Gene Symbol: mei2
Description: RNA-binding protein Mei2
Alias: RNA-binding protein Mei2
Species: fission yeast

Top Publications

  1. Sato M, Watanabe Y, Akiyoshi Y, Yamamoto M. 14-3-3 protein interferes with the binding of RNA to the phosphorylated form of fission yeast meiotic regulator Mei2p. Curr Biol. 2002;12:141-5 pubmed
    ..This model will explain, at least partly, why phosphorylation by Pat1 kinase inhibits the meiosis-inducing activity of Mei2p. ..
  2. Watanabe Y, Yamamoto M. S. pombe mei2+ encodes an RNA-binding protein essential for premeiotic DNA synthesis and meiosis I, which cooperates with a novel RNA species meiRNA. Cell. 1994;78:487-98 pubmed
    ..Here, we show that S. pombe mei2, which is essential for the initiation of premeiotic DNA synthesis, encodes an RNA-binding protein...
  3. St André O, Lemieux C, Perreault A, Lackner D, Bahler J, Bachand F. Negative regulation of meiotic gene expression by the nuclear poly(a)-binding protein in fission yeast. J Biol Chem. 2010;285:27859-68 pubmed publisher
    ..Our findings have therefore uncovered a mode of gene regulation whereby a poly(A)-binding protein promotes RNA degradation in the nucleus to prevent untimely expression. ..
  4. Harigaya Y, Tanaka H, Yamanaka S, Tanaka K, Watanabe Y, Tsutsumi C, et al. Selective elimination of messenger RNA prevents an incidence of untimely meiosis. Nature. 2006;442:45-50 pubmed
    ..these foci precipitate to a single focus, which coincides with the dot formed by the master meiosis-regulator Mei2. A meiotic arrest due to the loss of the Mei2 dot is released by a reduction in Mmi1 activity...
  5. Shimada T, Yamashita A, Yamamoto M. The fission yeast meiotic regulator Mei2p forms a dot structure in the horse-tail nucleus in association with the sme2 locus on chromosome II. Mol Biol Cell. 2003;14:2461-9 pubmed
    ..We speculate that the Mei2p dot is a specialized structure, either to foster the assembly of Mei2p and meiRNA or to perform some unidentified function indispensable for meiosis I. ..
  6. Yamashita A, Watanabe Y, Yamamoto M. Microtubule-associated coiled-coil protein Ssm4 is involved in the meiotic development in fission yeast. Genes Cells. 1997;2:155-66 pubmed
    ..To dissect the function of this RNA and its partner RNA-binding protein Mei2, we screened for high-copy-number suppressors of the arrest prior to the first meiotic division caused by loss of ..
  7. Watanabe Y, Shinozaki Yabana S, Chikashige Y, Hiraoka Y, Yamamoto M. Phosphorylation of RNA-binding protein controls cell cycle switch from mitotic to meiotic in fission yeast. Nature. 1997;386:187-90 pubmed
    ..Here we show that the RNA-binding protein Mei2 is a substrate of Pat1 kinase and that dephosphorylation of Mei2 is sufficient to switch cells from the mitotic ..
  8. Kitamura K, Katayama S, Dhut S, Sato M, Watanabe Y, Yamamoto M, et al. Phosphorylation of Mei2 and Ste11 by Pat1 kinase inhibits sexual differentiation via ubiquitin proteolysis and 14-3-3 protein in fission yeast. Dev Cell. 2001;1:389-99 pubmed
    Fission yeast Pat1 kinase inhibits sexual differentiation by phosphorylating the meiotic inducer Mei2 and the transcription factor Ste11. Here, we show how Pat1 downregulates these proteins...
  9. Yamashita A, Watanabe Y, Nukina N, Yamamoto M. RNA-assisted nuclear transport of the meiotic regulator Mei2p in fission yeast. Cell. 1998;95:115-23 pubmed
    ..These results indicate that meiRNA contributes to the promotion of meiosis I exclusively as a cofactor that assists nuclear transport of Mei2p. ..

More Information


  1. Sukegawa Y, Yamashita A, Yamamoto M. The fission yeast stress-responsive MAPK pathway promotes meiosis via the phosphorylation of Pol II CTD in response to environmental and feedback cues. PLoS Genet. 2011;7:e1002387 pubmed publisher
    The RRM-type RNA-binding protein Mei2 is a master regulator of meiosis in fission yeast, in which it stabilizes meiosis-specific mRNAs by blocking their destruction...
  2. Alvarez B, Moreno S. Fission yeast Tor2 promotes cell growth and represses cell differentiation. J Cell Sci. 2006;119:4475-85 pubmed interfering with the functions of the transcription factor Ste11 and the meiosis-promoting RNA-binding protein Mei2. Thus, our data reveal a unique regulatory function of the Tor pathway - ensuring that growth and cell ..
  3. Shinozaki Yabana S, Watanabe Y, Yamamoto M. Novel WD-repeat protein Mip1p facilitates function of the meiotic regulator Mei2p in fission yeast. Mol Cell Biol. 2000;20:1234-42 pubmed
    ..These results suggest that Mip1p assists functional expression of a number of proteins required for proliferation and sexual development in fission yeast. ..
  4. Jeffares D, Phillips M, Moore S, Veit B. A description of the Mei2-like protein family; structure, phylogenetic distribution and biological context. Dev Genes Evol. 2004;214:149-58 pubmed
    The Schizosaccharomyces pombe Mei2 gene encodes an RNA recognition motif (RRM) protein that stimulates meiosis upon binding a specific non-coding RNA and subsequent accumulation in a "mei2-dot" in the nucleus...
  5. Yamashita A, Takayama T, Iwata R, Yamamoto M. A novel factor Iss10 regulates Mmi1-mediated selective elimination of meiotic transcripts. Nucleic Acids Res. 2013;41:9680-7 pubmed publisher
    ..During meiosis, Mmi1 is sequestered by a chromosome-associated dot structure, Mei2 dot, allowing meiosis-specific transcripts to be stably expressed...
  6. Tanaka Y, Okuzaki D, Yabuta N, Yoneki T, Nojima H. Rad24 is essential for proliferation of diploid cells in fission yeast. FEBS Lett. 2000;472:254-8 pubmed
    ..We found that a cumulative deletion of mei2(+) gene almost completely suppressed this defect, and demonstrated using two-hybrid analysis that Rad24 protein ..
  7. Matsuyama A, Yabana N, Watanabe Y, Yamamoto M. Schizosaccharomyces pombe Ste7p is required for both promotion and withholding of the entry to meiosis. Genetics. 2000;155:539-49 pubmed
    ..These observations suggest that Ste7p may have a function to suppress the onset of meiosis until the conjugation process has been duly completed. ..
  8. DeVoti J, Seydoux G, Beach D, McLeod M. Interaction between ran1+ protein kinase and cAMP dependent protein kinase as negative regulators of fission yeast meiosis. EMBO J. 1991;10:3759-68 pubmed
    ..unregulated cAPK activity or unregulated ran1+ kinase activity is due to inability to induce transcription of the mei2+ gene, which is required for meiotic initiation...
  9. Yamamoto M. The selective elimination of messenger RNA underlies the mitosis-meiosis switch in fission yeast. Proc Jpn Acad Ser B Phys Biol Sci. 2010;86:788-97 pubmed
    ..environmental conditions including the nutrient status converge on the activity of an RRM-type RNA-binding protein, Mei2. This protein plays pivotal roles in both the induction and progression of meiosis and has now been found to govern ..
  10. Otsubo Y, Yamashita A, Ohno H, Yamamoto M. S. pombe TORC1 activates the ubiquitin-proteasomal degradation of the meiotic regulator Mei2 in cooperation with Pat1 kinase. J Cell Sci. 2014;127:2639-46 pubmed publisher
    ..that fission yeast TORC1, which promotes vegetative growth and suppresses sexual development, can phosphorylate Mei2 (a specific factor involved in switching the cell fate) in vitro...