Gene Symbol: mes1
Description: protein Mes1
Alias: protein Mes1
Species: fission yeast
Izawa D, Goto M, Yamashita A, Yamano H, Yamamoto M. Fission yeast Mes1p ensures the onset of meiosis II by blocking degradation of cyclin Cdc13p. Nature. 2005;434:529-33 pubmed
..However, fission yeast Mes1p is essential for MII but dispensable for mitosis. The mes1-B44 mutant arrests before MII...
Kimata Y, Trickey M, Izawa D, Gannon J, Yamamoto M, Yamano H. A mutual inhibition between APC/C and its substrate Mes1 required for meiotic progression in fission yeast. Dev Cell. 2008;14:446-54 pubmed publisher
..Here we show that fission yeast Mes1 is a substrate of the APC/C as well as an inhibitor, allowing autoregulation of the APC/C in meiosis...
Xu X, Zhang Z, Gu L, Wang F. [BTLA Characterization and its association with disease progression in patients with chronic HIV-1 infection.]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009;25:1158-60 pubmed
..Manipulation of BTLA inhibitory pathway may present an alternative strategy for overcoming immune activation for this disease. ..
Arata M, Sato M, Yamashita A, Yamamoto M. The RNA-binding protein Spo5 promotes meiosis II by regulating cyclin Cdc13 in fission yeast. Genes Cells. 2014;19:225-38 pubmed publisher
Kimata Y, Kitamura K, Fenner N, Yamano H. Mes1 controls the meiosis I to meiosis II transition by distinctly regulating the anaphase-promoting complex/cyclosome coactivators Fzr1/Mfr1 and Slp1 in fission yeast. Mol Biol Cell. 2011;22:1486-94 pubmed publisher
..We previously showed that the fission yeast meiosis-specific protein Mes1 binds to a coactivator and inhibits APC/C; however, regulation of the Mes1-mediated APC/C inhibition remains ..
Aoi Y, Arai K, Miyamoto M, Katsuta Y, Yamashita A, Sato M, et al
. Cuf2 boosts the transcription of APC/C activator Fzr1 to terminate the meiotic division cycle. EMBO Rep. 2013;14:553-60 pubmed publisher
..fzr1? also enters a third nuclear division. Thus, Cuf2 ensures termination of the M-phase cycle by boosting Fzr1 expression to generate functional gametes. ..