo meiosis...
- Mach K, Cheng Q, Albright C. ras1 and pat1 alleles interact to quantitatively and qualitatively alter conjugation in fission yeast. Curr Genet. 1998;34:172-82 pubmed..A novel allele of pat1, pat1-e1, was isolated that increases the mating of ras1-D43E mutants to near wild-type levels but does not ..
- Amorim M, Cotobal C, Duncan C, Mata J. Global coordination of transcriptional control and mRNA decay during cellular differentiation. Mol Syst Biol. 2010;6:380 pubmed publisher..Our data provide insight into the topology of regulatory networks integrating transcriptional and posttranscriptional controls. ..
- Ayte J, Schweitzer C, Zarzov P, Nurse P, DeCaprio J. Feedback regulation of the MBF transcription factor by cyclin Cig2. Nat Cell Biol. 2001;3:1043-50 pubmed..Cig2p can bind to Res2p, promote the phosphorylation of Res1p and inhibit MBF-dependent gene transcription. Cig2p thus forms an autoregulating feedback-inhibition loop with MBF which is important for normal regulation of the cell cycle. ..
- Wurm J, Overbeck J, Sprangers R. The S. pombe mRNA decapping complex recruits cofactors and an Edc1-like activator through a single dynamic surface. RNA. 2016;22:1360-72 pubmed publisher..pombe Dcp1 can interact with proline-rich sequences in the exonuclease Xrn1, the scaffolding protein Pat1, the helicase Dhh1, and the C-terminal disordered region of Dcp2...
- Alvarez B, Moreno S. Fission yeast Tor2 promotes cell growth and represses cell differentiation. J Cell Sci. 2006;119:4475-85 pubmed..Thus, our data reveal a unique regulatory function of the Tor pathway - ensuring that growth and cell differentiation become mutually exclusive and that the choice between them depends on environmental conditions. ..
- Oowatari Y, Jeong H, Tanae K, Nakagawa T, Kawamukai M. Regulation and role of an RNA-binding protein Msa2 in controlling the sexual differentiation of fission yeast. Curr Genet. 2011;57:191-200 pubmed publisher..mutants for their ability to inhibit sexual differentiation and their suppressive effect on a temperature sensitive pat1 mutant...
- Forsburg S, Nurse P. Analysis of the Schizosaccharomyces pombe cyclin puc1: evidence for a role in cell cycle exit. J Cell Sci. 1994;107 ( Pt 3):601-13 pubmed..We conclude that puc1 contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. ..
- Davey J, Nielsen O. Mutations in cyr1 and pat1 reveal pheromone-induced G1 arrest in the fission yeast Schizosaccharomyces pombe. Curr Genet. 1994;26:105-12 pubmed..The second mutant contains the temperature-sensitive pat1-114 allele...
- Matsuyama A, Yabana N, Watanabe Y, Yamamoto M. Schizosaccharomyces pombe Ste7p is required for both promotion and withholding of the entry to meiosis. Genetics. 2000;155:539-49 pubmed..The temperature-sensitive pat1-114 mutant underwent ectopic conjugation at the semirestrictive temperature when its genetic background was ste7(+),..
- Sato M, Watanabe Y, Akiyoshi Y, Yamamoto M. 14-3-3 protein interferes with the binding of RNA to the phosphorylated form of fission yeast meiotic regulator Mei2p. Curr Biol. 2002;12:141-5 pubmedThe switch from mitosis to meiosis is controlled by the Pat1(Ran1) kinase-Mei2p system in Schizosaccharomyces pombe...
- Zheng L, Schwartz C, Wee L, Oliferenko S. The fission yeast transforming acidic coiled coil-related protein Mia1p/Alp7p is required for formation and maintenance of persistent microtubule-organizing centers at the nuclear envelope. Mol Biol Cell. 2006;17:2212-22 pubmed..When microtubule polymerization was allowed, MTOCs were efficiently assembled de novo. We propose a model where MTOC emergence is a self-organizing process requiring the continuous association of microtubules with nucleation sites. ..
- Krapp A, Collin P, Cokoja A, Dischinger S, Cano E, Simanis V. The Schizosaccharomyces pombe septation initiation network (SIN) is required for spore formation in meiosis. J Cell Sci. 2006;119:2882-91 pubmed..The protein kinases Sid1p and Cdc7p do not associate with the spindle pole body until meiosis II, when forespore membrane deposition begins. These data indicate a role for the SIN in regulating spore formation during meiosis. ..
- DeVoti J, Seydoux G, Beach D, McLeod M. Interaction between ran1+ protein kinase and cAMP dependent protein kinase as negative regulators of fission yeast meiosis. EMBO J. 1991;10:3759-68 pubmed..The mei3+ gene product acts as a meiotic inducer by binding to and inhibiting the ran1+ protein kinase. Inactivation of ran1+ kinase is both necessary and sufficient to allow meiotic differentiation...
- Win T, Draper S, Read R, Pearce J, Norbury C, Wang S. Requirement of fission yeast Cid14 in polyadenylation of rRNAs. Mol Cell Biol. 2006;26:1710-21 pubmed..Polyadenylation-assisted nuclear RNA turnover is therefore likely to be a common eukaryotic mechanism affecting diverse biological processes. ..
- Otsubo Y, Yamashita A, Ohno H, Yamamoto M. S. pombe TORC1 activates the ubiquitin-proteasomal degradation of the meiotic regulator Mei2 in cooperation with Pat1 kinase. J Cell Sci. 2014;127:2639-46 pubmed publisher..Based on these data, we propose that TORC1 contributes to the suppression of sexual development by phosphorylating Mei2, in addition to controlling the cellular metabolic status. ..
- Nielsen O, Egel R. The pat1 protein kinase controls transcription of the mating-type genes in fission yeast. EMBO J. 1990;9:1401-6 pubmed..Conjugation can also be induced in pat1-ts mutants by a shift to a semi-permissive temperature...
- Sukegawa Y, Yamashita A, Yamamoto M. The fission yeast stress-responsive MAPK pathway promotes meiosis via the phosphorylation of Pol II CTD in response to environmental and feedback cues. PLoS Genet. 2011;7:e1002387 pubmed publisher..This study also demonstrates clearly that the stress-responsive MAP kinase pathway can modulates gene expression through phosphorylation of Pol II CTD. ..
- Zhang M, Wu P, Kelly F, Nurse P, Hang H. Quantitative control of protein S-palmitoylation regulates meiotic entry in fission yeast. PLoS Biol. 2013;11:e1001597 pubmed publisher..We propose that control of palmitoyltransferase activity levels provides a fundamental mechanism for modulating palmitoylomes and cellular functions. ..
- Lino Y, Yamamoto M. Mutants of Schizosaccharomyces pombe which sporulate in the haploid state. Mol Gen Genet. 1985;198:416-21 pubmed..The mutants are all recessive and define a single gene pat1. The pat1 gene maps very close to the centromere of chromosome II...
- Shinozaki Yabana S, Watanabe Y, Yamamoto M. Novel WD-repeat protein Mip1p facilitates function of the meiotic regulator Mei2p in fission yeast. Mol Cell Biol. 2000;20:1234-42 pubmed..These results suggest that Mip1p assists functional expression of a number of proteins required for proliferation and sexual development in fission yeast. ..
- Tanabe K, Ito N, Wakuri T, Ozoe F, Umeda M, Katayama S, et al. Sla1, a Schizosaccharomyces pombe homolog of the human La protein, induces ectopic meiosis when its C terminus is truncated. Eukaryot Cell. 2003;2:1274-87 pubmed..Strikingly, Sla1DeltaC induced haploid meiosis in a heterothallic strain, similar to the pat1-114 or mei2-SATA mutation...
- Willer M, Hoffmann L, Styrkarsdottir U, Egel R, Davey J, Nielsen O. Two-step activation of meiosis by the mat1 locus in Schizosaccharomyces pombe. Mol Cell Biol. 1995;15:4964-70 pubmed..The mat1-Pm and mat1-Mm products complete the initiation of meiosis by activating transcription of the mei3 gene. ..
- Rotondo G, Gillespie M, Frendewey D. Rescue of the fission yeast snRNA synthesis mutant snm1 by overexpression of the double-strand-specific Pac1 ribonuclease. Mol Gen Genet. 1995;247:698-708 pubmed..The pac1+ gene was previously identified as a suppressor of the ran1 mutant and by its ability to cause sterility when overexpressed...
- Iino Y, Sugimoto A, Yamamoto M. S. pombe pac1+, whose overexpression inhibits sexual development, encodes a ribonuclease III-like RNase. EMBO J. 1991;10:221-6 pubmedThe Schizosaccharomyces pombe pac1 gene is a multicopy suppressor of the pat1 temperature-sensitive mutation, which directs uncontrolled meiosis at the restrictive temperature...