Gene Symbol: int6
Description: eukaryotic translation initiation factor 3 subunit E
Alias: yin6, eukaryotic translation initiation factor 3 subunit E
Species: fission yeast

Top Publications

  1. Akiyoshi Y, Clayton J, Phan L, Yamamoto M, Hinnebusch A, Watanabe Y, et al. Fission yeast homolog of murine Int-6 protein, encoded by mouse mammary tumor virus integration site, is associated with the conserved core subunits of eukaryotic translation initiation factor 3. J Biol Chem. 2001;276:10056-62 pubmed
    ..not encode a protein closely related to murine Int-6, fission yeast does encode an Int-6 ortholog, designated here Int6. We found that fission yeast Int6/eIF3e is a cytoplasmic protein associated with 40 S ribosomes...
  2. Dunand Sauthier I, Walker C, Wilkinson C, Gordon C, Crane R, Norbury C, et al. Sum1, a component of the fission yeast eIF3 translation initiation complex, is rapidly relocalized during environmental stress and interacts with components of the 26S proteasome. Mol Biol Cell. 2002;13:1626-40 pubmed
    ..Sum1 is associated with the 40S ribosome and interacts stably with Int6, an eIF3 component, in vivo, suggesting that Sum1 is a component of the eIF3 complex...
  3. Yen H, Gordon C, Chang E. Schizosaccharomyces pombe Int6 and Ras homologs regulate cell division and mitotic fidelity via the proteasome. Cell. 2003;112:207-17 pubmed
    Yin6 is a yeast homolog of Int6, which is implicated in tumorigenesis. We show that Yin6 binds to and regulates proteasome activity...
  4. Sha Z, Yen H, Scheel H, Suo J, Hofmann K, Chang E. Isolation of the Schizosaccharomyces pombe proteasome subunit Rpn7 and a structure-function study of the proteasome-COP9-initiation factor domain. J Biol Chem. 2007;282:32414-23 pubmed
    ..We have previously characterized the PCI protein Yin6, a fission yeast ortholog of the mammalian Int6 that has been implicated in breast oncogenesis, and demonstrated ..
  5. Sha Z, Brill L, Cabrera R, Kleifeld O, Scheliga J, Glickman M, et al. The eIF3 interactome reveals the translasome, a supercomplex linking protein synthesis and degradation machineries. Mol Cell. 2009;36:141-52 pubmed publisher
  6. Bandyopadhyay A, Matsumoto T, Maitra U. Fission yeast Int6 is not essential for global translation initiation, but deletion of int6(+) causes hypersensitivity to caffeine and affects spore formation. Mol Biol Cell. 2000;11:4005-18 pubmed
    Mammalian INT6 protein has been considered to be a subunit of the eukaryotic translation initiation factor, eIF3. The Int6 locus is also known as a common integration site of mouse mammary tumor virus (MMTV)...
  7. Yen H, Chang E. Yin6, a fission yeast Int6 homolog, complexes with Moe1 and plays a role in chromosome segregation. Proc Natl Acad Sci U S A. 2000;97:14370-5 pubmed
    ..We isolated an Int6 homolog from fission yeast, Yin6, by its binding to a conserved protein in the Ras pathway, Moe1...
  8. Bandyopadhyay A, Lakshmanan V, Matsumoto T, Chang E, Maitra U. Moe1 and spInt6, the fission yeast homologues of mammalian translation initiation factor 3 subunits p66 (eIF3d) and p48 (eIF3e), respectively, are required for stable association of eIF3 subunits. J Biol Chem. 2002;277:2360-7 pubmed
    ..These phenotypes of Deltamoe1 cells are similar to those reported previously for deletion of the fission yeast int6(+) gene that encodes the fission yeast homologue of the p48/Int6/eIF3e subunit of mammalian eIF3...
  9. Crane R, Craig R, Murray R, Dunand Sauthier I, Humphrey T, Norbury C. A fission yeast homolog of Int-6, the mammalian oncoprotein and eIF3 subunit, induces drug resistance when overexpressed. Mol Biol Cell. 2000;11:3993-4003 pubmed
    ..Fission yeast Int6 was shown to interact with other presumptive components of eIF3 in vivo, and was present in size fractions ..

More Information


  1. Otero J, Suo J, Gordon C, Chang E. Int6 and Moe1 interact with Cdc48 to regulate ERAD and proper chromosome segregation. Cell Cycle. 2010;9:147-61 pubmed
    b>Int6/eIF3e is implicated in tumorigenesis, but its molecular functions remain unclear...
  2. Shah M, Su D, Scheliga J, Pluskal T, Boronat S, Motamedchaboki K, et al. A Transcript-Specific eIF3 Complex Mediates Global Translational Control of Energy Metabolism. Cell Rep. 2016;16:1891-902 pubmed publisher
    ..Thus, via its eIF3d-eIF3e module, eIF3 orchestrates an mRNA-specific translational mechanism controlling energy metabolism that may be disrupted in cancer. ..
  3. Nemoto N, Udagawa T, Ohira T, Jiang L, Hirota K, Wilkinson C, et al. The roles of stress-activated Sty1 and Gcn2 kinases and of the protooncoprotein homologue Int6/eIF3e in responses to endogenous oxidative stress during histidine starvation. J Mol Biol. 2010;404:183-201 pubmed publisher
    ..The translation factor subunit Int6/eIF3e promotes Sty1-dependent response by increasing the abundance of Atf1, a transcription factor targeted by Sty1...
  4. Ray A, Bandyopadhyay A, Matsumoto T, Deng H, Maitra U. Fission yeast translation initiation factor 3 subunit eIF3h is not essential for global translation initiation, but deletion of eif3h+ affects spore formation. Yeast. 2008;25:809-23 pubmed publisher
    ..The implications of these results in relation to the functions of eIF3h in Sz. pombe are discussed. ..
  5. Zhou C, Arslan F, Wee S, Krishnan S, Ivanov A, Oliva A, et al. PCI proteins eIF3e and eIF3m define distinct translation initiation factor 3 complexes. BMC Biol. 2005;3:14 pubmed
    ..We propose that the PCI proteins eIF3e and eIF3m define distinct eIF3 complexes that may assist in the translation of different sets of mRNAs. ..
  6. Matsumoto S, Bandyopadhyay A, Kwiatkowski D, Maitra U, Matsumoto T. Role of the Tsc1-Tsc2 complex in signaling and transport across the cell membrane in the fission yeast Schizosaccharomyces pombe. Genetics. 2002;161:1053-63 pubmed
    ..We also show that fission yeast Int6 is involved in a similar process, but functions in an independent genetic pathway.
  7. Udagawa T, Nemoto N, Wilkinson C, Narashimhan J, Jiang L, Watt S, et al. Int6/eIF3e promotes general translation and Atf1 abundance to modulate Sty1 MAPK-dependent stress response in fission yeast. J Biol Chem. 2008;283:22063-75 pubmed publisher
    ..Here we report that the fission yeast int6(+) is required for overcoming stress imposed by histidine starvation, using the drug 3-aminotriazole (3AT)...
  8. Jenkins C, Mata J, Crane R, Thomas B, Akoulitchev A, Bahler J, et al. Activation of AP-1-dependent transcription by a truncated translation initiation factor. Eukaryot Cell. 2005;4:1840-50 pubmed
    b>Int6/eIF3e is a highly conserved subunit of eukaryotic translation initiation factor 3 (eIF3) that has also been reported to interact with subunits of the proteasome and the COP9 signalosome...
  9. Cabrera R, Sha Z, Vadakkan T, Otero J, Kriegenburg F, Hartmann Petersen R, et al. Proteasome nuclear import mediated by Arc3 can influence efficient DNA damage repair and mitosis in Schizosaccharomyces pombe. Mol Biol Cell. 2010;21:3125-36 pubmed publisher
    ..These data suggest that proteasomes display Arc3-dependent mobility in the cell, and mobile proteasomes can efficiently access substrates throughout the cell, allowing them to effectively regulate cell-compartment-specific activities. ..