Gene Symbol: ptr3
Description: ubiquitin-activating enzyme E1
Alias: SPBC211.09, uba1, ubiquitin-activating enzyme E1
Species: fission yeast
Wei Y, Diao L, Lu S, Wang H, Suo F, Dong M, et al
. SUMO-Targeted DNA Translocase Rrp2 Protects the Genome from Top2-Induced DNA Damage. Mol Cell. 2017;66:581-596.e6 pubmed publisher
..The budding yeast homolog of Rrp2, Uls1, plays a similar role, indicating that this genome protection mechanism is widely employed, a finding with implications for cancer treatment. ..
Olsen S, Lima C. Structure of a ubiquitin E1-E2 complex: insights to E1-E2 thioester transfer. Mol Cell. 2013;49:884-96 pubmed publisher
..Comparison to a Ub E1/Ub/ATP·Mg structure reveals conformational changes in the E1 that bring the E1 and E2 active sites together...
Tsutsui Y, Kurokawa Y, Ito K, Siddique M, Kawano Y, Yamao F, et al
. Multiple regulation of Rad51-mediated homologous recombination by fission yeast Fbh1. PLoS Genet. 2014;10:e1004542 pubmed publisher
Raychaudhuri S, Espenshade P. Endoplasmic Reticulum Exit of Golgi-resident Defective for SREBP Cleavage (Dsc) E3 Ligase Complex Requires Its Activity. J Biol Chem. 2015;290:14430-40 pubmed publisher
..These results define enzyme activity-dependent sorting as an autoregulatory mechanism for protein trafficking. ..
Lv Z, Rickman K, Yuan L, Williams K, Selvam S, Woosley A, et al
. S.Â pombe Uba1-Ubc15 Structure Reveals a Novel Regulatory Mechanism of Ubiquitin E2 Activity. Mol Cell. 2017;65:699-714.e6 pubmed publisher
..Here, we report the structure of S.Â pombe Uba1 in complex with Ubc15, a Ub E2 with intrinsically low E1-E2Â Ub thioester transfer activity...
Lv Z, Yuan L, Atkison J, Aldana Masangkay G, Chen Y, Olsen S. Domain alternation and active site remodeling are conserved structural features of ubiquitin E1. J Biol Chem. 2017;292:12089-12099 pubmed publisher
..Here, we present a structure of Schizosaccharomyces pombe Uba1 in which the second catalytic cysteine half-domain (SCCH domain) harboring the catalytic cysteine has undergone a ..
Azad A, Tani T, Shiki N, Tsuneyoshi S, Urushiyama S, Ohshima Y. Isolation and molecular characterization of mRNA transport mutants in Schizosaccharomyces pombe. Mol Biol Cell. 1997;8:825-41 pubmed
..Localization of a nucleoplasmin-green fluorescent protein fusion suggests that ptr2 and ptr3 have defects also in nuclear protein import...