Gene Symbol: pcr1
Description: transcription factor Pcr1
Alias: mts2, transcription factor Pcr1
Species: fission yeast

Top Publications

  1. Sansó M, Gogol M, Ayte J, Seidel C, Hidalgo E. Transcription factors Pcr1 and Atf1 have distinct roles in stress- and Sty1-dependent gene regulation. Eukaryot Cell. 2008;7:826-35 pubmed publisher
    ..The Atf1 protein forms a heterodimer with Pcr1, but the specific role of this association is controversial...
  2. Reiter W, Watt S, Dawson K, Lawrence C, Bahler J, Jones N, et al. Fission yeast MAP kinase Sty1 is recruited to stress-induced genes. J Biol Chem. 2008;283:9945-56 pubmed publisher
    ..Both Atf1 and its binding partner Pcr1 are required for association of Sty1 with Atf1-dependent promoters, suggesting that this heterodimer must be intact ..
  3. Kon N, Krawchuk M, Warren B, Smith G, Wahls W. Transcription factor Mts1/Mts2 (Atf1/Pcr1, Gad7/Pcr1) activates the M26 meiotic recombination hotspot in Schizosaccharomyces pombe. Proc Natl Acad Sci U S A. 1997;94:13765-70 pubmed
    ..A heterodimeric M26 DNA binding protein, composed of subunits Mts1 and Mts2, has been identified and purified 40,000-fold...
  4. Wahls W, Smith G. A heteromeric protein that binds to a meiotic homologous recombination hot spot: correlation of binding and hot spot activity. Genes Dev. 1994;8:1693-702 pubmed
    ..We have purified 40,000-fold a heteromeric protein, containing polypeptides Mts1 (70 kD) and Mts2 (28 kD), that binds to the M26 site...
  5. Davidson M, Shandilya H, Hirota K, Ohta K, Wahls W. Atf1-Pcr1-M26 complex links stress-activated MAPK and cAMP-dependent protein kinase pathways via chromatin remodeling of cgs2+. J Biol Chem. 2004;279:50857-63 pubmed
    ..Pathway integration is achieved via Spc1-dependent binding of Atf1-Pcr1 heterodimer to an M26 DNA site in the cgs2+ promoter, which remodels chromatin to regulate expression of cgs2+ and ..
  6. Kim H, Choi E, Shin J, Jang Y, Park S. Regulation of Swi6/HP1-dependent heterochromatin assembly by cooperation of components of the mitogen-activated protein kinase pathway and a histone deacetylase Clr6. J Biol Chem. 2004;279:42850-9 pubmed
    ..Here we find that activating transcription factor (Atf1) and Pcr1, the fission yeast bZIP transcription factors homologous to human ATF-2, are crucial for proper histone ..
  7. Jia S, Noma K, Grewal S. RNAi-independent heterochromatin nucleation by the stress-activated ATF/CREB family proteins. Science. 2004;304:1971-6 pubmed
    ..Here, we report that Atf1 and Pcr1, two ATF/CREB family proteins, act in a parallel mechanism to the RNAi pathway for heterochromatin nucleation...
  8. Watanabe Y, Yamamoto M. Schizosaccharomyces pombe pcr1+ encodes a CREB/ATF protein involved in regulation of gene expression for sexual development. Mol Cell Biol. 1996;16:704-11 pubmed
    The Schizosaccharomyces pombe pcr1 gene encodes a bZIP protein that apparently belongs to the cyclic AMP response element (CRE)-binding protein/activating transcription factor family...
  9. Takeda T, Toda T, Kominami K, Kohnosu A, Yanagida M, Jones N. Schizosaccharomyces pombe atf1+ encodes a transcription factor required for sexual development and entry into stationary phase. EMBO J. 1995;14:6193-208 pubmed
    ..Thus Atf1 is a transcription factor that plays an important role in the response of cells to adverse environmental conditions, which is to exit the mitotic cell cycle and either sexually differentiate or enter a resting state. ..

More Information


  1. Kanoh J, Watanabe Y, Ohsugi M, Iino Y, Yamamoto M. Schizosaccharomyces pombe gad7+ encodes a phosphoprotein with a bZIP domain, which is required for proper G1 arrest and gene expression under nitrogen starvation. Genes Cells. 1996;1:391-408 pubmed
    ..Gad7 was co-immunoprecipitated with another bZIP protein Pcr1, suggesting that the two proteins form a heterodimer in vivo...
  2. Ohmiya R, Kato C, Yamada H, Aiba H, Mizuno T. Isolation of multicopy suppressors of the calcium sensitivity of a mutant lacking the bZIP transcription factor Atf1 in fission yeast. Mol Gen Genet. 1999;261:297-306 pubmed
    ..g., Atf1, Pcr1, Pap1), which function downstream of the Sty1 mitogen-activated protein kinase (MAPK) cascade which is involved in ..
  3. Yamada T, Mizuno K, Hirota K, Kon N, Wahls W, Hartsuiker E, et al. Roles of histone acetylation and chromatin remodeling factor in a meiotic recombination hotspot. EMBO J. 2004;23:1792-803 pubmed
    ..b>Pcr1. Chromatin remodeling occurs meiotically around M26...
  4. Kon N, Schroeder S, Krawchuk M, Wahls W. Regulation of the Mts1-Mts2-dependent ade6-M26 meiotic recombination hot spot and developmental decisions by the Spc1 mitogen-activated protein kinase of fission yeast. Mol Cell Biol. 1998;18:7575-83 pubmed
    ..hot spot in the ade6 gene of Schizosaccharomyces pombe is activated by the heterodimeric M26 binding protein Mts1-Mts2. The individual Mts1 (Atf1, Gad7) and Mts2 (Pcr1) proteins are also transcription factors involved in developmental ..
  5. Paredes V, Franco A, Madrid M, Soto T, Vicente Soler J, Gacto M, et al. Transcriptional and post-translational regulation of neutral trehalase in Schizosaccharomyces pombe during thermal stress. Yeast. 2004;21:593-603 pubmed
    ..Unlike what happens under osmostress or oxidative treatments, Sty1p has no role in the post-translational activation of neutral trehalase induced by heat shock in the fission yeast. ..
  6. Gao J, Davidson M, Wahls W. Distinct regions of ATF/CREB proteins Atf1 and Pcr1 control recombination hotspot ade6-M26 and the osmotic stress response. Nucleic Acids Res. 2008;36:2838-51 pubmed publisher
    ..We defined systematically the organization of Atf1 and its heterodimer partner Pcr1, which is required for a subset of Atf1-dependent functions...
  7. Yamada S, Okamura M, Oda A, Murakami H, Ohta K, Yamada T. Correlation of Meiotic DSB Formation and Transcription Initiation Around Fission Yeast Recombination Hotspots. Genetics. 2017;206:801-809 pubmed publisher
    ..similar to the cyclic AMP response element and activated by the ATF/CREB family transcription factor dimer Atf1-Pcr1. We first focused on one of those hotspots, ade6-3049, and Atf1...
  8. Gaits F, Degols G, Shiozaki K, Russell P. Phosphorylation and association with the transcription factor Atf1 regulate localization of Spc1/Sty1 stress-activated kinase in fission yeast. Genes Dev. 1998;12:1464-73 pubmed
    ..Nuclear localization of Atf1 requires Pcr1, a heterodimerization partner of Atf1...
  9. Wahls W. RNA associated with a heterodimeric protein that activates a meiotic homologous recombination hot spot: RL/RT/PCR strategy for cloning any unknown RNA or DNA. PCR Methods Appl. 1994;3:272-7 pubmed
    ..We have achieved 40,000-fold purification of a heterodimeric DNA-binding protein, Mts1/Mts2, that activates the recombination hot spot. Physical studies suggested the presence of a third subunit...
  10. Kato H, Kira S, Kawamukai M. The transcription factors Atf1 and Pcr1 are essential for transcriptional induction of the extracellular maltase Agl1 in fission yeast. PLoS ONE. 2013;8:e80572 pubmed publisher
    ..This was dependent on Atf1 and Pcr1, which are highly conserved transcription factors that regulate stress-responsive genes in various stress ..
  11. Togashi N, Yamashita A, Sato M, Yamamoto M. Functional significance of nuclear export and mRNA binding of meiotic regulator Spo5 in fission yeast. BMC Microbiol. 2014;14:188 pubmed publisher
    ..We identified pcr1+ mRNA as one of the critical targets of Spo5...
  12. Bandyopadhyay S, Ghosh P, Basu S, Paul M, Alam S, Das E, et al. Antagonistic regulation of cyclin expression by the bZIP transcription factors Pcr1 and Atf1 during G2/M transition. FEMS Microbiol Lett. 2017;364: pubmed publisher
    ..We show that the transcription factor Pcr1 can specifically inhibit the recruitment of Atf1 on cdc13 promoter and thereby prevent Atf1-mediated ..
  13. Noma K, Sugiyama T, Cam H, Verdel A, Zofall M, Jia S, et al. RITS acts in cis to promote RNA interference-mediated transcriptional and post-transcriptional silencing. Nat Genet. 2004;36:1174-80 pubmed
    ..This tethering promotes the processing of transcripts and generation of additional siRNAs for heterochromatin maintenance. ..
  14. Cherkasova V, Maury L, Bacikova D, Pridham K, Bahler J, Maraia R. Altered nuclear tRNA metabolism in La-deleted Schizosaccharomyces pombe is accompanied by a nutritional stress response involving Atf1p and Pcr1p that is suppressible by Xpo-t/Los1p. Mol Biol Cell. 2012;23:480-91 pubmed publisher
    ..pombe through its effects on nuclear tRNA processing and probably nuclear export. Finally, the results are discussed in the context of stress response programs in Saccharomyces cerevisiae. ..
  15. Rougemaille M, Braun S, Coyle S, Dumesic P, Garcia J, Isaac R, et al. Ers1 links HP1 to RNAi. Proc Natl Acad Sci U S A. 2012;109:11258-63 pubmed publisher
    ..Through the interactions described here, Ers1 may promote RNAi by tethering the corresponding enzyme complexes to HP1-coated chromatin, thereby placing them in proximity to the nascent noncoding RNA substrate...
  16. Janoo R, Neely L, Braun B, Whitehall S, Hoffman C. Transcriptional regulators of the Schizosaccharomyces pombe fbp1 gene include two redundant Tup1p-like corepressors and the CCAAT binding factor activation complex. Genetics. 2001;157:1205-15 pubmed
    ..In strains lacking tup11 and tup12, the atf1-pcr1 transcriptional activator continues to play a central role in fbp1-lacZ expression; however, spc1 MAPK ..
  17. Deng X, Zhou H, Zhang G, Wang W, Mao L, Zhou X, et al. Sgf73, a subunit of SAGA complex, is required for the assembly of RITS complex in fission yeast. Sci Rep. 2015;5:14707 pubmed publisher
    ..Our study unveils a moonlighting function of a SAGA subunit. It suggests Sgf73 is a novel factor that promotes assembly of RITS and RNAi-mediated heterochromatin formation. ..