mms2

Summary

Gene Symbol: mms2
Description: ubiquitin-conjugating enzyme Mms2
Alias: spm2, ubiquitin-conjugating enzyme Mms2
Species: fission yeast

Top Publications

  1. Ranatunga N, Forsburg S. Characterization of a Novel MMS-Sensitive Allele of Schizosaccharomyces pombe mcm4. G3 (Bethesda). 2016;6:3049-3063 pubmed publisher
    ..Surprisingly, we found that the deletion of rif1+ suppressed the MMS-sensitive phenotype without affecting temperature sensitivity. Together, these data suggest that mcm4-c106 destabilizes replisome structure. ..
  2. Brown M, Zhu Y, Hemmingsen S, Xiao W. Structural and functional conservation of error-free DNA postreplication repair in Schizosaccharomyces pombe. DNA Repair (Amst). 2002;1:869-80 pubmed
    ..In the budding yeast Saccharomyces cerevisiae, MMS2 plays a key role in the error-free PRR pathway: the mms2 null mutant displays an increased spontaneous mutation ..
  3. Wen R, Torres Acosta J, Pastushok L, Lai X, Pelzer L, Wang H, et al. Arabidopsis UEV1D promotes Lysine-63-linked polyubiquitination and is involved in DNA damage response. Plant Cell. 2008;20:213-27 pubmed publisher
    ..The ubiquitin-conjugating enzyme Ubc13 and the Ubc enzyme variant (Uev) methyl methanesulfonate2 (Mms2) are required for this process...
  4. Dolan W, Le A, Schmidt H, Yuan J, Green M, Forsburg S. Fission yeast Hsk1 (Cdc7) kinase is required after replication initiation for induced mutagenesis and proper response to DNA alkylation damage. Genetics. 2010;185:39-53 pubmed publisher
    ..We conclude that Hsk1-Dfp1 kinase functions post-initiation to maintain replication fork stability, an activity potentially mediated by the C terminus of Dfp1. ..
  5. Groocock L, Prudden J, Perry J, Boddy M. The RecQ4 orthologue Hrq1 is critical for DNA interstrand cross-link repair and genome stability in fission yeast. Mol Cell Biol. 2012;32:276-87 pubmed publisher
    ..Genetic epistasis analyses reveal that Hrq1 acts parallel to the PCNA/Ubc13/Mms2-dependent postreplication repair (PRR) pathway...
  6. Mastro T, Forsburg S. Increased meiotic crossovers and reduced genome stability in absence of Schizosaccharomyces pombe Rad16 (XPF). Genetics. 2014;198:1457-72 pubmed publisher
    ..Thus, the XPF/XPA module of the nucleotide excision repair pathway is incorporated into multiple aspects of genome maintenance even in the absence of external DNA damage. ..
  7. Frampton J, Irmisch A, Green C, Neiss A, Trickey M, Ulrich H, et al. Postreplication repair and PCNA modification in Schizosaccharomyces pombe. Mol Biol Cell. 2006;17:2976-85 pubmed
    ..We show that PCNA modification and cell cycle checkpoints represent two independent signals in response to DNA damage. Finally, we unexpectedly find that PCNA is ubiquitinated in response to DNA damage when cells are arrested in G2. ..