rad17

Summary

Gene Symbol: rad17
Description: RFC-like checkpoint protein Rad17
Alias: RFC-like checkpoint protein Rad17
Species: fission yeast

Top Publications

  1. Kai M, Tanaka H, Wang T. Fission yeast Rad17 associates with chromatin in response to aberrant genomic structures. Mol Cell Biol. 2001;21:3289-301 pubmed
    Fission yeast checkpoint protein Rad17 is required for the DNA integrity checkpoint responses. A fraction of Rad17 is chromatin bound independent of the other checkpoint proteins throughout the cell cycle...
  2. Yin L, Locovei A, D URSO G. Activation of the DNA damage checkpoint in mutants defective in DNA replication initiation. Mol Biol Cell. 2008;19:4374-82 pubmed publisher
  3. Synnes M, Nilssen E, Boye E, Grallert B. A novel chk1-dependent G1/M checkpoint in fission yeast. J Cell Sci. 2002;115:3609-18 pubmed
    ..We also show that commitment to cutting occurs already in early G1 phase. ..
  4. Harris S, Kemplen C, Caspari T, Chan C, Lindsay H, Poitelea M, et al. Delineating the position of rad4+/cut5+ within the DNA-structure checkpoint pathways in Schizosaccharomyces pombe. J Cell Sci. 2003;116:3519-29 pubmed
    ..allele of rad4+/cut5+ acts as a dominant suppressor of the checkpoint deficiencies of rad3-, rad26- and rad17- mutants...
  5. Arroyo M, Wang T. Mutant PCNA alleles are associated with cdc phenotypes and sensitivity to DNA damage in fission yeast. Mol Gen Genet. 1998;257:505-18 pubmed
    ..A model for how pcn1-3 defects may affect DNA repair and replication is presented. ..
  6. Tan S, Wang T. Analysis of fission yeast primase defines the checkpoint responses to aberrant S phase initiation. Mol Cell Biol. 2000;20:7853-66 pubmed
    ..Thus, the Cds1-mediated intra-S phase checkpoint response induced by hydroxyurea can also be distinguished from the S-M phase checkpoint response that requires the initiation DNA synthesis by Polalpha. ..
  7. Smeets M, Francesconi S, Baldacci G. High dosage Rhp51 suppression of the MMS sensitivity of DNA structure checkpoint mutants reveals a relationship between Crb2 and Rhp51. Genes Cells. 2003;8:573-86 pubmed
    ..We conclude that fission yeast Crb2 and Rhp51 function in two parallel, tightly connected and coordinately regulated pathways. ..
  8. Kim J, Robertson K, Mylonas K, Gray F, Charapitsa I, MacNeill S. Contrasting effects of Elg1-RFC and Ctf18-RFC inactivation in the absence of fully functional RFC in fission yeast. Nucleic Acids Res. 2005;33:4078-89 pubmed
    ..Consistent with this, the deletion of elg1+ is shown to restore viability to rfc1-44 ctf18Delta cells. ..
  9. Yoshida S, Al Amodi H, Nakamura T, McInerny C, Shimoda C. The Schizosaccharomyces pombe cdt2(+) gene, a target of G1-S phase-specific transcription factor complex DSC1, is required for mitotic and premeiotic DNA replication. Genetics. 2003;164:881-93 pubmed
    ..These observations suggest that cdt2(+) plays an important role in DNA replication in both the mitotic and the meiotic life cycles of fission yeast. ..

More Information

Publications35

  1. Ansbach A, Noguchi C, Klansek I, Heidlebaugh M, Nakamura T, Noguchi E. RFCCtf18 and the Swi1-Swi3 complex function in separate and redundant pathways required for the stabilization of replication forks to facilitate sister chromatid cohesion in Schizosaccharomyces pombe. Mol Biol Cell. 2008;19:595-607 pubmed
    ..We propose that RFC(Ctf18) and the Swi1-Swi3 complex function in separate and redundant pathways essential for replication fork stabilization to facilitate sister chromatid cohesion in fission yeast. ..
  2. al Khodairy F, Fotou E, Sheldrick K, Griffiths D, Lehmann A, Carr A. Identification and characterization of new elements involved in checkpoint and feedback controls in fission yeast. Mol Biol Cell. 1994;5:147-60 pubmed
    ..d) shares the phenotype reported for the "checkpoint rad" mutants rad1, rad3, rad9, rad17, and hus1, which are defective in the radiation checkpoint and in the feedback controls that ensure the order of ..
  3. Calonge T, O Connell M. Antagonism of Chk1 signaling in the G2 DNA damage checkpoint by dominant alleles of Cdr1. Genetics. 2006;174:113-23 pubmed
    ..We conclude that regulation of Wee1 by Cdr1 and possibly by related kinases is an important antagonist of Chk1 signaling and represents a novel negative regulation of cell cycle arrest promoted by this checkpoint. ..
  4. Kai M, Wang T. Checkpoint activation regulates mutagenic translesion synthesis. Genes Dev. 2003;17:64-76 pubmed
    ..exhibit a mutator phenotype, which can be significantly affected by mutations in the checkpoint elements Cds1 and Rad17 or translesion synthesis polymerases DinB and Polzeta...
  5. Akai Y, Kurokawa Y, Nakazawa N, Tonami Murakami Y, Suzuki Y, Yoshimura S, et al. Opposing role of condensin hinge against replication protein A in mitosis and interphase through promoting DNA annealing. Open Biol. 2011;1:110023 pubmed publisher
    ..We show that 16 suppressor mutations of cut14-Y1 were all mapped within the hinge domain, which surrounded the original L543 mutation site. ..
  6. Griffiths D, Barbet N, McCready S, Lehmann A, Carr A. Fission yeast rad17: a homologue of budding yeast RAD24 that shares regions of sequence similarity with DNA polymerase accessory proteins. EMBO J. 1995;14:5812-23 pubmed
    ..The rad17 locus of Schizosaccharomyces pombe is one of seven known radiation-sensitive (rad) loci which are absolutely ..
  7. Wang S, Toda T, MacCallum R, Harris A, Norbury C. Cid1, a fission yeast protein required for S-M checkpoint control when DNA polymerase delta or epsilon is inactivated. Mol Cell Biol. 2000;20:3234-44 pubmed
    ..Genetic data suggest that Cid1 acts in association with Crb2/Rhp9 and through the checkpoint-signaling kinase Chk1 to inhibit unscheduled mitosis specifically when DNA polymerase delta or epsilon is inhibited. ..
  8. Griffiths D, Uchiyama M, Nurse P, Wang T. A novel mutant allele of the chromatin-bound fission yeast checkpoint protein Rad17 separates the DNA structure checkpoints. J Cell Sci. 2000;113 ( Pt 6):1075-88 pubmed
    ..One such checkpoint mutant, rad17-d14, was found to display the cut phenotype following S-phase arrest by cdc20-M10, but not by the DNA synthesis ..
  9. Nakamura T, Moser B, Russell P. Telomere binding of checkpoint sensor and DNA repair proteins contributes to maintenance of functional fission yeast telomeres. Genetics. 2002;161:1437-52 pubmed
    ..On the basis of telomere lengths of mutant combinations of various checkpoint-related proteins (Rad1, Rad3, Rad9, Rad17, Rad26, Hus1, Crb2, Chk1, Cds1), Tel1, a telomere-binding protein (Taz1), and DNA repair proteins (Ku70, Rad32), ..
  10. Kanoh J, Francesconi S, Collura A, Schramke V, Ishikawa F, Baldacci G, et al. The fission yeast spSet1p is a histone H3-K4 methyltransferase that functions in telomere maintenance and DNA repair in an ATM kinase Rad3-dependent pathway. J Mol Biol. 2003;326:1081-94 pubmed
    ..Our results suggest that SpSet1p and the ATM kinase Rad3 function in a common genetic pathway linking chromatin to telomere length regulation and DNA repair. ..
  11. Caspari T, Dahlen M, Kanter Smoler G, Lindsay H, Hofmann K, Papadimitriou K, et al. Characterization of Schizosaccharomyces pombe Hus1: a PCNA-related protein that associates with Rad1 and Rad9. Mol Cell Biol. 2000;20:1254-62 pubmed
    ..Indirect immunofluorescence demonstrates that Hus1 is nuclear and that this localization depends on Rad17. We show that Rad17 defines a distinct protein complex in soluble extracts that is separate from Rad1, Rad9, and ..
  12. Taricani L, Wang T. Rad4TopBP1, a scaffold protein, plays separate roles in DNA damage and replication checkpoints and DNA replication. Mol Biol Cell. 2006;17:3456-68 pubmed
    ..to associate with all three replicative polymerases and checkpoint proteins Rad3ATR-Rad26ATRIP, Hus1, Rad9, and Rad17 but has a compromised association with Crb3...
  13. Janes S, Schmidt U, Ashour Garrido K, Ney N, Concilio S, Zekri M, et al. Heat induction of a novel Rad9 variant from a cryptic translation initiation site reduces mitotic commitment. J Cell Sci. 2012;125:4487-97 pubmed publisher
    ..Rad9 is a highly conserved subunit of the Rad9-Rad1-Hus1 (9-1-1) checkpoint-clamp that is loaded by Rad17 onto damaged chromatin. At the DNA, Rad9 activates the checkpoint kinases Rad3(ATR) and Chk1 to arrest cells in G2...
  14. Sheedy D, Dimitrova D, Rankin J, Bass K, Lee K, Tapia Alveal C, et al. Brc1-mediated DNA repair and damage tolerance. Genetics. 2005;171:457-68 pubmed
    ..Activation of this pathway through overproduction of Brc1 bypasses a repair defect in smc6-74, reestablishing resolution of lesions by recombination. ..
  15. Murakami H, Nurse P. Meiotic DNA replication checkpoint control in fission yeast. Genes Dev. 1999;13:2581-93 pubmed
    ..This second checkpoint is meiosis specific and may reflect processes occurring only during meiosis such as increased recombination rates, an extended duration of nuclear division, or homolog chromosome pairing. ..
  16. Shimada M, Nabeshima K, Tougan T, Nojima H. The meiotic recombination checkpoint is regulated by checkpoint rad+ genes in fission yeast. EMBO J. 2002;21:2807-18 pubmed
    ..Consistently, the induction of an excess of extrinsic DSBs by ionizing radiation delayed meiotic progression in a rad17(+)-dependent manner...
  17. Dolan W, Le A, Schmidt H, Yuan J, Green M, Forsburg S. Fission yeast Hsk1 (Cdc7) kinase is required after replication initiation for induced mutagenesis and proper response to DNA alkylation damage. Genetics. 2010;185:39-53 pubmed publisher
    ..We conclude that Hsk1-Dfp1 kinase functions post-initiation to maintain replication fork stability, an activity potentially mediated by the C terminus of Dfp1. ..
  18. Muris D, Vreeken K, Carr A, Murray J, Smit C, Lohman P, et al. Isolation of the Schizosaccharomyces pombe RAD54 homologue, rhp54+, a gene involved in the repair of radiation damage and replication fidelity. J Cell Sci. 1996;109 ( Pt 1):73-81 pubmed
    ..Furthermore, the rhp54 mutation in either a rad17 or a cdc2...
  19. Saito T, Tougan T, Kasama T, Okuzaki D, Nojima H. Mcp7, a meiosis-specific coiled-coil protein of fission yeast, associates with Meu13 and is required for meiotic recombination. Nucleic Acids Res. 2004;32:3325-39 pubmed
    ..Taken together, we conclude that Mcp7 associates with Meu13 and together they play a key role in meiotic recombination. ..
  20. Saitoh S, Chabes A, McDonald W, Thelander L, Yates J, Russell P. Cid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA. Cell. 2002;109:563-73 pubmed
    ..cid13 mutants have reduced dNTP pools and are sensitive to hydroxyurea, an RNR inhibitor. We propose that Cid13 defines a cytoplasmic form of poly(A) polymerase important for DNA replication and genome maintenance. ..
  21. Marchetti M, Kumar S, Hartsuiker E, Maftahi M, Carr A, Freyer G, et al. A single unbranched S-phase DNA damage and replication fork blockage checkpoint pathway. Proc Natl Acad Sci U S A. 2002;99:7472-7 pubmed
    ..These results suggest that, in fission yeast, the signal activating the intra-S-phase checkpoint is generated only when replication forks encounter DNA damage. ..
  22. Taylor M, Moore K, Murray J, Aves S, Price C. Mcm10 interacts with Rad4/Cut5(TopBP1) and its association with origins of DNA replication is dependent on Rad4/Cut5(TopBP1). DNA Repair (Amst). 2011;10:1154-63 pubmed publisher
    ..Comparison of the levels of chromatin association at origins of replication and stalled replication forks and the differential requirement for Rad9 suggest functional differences for Rad4(TopBP1) at these distinct sites. ..
  23. Katayama S, Kitamura K, Lehmann A, Nikaido O, Toda T. Fission yeast F-box protein Pof3 is required for genome integrity and telomere function. Mol Biol Cell. 2002;13:211-24 pubmed
    ..The results highlight a role of the SCF(Pof3) ubiquitin ligase in genome integrity via maintaining chromatin structures. ..
  24. Shimada M, Okuzaki D, Tanaka S, Tougan T, Tamai K, Shimoda C, et al. Replication factor C3 of Schizosaccharomyces pombe, a small subunit of replication factor C complex, plays a role in both replication and damage checkpoints. Mol Biol Cell. 1999;10:3991-4003 pubmed
    ..Association of Rfc3 and Rad17 in vivo and a significant reduction of the phosphorylated form of Chk1 in rfc3-1 cells after treatments with MMS ..
  25. Khair L, Chang Y, Subramanian L, Russell P, Nakamura T. Roles of the checkpoint sensor clamp Rad9-Rad1-Hus1 (911)-complex and the clamp loaders Rad17-RFC and Ctf18-RFC in Schizosaccharomyces pombe telomere maintenance. Cell Cycle. 2010;9:2237-48 pubmed
    ..In addition, the Rad9-Rad1-Hus1 (911) and Rad17-RFC complexes work downstream of Rad3 (ATR) in fission yeast telomere maintenance...
  26. Furuya K, Miyabe I, Tsutsui Y, Paderi F, Kakusho N, Masai H, et al. DDK phosphorylates checkpoint clamp component Rad9 and promotes its release from damaged chromatin. Mol Cell. 2010;40:606-18 pubmed publisher
    ..We propose that Rad9 phosphorylation by DDK releases Rad9 from DNA damage sites to facilitate DNA repair. ..