Gene Symbol: nrm1
Description: protein nrm1
Alias: protein nrm1
Species: fission yeast

Top Publications

  1. Ayte J, Schweitzer C, Zarzov P, Nurse P, DeCaprio J. Feedback regulation of the MBF transcription factor by cyclin Cig2. Nat Cell Biol. 2001;3:1043-50 pubmed
    ..Cig2p can bind to Res2p, promote the phosphorylation of Res1p and inhibit MBF-dependent gene transcription. Cig2p thus forms an autoregulating feedback-inhibition loop with MBF which is important for normal regulation of the cell cycle. ..
  2. Caetano C, Klier S, de Bruin R. Phosphorylation of the MBF repressor Yox1p by the DNA replication checkpoint keeps the G1/S cell-cycle transcriptional program active. PLoS ONE. 2011;6:e17211 pubmed publisher
    ..This report shows that Yox1p binding to MBF is Nrm1-dependent and that Yox1p and Nrm1p require each other to bind and repress MBF targets...
  3. Kelly T, Martin G, Forsburg S, Stephen R, Russo A, Nurse P. The fission yeast cdc18+ gene product couples S phase to START and mitosis. Cell. 1993;74:371-82 pubmed
    ..In addition, the product of the cdc18+ gene is part of the checkpoint control that prevents mitosis from occurring until S phase is completed. Thus, cdc18+ plays a key role in coupling S phase to START and mitosis. ..
  4. de Bruin R, Kalashnikova T, Chahwan C, McDonald W, Wohlschlegel J, Yates J, et al. Constraining G1-specific transcription to late G1 phase: the MBF-associated corepressor Nrm1 acts via negative feedback. Mol Cell. 2006;23:483-96 pubmed
    G1-specific transcription in yeast depends upon SBF and MBF. We have identified Nrm1 (negative regulator of MBF targets 1), as a stable component of MBF...
  5. de Bruin R, Kalashnikova T, Aslanian A, Wohlschlegel J, Chahwan C, Yates J, et al. DNA replication checkpoint promotes G1-S transcription by inactivating the MBF repressor Nrm1. Proc Natl Acad Sci U S A. 2008;105:11230-5 pubmed publisher
    ..We show that Nrm1, an MBF-specific transcriptional repressor acting at the transition from G(1) to S phase of the cell cycle, is at ..
  6. Aligianni S, Lackner D, Klier S, Rustici G, Wilhelm B, Marguerat S, et al. The fission yeast homeodomain protein Yox1p binds to MBF and confines MBF-dependent cell-cycle transcription to G1-S via negative feedback. PLoS Genet. 2009;5:e1000626 pubmed publisher
    ..high transcription of MBF target genes and loss of their cell cycle-regulated expression, similar to deletion of nrm1. Genome-wide location analyses of Yox1p and the MBF component Cdc10p reveal dozens of genes whose promoters are ..
  7. Dutta C, Rhind N. The role of specific checkpoint-induced S-phase transcripts in resistance to replicative stress. PLoS ONE. 2009;4:e6944 pubmed publisher
    ..These results demonstrate the general importance of checkpoint regulation of G1/S transcription in response to replicative stress and elucidate the specific roles of Mik1 and Mrc1 in the checkpoint. ..
  8. Yoshida S, Al Amodi H, Nakamura T, McInerny C, Shimoda C. The Schizosaccharomyces pombe cdt2(+) gene, a target of G1-S phase-specific transcription factor complex DSC1, is required for mitotic and premeiotic DNA replication. Genetics. 2003;164:881-93 pubmed
    ..These observations suggest that cdt2(+) plays an important role in DNA replication in both the mitotic and the meiotic life cycles of fission yeast. ..
  9. Limbo O, Chahwan C, Yamada Y, de Bruin R, Wittenberg C, Russell P. Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination. Mol Cell. 2007;28:134-46 pubmed
    ..Transcription of ctp1(+) is periodic during the cell cycle, with the onset of its expression coinciding with the start of DNA replication. These data suggest that regulation of Ctp1 underlies cell-cycle control of HR. ..

More Information


  1. Ivanova T, Alves Rodrigues I, Gómez Escoda B, Dutta C, DeCaprio J, Rhind N, et al. The DNA damage and the DNA replication checkpoints converge at the MBF transcription factor. Mol Biol Cell. 2013;24:3350-7 pubmed publisher
    ..Thus Yox1 and Cdc10 couple normal cell cycle regulation in unperturbed conditions and the DNA replication and DNA damage checkpoints into a single transcriptional complex. ..
  2. Caetano C, Limbo O, Farmer S, Klier S, Dovey C, Russell P, et al. Tolerance of deregulated G1/S transcription depends on critical G1/S regulon genes to prevent catastrophic genome instability. Cell Rep. 2014;9:2279-89 pubmed publisher
    ..We report that deregulating the MBF G1/S regulon by eliminating the Nrm1 corepressor increases replication errors...