Gene Symbol: mei4
Description: meiotic forkhead transcription factor Mei4
Alias: dot4, meiotic forkhead transcription factor Mei4
Species: fission yeast

Top Publications

  1. Abe H, Shimoda C. Autoregulated expression of Schizosaccharomyces pombe meiosis-specific transcription factor Mei4 and a genome-wide search for its target genes. Genetics. 2000;154:1497-508 pubmed
    The Schizosaccharomyces pombe mei4(+) gene encoding a forkhead transcription factor is necessary for the progression of meiosis and sporulation...
  2. Okuzaki D, Satake W, Hirata A, Nojima H. Fission yeast meu14+ is required for proper nuclear division and accurate forespore membrane formation during meiosis II. J Cell Sci. 2003;116:2721-35 pubmed
    ..Its transcription is dependent on the meiosis-specific transcription factor Mei4. In meu14Delta cells, the segregation and modification of the SPBs (spindle pole bodies) and microtubule elongation ..
  3. Ogino K, Masai H. Rad3-Cds1 mediates coupling of initiation of meiotic recombination with DNA replication. Mei4-dependent transcription as a potential target of meiotic checkpoint. J Biol Chem. 2006;281:1338-44 pubmed
    ..On the other hand, the transcriptional induction of the mei4+ transcription factor and cdc25+ phosphatase, which is significantly suppressed by hydroxyurea in the wild-type ..
  4. Horie S, Watanabe Y, Tanaka K, Nishiwaki S, Fujioka H, Abe H, et al. The Schizosaccharomyces pombe mei4+ gene encodes a meiosis-specific transcription factor containing a forkhead DNA-binding domain. Mol Cell Biol. 1998;18:2118-29 pubmed
    The mei4+ gene of the fission yeast Schizosaccharomyces pombe was cloned by functional complementation. The mei4 disruptant failed to complete meiosis-I but could proliferate normally...
  5. Murakami Tonami Y, Yamada Namikawa C, Tochigi A, Hasegawa N, Kojima H, Kunimatsu M, et al. Mei4p coordinates the onset of meiosis I by regulating cdc25+ in fission yeast. Proc Natl Acad Sci U S A. 2007;104:14688-93 pubmed
    ..yeast, the forkhead-type transcription factor Mei4p is required for expression of many genes during meiosis, with mei4 mutant cells arresting before meiosis I...
  6. Mata J, Wilbrey A, Bahler J. Transcriptional regulatory network for sexual differentiation in fission yeast. Genome Biol. 2007;8:R217 pubmed
    ..regulation by examining transcriptomes after genetic perturbations (gene deletion and/or overexpression) of rep1, mei4, atf21 and atf31, which encode known transcription factors controlling sexual differentiation...
  7. Moiseeva V, Amelina H, Collopy L, Armstrong C, Pearson S, Tomita K. The telomere bouquet facilitates meiotic prophase progression and exit in fission yeast. Cell Discov. 2017;3:17041 pubmed publisher
    ..Our findings illustrate that chromosome contact with the nuclear membrane synchronises meiotic progression of the nucleoplasmic chromosomes with that of the cytoplasmic SPB. ..
  8. Nakamura Kubo M, Hirata A, Shimoda C, Nakamura T. The fission yeast pleckstrin homology domain protein Spo7 is essential for initiation of forespore membrane assembly and spore morphogenesis. Mol Biol Cell. 2011;22:3442-55 pubmed publisher
    ..Our study suggests that Spo7 coordinates formation of the leading edge and initiation of FSM assembly, thereby accomplishing accurate formation of the FSM...
  9. Nakase Y, Hirata A, Shimoda C, Nakamura T. Ectopic overproduction of a sporulation-specific transcription factor induces assembly of prespore-like membranous compartments in vegetative cells of fission yeast. Genetics. 2009;183:1195-9 pubmed publisher
    b>Mei4 is a key sporulation-specific transcription factor in fission yeast...

More Information


  1. Shimada M, Yamada Namikawa C, Murakami Tonami Y, Yoshida T, Nakanishi M, Urano T, et al. Cdc2p controls the forkhead transcription factor Fkh2p by phosphorylation during sexual differentiation in fission yeast. EMBO J. 2008;27:132-42 pubmed
    ..We propose that functional interaction between Cdks and forkhead transcription factors may link the mitotic cell cycle and sexual differentiation. ..
  2. Ruan K, Yamamoto T, Asakawa H, Chikashige Y, Masukata H, Haraguchi T, et al. Meiotic nuclear movements in fission yeast are regulated by the transcription factor Mei4 downstream of a Cds1-dependent replication checkpoint pathway. Genes Cells. 2015;20:160-72 pubmed publisher
    ..that this prolongation was caused by the Cds1-dependent replication checkpoint, which represses expression of the mei4(+) gene encoding a meiosis-specific transcription factor...
  3. Sugiyama T, Thillainadesan G, Chalamcharla V, Meng Z, Balachandran V, Dhakshnamoorthy J, et al. Enhancer of Rudimentary Cooperates with Conserved RNA-Processing Factors to Promote Meiotic mRNA Decay and Facultative Heterochromatin Assembly. Mol Cell. 2016;61:747-759 pubmed publisher
    ..Our results reveal connections among Erh1, CCR4-NOT, Pir2/ARS2, and RNAi, which target heterochromatin to regulate gene expression and protect genome integrity. ..
  4. Nakamura T, Abe H, Hirata A, Shimoda C. ADAM family protein Mde10 is essential for development of spore envelopes in the fission yeast Schizosaccharomyces pombe. Eukaryot Cell. 2004;3:27-39 pubmed a gene possessing a FLEX element, which forms a binding site for the meiosis-specific transcription factor Mei4. In fact, mde10+ is transcribed only in diploid cells that are induced to meiosis in a Mei4-dependent manner...
  5. Nakamura T, Nakamura Kubo M, Nakamura T, Shimoda C. Novel fission yeast Cdc7-Dbf4-like kinase complex required for the initiation and progression of meiotic second division. Mol Cell Biol. 2002;22:309-20 pubmed
    ..These results suggest that Spo4 is a Cdc7 kinase whose primary role is in meiosis, not in DNA replication. This is the first report of an organism which has two Cdc7-related kinase complexes with different biological functions. ..
  6. Sugiyama T, Sugioka Sugiyama R. Red1 promotes the elimination of meiosis-specific mRNAs in vegetatively growing fission yeast. EMBO J. 2011;30:1027-39 pubmed publisher
    ..These results demonstrate that Red1 is involved in DSR-directed RNA decay to prevent ectopic expression of meiotic mRNAs in vegetative cells. ..
  7. Ioannoni R, Brault A, Labbé S. Cuf2 Is a Transcriptional Co-Regulator that Interacts with Mei4 for Timely Expression of Middle-Phase Meiotic Genes. PLoS ONE. 2016;11:e0151914 pubmed publisher
    ..Cuf2 operates through a transcriptional mechanism, it is unable to perform its function in the absence of the Mei4 transcription factor, which is a member of the conserved forkhead protein family...
  8. Moldón A, Malapeira J, Gabrielli N, Gogol M, Gómez Escoda B, Ivanova T, et al. Promoter-driven splicing regulation in fission yeast. Nature. 2008;455:997-1000 pubmed publisher
    ..This regulation is dependent on two transcription factors of the forkhead family, Mei4 (ref. 2) and Fkh2 (ref. 3)...
  9. Plante S, Ioannoni R, Beaudoin J, Labbe S. Characterization of Schizosaccharomyces pombe copper transporter proteins in meiotic and sporulating cells. J Biol Chem. 2014;289:10168-81 pubmed publisher
    ..exclusively dependent on the presence of Cuf1, ctr6(+) gene expression relies on two distinct regulators, Cuf1 and Mei4. Ctr4 and Ctr5 proteins co-localize at the plasma membrane shortly after meiotic induction, whereas Ctr6 is located ..
  10. Alves Rodrigues I, Ferreira P, Moldón A, Vivancos A, Hidalgo E, Guigó R, et al. Spatiotemporal Control of Forkhead Binding to DNA Regulates the Meiotic Gene Expression Program. Cell Rep. 2016;14:885-895 pubmed publisher
    ..b>Mei4 is a forkhead transcription factor that controls the expression of mid-meiotic genes...
  11. Young J, Hyppa R, Smith G. Conserved and nonconserved proteins for meiotic DNA breakage and repair in yeasts. Genetics. 2004;167:593-605 pubmed
    ..DNA breakage required the S. pombe midmeiosis transcription factor Mei4, but the structurally unrelated midmeiosis transcription factor Ndt80 is not required for breakage in S. cerevisiae...
  12. Kakihara Y, Nabeshima K, Hirata A, Nojima H. Overlapping omt1+ and omt2+ genes are required for spore wall maturation in Schizosaccharomyces pombe. Genes Cells. 2003;8:547-58 pubmed
    ..Generation of overlapped RNA may be due to loose regulation of transcription termination during meiosis of S. pombe. ..