Gene Symbol: pop3
Description: WD repeat protein Pop3
Alias: wat1, WD repeat protein Pop3
Species: fission yeast
Ochotorena I, Hirata D, Kominami K, Potashkin J, Sahin F, Wentz Hunter K, et al
. Conserved Wat1/Pop3 WD-repeat protein of fission yeast secures genome stability through microtubule integrity and may be involved in mRNA maturation. J Cell Sci. 2001;114:2911-20 pubmed
..In this study, we have characterised fission yeast pop3-5235, a diploidising mutant that is impaired in genome stability...
Hayashi T, Hatanaka M, Nagao K, Nakaseko Y, Kanoh J, Kokubu A, et al
. Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits. Genes Cells. 2007;12:1357-70 pubmed
..that, in addition to the six previously identified subunits (Tor1, Tor2, Mip1/Raptor, Ste20/Rictor, Sin1/Avo1 and Wat1/Lst8), comprise the TOR complexes (TORCs). All of the subunits so far examined are multiply phosphorylated...
Tatebe H, Morigasaki S, Murayama S, Zeng C, Shiozaki K. Rab-family GTPase regulates TOR complex 2 signaling in fission yeast. Curr Biol. 2010;20:1975-82 pubmed publisher
..The Ryh1 GTPase and the TORC2-Gad8 pathway are required for vacuolar integrity and cellular stress resistance in S. pombe. ..
Verma S, Ranjan R, Kumar V, Siddiqi M, Ahmed S. Wat1/pop3, a conserved WD repeat containing protein acts synergistically with checkpoint kinase Chk1 to maintain genome ploidy in fission yeast S. pombe. PLoS ONE. 2014;9:e89587 pubmed publisher
..We have isolated a novel mutant allele of wat1, a WD repeat containing protein that exhibits conditional synthetic lethality with chk1 knock out...
Matsuo T, Otsubo Y, Urano J, Tamanoi F, Yamamoto M. Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast. Mol Cell Biol. 2007;27:3154-64 pubmed
..The Lst8 homologue, Wat1, binds to both Tor1 and Tor2...
Baker K, Kirkham S, Hálová L, Atkin J, Franz Wachtel M, Cobley D, et al
. TOR complex 2 localises to the cytokinetic actomyosin ring and controls the fidelity of cytokinesis. J Cell Sci. 2016;129:2613-24 pubmed publisher
..Thus, TORC2 localisation to the CAR, and TORC2-dependent Acp1 phosphorylation contributes to timely control and the fidelity of cytokinesis and cell division. ..
Ahamad N, Verma S, Ahmed S. Activation of Checkpoint Kinase Chk1 by Reactive Oxygen Species Resulting from Disruption of wat1/pop3 in Schizosaccharomyces pombe. Genetics. 2016;204:1397-1406 pubmed
..Here, we report that the disruption of wat1, a WD repeat-containing protein, leads to the phosphorylation of Chk1...
Tatebe H, Murayama S, Yonekura T, Hatano T, Richter D, Furuya T, et al
. Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit. elife. 2017;6: pubmed publisher
..The specific substrate-recognition function is conserved in human Sin1CRIM, which may represent a potential target for novel anticancer drugs that prevent activation of the mTORC2 substrates such as AKT. ..
Alvarez B, Moreno S. Fission yeast Tor2 promotes cell growth and represses cell differentiation. J Cell Sci. 2006;119:4475-85 pubmed
..Thus, our data reveal a unique regulatory function of the Tor pathway - ensuring that growth and cell differentiation become mutually exclusive and that the choice between them depends on environmental conditions. ..